Homeobox Genes in Odontogenic Lesions: A Scoping Review
ConclusionsThis paper summarized and reviews the possible link between homeobox gene expression in odontogenic lesions. Based on the current available data, there are insufficient evidence to support any definite role of homeobox gene in odontogenic lesions. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - November 7, 2022 Category: Pathology Source Type: research
Lack of Association Between oral Squamous cell Carcinoma and Li-Fraumeni Syndrome
(Source: Head and Neck Pathology)
Source: Head and Neck Pathology - November 7, 2022 Category: Pathology Source Type: research
Diagnostic role of DOG-1, GFAP and B-catenin in Basal cell Adenoma and Cellular Pleomorphic Adenoma of the Salivary Gland
ConclusionOur work supports the use of a concise IHC panel to improve the diagnostic accuracy of benign salivary gland tumors with overlapping histologic features. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - October 28, 2022 Category: Pathology Source Type: research
A Survey of Human Papillomavirus and Epstein-Barr virus Immunohistochemical Status in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC)
ConclusionThe level of P16 positive biomarker was high in patients with HNSCC. However, the EBV/LMP1 positive biomarker was moderate in patients. There was a relationship between EBV/LMP1 biomarker expression and vascular invasion in HNSCC patients, as well as between P16 biomarker and EBV/LMP1 biomarker staining. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - October 27, 2022 Category: Pathology Source Type: research
Lingual Alveolar Soft Part Sarcoma in a 78-Year-Old Woman: A Case Report and Comprehensive Review of the Literature from 1952 to 2022
ConclusionsASPS should be included in the differential diagnoses in cases of any slow-growing lingual masses (especially vascular ones) with non-specific clinical pictures, regardless of the patient ’s age. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - October 27, 2022 Category: Pathology Source Type: research
Laminin Immunostaining in Biopsies as a Useful Biomarker of Early Invasion in Actinic Cheilitis and Differential Diagnosis Between Actinic Cheilitis and Lip Cancer: New Insights
ConclusionLaminin immunostaining could be useful in identifying AC cases suspected of early invasion. It could also contribute to the histopathological differential diagnosis between AC with low- and high-grade ED and between AC and invasive LSCC. The findings of this study provide new insights into the mechanism involved in the progression process of AC into LSCC, encouraging preclinical studies that may document the stochastic role of laminin in this process. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - October 27, 2022 Category: Pathology Source Type: research
Epstein-Barr Virus Detection and LMP-1 Expression in Thai Patients with Oral Squamous Cell Carcinoma
ConclusionThe prevalence of EBV infection in OSCC in this group of Thai patients was 21%. Most of EBV-positive OSCC cases showed LMP-1 expression but a lack of EBER expression. From our findings, we presume that EBV may take some roles in OSCC development in this group of participants. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - October 18, 2022 Category: Pathology Source Type: research
Case Report: Giant Thyroid Angiolipoma —Challenging Clinical Diagnosis and Novel Genetic Alterations
ConclusionOurs is the third published case report of this rare entity. To date, no lipomatous thyroid tumor has undergone extensive genomic testing. Next-generation sequencing of our case revealed multiple genetic alterations, supporting the concept of angiolipomas being true neoplasms. Whereas the two previously reported cases in the literature were radiographically much smaller and appeared indolent, the large tumor in our case exhibited radiographic features concerning for liposarcoma, which belied the benign final pathologic diagnosis. Our case demonstrates that conservative surgical management (partial thyroidectomy) ...
Source: Head and Neck Pathology - October 18, 2022 Category: Pathology Source Type: research
Author Correction: Oral Squamous Cell Carcinoma Frequency in Young Patients from Referral Centers Around the World
(Source: Head and Neck Pathology)
Source: Head and Neck Pathology - October 14, 2022 Category: Pathology Source Type: research
Morphologic and Ancillary Studies of Pediatric Acinic Cell Carcinoma: A Single Institute Experience
ConclusionsOur study reveals that pediatric AciCCs often present with tumor-associated lymphoid proliferation (TALP) and sclerosis. Special stains such as reticulin histochemistry and NR4A3 immunohistochemistry are helpful to separate tumor from adjacent benign parenchyma. The ancillary study is helpful for the diagnosis of small specimens. Our study is limited by its low case number, but we hope that our results will promote more studies on this rare salivary gland tumor in the pediatric population. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - September 28, 2022 Category: Pathology Source Type: research
Frozen Section Evaluation for Surgical Margins in Laryngeal Squamous Cell Carcinoma: Is it a Reliable Method for Partial and Total Laryngectomies?
ConclusionOur study shows that the surgical method applied has no effect on discordances. However, sampling errors are likely to be more common in partial laryngectomy procedures. It should be kept in mind that the sensitivity of frozen section evaluation is low. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - September 28, 2022 Category: Pathology Source Type: research
A 10-Year Review of Intraoral Salivary Gland Tumor Diagnoses: Diagnostic Challenges and Inter-Observer Agreement
ConclusionDiagnostic challenges in IMSGT incisional biopsies were infrequent, especially if multiple pathologists were consulted. PA, PAC, AdCC, and adenocarcinoma NOS were the histologic types more commonly posing diagnostic challenges. Younger patient age, smaller tumor size, and larger biopsy are associated with a definitive diagnosis. This data highlights the importance of appropriate sampling in IMSGT. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - September 28, 2022 Category: Pathology Source Type: research
Simultaneous Expression of PD-1 and PD-L1 in Peripheral and Central Immune Cells and Tumor Cells in the Benign and Malignant Salivary Gland Tumors Microenvironment
ConclusionThe simultaneous presentation of PD-1 and PD-L1 in TCs and ICs of SGTs, their significant association with disease severity as well as the positive correlation between these immune checkpoints may suggest the therapeutic potential of anti-PD-1 and anti-PDL-1 combinational immunotherapy for SGTs. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - September 28, 2022 Category: Pathology Source Type: research
Biphenotypic Sinonasal Sarcoma with a Novel PAX3::FOXO6 Fusion: A Case Report and Review of the Literature
ConclusionsAlthough aPAX3::FOXO6 gene fusion has never been reported, this finding combined with the morphologic and immunophenotypic features supports the diagnosis of supports the diagnosis of BSS. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - September 28, 2022 Category: Pathology Source Type: research
A Low Grade Nasopharyngeal sarcoma With FUS::NACC1 Fusion and Immunohistochemical Evidence of Epithelial Differentiation: Expanding the Clinicopathologic Spectrum of an Emerging Entity
ConclusionThese findings confirm the previously-reported recurrent storiform histology in sarcomas withEWSR1/FUS::NACC1 fusion while simultaneously expanding the immunohistochemical spectrum of this entity to include overt epithelial differentiation. With involvement of a head and neck mucosal site, these findings also expand the differential diagnosis to include multiple mesenchymal entities including spindle cell squamous cell carcinoma. Further recognition of this emerging entity via expanded RNA sequencing panels will be necessary to determine the prevalence of these unique features. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - September 28, 2022 Category: Pathology Source Type: research
