Xanthoma of the Jaw Bones: Cases Series and Review of Literature
ConclusionXJB is a rare lesion of unknown etiology, which may mimic other benign or reactive jaw lesions. Due to its rarity and the potential diagnostic challenges it presents, clinicians must remain vigilant and consider CXJ in their differential when assessing radiolucent jaw anomalies. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 19, 2024 Category: Pathology Source Type: research
Ten Ways to Improve Getting a Scientific Manuscript Accepted
ConclusionA discussion of relevant components in manuscript writing and journal submission to improve your chances of acceptance. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 19, 2024 Category: Pathology Source Type: research
BRAF p.V600E Mutational Status Does Not Correlate with Biological Behavior in Conventional Ameloblastomas: A Disease-Free Survival Analysis
ConclusionBRAF p.V600E mutation emerges as a prevalent molecular aberration in ameloblastomas. Nevertheless, it does not seem to significantly affect the tumor proliferative activity, CD138/syndecan-1-mediated cell adhesion, or disease-free survival outcomes. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 19, 2024 Category: Pathology Source Type: research
Unraveling the Genetic Web: H-Ras Expression and Mutation in Oral Squamous Cell Carcinoma —A Systematic Review
ConclusionThis review sheds light on the prevalence of H-Ras mutations, their association with clinical characteristics, and their potential implications for OSCC prognosis. It also enhances our comprehension of the molecular mechanisms that underlie OSCC and paves the way for further research into targeted treatments based on H-Ras alterations. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 19, 2024 Category: Pathology Source Type: research
Enigma of Acantholytic and Clear Cell Changes in Oral Squamous Cell Carcinoma
AbstractOnly limited cases have been reported about the clear cell variant of squamous cell carcinoma occurring in the oral cavity. The present study regards the case showing the histopathological features of both the clear cell and acantholytic variants of oral squamous cell carcinoma. A review of the literature has been done to understand the pathogenesis of those changes. Also, a hypothesis has been given that the clear cell changes could be the consequences of the cascades of the acantholytic process and not a separate entity. Therefore, more research is required to confirm this hypothesis and understand the prognosis ...
Source: Head and Neck Pathology - March 15, 2024 Category: Pathology Source Type: research
Chronic Lymphocytic Thyroiditis with Oncocytic Metaplasia Influences PD-L1 Expression in Papillary Thyroid Carcinoma
ConclusionsOur study underscores the intricate interplay between chronic lymphocytic thyroiditis with oncocytic metaplasia and PD-L1 expression in papillary thyroid carcinoma. The observed link suggests a potential avenue for therapeutic intervention using anti-PD-1/PD-L1 therapies in surgery-refractory PTC. Understanding the dynamics of immune checkpoint regulation in the context of the tumor microenvironment is crucial for devising effective treatment strategies. Future research endeavors should delve deeper into the molecular mechanisms underlying this interaction and explore its implications for patient outcomes. As th...
Source: Head and Neck Pathology - March 8, 2024 Category: Pathology Source Type: research
Immunophenotypic and Gene Expression Analyses of the Inflammatory Microenvironment in High-Grade Oral Epithelial Dysplasia and Oral Lichen Planus
ConclusionsThe immune microenvironment distinguishes OED and OLP, suggesting diagnostic potential. Upregulated genes indicate cytotoxic immune response in OED. Downregulation ofTRADD,CX3CL1, andILI24 implies dysregulation inTNFR1 signaling, immune recruitment, and tumor suppression. This study contributes to the foundation for understanding immune interactions in OED and OLP, offering insights into future objective diagnostic avenues. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 8, 2024 Category: Pathology Source Type: research
Primary Oropharyngeal SMARCA4-Deficient Carcinoma: Expanding the Diagnostic Spectrum in Head and Neck Cancer
We present an unusual case of SMARCA4-deficient carcinoma of the oropharynx (palatine tonsil) which is the first case in the literature, expanding the topographic distribution of SMARCA4-deficient tumors in the head and neck region and emphasizing the importance of BRG1 as an essential immunohistochemical marker for the diagnosis of this distinct entity. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - March 8, 2024 Category: Pathology Source Type: research
Melanotic Neuroectodermal Tumor of Infancy: A Case Image
AbstractMelanotic neuroectodermal tumor of infancy (MNTI) is a rare benign neoplasm that can be mistaken for malignancies due to its unfamiliarity among clinicians and aggressive clinical appearance. We herein contributed by reporting an additional case of MNTI characterized by an extensive extraoral protrusion in a 2-month-old infant. The lesion involved the anterior maxilla, cheek, and infraorbital region, resulting the displacement of the nose to the contralateral side, and measuring approximately 10 cm in size. Surgical resection of the lesion was performed. After a 6-month follow-up, the patient has shown no evidenc...
Source: Head and Neck Pathology - March 8, 2024 Category: Pathology Source Type: research
Utility of UV Signature Mutations in the Diagnostic Assessment of Metastatic Head and Neck Carcinomas of Unknown Primary
ConclusionThe management of metastatic cutaneous carcinomas significantly differs from other HNCUP especially metastatic HR-HPV-associated SCC; therefore, the observation of a high percentage of C →T with CC →TT substitutions should be routinely incorporated in next generation sequencing reports of HNCUP. UV mutational signatures testing is a robust diagnostic tool that can be utilized in daily clinical practice. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - February 23, 2024 Category: Pathology Source Type: research
Dynamic Role of miRNAs in Salivary Gland Carcinomas: From Biomarkers to Therapeutic Targets
ConclusionIn the future, these miRNAs may eventually constitute useful diagnostic and prognostic biomarkers that may lead to a better understanding of SGCs oncogenesis. Additionally, the development of therapeutic agents based on miRNAs may be a promising target in SGC treatment. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - February 23, 2024 Category: Pathology Source Type: research
Primary Oral Mixed Neuroendocrine –Non-neuroendocrine Neoplasm (MiNEN): A Rare Case Report and Review of the Literature
We present a case of primary oral MiNEN in a 64-year-old male located on the left side of lower gingiva. Biopsy raised suspicion of neuroendocrine carcinoma (NEC) and the patient underwent partial mandibulectomy. The resected specimen showed two distinct compon ents of NEC and squamous cell carcinoma (SCC) with the confirmation of immunohistochemical markers. There has been no sign of recurrence nor metastasis 6 years after the surgery. In addition, we have conducted a review of published cases with potential relevance to this entity, resulting in five ca ses. The diverse terminology reinforces the need for a standardized...
Source: Head and Neck Pathology - February 23, 2024 Category: Pathology Source Type: research
Pleomorphic Adenoma with a Novel Gene Rearrangement —LINC01606::PLAG1
ConclusionTo the best of our knowledge, this is the first documented case of a long non-coding RNA (lnc-RNA) serving as a rearrangement partner with thePLAG1 gene. We reviewed the molecular characteristics of this entity and explored the potential role ofLINC01606::PLAG1 in the tumorigenesis of pleomorphic adenoma. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - February 23, 2024 Category: Pathology Source Type: research
Sinonasal Differentiated Papillary NUT Carcinoma
(Source: Head and Neck Pathology)
Source: Head and Neck Pathology - February 21, 2024 Category: Pathology Source Type: research
Spindle Cell Tumors of the Sinonasal Tract: A Diagnostic Update with Focus on Ancillary Workup
AbstractSpindle cell neoplasms arising in the head and neck may be challenging to recognize due to their relative rarity. While underlying molecular alterations are increasingly elucidated, testing for these features may not be readily available. In most cases, combinations of key morphologic features and diagnostic immunohistochemical markers can be used to replace molecular diagnostics. Conversely, some molecular alterations and expression of their surrogate biomarkers are not specific for any one entity, and it is important to recognize these to avoid diagnostic pitfalls. In this review, we discuss both old and new spin...
Source: Head and Neck Pathology - February 16, 2024 Category: Pathology Source Type: research
