SMARCB1-Deficient Skull Base Chondrosarcoma with 12p Duplication Presenting as Somatic-Type Malignancy Arising from Metastatic Seminoma
AbstractSomatic-type malignancy (STM) can occur infrequently within a primary or metastatic testicular germ cell tumor (TGCT) and is associated with dismal prognosis and survival. STM with chondrosarcomatous features is exceedingly rare and head and neck involvement has not been previously documented. A 39-year-old white man presented with nasal obstruction and epistaxis. Imaging disclosed a 6.9-cm expansile tumor involving the nasal cavity and skull base with intraorbital and intracranial extension. The histopathologic properties of the tumor were compatible with chondrosarcoma, grade II-III. Immunohistochemically, malign...
Source: Head and Neck Pathology - January 18, 2024 Category: Pathology Source Type: research
Gnathic Schwannomas: A Report of Two Cases and Systematic Review of the Literature
ConclusionAll cases were treated surgically, with an average follow-up interval of 22.9 months and a recurrence rate of 5.4% (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - December 6, 2023 Category: Pathology Source Type: research
Prevalence of BRAF p.V600E and Detection Methods in Benign Mixed and Malignant Odontogenic Tumors: A Systematic Review
ConclusionIn general, theBRAF p.V600E variant exhibited a prominent prevalence in mixed and malignant odontogenic tumors. However, most of the findings are based on small cohorts of patients and further studies with larger cohorts are needed. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - December 6, 2023 Category: Pathology Source Type: research
Evaluation of Diagnostic Significance of Salivary miRNA-184 and miRNA-21 in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders
ConclusionSalivary miRNA-21 and miRNA-184 may be beneficial for the early detection of OSCC and OPMD. Also, saliva can be used for detecting neoplastic transformation of oral mucosa since it is non-invasive and easily accessible. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - November 28, 2023 Category: Pathology Source Type: research
Diagnosis of Adenoid Cystic Carcinoma with Striking Tubular Hypereosinophilia by MYB and EWSR1 Breakapart Fluorescence In Situ Hybridization
ConclusionAwareness of unusual histological subtypes of AdCC, such as AdCC-STE, is imperative, as it may be misdiagnosed as PAC and EMC, among others. Presence of basophilic matrix and squamoid morules in a biphasic tumor even with hypereosinophilic rather than basaloid myoepithelial appearance should raise suspicion for AdCC-STE, and prompt molecular testing for confirmation. With wider accessibility, lower cost and significantly shorter turn-around-time when compared to RNA sequencing, FISH can be employed for confirmation of diagnosis, especially in low- and middle-income countries. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - November 27, 2023 Category: Pathology Source Type: research
Non-Calcifying/Langerhans Cell-Rich Calcifying Epithelial Odontogenic Tumour: A Critical Review of the Rare and Distinctive Entity
ConclusionThe NCLC subtype of CEOT is unique as it contains significant numbers of Langerhans cells and has clinicopathological features distinctive from classic CEOT. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - November 27, 2023 Category: Pathology Source Type: research
Maxillary Surgical Ciliated Cyst After Orthognathic Surgery
In conclusion, this case highlights the importance of accurate diagnosis and appropriate treatment approaches for surgical ciliated cysts to ensur e favorable patient outcomes. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - November 27, 2023 Category: Pathology Source Type: research
Recurrent Oropharyngeal Squamous Cell Carcinomas Maintain Anti-tumor Immunity and Multinucleation Levels Following Completion of Radiation
ConclusionExposure to chemo-radiation and recurrence following treatment preserves critical features of intrinsic tumor biology and the tumor immune microenvironment suggesting that novel treatment regimens may be as effective in the salvage setting as in the definitive intent setting. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - November 23, 2023 Category: Pathology Source Type: research
Historical Notes on Ossifying Fibroma of the Mandible
(Source: Head and Neck Pathology)
Source: Head and Neck Pathology - November 9, 2023 Category: Pathology Source Type: research
The First Report of Cytology of DEK::AFF2 Fusion-Associated Papillary Squamous Cell Carcinoma on Fine-Needle Aspiration
AbstractDEK::AFF2 fusion-associated papillary squamous cell carcinoma is a recently characterized sinonasal malignancy defined by its unique translocation.DEK::AFF2 carcinomas may be deceptively monotonous and lack keratinization, resembling transitional epithelium. The lack of traditional cytological atypia presents diagnostic challenges. Our case describes the first report of fine-needle aspiration cytology of a lymph node involved byDEK::AFF2 carcinoma in a patient with previously resected sinonasal inverted papilloma with carcinomatous transformation six years prior to presentation. This aspirate consisted of a lymphoi...
Source: Head and Neck Pathology - November 8, 2023 Category: Pathology Source Type: research
Assessing PD-L1 Expression in Head and Neck Squamous Cell Carcinoma: Trials and Tribulations
AbstractImmune checkpoint inhibitors have improved the outcome of patients diagnosed with inoperable recurrent or metastatic head and neck squamous cell carcinoma. However, as only a subset of head and neck cancer patients benefit from this treatment, biomarkers predicting treatment response help guide physicians in their clinical decision-making. PD-L1 expression assessed by immunohistochemistry is the single most clinically relevant biomarker predicting response to PD-1-blocking antibodies. Here, we discuss in which clinical context assessment of PD-L1 expression is instrumental for the choice of therapy, how pathologist...
Source: Head and Neck Pathology - November 6, 2023 Category: Pathology Source Type: research
Clinicopathological Features of Metastasis to the Oral and Maxillofacial Region —Multicenter Study
ConclusionAlthough this is a rare condition, clinicians should be aware that any oral lesions have the possibility of being metastatic, particularly in individuals with a previous history of cancer. The findings from this study could assist clinicians in prompt diagnosing these lesions and subsequent conducting oncologic assessments and treatment. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - October 30, 2023 Category: Pathology Source Type: research
Revisiting the History of Odontoma, with Special Reference to Its Original Illustration
ConclusionIn view of their fundamental achievements, the names of Wedl, Salter, Broca and Bland Sutton have been closely associated with the true history of odontoma. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - October 19, 2023 Category: Pathology Source Type: research
Challenging Tumor Heterogeneity with HER2, p16 and Somatostatin Receptor 2 Expression in a Case of EBV-Associated Lymphoepithelial Carcinoma of the Salivary Gland
ConclusionThese findings suggest tumor heterogeneity and lack of genomic aberrations in EBV-associated LECSGs. The heterogenous and unusual immunohistochemical features explain the diagnostic difficulties and simultaneously extend the immunophenotype spectrum of this tumor entity. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - October 17, 2023 Category: Pathology Source Type: research
Qualitative Assessment of Collagen and Elastic Fibers in Oral Submucous Fibrosis (OSMF), OSMF with Dysplasia and Oral Squamous Cell Carcinoma Arising from OSMF: A Histochemical Study
ConclusionWith advancement of stage there is increased collagenization of OSMF, as the condition acquires dysplastic changes and turns malignant, microenvironment alters resulting in increased activity of collagenases. However, the arrangement of more resistant elastic fibres depicts the better outcome, once OSMF shows malignant transformation, limiting locoregional and distant spread. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - October 16, 2023 Category: Pathology Source Type: research
