Histopathological Analysis of Nodal Disease After Chemoradiation Reveals Viable Tumor Cells as the most Important Prognostic Factor in Head and Neck Squamous Cell Carcinoma
ConclusionWe could confirm the presence of viable tumor cells as a relevant negative prognostic factor after (chemo) radiation. The amount (area) of viable tumor cells further substratified patients with worse LRRFS. None of the other parameters correlated with a distinctive worse outcome. Importantly, the presence of (swirled) keratin debris alone should not be considered viable tumor cells (ypN0). (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - May 17, 2023 Category: Pathology Source Type: research
Proceedings of the North American Society of Head and Neck Pathology Companion Meeting, New Orleans, LA, March 12, 2023: Oral Cavity Dysplasia: Why Does Histologic Grading Continue to be Contentious?
AbstractHead and neck squamous cell carcinoma (HNSCC) is the world ’s 6th most common malignancy. Oral cavity SCC (OCSCC) represents approximately one third of the HNSCC cases diagnosed annually in the United States. Despite therapeutic advances, OCSCC is frequently lethal, with a modest 5-year survival. Because OCSCC is often preceded by premalignant lesions, it is an ideal disease for screening initiatives. The conventional visual and tactile exam (CVTE), coupled with a tissue biopsy, remains the gold standard. However, CVTE alone cannot reliably differentiate between reactive/inflammatory and dysplastic lesions. Furth...
Source: Head and Neck Pathology - May 15, 2023 Category: Pathology Source Type: research
Proceedings of the North American Society of Head and Neck Pathology Companion Meeting, New Orleans, LA, March 12, 2023: Classification of Salivary Gland Tumors: Remaining Controversial Issues?
AbstractThe salivary gland section in the 5th edition of the World Health Organization Classification of Head and Neck Tumours includes a description of several new entities. In addition, numerous tumor variants were described and new concepts proposed, most of which have been based on recent molecular discoveries. However, there are still some controversial issues that remain to be resolved, and some of them are discussed in this review. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - May 15, 2023 Category: Pathology Source Type: research
Proceedings of the 2023 North American Society of Head and Neck Pathology Companion Meeting, New Orleans, LA, March 12, 2023: Navigating New Developments in High Grade Sinonasal Neuroendocrine and Neuroectodermal Neoplasms
AbstractAlthough the definitions of sinonasal neuroendocrine and neuroectodermal neoplasms did not change substantially in the 5th edition WHO Classification of Head and Neck Tumours, the diagnosis of olfactory neuroblastoma (ONB), small cell neuroendocrine carcinoma, and large cell neuroendocrine carcinoma remains quite challenging in practice. Ambiguities surrounding the amount of keratin expression allowable in ONB and the amount of neuroendocrine differentiation seen in sinonasal undifferentiated carcinoma (SNUC) lead to significant diagnostic discrepancies at the high grade end of this tumor spectrum. Furthermore, a g...
Source: Head and Neck Pathology - May 15, 2023 Category: Pathology Source Type: research
Differentiated Papillary NUT Carcinoma: An Unexpected, Deceptively Bland Presentation of a Sinonasal Carcinoma
ConclusionsWe describe aNUT::NSD3 gene fusion-associated NUT carcinoma of the sinonasal tract with a deceptively well-differentiated papillary growth pattern, thus expanding the morphological spectrum of this typically poorly differentiated neoplasm. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - April 28, 2023 Category: Pathology Source Type: research
Immunoexpression of Autophagy-Related Proteins in Salivary Gland Tumors: An Exploratory Study
ConclusionsThe results suggest the participation of autophagy in the pathogenesis of PA, PAC, MEC, and ACC of salivary glands. Upregulation of autophagy and reduced nuclear translocation of p62 may contribute to the aggressive biological behavior of salivary gland ACC. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - April 28, 2023 Category: Pathology Source Type: research
A Systematic Review of the Granular Cell Odontogenic Fibroma and Report of a New Case
ConclusionGCOF remains controversial due to the still unsolved histogenesis. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - April 28, 2023 Category: Pathology Source Type: research
Adenoid Ameloblastoma with BRAF p.V600E Mutation Revealing Ameloblastomatous Origin: A First Case Report
ConclusionThis case report is the first to provide genetic evidence on the ameloblastomatous origin of AdAM with aBRAF p.V600E mutation. A larger series of AdAM groups ’ molecular testing is needed to aptly classify them and prognosticate the best treatment. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - April 24, 2023 Category: Pathology Source Type: research
Intraoral Minor Salivary Gland Tumors: A Retrospective, Clinicopathologic, Single-Center Study of 432 Cases in Japan and a Comparison with Epidemiological Data
ConclusionsUnderstanding the features of intraoral minor salivary gland tumors is useful for diagnosis. Our study provides important epidemiological data (patient differences in age at occurrence, sex, and site of origin) that will inform clinicians and researchers. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - April 19, 2023 Category: Pathology Source Type: research
Mycobacterial Spindle Cell Pseudotumor of the Nasal Cavity
ConclusionAlthough exceptionally rare, MSCP should be considered in the differential diagnosis of nodular lesions of the nasal cavity that are characterized microscopically by marked spindle cell proliferation in a vague storiform pattern, admixed with a lymphocytic or mixed inflammatory infiltrate. A negative medical history for HIV infection and medication-induced immunosuppression should not preclude a diagnosis of MSCP, particularly in extranodal sites. Once the diagnosis is established, prognosis appears to be excellent for nasal MSCP following conservative surgical excision. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - April 7, 2023 Category: Pathology Source Type: research
Epstein –Barr Virus-Associated Lymphoepithelial Carcinoma Arising in a Salivary Sebaceous Lymphadenoma
ConclusionWe report the first case of an Epstein –Barr virus-associated lymphoepithelial carcinoma arising from a sebaceous lymphadenoma. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - April 6, 2023 Category: Pathology Source Type: research
The Challenge of “Monomorphic” Mucoepidermoid Carcinoma—Report of a Rare Case with Pure Spindle-Clear Cell Morphology
ConclusionsMucoepidermoid carcinoma featuring a uniform ( “monomorphic”) population of neoplastic cells is a novel observation. A confident diagnosis of mucoepidermoid carcinoma can be made upon detection of theCRTC1/3::MAML2 fusion. Our case increases the spectrum of histopathological appearances that mucoepidermoid carcinoma may display. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - April 4, 2023 Category: Pathology Source Type: research
Odontogenic Carcinosarcoma: An Updated Literature Review and Report of a Case
ConclusionThis case showed the tendency of untreated ameloblastoma to undergo malignant changes in the long term. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 31, 2023 Category: Pathology Source Type: research
Acknowledgment to Reviewers
(Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 21, 2023 Category: Pathology Source Type: research
Top 10 Histological Mimics of Neuroendocrine Carcinoma You Should Not Miss in the Head and Neck
ConclusionAs patients with NEC may require specific adjuvant treatment and follow-up, knowledge regarding differential diagnoses and potential pitfalls is therefore clinically relevant. In this review, the top ten morphological and/or immunohistochemical mimics of NEC are detailed in terms of histology, immunohistochemistry, and molecular genetics. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 20, 2023 Category: Pathology Source Type: research
