PRAME Staining in Sinonasal Mucosal Melanoma: A Single-Center Experience
ConclusionWe show that expression of PRAME is common in sinonasal MM, making PRAME a useful ancillary diagnostic tool and a potential therapeutic target in sinonasal MM. The demonstrated occurrence of extensive presence of PRAME-positive melanocytes in the surrounding mucosa of sinonasal MM might explain the multifocal nature of melanoma in the (sinonasal) mucosa, and would be an extra argument for a PRAME targeting treatment in preventing local disease recurrence. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - December 31, 2022 Category: Pathology Source Type: research
Cancer Microenvironment Defines Tumor-Infiltrating Lymphocyte Density and Tertiary Lymphoid Structure Formation in Laryngeal Cancer
ConclusionPoor immune response is related to hypoxic background and anaerobic metabolism, as well as increased invasive and metastatic ability. Regulatory TIL markers are linked with increased angiogenic potential. The prognostic, predictive, and therapy-guiding value of TILs in clinical practice demands thorough investigation. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - December 31, 2022 Category: Pathology Source Type: research
Prognostic Genomic Markers of Pathological Stage in Oral Squamous Cell Carcinoma
ConclusionThe genetic mutation type and ratio of tumor heterogeneity are different for each stage of OSCC, and stratification of OSCC patients with differential therapeutic efficacy is needed. Risk genes of both high and low stages must be identified in patients diagnosed with low-stage OSCC. Mutations inNOMO1,ZNF333, andWIZ should be considered as potential prognostic markers. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - December 31, 2022 Category: Pathology Source Type: research
A Subset of Salivary Intercalated Duct Lesions Harbors Recurrent CTNNB1 and HRAS Mutations: A Molecular Link to Basal Cell Adenoma and Epithelial-Myoepithelial Carcinoma?
ConclusionDespite substantial heterogeneity, these findings confirm that a majority of IDLs are genuinely neoplastic, and some demonstrate molecular overlap with both BCA and EMC, supporting their theorized role as precursors to these tumors. Nevertheless, no oncogenic drivers were present in a significant subset of cases, suggesting that some IDLs may be truly reactive and hyperplastic. As such, IDL appear to represent a diverse morphologic and molecular spectrum that include both neoplastic and hyperplastic lesions. Reconsideration of the boundary between IDL and BCA in the future may be necessary to simplify classificat...
Source: Head and Neck Pathology - December 8, 2022 Category: Pathology Source Type: research
Subcategorization of Perineural Invasion and Its Impact on Survival in Patients with Oral Squamous Cell Carcinoma
ConclusionsHistologic subcategorization of PNI did not have prognostic relevance in our study. Involvement of even small nerves was associated with poor prognosis. Addition of chemoradiation was seen to improve prognosis. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - December 8, 2022 Category: Pathology Source Type: research
Sclerosing Odontogenic Carcinoma: Report of a Case and Review of the Literature
ConclusionSclerosing odontogenic carcinoma is a rare, low-grade malignancy of odontogenic origin, which represents a diagnosis of exclusion in many cases. An immunohistochemical profile demonstrating positivity for markers including CK5/6, CK19, p63, and E-cadherin, in addition to a set of pertinent negative findings, can aid in the diagnosis of this tumor. This entity appears to lack metastatic potential despite its locally destructive behavior and a common histologic finding of perineural invasion. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - December 8, 2022 Category: Pathology Source Type: research
Lymphatic Vascular Density, the Expression of Podoplanin and Tumor Budding in Oral Squamous Cell Carcinoma
ConclusionThose findings support the hypothesis that tumor budding is a biological phenomenon associated with the progression and biological behavior of OSCC. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - December 8, 2022 Category: Pathology Source Type: research
Does Malignant Transformation of Basal Cell Adenoma Occur?
(Source: Head and Neck Pathology)
Source: Head and Neck Pathology - December 8, 2022 Category: Pathology Source Type: research
Oral Melanoacanthoma: Case Series of 33 Cases and Review of the Literature
ConclusionThe demographics and clinical presentation of OM in our series was similar to previous findings but encompasses wider variability of histologic presentation. Awareness of OM in the clinical and histologic differential diagnosis of pigmented lesions should be reinforced as many patients are concerned for melanoma and clinicians are often unware of this condition. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - December 7, 2022 Category: Pathology Source Type: research
Immunohistochemical Characterization of Gingival Fibromas
This study aims to expand upon the immunohistochemical characterization of GFs, and to confirm their osteoblastic phenotype.MethodsFormalin fixed, paraffin embedded GFs, POFs and fibroepithelial polyps (FEPs) of the gingiva were examined. Immunohistochemical staining was performed for special AT-rich sequence binding protein 2 (SATB2), runt-related transcription factor 2 (RUNX2), osteocalcin and alpha-smooth muscle actin ( αSMA). Sections were evaluated by light microscopy and the immunohistochemical staining patterns were assigned immunoreactive scores (IRS) based on percentage of stained cells and intensity of staining....
Source: Head and Neck Pathology - December 6, 2022 Category: Pathology Source Type: research
Analysis of H-ras Mutations and Immunohistochemistry in Recurrence Cases of High-Grade Oral Squamous Cell Carcinoma
ConclusionThese data may suggest that regardless of the causes and factors involved, Gly12Ala (G6266A) is associated with recurrence in high-grade OSCC tumors. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - November 14, 2022 Category: Pathology Source Type: research
Rhabdomyosarcoma with TFCP2 Rearrangement or Typical Co-expression of AE1/AE3 and ALK: Report of Three New Cases in the Head and Neck Region and Literature Review
ConclusionRMS withTFCP2 rearrangement is a rare and aggressive tumor with a particular predilection for craniofacial bones, especially the jaws. Knowing its clinicopathologic and immunohistochemical profile can avoid misdiagnosis. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - November 14, 2022 Category: Pathology Source Type: research
Diagnostic Reliability of CRTC1/3::MAML2 Gene Fusion Transcripts in Discriminating Histologically Similar Intraosseous Mucoepidermoid Carcinoma from Glandular Odontogenic Cyst: A Systematic Review and Meta-analysis
ConclusionsThe current evidence supports that in all cases with positive gene fusion transcript of theCRTC1/3::MAML2 was specific for IMEC and was significantly differentiating it from GOC. Whereas cases of IMEC with negative gene fusion transcript pose diagnostic difficulty in differentiating from a GOC which is negative forCRTC1/3::MAML2 expression. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - November 10, 2022 Category: Pathology Source Type: research
Mucosal Leishmaniasis of the lip: Report of an Exuberant case in a Young man
ConclusionClinicians should be aware of isolated forms of mucosal leishmaniasis of the lip, even in cases where the cutaneous lesion is undetected or clinically manifests as self-limiting. Knowing the endemic areas in the scenario of the dynamics of the ecoepidemiology of leishmaniasis is also essential for surveillance and counselling of the population. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - November 8, 2022 Category: Pathology Source Type: research
A Fibroblastic Reticular Cell Tumour Arising in the Oral Cavity: A Case Report and Review of the Literature
ConclusionHistiocytic and dendritic cell derived tumours are exceptionally rare within the head and neck region although a number of these tumours have been reported within the oral cavity. We present what we believe is the first reported case of a fibroblastic reticular cell tumour arising within the oral cavity. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - November 7, 2022 Category: Pathology Source Type: research
