Human Papillomavirus-Associated Oral Cavity Squamous Cell Carcinoma: An Entity with Distinct Morphologic and Clinical Features
ConclusionsHPV-associated OCSCC is an uncommon entity that shows certain distinct clinical and pathologic features. Recognition of these features may help pathologic diagnosis and could potentially help guide clinical management. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 8, 2022 Category: Pathology Source Type: research
Proposal of Diagnostic Approach of Periodontal Primary Non Hodgkin Lymphoma of Bone with Flow Cytometry as an Essential Diagnostic Component
ConclusionBased on our institution ’s experience and the literature review conclusions, we propose the University of Texas Medical Branch diagnostic approach for PB-NHL and suggest that FNA and FC should be utilized as the essential diagnostic component. The fast and efficient diagnosis of PB-NHL can facilitate the correct treatmen t and sufficiently improve patient care. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 8, 2022 Category: Pathology Source Type: research
Targeted molecular profiling of salivary duct carcinoma with rhabdoid features highlights parallels to other apocrine and discohesive neoplasms: which phenotype should drive classification?
ConclusionsOverall, our findings confirm frequentCDH1 mutations and e-cadherin inactivation in SDC-RF, similar to discohesive tumors from other sites. We also highlight an apocrine molecular profile similar to conventional SDC. However, occasionalAKT1 mutation and signet-ring features suggest SDC-RF may also be related to mucinous adenocarcinoma. As more salivary tumors with discohesive growth are identified, it may become clearer whether SDC-RF should remain in the SDC family or be recognized as a separate entity. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 6, 2022 Category: Pathology Source Type: research
Evaluation of Expression Of ADAM 10 as a Predictor of Lymph Node Metastasis in Oral Squamous Cell Carcinoma —An Immunohistochemical Study
ConclusionConsidering the findings of a higher percentage of ADAM10 positive cells, higher staining intensity, and higher staining index, the overexpression of ADAM10 can be used as an independent marker for OSCC patients to predict the lymph node metastasis. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - June 30, 2022 Category: Pathology Source Type: research
A Case of HPV-Associated Oropharyngeal Squamous Cell Carcinoma with Block-Like, Partial Loss of p16 Expression
ConclusionThis unusual case illustrates a potential diagnostic pitfall, and it raises important questions regarding molecular mechanisms and prognostic implications of p16 staining in oropharyngeal squamous cell carcinoma. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - June 30, 2022 Category: Pathology Source Type: research
Intrathyroidal Plasmacytoma with Pleomorphic Multilobated Bizarre Cells: A Rare Primary Clinicopathological Presentation Mimicking Anaplastic Carcinoma of Thyroid
ConclusionThe present case emphasizes the diligent use of IHC in such cases given different therapeutic and prognostic implications. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - June 14, 2022 Category: Pathology Source Type: research
Extranodal MALT Lymphoma in the Oral Cavity: A Series of Three Cases with Review of Literature
ConclusionMALT lymphoma of oral cavity shows a wide spectrum of morphology with presence of transformed cells, that may lead to misdiagnosis of DLBL. Treatment guidelines are not well established but a tendency to excise MALT lymphomas of oral cavity has been observed. Nevertheless, MALT lymphoma of oral cavity appears to be an indolent disease. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - June 8, 2022 Category: Pathology Source Type: research
Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study
ConclusionsThis multicentre investigation presents the largest cohort study to date analysing salivary gland tumour data from tertiary centres scattered across the globe. These findings should serve as a baseline for future studies evaluating the epidemiological landscape of these tumours. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - May 27, 2022 Category: Pathology Source Type: research
Oral Lichen Planus: Associations Between Histomorphometric Characteristics and White and Red Lesions
This study aimed to verify the association between white and red lesions and histomorphometric characteristics of OLP lesions. This retrospective cross-sectional study assessed 48 hematoxylin- and eosin-stained histological sections from incisional biopsies obtained from OLP cases. A single previously calibrated evaluator performed the light microscopy analyses to evaluate morphological and morphometric parameters. Analyses of associations among variables were performed using the Fisher ’s exact test. Morphometric variables were assessed using the Mann–Whitney non-parametric test. Comparisons among the three groups (ag...
Source: Head and Neck Pathology - May 17, 2022 Category: Pathology Source Type: research
Metastases to the Parotid Gland: Study from a Tertiary Care Centre
ConclusionsIntraparotid metastases encompass a wide spectrum, often mimicking primary salivary gland neoplasms, particularly on limited samples. Metastases should be considered when histological/cytological features are unusual; detailed clinical information and ancillary techniques aid in arriving at an accurate diagnosis. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - May 16, 2022 Category: Pathology Source Type: research
MDM2 Gene Amplification and Expression of MDM2 and CDK4 are Rare in Ossifying Fibroma of Craniofacial Bones
AbstractOssifying fibroma of the craniofacial bones is a fibro-osseous lesion characterized by varied patterns of bone formation in a fibroblastic stroma. Ossifying fibroma is a putatively benign lesion with no reports of malignant transformation or metastasis. Differentiation from other fibro-osseous lesions can be challenging necessitating synthesis of clinical, radiological and pathological findings. The molecular pathogenesis of ossifying fibroma is poorly understood but recent studies have reportedMDM2 gene amplification and chromosomal copy number changes in a subset of ossifying fibromas.MDM2 amplification in ossify...
Source: Head and Neck Pathology - May 11, 2022 Category: Pathology Source Type: research
Immunohistochemical Expression Pattern of Theragnostic Targets SSTR2 and PSMA in Endolymphatic Sac Tumors: A Single Institution Case Series
ConclusionsOur results show a high rate of PSMA and SSTR2A expression in the tumor vasculature of endolymphatic sac tumors. PSMA and SSTR2A can be targeted with appropriate radioligands for diagnostic and therapeutic purposes. This finding provides a rationale for prospective clinical studies to test this approach as a sensitive screening tool for patients with suspected endolymphatic sac tumors including an improved management of von Hippel –Lindau syndrome. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - May 11, 2022 Category: Pathology Source Type: research
Sclerosing Paragangliomas: Correlations of Histological Features with Patients ’ Genotype and Vesicular Monoamine Transporter Expression
AbstractParagangliomas and pheochromocytomas are rare neuroendocrine tumors, carrying a germ-line mutation in 40% patients. Sclerosis is a rare histological feature in these tumors. We investigated the possible correlations between histological findings, first sclerosis, immunoreactivity for vesicular catecholamine transporters (VMAT1/VMAT2) and patients ’ genotype in a consecutive series of 57 tumors (30 paragangliomas and 27 pheochromocytomas) from 55 patients. The M-GAPP grading system, sclerosis (0–3 scale) and VMAT1/VMAT2 (0–6 scale) immunoreactivity scores were assessed. Germ-line mutations of Succinate Dehydro...
Source: Head and Neck Pathology - May 7, 2022 Category: Pathology Source Type: research
Base of tongue metastasis of cutaneous malignant melanoma with rhabdoid and neuroendocrine features: Report of a rare case and review of the literature
AbstractMetastatic malignant melanoma (MM) represents a highly aggressive cancer associated with overall poor prognosis. Various anatomic sites can be affected, including the oral cavity and the oropharynx. It may mimic other entities by assuming a variety of clinical appearances and exhibiting a plethora of microscopic variations. Herein, we present a case of a 63-year-old male with a MM metastasizing to the base of tongue, which developed 5 years after the original diagnosis and treatment of cutaneous MM of the chest and heralded its relapse; subsequently, neurological symptoms developed as a result of metastasis to the ...
Source: Head and Neck Pathology - May 6, 2022 Category: Pathology Source Type: research
Peripheral Ossifying Fibroma and Peripheral Odontogenic Fibroma: Close Relatives or Family?
(Source: Head and Neck Pathology)
Source: Head and Neck Pathology - May 6, 2022 Category: Pathology Source Type: research
