Intraoral Minor Salivary Gland Tumors: A Retrospective, Clinicopathologic, Single-Center Study of 432 Cases in Japan and a Comparison with Epidemiological Data
ConclusionsUnderstanding the features of intraoral minor salivary gland tumors is useful for diagnosis. Our study provides important epidemiological data (patient differences in age at occurrence, sex, and site of origin) that will inform clinicians and researchers. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - April 19, 2023 Category: Pathology Source Type: research
Mycobacterial Spindle Cell Pseudotumor of the Nasal Cavity
ConclusionAlthough exceptionally rare, MSCP should be considered in the differential diagnosis of nodular lesions of the nasal cavity that are characterized microscopically by marked spindle cell proliferation in a vague storiform pattern, admixed with a lymphocytic or mixed inflammatory infiltrate. A negative medical history for HIV infection and medication-induced immunosuppression should not preclude a diagnosis of MSCP, particularly in extranodal sites. Once the diagnosis is established, prognosis appears to be excellent for nasal MSCP following conservative surgical excision. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - April 7, 2023 Category: Pathology Source Type: research
Epstein –Barr Virus-Associated Lymphoepithelial Carcinoma Arising in a Salivary Sebaceous Lymphadenoma
ConclusionWe report the first case of an Epstein –Barr virus-associated lymphoepithelial carcinoma arising from a sebaceous lymphadenoma. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - April 6, 2023 Category: Pathology Source Type: research
The Challenge of “Monomorphic” Mucoepidermoid Carcinoma—Report of a Rare Case with Pure Spindle-Clear Cell Morphology
ConclusionsMucoepidermoid carcinoma featuring a uniform ( “monomorphic”) population of neoplastic cells is a novel observation. A confident diagnosis of mucoepidermoid carcinoma can be made upon detection of theCRTC1/3::MAML2 fusion. Our case increases the spectrum of histopathological appearances that mucoepidermoid carcinoma may display. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - April 4, 2023 Category: Pathology Source Type: research
Odontogenic Carcinosarcoma: An Updated Literature Review and Report of a Case
ConclusionThis case showed the tendency of untreated ameloblastoma to undergo malignant changes in the long term. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 31, 2023 Category: Pathology Source Type: research
Acknowledgment to Reviewers
(Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 21, 2023 Category: Pathology Source Type: research
Top 10 Histological Mimics of Neuroendocrine Carcinoma You Should Not Miss in the Head and Neck
ConclusionAs patients with NEC may require specific adjuvant treatment and follow-up, knowledge regarding differential diagnoses and potential pitfalls is therefore clinically relevant. In this review, the top ten morphological and/or immunohistochemical mimics of NEC are detailed in terms of histology, immunohistochemistry, and molecular genetics. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 20, 2023 Category: Pathology Source Type: research
Top 10 Significant Spindled Head and Neck Lesions to Scrutinze
ConclusionMorphologic evaluation is central to the work up of sinonasal spindle cell lesions –in particular, cellular morphology, tumor architecture and growth pattern, and the presence of admixed epithelial elements – however, focused immunohistochemical analysis of neural, myogenic, rhabdomyoblastic, epithelial, and/or melanocytic marker expression and/or ancillary tests for tumor-spe cific molecular alterations may be necessary for definitive diagnosis. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 16, 2023 Category: Pathology Source Type: research
Top Ten Lymphoproliferative Lesions Not to Miss When Evaluating Oral Ulcer Biopsies
ConclusionEach of these lesions are diagnosed by evaluating their histology, along with their phenotypic profile, which is sometimes enhanced by pertinent molecular findings. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 16, 2023 Category: Pathology Source Type: research
Cystic Lesions of the Jaws: The Top 10 Differential Diagnoses to Ponder
ConclusionCystic lesions of the maxilla and mandible may be odontogenic or non-odontogenic. The most common cystic lesions are the reactive periapical cyst, and the dentigerous cyst (which is developmental in nature). It is important to note that cystic neoplasms also occur in the jaws, and that the presence of inflammation may obscure the diagnostic histologic features of lesions like odontogenic keratocyst and unicystic ameloblastoma. Ancillary testing is of limited diagnostic value in most scenarios. However, both clinical and radiographic information (such as the location, size, duration, associated symptoms, and morph...
Source: Head and Neck Pathology - March 16, 2023 Category: Pathology Source Type: research
Top 10 Nested Pattern Head and Neck Lesions to Notice
ConclusionIn this review, we discuss the morphologic and immunohistochemical features of the covered entities as a guide to differential diagnosis when nested-patterned head and neck lesions are encountered. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 16, 2023 Category: Pathology Source Type: research
Top 10 Differential Diagnoses for Desmoplastic Melanoma
ConclusionDesmoplastic melanoma is often a difficult diagnosis to make, as it frequently shows nonspecific clinical findings and overlapping histologic features with many other tumors. However, the potential clinical and prognostic consequences of misdiagnosis as another entity are great. Therefore, this diagnosis must always be kept in mind when encountering spindle cell tumors affecting the head and neck area. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 16, 2023 Category: Pathology Source Type: research
Genomic Profiling of the Craniofacial Ossifying Fibroma by Next-Generation Sequencing
ConclusionsHere, we provided a comprehensive molecular characterization of OF that reveals a heterogeneous genetic profile with occasional large-scale CNAs (n = 6, 35%).FOS,FOSB, andTBX3 genes that regulate AP-1 transcriptional complex are frequently altered in OF (n = 7, 41%), chiefly in juvenile trabecular OF. These genes encode transcription factors that act as downstream effectors of the MAP kinase signaling pathway.MDM2 amplification is an exceedingly rare event in OF, if present at all, so identification of this event should continue to raise concern for low-grade gnathic osteosarcoma. In summary, our finding...
Source: Head and Neck Pathology - March 16, 2023 Category: Pathology Source Type: research
Top Ten Differentials to Mull Over for Head and Neck Myoepithelial Neoplasms
ConclusionIn this review, we summarize the characteristic histologic features, useful immunohistochemical panel, and common molecular alterations of myoepithelial tumors and their top differential diagnoses. A logical stepwise algorithmic approach and an immunohistochemical panel to include multiple myoepithelial markers are essential to establish the correct diagnosis. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 16, 2023 Category: Pathology Source Type: research
Top Ten Oncocytic Head and Neck Lesions to Contemplate
ConclusionsCorrect diagnosis of oncocytic head and neck lesions requires a knowledge of the spectrum of possible entities, their characteristic sites of occurrence, architecture, histomorphology, and immunohistochemistry. Oncocytic subtypes of several newly described entities are now recognized. Both epithelial and non-epithelial mimics of oncocytes exist. The molecular features of oncocytic tumors can be helpful in their diagnosis and understanding their pathogenesis. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 16, 2023 Category: Pathology Source Type: research
