Ciclopirox mitigates inflammatory response in LPS-induced septic shock via inactivation of SORT1-mediated wnt/ β-Catenin signaling pathway
Conclusions: In sum, we found that CPX protected against LPS-induced septic shock by mitigating inflammation via SORT1-mediated Wnt/β-Catenin signaling pathway.PMID:37606515 | DOI:10.1080/08923973.2023.2231628 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 22, 2023 Category: Allergy & Immunology Authors: Liangliang Zhou Yingfeng He Yijun Deng Xinxin Li Wei Wang Jianjun Chen Source Type: research

Protective Effect of Pregabalin on Renal and Renal Endothelial Damage in Sepsis Induced by Lipopolysaccharide
Immunopharmacol Immunotoxicol. 2023 Aug 22:1-16. doi: 10.1080/08923973.2023.2250911. Online ahead of print.ABSTRACTWe investigated the protective effects of pregabalin (PRG) on kidney and renal endothelial damage in sepsis induced by Lipopolysaccharide (LPS). Rats randomly divided into three groups as control, LPS and LPS + PRG. Saline solution was administered 30 mg/kg orally and 5 mg/kg intraperitoneally (i.p.) to the control group. LPS was applied as 5 mg/kg, i.p. to the LPS group. In the LPS + PRG group, PRG at 30 mg/kg orally and one hour before LPS administration, one hour later 5 mg/kg i.p. LPS was applied. Rats wer...
Source: Immunopharmacology and Immunotoxicology - August 22, 2023 Category: Allergy & Immunology Authors: Dilek Çevik Nurhan G ümral Rahime Aslanko ç Özlem Özmen Arzu Yal çın O ğuzhan Kavrık Source Type: research

Ciclopirox mitigates inflammatory response in LPS-induced septic shock via inactivation of SORT1-mediated wnt/ β-Catenin signaling pathway
Conclusions: In sum, we found that CPX protected against LPS-induced septic shock by mitigating inflammation via SORT1-mediated Wnt/β-Catenin signaling pathway.PMID:37606515 | DOI:10.1080/08923973.2023.2231628 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 22, 2023 Category: Allergy & Immunology Authors: Liangliang Zhou Yingfeng He Yijun Deng Xinxin Li Wei Wang Jianjun Chen Source Type: research

Macrophages morphology and cytokine reeducation by < em > ex situ < /em > copper thiol complexes
CONCLUSIONS: The capacity of copper thiol complexes to reeducate M1 to M2 morphoexpression can be promising for cell protection by using copper thiol penicillamine or immuno-regeneration of tissues when using copper thiol cysteine.PMID:37584252 | DOI:10.1080/08923973.2023.2245559 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 16, 2023 Category: Allergy & Immunology Authors: Jorge Xool-Tamayo V íctor Ermilo Arana-Argaez Fabiola Villa-de la Torre Ivan Chan-Zapata Rossana F Vargas-Coronado Juan V Cauich-Rodr íguez Source Type: research

mTORC1 inhibition may improve T lymphocytes affected by aging
DISCUSSION: In line with studies noting mTOR inhibitors as antiaging drugs, Metformin and Everolimus may improve T cells affected from aging in vitro, and a decrease in intracellular oxidative stress may be one of their mechanism of function.PMID:37581412 | DOI:10.1080/08923973.2023.2232101 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 15, 2023 Category: Allergy & Immunology Authors: F Asghari M H Karimi A A Pourfathollah Source Type: research

Immunomodulatory effect of vitamin D supplementation on Beh çet's disease patients: effect on nitric oxide and Th17/Treg cytokines production
Conclusions: Collectively, our data suggest that vitamin D supplementation in combination with conventional treatments has a beneficial effect and could constitute a good therapeutic candidate for alleviating inflammatory responses during Behçet disease.PMID:37535442 | DOI:10.1080/08923973.2023.2239490 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 3, 2023 Category: Allergy & Immunology Authors: Randa Oubouchou Zineb Ait Arab -Djeraba Yassmine Kemikem Fifi Otmani Chafia Touil-Boukoffa Source Type: research