Prognostic impact of MUC1 and potential regulatory miR-145 and miR-21 expression in salivary mucoepidermoid carcinoma
ConclusionOur results support the tumor suppressor role of miR-145 and the oncogenic role of miR-21 in salivary gland MEC. Also, MUC1 and miR-145 overexpression, as well as miR-21 suppression, show promising association with histologic tumor grade and clinical stage. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - August 18, 2022 Category: Pathology Source Type: research

Basal Cell Adenoma and Basal Cell Adenocarcinoma: a 50-year Experience From a Single Institution
ConclusionsThe importance of adequate excision is reinforced in BCA, with no recurrences occurring when margins were negative. Contrary to previous reports, BCAd was not associated with a good prognosis. A better understanding of the genetics of these neoplasms may identify therapeutic options when dealing with inoperable or metastatic disease. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - August 10, 2022 Category: Pathology Source Type: research

GLI1-Altered Soft Tissue Tumors of the Head and Neck: Frequent Oropharyngeal Involvement, p16 Immunoreactivity, and Detectable Alterations by DDIT3 Break Apart FISH
ConclusionHere we show thatGLI1-altered soft tissue tumors are frequently positive for p16 and can occur in tonsillar regions of the oropharynx. As such, positive p16 immunohistochemistry alone cannot be used as evidence for the diagnosis of HPV-related squamous cell carcinoma as strong and diffuse p16 expression may also occur inGLI1-altered soft tissue tumors. Commercially availableDDIT3 break apart FISH, which is readily available in many cytogenetic laboratories, may be useful as a sensitive surrogate test forGLI1 fusions and amplifications. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - August 6, 2022 Category: Pathology Source Type: research

Clinical, Radiographic and Histopathological Analysis of Craniopharyngiomas and Ameloblastomas: A Systematic Review
ConclusionsThis histopathological similarity is related to their origin, since both craniopharyngiomas and ameloblastomas share a relationship with the oral cavity, either partially, as in the case of craniopharyngiomas, or totally, as in ameloblastomas, not comprising the same lesion in different locations. It is important to note that the differential morphogenetic evidence observed herein between these lesions opens up a new field of study aiming at better treatment alternatives in the future. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - August 3, 2022 Category: Pathology Source Type: research

Human Papillomavirus-Associated Combined Neuroendocrine and Squamous Cell Carcinoma of the Sinonasal Tract
We describe a case of HPV-associated combined neuroendocrine and SCC of the sinonasal tract. Recognition of HPV association with this entity avoids diagnostic pitfalls. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - August 3, 2022 Category: Pathology Source Type: research

Infiltration of Mature KLRG1 Expressing Cytotoxic T Cells in Oral Lichen Planus
ConclusionsOLP oral mucosa T cell infiltration includes KLRG1  + highly differentiated cytotoxic T cells, suggesting continued antigen exposure driving T cells to a highly differentiated phenotype. The known phenotype of these cells, together with microarray detected increases in cytotoxic molecules, suggests that highly differentiated cytotoxic T cells co ntribute to oral mucosa injury in OLP. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 29, 2022 Category: Pathology Source Type: research

Prognostic Relevance of Lymphatic Vessel Density in Squamous Cell Carcinomas of the Oral Cavity: A Systematic Review and Meta-Analysis
ConclusionsThis meta-analysis helps to generate pathfinding evidence for a noteworthy role of Lymphatic Vessel Density evaluation in suggesting OSCC prognosis. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 29, 2022 Category: Pathology Source Type: research

Endotype of Chronic Rhinosinusitis with Nasal Polyps in Morocco
ConclusionsThe CRSwNP endotype in our region would mainly be type 2. However, our results must be confirmed by multicenter studies involving a large number of patients. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 26, 2022 Category: Pathology Source Type: research

Keratoameloblastoma: A Report of Seven New Cases and Review of Literature
ConclusionThis case series reports seven additional cases of KA, taking the total to 26 reported cases. The identification of subtle histologic features, including focal stellate reticulum-like central areas, subnuclear vacuolisation and lamellated-type central keratinisation, are key in diagnosing KA. The radiologic features will often indicate signs of aggressiveness such as cortical destruction, differentiating KA from OKC. All cases were completely negative for calretinin IHC, limiting its use in distinguishing KA from OKC. Further large series are needed to expand the current understanding of this rare variant of amel...
Source: Head and Neck Pathology - July 21, 2022 Category: Pathology Source Type: research

Sine Qua Non: Oncocytoma
AbstractOncocytomas of the salivary gland are uncommon neoplasms that are characterized by polygonal cells with abundant granular eosinophilic cytoplasm and relatively uniform nuclei. They are benign in nature and have a low recurrence rate with complete surgical excision. Though uncommon, oncocytic and clear cell variants of malignant tumors may histologically mimic oncocytomas and identification of their distinguishing features is essential. A classic example of an oncocytoma is discussed. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 14, 2022 Category: Pathology Source Type: research

NKX3.1 Expression in Salivary Gland “Intraductal” Papillary Mucinous Neoplasm: A Low-Grade Subtype of Salivary Gland Mucinous Adenocarcinoma
ConclusionThe findings suggest that SG IPMN is a low-grade subtype of mucinous adenocarcinoma which may be derived from mucinous acinar cells of the minor salivary gland. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 14, 2022 Category: Pathology Source Type: research

Inter- and Intrarater Reliability and Agreement Among Danish Head and Neck Pathologists Assessing Extranodal Extension in Lymph Node Metastases from Oropharyngeal Squamous Cell Carcinomas
ConclusionWe found a moderate level of reliability and agreement among pathologists for ENE in lymph node metastases from oropharyngeal squamous cell carcinomas. The intrarater reliability and agreement was generally higher than interrater measures. Interrater agreement was slightly improved by standardized assessment. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 13, 2022 Category: Pathology Source Type: research

Human Papillomavirus-Associated Oral Cavity Squamous Cell Carcinoma: An Entity with Distinct Morphologic and Clinical Features
ConclusionsHPV-associated OCSCC is an uncommon entity that shows certain distinct clinical and pathologic features. Recognition of these features may help pathologic diagnosis and could potentially help guide clinical management. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 8, 2022 Category: Pathology Source Type: research

Proposal of Diagnostic Approach of Periodontal Primary Non Hodgkin Lymphoma of Bone with Flow Cytometry as an Essential Diagnostic Component
ConclusionBased on our institution ’s experience and the literature review conclusions, we propose the University of Texas Medical Branch diagnostic approach for PB-NHL and suggest that FNA and FC should be utilized as the essential diagnostic component. The fast and efficient diagnosis of PB-NHL can facilitate the correct treatmen t and sufficiently improve patient care. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 8, 2022 Category: Pathology Source Type: research

Targeted molecular profiling of salivary duct carcinoma with rhabdoid features highlights parallels to other apocrine and discohesive neoplasms: which phenotype should drive classification?
ConclusionsOverall, our findings confirm frequentCDH1 mutations and e-cadherin inactivation in SDC-RF, similar to discohesive tumors from other sites. We also highlight an apocrine molecular profile similar to conventional SDC. However, occasionalAKT1 mutation and signet-ring features suggest SDC-RF may also be related to mucinous adenocarcinoma. As more salivary tumors with discohesive growth are identified, it may become clearer whether SDC-RF should remain in the SDC family or be recognized as a separate entity. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 6, 2022 Category: Pathology Source Type: research