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T-cell metabolism in rheumatoid arthritis: focus on mitochondrial and lysosomal dysfunction
Discussion: T-cells are identified as the primary initiators of immunological abnormalities in RA. These RA T-cells show a distinct metabolic pattern compared to the healthy individuals. Dampened glycolytic flux, poor ATP production, and shifting of glucose to the pentose phosphate pathway resulting in increased NADPH and decreased ROS levels are the common metabolic patterns observed in RA T-cells. Defective mtDNA due to lack of MRE11A gene, a key molecular actor for resection, and inefficient lysosomal function due to misplacement of AMPK on the lysosomal surface were found to be responsible for mitochondrial and lysosom...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Asmita Parab Lokesh Kumar Bhatt Source Type: research

Immuno-metabolic reprogramming of T cell: a new frontier for pharmacotherapy of Rheumatoid arthritis
Immunopharmacol Immunotoxicol. 2024 Mar 25:1-11. doi: 10.1080/08923973.2024.2330636. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a persistent autoimmune condition characterized by ongoing inflammation primarily affecting the synovial joint. This inflammation typically arises from an increase in immune cells such as neutrophils, macrophages, and T cells (TC). TC is recognized as a major player in RA pathogenesis. The involvement of HLA-DRB1 and PTPN-2 among RA patients confirms the TC involvement in RA. Metabolism of TC is maintained by various other factors like cytokines, mitochondrial proteins & other ...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Sourav Mondal Sarthak Saha Debjeet Sur Source Type: research

Immunosuppressants against acute kidney injury: what to prefer or to avoid?
Conclusion: Understanding the effects of immunosuppressants on AKI is crucial for optimizing patient care. This review highlights the need for further research to determine the most suitable immunosuppressants for AKI patients, considering both their efficacy and potential side effects.PMID:38477877 | DOI:10.1080/08923973.2024.2330641 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Swati Mishra Vishwadeep Shelke Neha Dagar Maciej Lech Anil Bhanudas Gaikwad Source Type: research

T-cell metabolism in rheumatoid arthritis: focus on mitochondrial and lysosomal dysfunction
Discussion: T-cells are identified as the primary initiators of immunological abnormalities in RA. These RA T-cells show a distinct metabolic pattern compared to the healthy individuals. Dampened glycolytic flux, poor ATP production, and shifting of glucose to the pentose phosphate pathway resulting in increased NADPH and decreased ROS levels are the common metabolic patterns observed in RA T-cells. Defective mtDNA due to lack of MRE11A gene, a key molecular actor for resection, and inefficient lysosomal function due to misplacement of AMPK on the lysosomal surface were found to be responsible for mitochondrial and lysosom...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Asmita Parab Lokesh Kumar Bhatt Source Type: research

Immuno-metabolic reprogramming of T cell: a new frontier for pharmacotherapy of Rheumatoid arthritis
Immunopharmacol Immunotoxicol. 2024 Mar 25:1-11. doi: 10.1080/08923973.2024.2330636. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a persistent autoimmune condition characterized by ongoing inflammation primarily affecting the synovial joint. This inflammation typically arises from an increase in immune cells such as neutrophils, macrophages, and T cells (TC). TC is recognized as a major player in RA pathogenesis. The involvement of HLA-DRB1 and PTPN-2 among RA patients confirms the TC involvement in RA. Metabolism of TC is maintained by various other factors like cytokines, mitochondrial proteins & other ...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Sourav Mondal Sarthak Saha Debjeet Sur Source Type: research

Immunosuppressants against acute kidney injury: what to prefer or to avoid?
Conclusion: Understanding the effects of immunosuppressants on AKI is crucial for optimizing patient care. This review highlights the need for further research to determine the most suitable immunosuppressants for AKI patients, considering both their efficacy and potential side effects.PMID:38477877 | DOI:10.1080/08923973.2024.2330641 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Swati Mishra Vishwadeep Shelke Neha Dagar Maciej Lech Anil Bhanudas Gaikwad Source Type: research

T-cell metabolism in rheumatoid arthritis: focus on mitochondrial and lysosomal dysfunction
Discussion: T-cells are identified as the primary initiators of immunological abnormalities in RA. These RA T-cells show a distinct metabolic pattern compared to the healthy individuals. Dampened glycolytic flux, poor ATP production, and shifting of glucose to the pentose phosphate pathway resulting in increased NADPH and decreased ROS levels are the common metabolic patterns observed in RA T-cells. Defective mtDNA due to lack of MRE11A gene, a key molecular actor for resection, and inefficient lysosomal function due to misplacement of AMPK on the lysosomal surface were found to be responsible for mitochondrial and lysosom...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Asmita Parab Lokesh Kumar Bhatt Source Type: research

Immuno-metabolic reprogramming of T cell: a new frontier for pharmacotherapy of Rheumatoid arthritis
Immunopharmacol Immunotoxicol. 2024 Mar 25:1-11. doi: 10.1080/08923973.2024.2330636. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a persistent autoimmune condition characterized by ongoing inflammation primarily affecting the synovial joint. This inflammation typically arises from an increase in immune cells such as neutrophils, macrophages, and T cells (TC). TC is recognized as a major player in RA pathogenesis. The involvement of HLA-DRB1 and PTPN-2 among RA patients confirms the TC involvement in RA. Metabolism of TC is maintained by various other factors like cytokines, mitochondrial proteins & other ...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Sourav Mondal Sarthak Saha Debjeet Sur Source Type: research

Immunosuppressants against acute kidney injury: what to prefer or to avoid?
Conclusion: Understanding the effects of immunosuppressants on AKI is crucial for optimizing patient care. This review highlights the need for further research to determine the most suitable immunosuppressants for AKI patients, considering both their efficacy and potential side effects.PMID:38477877 | DOI:10.1080/08923973.2024.2330641 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Swati Mishra Vishwadeep Shelke Neha Dagar Maciej Lech Anil Bhanudas Gaikwad Source Type: research

T-cell metabolism in rheumatoid arthritis: focus on mitochondrial and lysosomal dysfunction
Discussion: T-cells are identified as the primary initiators of immunological abnormalities in RA. These RA T-cells show a distinct metabolic pattern compared to the healthy individuals. Dampened glycolytic flux, poor ATP production, and shifting of glucose to the pentose phosphate pathway resulting in increased NADPH and decreased ROS levels are the common metabolic patterns observed in RA T-cells. Defective mtDNA due to lack of MRE11A gene, a key molecular actor for resection, and inefficient lysosomal function due to misplacement of AMPK on the lysosomal surface were found to be responsible for mitochondrial and lysosom...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Asmita Parab Lokesh Kumar Bhatt Source Type: research

Immuno-metabolic reprogramming of T cell: a new frontier for pharmacotherapy of Rheumatoid arthritis
Immunopharmacol Immunotoxicol. 2024 Mar 25:1-11. doi: 10.1080/08923973.2024.2330636. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a persistent autoimmune condition characterized by ongoing inflammation primarily affecting the synovial joint. This inflammation typically arises from an increase in immune cells such as neutrophils, macrophages, and T cells (TC). TC is recognized as a major player in RA pathogenesis. The involvement of HLA-DRB1 and PTPN-2 among RA patients confirms the TC involvement in RA. Metabolism of TC is maintained by various other factors like cytokines, mitochondrial proteins & other ...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Sourav Mondal Sarthak Saha Debjeet Sur Source Type: research

Immunosuppressants against acute kidney injury: what to prefer or to avoid?
Conclusion: Understanding the effects of immunosuppressants on AKI is crucial for optimizing patient care. This review highlights the need for further research to determine the most suitable immunosuppressants for AKI patients, considering both their efficacy and potential side effects.PMID:38477877 | DOI:10.1080/08923973.2024.2330641 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Swati Mishra Vishwadeep Shelke Neha Dagar Maciej Lech Anil Bhanudas Gaikwad Source Type: research

T-cell metabolism in rheumatoid arthritis: focus on mitochondrial and lysosomal dysfunction
Discussion: T-cells are identified as the primary initiators of immunological abnormalities in RA. These RA T-cells show a distinct metabolic pattern compared to the healthy individuals. Dampened glycolytic flux, poor ATP production, and shifting of glucose to the pentose phosphate pathway resulting in increased NADPH and decreased ROS levels are the common metabolic patterns observed in RA T-cells. Defective mtDNA due to lack of MRE11A gene, a key molecular actor for resection, and inefficient lysosomal function due to misplacement of AMPK on the lysosomal surface were found to be responsible for mitochondrial and lysosom...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Asmita Parab Lokesh Kumar Bhatt Source Type: research

Immuno-metabolic reprogramming of T cell: a new frontier for pharmacotherapy of Rheumatoid arthritis
Immunopharmacol Immunotoxicol. 2024 Mar 25:1-11. doi: 10.1080/08923973.2024.2330636. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a persistent autoimmune condition characterized by ongoing inflammation primarily affecting the synovial joint. This inflammation typically arises from an increase in immune cells such as neutrophils, macrophages, and T cells (TC). TC is recognized as a major player in RA pathogenesis. The involvement of HLA-DRB1 and PTPN-2 among RA patients confirms the TC involvement in RA. Metabolism of TC is maintained by various other factors like cytokines, mitochondrial proteins & other ...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Sourav Mondal Sarthak Saha Debjeet Sur Source Type: research

Immunosuppressants against acute kidney injury: what to prefer or to avoid?
Conclusion: Understanding the effects of immunosuppressants on AKI is crucial for optimizing patient care. This review highlights the need for further research to determine the most suitable immunosuppressants for AKI patients, considering both their efficacy and potential side effects.PMID:38477877 | DOI:10.1080/08923973.2024.2330641 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Swati Mishra Vishwadeep Shelke Neha Dagar Maciej Lech Anil Bhanudas Gaikwad Source Type: research