True Oncocytic Acinic Cell Carcinoma: A Case Image
AbstractA 67-year-old female with a history of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) presented with right sided otalgia and a 2-3 cm firm, tender right posterior parotid mass. Fine needle aspiration biopsy (FNAB) established a diagnosis of acinic cell carcinoma (AciCC). Further workup demonstrated lung nodules which were confirmed by FNAB to represent metastatic AciCC. A right radical parotidectomy with sacrifice of the facial nerve, segmental mandibulectomy, and selective neck dissection (levels II-IV) was performed. Microscopically, the tumor displayed an infiltrative border with a solid multi...
Source: Head and Neck Pathology - August 4, 2023 Category: Pathology Source Type: research
Low-Grade Myofibroblastic Sarcoma of the Oral and Maxillofacial Region: An International Clinicopathologic Study of 13 Cases and Literature Review
This study aimed to report 13 new cases of LGMS arising in the oral and maxillofacial region. This study included LGMS cases from five oral and maxillofacial pathology laboratories in four different countries (Brazil, Peru, Guatemala, and South Africa). Their clinical, radiographic, histopatholog ical, and immunohistochemical findings were evaluated. In this current international case series, most patients were females with a mean age of 38.7 years, and commonly presenting a nodular lesion in maxilla. Microscopically, all cases showed a neoplasm formed by oval to spindle cells in a fibrous stroma with myxoid and dense ar...
Source: Head and Neck Pathology - August 4, 2023 Category: Pathology Source Type: research
A Systematic Review of Adenoid Ameloblastoma: A Newly Recognized Entity
ConclusionThe small number of reported cases, the existence of erroneous diagnoses, and the adoption of initial conservative management make it difficult to determine whether AdAM has a higher risk of recurrence or more aggressive biological behavior than conventional ameloblastomas. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - August 4, 2023 Category: Pathology Source Type: research
Lipoblastoma Arising in the Head and Neck: A Clinicopathologic Analysis of 20 Cases
ConclusionsLPBs arising in the head and neck region are not uncommon and occurred at a rate of 9% in our cohort. They should be kept in the differential diagnosis when a fatty tumor is encountered in an older child or occurring at an unusual location. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 24, 2023 Category: Pathology Source Type: research
Protease-Activated Receptor 1 (PAR1) Expression Contributes to HPV-Associated Oropharyngeal Cancer Prognosis
ConclusionOur results suggest that PAR1 expression affects the prognosis and recurrence rate of HPV-associated oropharyngeal cancer. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 24, 2023 Category: Pathology Source Type: research
Significance of Worst Pattern of Invasion-5 in Early-Stage Oral Cavity Squamous Cell Carcinoma
ConclusionSatellite nodules and extratumoural LVI correlated significantly with survival outcomes in our early-stage OSCC cohort. Further study is required to investigate the benefit of adjuvant treatment in these cases and to ascertain if WPOI-5 parameters including satellite nodules should be mandatory reporting data elements. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 24, 2023 Category: Pathology Source Type: research
p-mTOR, p-ERK and PTEN Expression in Tumor Biopsies and Organoids as Predictive Biomarkers for Patients with HPV Negative Head and Neck Cancer
ConclusionsHigh p-mTOR expression predicts and high p-ERK expression tends to predict worse treatment outcome in HPV negative HNSCC patients treated with chemoradiation, providing additional evidence that these markers are candidate prognostic biomarkers for survival in this patient population. Also this study shows that the use of HNSCC organoids for biomarker research has potential. The role of PTEN expression as prognostic biomarker remains unclear, as consistent evidence on its prognostic and predictive value is lacking. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 24, 2023 Category: Pathology Source Type: research
Odontogenic Carcinosarcoma: Clinicopathologic and Molecular Features of Three Cases, a Literature Review and Nomenclature Proposal
ConclusionOCS is a rare but aggressive malignancy, often arising from precursor tumors and may represent a terminal phenotype rather than a distinct entity. We describe novel clear-cell and sclerosing morphologies. Wnt pathway alterations appear important. Mitotic rates and necrosis may be adverse prognosticators. In keeping with nomenclature trends in other sites, OCS may be more appropriately designated as “biphasic sarcomatoid odontogenic carcinomas.” (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 24, 2023 Category: Pathology Source Type: research
HN-CLEAR: Head and Neck Consensus Language for Ease and Reproducibility, a Multidisciplinary Consensus Mechanism for Head and Neck Pathology
(Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 24, 2023 Category: Pathology Source Type: research
Verruciform Xanthoma: Clinical and Morphologic Spectrum Across Oral, Genital, and Cutaneous Sites
ConclusionsFamiliarity with the broad morphological spectrum of VX, including the presence and degree of wedge-shaped parakeratosis, keratin projections above the epithelium/epidermis, and associated underlying inflammation, will be helpful in diagnosing it in unusual locations. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - July 7, 2023 Category: Pathology Source Type: research
Biphenotypic Sinonasal Sarcoma with a Novel PAX7::PPARGC1 Fusion: Expanding the Spectrum of Gene Fusions Beyond the PAX3 Gene
AbstractBiphenotypic sinonasal sarcoma (BSNS) is a rare low-grade malignancy occurring in the sinonasal tract that is characterized by dual neural and myogenic differentiation. Rearrangements involving thePAX3 gene, usually withMAML3, are a hallmark of this tumor type and their identification are useful for diagnosis. Rarely, aMAML3 rearrangement without associatedPAX3 rearrangement has been described. Other gene fusions have not been previously reported. Herein, we report a 22 year-old woman with a BSNS harboring a novel gene fusion involving thePAX7 gene (specificallyPAX7::PPARGC1A), which is a paralogue ofPAX3. The hist...
Source: Head and Neck Pathology - June 28, 2023 Category: Pathology Source Type: research
Liprin- α1 Expression in Tumor-Infiltrating Lymphocytes Associates with Improved Survival in Patients with HPV-Positive Oropharyngeal Squamous Cell Carcinoma
ConclusionsIncreased liprin- α1 expression in the TILs is associated with favorable prognosis in OPSCC, especially among HPV-positive patients. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - June 19, 2023 Category: Pathology Source Type: research
Exploration of Digital Image Analysis for Ki67 Quantification in the Grading of Medullary Thyroid Carcinoma: A Pilot Study with 85 Cases
ConclusionOur study highlights the utility of DIA in quantifying Ki67PI for MTC and can serve as an adjunct for grading in conjunction with the other criteria of mitotic activity and necrosis. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - June 9, 2023 Category: Pathology Source Type: research
Proceedings of the 2023 North American Society of Head and Neck Pathology Companion Meeting, New Orleans, LA, March 12, 2023: Odontogenic Tumors: Have We Achieved an Evidence-Based Classification
ConclusionWhile controversial issues surrounding classification and discrete tumor entities are addressed in the WHO chapter, ambiguities inevitably remain. This review will examine several groups of odontogenic tumors to highlight persistent knowledge gaps, unmet needs and unresolved controversies. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - June 6, 2023 Category: Pathology Source Type: research
Adverse Reactions Associated with Dermal Fillers in the Oral and Maxillofacial Region: A Venezuelan Experience
ConclusionReflecting the dramatic increase in cosmetic procedures with soft tissue fillers, this study contributed by reporting six cases of foreign body reaction involving the oral and maxillofacial region, confirmed with biopsy and histopathology. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - May 29, 2023 Category: Pathology Source Type: research
