Fullerene C < sub > 60 < /sub > reduces acute lung injury by suppressing oxidative stress-mediated DMBA-induced apoptosis and autophagy by regulation of cytochrome-C/Caspase-3/Beclin-1/IL-1 α/HO-1/p53 signaling pathways in rats
The objective of this study was to evaluate the effect of fullerene C60 nanoparticles against 7,12-dimethylbenz[a]anthracene (DMBA)-induced lung tissue damage in rats. 15 Wistar albino (8 weeks old) female rats were assigned into four groups: Control Group (C), Fullerene C60, DMBA, and Fullerene C60+DMBA. The rats in the DMBA and Fullerene C60+DMBA groups were administered DMBA (45 mg/kg bw, oral gavage). The rats in Fullerene C60, DMBA and Fullerene C60+DMBA groups were administered with Fullerene C60 (1.7 mg/kg bw, oral gavage). Expression levels of cytochrome-c, caspase-3, beclin-1, IL-1α, HO-1 and p53 proteins in lung...
Source: Free Radical Research - August 16, 2023 Category: Research Authors: Seda Beyaz Abdullah Aslan Ozlem Gok Ibrahim Hanifi Ozercan Can Ali Agca Source Type: research
Defense systems to avoid ferroptosis caused by lipid peroxidation-mediated membrane damage
Free Radic Res. 2023 Aug 9:1-20. doi: 10.1080/10715762.2023.2244155. Online ahead of print.ABSTRACTThe presence of hydrogen peroxide along with ferrous iron produces hydroxyl radicals that preferably oxidize polyunsaturated fatty acids (PUFA) to alkyl radicals (L•). The reaction of L• with an oxygen molecule produces lipid peroxyl radical (LOO•) that collectively trigger chain reactions, which results in the accumulation of lipid peroxidation products (LOOH). Oxygenase enzymes, such as lipoxygenase, also stimulate the peroxidation of PUFA. The production of phospholipid hydroperoxides (P-LOOH) can result in the destr...
Source: Free Radical Research - August 8, 2023 Category: Research Authors: Junichi Fujii Ken-Ichi Yamada Source Type: research
DhHP-6 alleviates inflammation and reduces vascular permeability by eliminating reactive oxygen species
Free Radic Res. 2023 Aug 3:1-13. doi: 10.1080/10715762.2023.2243030. Online ahead of print.ABSTRACTInflammation is a defensive immune response to external stimuli. However, uncontrolled inflammation may cause potential damage to the host. Therefore, timely control of uncontrolled inflammation is particularly important. Previous studies have found that small molecules with antioxidant activity, such as peroxidase mimic enzymes, can inhibit the development of inflammation. DhHP-6 is a new peptide mimic of peroxidase previously designed by our laboratory. Here, we explored its anti-inflammatory activity in vitro and in vivo. ...
Source: Free Radical Research - August 3, 2023 Category: Research Authors: Fanwei Meng Junfeng Ke Feng Guo Jiaqing Yan Liping Wang Source Type: research
