N-acetylcysteine modulates redox imbalance and inflammation in macrophages and mice exposed to formaldehyde
In conclusion, both in in vitro and in vivo models, NAC administration exerted protective effects, which modulated the inflammatory response and redox imbalance, thus preventing the development airway injury induced by formaldehyde exposure.PMID:37987619 | DOI:10.1080/10715762.2023.2284636 (Source: Free Radical Research)
Source: Free Radical Research - November 21, 2023 Category: Research Authors: Elena Cecilia Marcano-G ómez Ana Beatriz Farias de Souza Pedro Alves Machado-Junior Andrea Jazel Rodr íguez-Herrera Thalles de Freitas Castro Sirlaine Pio Gomes da Silva Ramony Gonzaga Vieira Andr é Talvani Katiane de Oliveira Pinto Coelho Nogueira Las Source Type: research
The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets
Free Radic Res. 2023 Nov 16:1-19. doi: 10.1080/10715762.2023.2284637. Online ahead of print.ABSTRACTNADPH oxidase 4 (NOX4) inhibition has been reported to mitigate diabetes induced beta-cell dysfunction and improve survival in vitro, as well as counteract high fat diet induced glucose intolerance in mice. We investigated the anti-diabetic effects of the selective NOX4 inhibitor GLX7013159 in vivo in athymic diabetic mice transplanted with human islets over a period of 4 weeks.The GLX7013159-treated mice achieved lower blood glucose and water consumption throughout the treatment period. Furthermore, GLX7013159 treatment res...
Source: Free Radical Research - November 16, 2023 Category: Research Authors: Andris Elksnis Nils Welsh Per Wikstr öm Joey Lau Per-Ola Carlsson Source Type: research
Arachidonic acid: reconciling the dichotomy of its oxidative cascade through specific deuteration
Free Radic Res. 2023 Oct 28:1-11. doi: 10.1080/10715762.2023.2277145. Online ahead of print.ABSTRACTA new approach to attenuating pathological inflammatory reactions by buffering the eicosanoid pathways with oxidation-resistant hexadeuterated arachidonic acid (D-ARA) is discussed. Enzymatic processing of ARA, released by phospholipase A2, by lipoxygenases, cyclooxygenases, and cytochromes yields a wide range of bioactive eicosanoids, including pro-inflammation, pro-angiogenesis and pro-thrombosis species that, when produced in excess, are an underlying cause of pathology. Conversely, some products of ARA oxidation possess ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: J Thomas Brenna Marina G Sergeeva Nikolay B Pestov Tatyana V Korneenko Mikhail S Shchepinov Source Type: research
Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen
This study revealed that blue light irradiation triggered apoptosis and oxidative stress in all-trans-retinal (atRAL)-exposed ARPE-19 cells by generating singlet oxygen (1O2), leading to significant cell death. We found that astaxanthin, a potent anti-oxidative xanthophyll abundant in several marine organisms including microalgae, salmon, and shrimp, significantly suppresses blue light-induced apoptotic cell death of atRAL-exposed ARPE-19 cells by scavenging 1O2. Mechanistic studies using the blue-light irradiated cells also demonstrated that the cytoprotective effects of astaxanthin can be attributed to scavenging of 1O2 ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Mana Kitao Ai Yamaguchi Takuma Tomioka Kenji Kai Yuki Kamei Kenji Sugimoto Mitsugu Akagawa Source Type: research
Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy
This study provides a novel insight into germacrone-mediated protection against DN progression and further confirms that antioxidant pharmacological strategies facilitate the treatment of DN.PMID:37897414 | DOI:10.1080/10715762.2023.2277143 (Source: Free Radical Research)
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Yunguang Wang Xinxin He Mengjiao Xue Wenbo Sun Qiang He Juan Jin Source Type: research
Arachidonic acid: reconciling the dichotomy of its oxidative cascade through specific deuteration
Free Radic Res. 2023 Oct 28:1-11. doi: 10.1080/10715762.2023.2277145. Online ahead of print.ABSTRACTA new approach to attenuating pathological inflammatory reactions by buffering the eicosanoid pathways with oxidation-resistant hexadeuterated arachidonic acid (D-ARA) is discussed. Enzymatic processing of ARA, released by phospholipase A2, by lipoxygenases, cyclooxygenases, and cytochromes yields a wide range of bioactive eicosanoids, including pro-inflammation, pro-angiogenesis and pro-thrombosis species that, when produced in excess, are an underlying cause of pathology. Conversely, some products of ARA oxidation possess ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: J Thomas Brenna Marina G Sergeeva Nikolay B Pestov Tatyana V Korneenko Mikhail S Shchepinov Source Type: research
Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen
This study revealed that blue light irradiation triggered apoptosis and oxidative stress in all-trans-retinal (atRAL)-exposed ARPE-19 cells by generating singlet oxygen (1O2), leading to significant cell death. We found that astaxanthin, a potent anti-oxidative xanthophyll abundant in several marine organisms including microalgae, salmon, and shrimp, significantly suppresses blue light-induced apoptotic cell death of atRAL-exposed ARPE-19 cells by scavenging 1O2. Mechanistic studies using the blue-light irradiated cells also demonstrated that the cytoprotective effects of astaxanthin can be attributed to scavenging of 1O2 ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Mana Kitao Ai Yamaguchi Takuma Tomioka Kenji Kai Yuki Kamei Kenji Sugimoto Mitsugu Akagawa Source Type: research
Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy
This study provides a novel insight into germacrone-mediated protection against DN progression and further confirms that antioxidant pharmacological strategies facilitate the treatment of DN.PMID:37897414 | DOI:10.1080/10715762.2023.2277143 (Source: Free Radical Research)
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Yunguang Wang Xinxin He Mengjiao Xue Wenbo Sun Qiang He Juan Jin Source Type: research
