Bis(1-methylimidazol-2-yl) diselenide and its evaluation as a chemical radio-protector: role of kinetic rate constants for ROS scavenging and glutathione peroxidase like activity
Free Radic Res. 2024 Jan 2:1-14. doi: 10.1080/10715762.2023.2299341. Online ahead of print.ABSTRACTBis(1-methylimidazol-2-yl) diselenide (MeImSe), a derivative of selenoneine, has been examined for bimolecular rate constants for scavenging of various radiolytically and non-radiolytically generated reactive oxygen species (ROS). Further, its potential to show glutathione peroxidase (GPx)-like activity and to protect in vitro models of DNA and lipid against radiation induced strand breakage and lipid peroxidation, respectively were studied. The results confirmed that MeImSe scavenged all major short-lived (hydroxyl radical) ...
Source: Free Radical Research - January 2, 2024 Category: Research Authors: K Makhijani L B Kumbhare M Nayak A Kunwar B G Singh Source Type: research
Cemtirestat dimerization in liposomes and erythrocytes exposed to peroxyl radicals was reverted by thiol-disulfide exchange with GSH
Free Radic Res. 2023 Dec 25:1-12. doi: 10.1080/10715762.2023.2298852. Online ahead of print.ABSTRACTIn the model system of DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine) liposomes exposed to peroxyl radicals generated by the azoinitiator AAPH, cemtirestat (CMTI-SH) inhibited lipid peroxidation more efficiently than the natural antioxidant glutathione. In the concentrations 100 to 500 µM, both CMTI-SH and GSH induced distinct lag phases in the initial stages of lipid peroxidation yet GSH produced consistently shorter induction periods (about twice) than equimolar CMTI-SH. Moreover, concentration dependence of lipid peroxi...
Source: Free Radical Research - December 25, 2023 Category: Research Authors: Lucia Kovacikova Marta S Prnova Pavol Bodo Milan Stefek Source Type: research
Recent advances in the antioxidant activity of metal-curcumin complexes: A combined computational and experimental review
Free Radic Res. 2023 Dec 25:1-35. doi: 10.1080/10715762.2023.2298857. Online ahead of print.ABSTRACTCurcumin, an extensively studied phytochemical compound, has gained attention for its potential therapeutic applications across a spectrum of diseases. Its notable attributes include its relatively high tolerability within the human body and its perceived absence of adverse side effects. This review article presents a comprehensive overview of the antioxidant effects exhibited by complexes formed by curcumin and curcumin derived ligands with metals like Mn, Cu, Fe, Zn, Ga and In, which leads to toxic effects beyond a certain...
Source: Free Radical Research - December 25, 2023 Category: Research Authors: Ankit Mittal Mudita Nagpal Vinod Kumar Vashistha Richa Arora Upasana Issar Source Type: research
Omaveloxolone ameliorates isoproterenol-induced pathological cardiac hypertrophy in mice
In this study, an isoproterenol (ISO)-induced pathological cardiac hypertrophy model was established to investigate the protective effect of omaveloxolone in vivo and in vitro. Our study first confirmed that omaveloxolone administration improved ISO-induced pathological cardiac hypertrophy in mice and neonatal cardiomyocytes. Omaveloxolone administration also diminished ISO-induced cardiac oxidative stress, inflammation and cardiomyocyte apoptosis. In addition, omaveloxolone administration activated the Nrf2 signaling pathway, and Nrf2 knockdown almost completely abolished the cardioprotective effect of omaveloxolone, indi...
Source: Free Radical Research - December 25, 2023 Category: Research Authors: Xianchao Li Yang Wu Yunzhao Yang Yaohua Wu Xi Yu Wenjuan Hu Source Type: research
A novel AluYb8 insertion-associated non-coding RNA, lncMUTYH, impairs mitochondrial function and dampens the M2-like polarization of macrophages
In this study, we identified a novel transcript associated with the AluYb8MUTYH variant, which revealed that this transcript is about 780 nucleotides in length with a poly-A tail, lacks protein-coding potential, referred to as lncMUTYH. The results from the reporter gene system confirmed that the lncMUTYH down-regulates MUTYH1 expression at the translational level. Site-directed mutagenesis on the 5'-terminal exon sequences of α-MUTYH and lncMUTYH constructs revealed that lncMUTYH can act as a trans-regulator that depends on the partial base pairing between its exonized AluYb8 sequence and the 5'UTR of α-MUTYH to impede ...
Source: Free Radical Research - December 25, 2023 Category: Research Authors: Gaochao Dong Xuewen Yin Yingkuan Liang Jingwen Chen Jie Wang Feng Jiang Chaochen Wang Wenwen Guo Yaping Wang Source Type: research
Cemtirestat dimerization in liposomes and erythrocytes exposed to peroxyl radicals was reverted by thiol-disulfide exchange with GSH
Free Radic Res. 2023 Dec 25:1-12. doi: 10.1080/10715762.2023.2298852. Online ahead of print.ABSTRACTIn the model system of DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine) liposomes exposed to peroxyl radicals generated by the azoinitiator AAPH, cemtirestat (CMTI-SH) inhibited lipid peroxidation more efficiently than the natural antioxidant glutathione. In the concentrations 100 to 500 µM, both CMTI-SH and GSH induced distinct lag phases in the initial stages of lipid peroxidation yet GSH produced consistently shorter induction periods (about twice) than equimolar CMTI-SH. Moreover, concentration dependence of lipid peroxi...
Source: Free Radical Research - December 25, 2023 Category: Research Authors: Lucia Kovacikova Marta S Prnova Pavol Bodo Milan Stefek Source Type: research
Recent advances in the antioxidant activity of metal-curcumin complexes: A combined computational and experimental review
Free Radic Res. 2023 Dec 25:1-35. doi: 10.1080/10715762.2023.2298857. Online ahead of print.ABSTRACTCurcumin, an extensively studied phytochemical compound, has gained attention for its potential therapeutic applications across a spectrum of diseases. Its notable attributes include its relatively high tolerability within the human body and its perceived absence of adverse side effects. This review article presents a comprehensive overview of the antioxidant effects exhibited by complexes formed by curcumin and curcumin derived ligands with metals like Mn, Cu, Fe, Zn, Ga and In, which leads to toxic effects beyond a certain...
Source: Free Radical Research - December 25, 2023 Category: Research Authors: Ankit Mittal Mudita Nagpal Vinod Kumar Vashistha Richa Arora Upasana Issar Source Type: research
Omaveloxolone ameliorates isoproterenol-induced pathological cardiac hypertrophy in mice
In this study, an isoproterenol (ISO)-induced pathological cardiac hypertrophy model was established to investigate the protective effect of omaveloxolone in vivo and in vitro. Our study first confirmed that omaveloxolone administration improved ISO-induced pathological cardiac hypertrophy in mice and neonatal cardiomyocytes. Omaveloxolone administration also diminished ISO-induced cardiac oxidative stress, inflammation and cardiomyocyte apoptosis. In addition, omaveloxolone administration activated the Nrf2 signaling pathway, and Nrf2 knockdown almost completely abolished the cardioprotective effect of omaveloxolone, indi...
Source: Free Radical Research - December 25, 2023 Category: Research Authors: Li Xianchao Yang Wu Yunzhao Yang Yaohua Wu Xi Yu Wenjuan Hu Source Type: research
A novel AluYb8 insertion-associated non-coding RNA, lncMUTYH, impairs mitochondrial function and dampens the M2-like polarization of macrophages
In this study, we identified a novel transcript associated with the AluYb8MUTYH variant, which revealed that this transcript is about 780 nucleotides in length with a poly-A tail, lacks protein-coding potential, referred to as lncMUTYH. The results from the reporter gene system confirmed that the lncMUTYH down-regulates MUTYH1 expression at the translational level. Site-directed mutagenesis on the 5'-terminal exon sequences of α-MUTYH and lncMUTYH constructs revealed that lncMUTYH can act as a trans-regulator that depends on the partial base pairing between its exonized AluYb8 sequence and the 5'UTR of α-MUTYH to impede ...
Source: Free Radical Research - December 25, 2023 Category: Research Authors: Gaochao Dong Xuewen Yin Yingkuan Liang Jingwen Chen Jie Wang Feng Jiang Chaochen Wang Wenwen Guo Yaping Wang Source Type: research
Cemtirestat dimerization in liposomes and erythrocytes exposed to peroxyl radicals was reverted by thiol-disulfide exchange with GSH
Free Radic Res. 2023 Dec 25:1-12. doi: 10.1080/10715762.2023.2298852. Online ahead of print.ABSTRACTIn the model system of DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine) liposomes exposed to peroxyl radicals generated by the azoinitiator AAPH, cemtirestat (CMTI-SH) inhibited lipid peroxidation more efficiently than the natural antioxidant glutathione. In the concentrations 100 to 500 µM, both CMTI-SH and GSH induced distinct lag phases in the initial stages of lipid peroxidation yet GSH produced consistently shorter induction periods (about twice) than equimolar CMTI-SH. Moreover, concentration dependence of lipid peroxi...
Source: Free Radical Research - December 25, 2023 Category: Research Authors: Lucia Kovacikova Marta S Prnova Pavol Bodo Milan Stefek Source Type: research
Recent advances in the antioxidant activity of metal-curcumin complexes: A combined computational and experimental review
Free Radic Res. 2023 Dec 25:1-35. doi: 10.1080/10715762.2023.2298857. Online ahead of print.ABSTRACTCurcumin, an extensively studied phytochemical compound, has gained attention for its potential therapeutic applications across a spectrum of diseases. Its notable attributes include its relatively high tolerability within the human body and its perceived absence of adverse side effects. This review article presents a comprehensive overview of the antioxidant effects exhibited by complexes formed by curcumin and curcumin derived ligands with metals like Mn, Cu, Fe, Zn, Ga and In, which leads to toxic effects beyond a certain...
Source: Free Radical Research - December 25, 2023 Category: Research Authors: Ankit Mittal Mudita Nagpal Vinod Kumar Vashistha Richa Arora Upasana Issar Source Type: research
