Hepatoprotective actions of melatonin by mainly modulating oxidative status and apoptosis rate in lipopolysaccharide-induced liver damage
This study aimed to evaluate the protective and therapeutic potential of melatonin in rats with lipopolysaccharide-induced sepsis.MAIN METHODS: Female Spraque-Dawley rats received single a dose of 7.5 mg/kg lipopolysaccharide in saline to create a 24-hour sepsis model. One of the other groups received melatonin at a dose of 10 mg/kg/day beginning 1 week before sepsis induction to the end of the experiment. The melatonin group received the same doses of melatonin for the same duration but not lipopolysaccharide. The vehicle group received the same doses of saline, the vehicle of melatonin, for the same duration. Twenty-four...
Source: Immunopharmacology and Immunotoxicology - December 5, 2023 Category: Allergy & Immunology Authors: Mukaddes Esrefo ğlu Tugce Kubra Kalkan Ersin Karatas Birsen Elibol E Rumeysa Hekimoglu Fatma Bedia Karakaya Cimen Arzu Hanim Yay Source Type: research

The transcriptomic profile shows the protective effects of celecoxib on cirrhotic splenomegaly
CONCLUSIONS: Celecoxib attenuates cirrhotic splenomegaly by inhibiting splenic immune cell proliferation, inflammation, and fibrogenesis. The current study sheds light on the therapeutic strategy of liver cirrhosis by targeting splenic abnormalities and provides COX-2 inhibitors as a novel medical treatment for cirrhotic splenomegaly.PMID:38047472 | DOI:10.1080/08923973.2023.2281282 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - December 4, 2023 Category: Allergy & Immunology Authors: Yanting Ye Shihang Tang Yang Tai Chong Zhao Chengwei Tang Zhiyin Huang Jinhang Gao Source Type: research

Songorine inhibits oxidative stress-related inflammation through PI3K/AKT/NRF2 signaling pathway to alleviate lipopolysaccharide-induced septic acute lung injury
CONCLUSION: Songorine inhibits oxidative stress-related inflammation in sepsis-induced ALI via the activation of the PI3K/AKT/NRF2 signaling pathway.PMID:37977206 | DOI:10.1080/08923973.2023.2281902 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - November 17, 2023 Category: Allergy & Immunology Authors: Jingjing Fang Qin Huang Chaolu Shi Lei Gai Xinnian Wang Biqing Yan Source Type: research