Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy
This study provides a novel insight into germacrone-mediated protection against DN progression and further confirms that antioxidant pharmacological strategies facilitate the treatment of DN.PMID:37897414 | DOI:10.1080/10715762.2023.2277143 (Source: Free Radical Research)
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Yunguang Wang Xinxin He Mengjiao Xue Wenbo Sun Qiang He Juan Jin Source Type: research
Arachidonic acid: reconciling the dichotomy of its oxidative cascade through specific deuteration
Free Radic Res. 2023 Oct 28:1-11. doi: 10.1080/10715762.2023.2277145. Online ahead of print.ABSTRACTA new approach to attenuating pathological inflammatory reactions by buffering the eicosanoid pathways with oxidation-resistant hexadeuterated arachidonic acid (D-ARA) is discussed. Enzymatic processing of ARA, released by phospholipase A2, by lipoxygenases, cyclooxygenases, and cytochromes yields a wide range of bioactive eicosanoids, including pro-inflammation, pro-angiogenesis and pro-thrombosis species that, when produced in excess, are an underlying cause of pathology. Conversely, some products of ARA oxidation possess ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: J Thomas Brenna Marina G Sergeeva Nikolay B Pestov Tatyana V Korneenko Mikhail S Shchepinov Source Type: research
Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen
This study revealed that blue light irradiation triggered apoptosis and oxidative stress in all-trans-retinal (atRAL)-exposed ARPE-19 cells by generating singlet oxygen (1O2), leading to significant cell death. We found that astaxanthin, a potent anti-oxidative xanthophyll abundant in several marine organisms including microalgae, salmon, and shrimp, significantly suppresses blue light-induced apoptotic cell death of atRAL-exposed ARPE-19 cells by scavenging 1O2. Mechanistic studies using the blue-light irradiated cells also demonstrated that the cytoprotective effects of astaxanthin can be attributed to scavenging of 1O2 ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Mana Kitao Ai Yamaguchi Takuma Tomioka Kenji Kai Yuki Kamei Kenji Sugimoto Mitsugu Akagawa Source Type: research
Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy
This study provides a novel insight into germacrone-mediated protection against DN progression and further confirms that antioxidant pharmacological strategies facilitate the treatment of DN.PMID:37897414 | DOI:10.1080/10715762.2023.2277143 (Source: Free Radical Research)
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Yunguang Wang Xinxin He Mengjiao Xue Wenbo Sun Qiang He Juan Jin Source Type: research
Arachidonic acid: reconciling the dichotomy of its oxidative cascade through specific deuteration
Free Radic Res. 2023 Oct 28:1-11. doi: 10.1080/10715762.2023.2277145. Online ahead of print.ABSTRACTA new approach to attenuating pathological inflammatory reactions by buffering the eicosanoid pathways with oxidation-resistant hexadeuterated arachidonic acid (D-ARA) is discussed. Enzymatic processing of ARA, released by phospholipase A2, by lipoxygenases, cyclooxygenases, and cytochromes yields a wide range of bioactive eicosanoids, including pro-inflammation, pro-angiogenesis and pro-thrombosis species that, when produced in excess, are an underlying cause of pathology. Conversely, some products of ARA oxidation possess ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: J Thomas Brenna Marina G Sergeeva Nikolay B Pestov Tatyana V Korneenko Mikhail S Shchepinov Source Type: research
Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen
This study revealed that blue light irradiation triggered apoptosis and oxidative stress in all-trans-retinal (atRAL)-exposed ARPE-19 cells by generating singlet oxygen (1O2), leading to significant cell death. We found that astaxanthin, a potent anti-oxidative xanthophyll abundant in several marine organisms including microalgae, salmon, and shrimp, significantly suppresses blue light-induced apoptotic cell death of atRAL-exposed ARPE-19 cells by scavenging 1O2. Mechanistic studies using the blue-light irradiated cells also demonstrated that the cytoprotective effects of astaxanthin can be attributed to scavenging of 1O2 ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Mana Kitao Ai Yamaguchi Takuma Tomioka Kenji Kai Yuki Kamei Kenji Sugimoto Mitsugu Akagawa Source Type: research
Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy
This study provides a novel insight into germacrone-mediated protection against DN progression and further confirms that antioxidant pharmacological strategies facilitate the treatment of DN.PMID:37897414 | DOI:10.1080/10715762.2023.2277143 (Source: Free Radical Research)
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Yunguang Wang Xinxin He Mengjiao Xue Wenbo Sun Qiang He Juan Jin Source Type: research
Arachidonic acid: reconciling the dichotomy of its oxidative cascade through specific deuteration
Free Radic Res. 2023 Oct 28:1-11. doi: 10.1080/10715762.2023.2277145. Online ahead of print.ABSTRACTA new approach to attenuating pathological inflammatory reactions by buffering the eicosanoid pathways with oxidation-resistant hexadeuterated arachidonic acid (D-ARA) is discussed. Enzymatic processing of ARA, released by phospholipase A2, by lipoxygenases, cyclooxygenases, and cytochromes yields a wide range of bioactive eicosanoids, including pro-inflammation, pro-angiogenesis and pro-thrombosis species that, when produced in excess, are an underlying cause of pathology. Conversely, some products of ARA oxidation possess ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: J Thomas Brenna Marina G Sergeeva Nikolay B Pestov Tatyana V Korneenko Mikhail S Shchepinov Source Type: research
Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen
This study revealed that blue light irradiation triggered apoptosis and oxidative stress in all-trans-retinal (atRAL)-exposed ARPE-19 cells by generating singlet oxygen (1O2), leading to significant cell death. We found that astaxanthin, a potent anti-oxidative xanthophyll abundant in several marine organisms including microalgae, salmon, and shrimp, significantly suppresses blue light-induced apoptotic cell death of atRAL-exposed ARPE-19 cells by scavenging 1O2. Mechanistic studies using the blue-light irradiated cells also demonstrated that the cytoprotective effects of astaxanthin can be attributed to scavenging of 1O2 ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Mana Kitao Ai Yamaguchi Takuma Tomioka Kenji Kai Yuki Kamei Kenji Sugimoto Mitsugu Akagawa Source Type: research
Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy
This study provides a novel insight into germacrone-mediated protection against DN progression and further confirms that antioxidant pharmacological strategies facilitate the treatment of DN.PMID:37897414 | DOI:10.1080/10715762.2023.2277143 (Source: Free Radical Research)
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Yunguang Wang Xinxin He Mengjiao Xue Wenbo Sun Qiang He Juan Jin Source Type: research
Arachidonic acid: reconciling the dichotomy of its oxidative cascade through specific deuteration
Free Radic Res. 2023 Oct 28:1-11. doi: 10.1080/10715762.2023.2277145. Online ahead of print.ABSTRACTA new approach to attenuating pathological inflammatory reactions by buffering the eicosanoid pathways with oxidation-resistant hexadeuterated arachidonic acid (D-ARA) is discussed. Enzymatic processing of ARA, released by phospholipase A2, by lipoxygenases, cyclooxygenases, and cytochromes yields a wide range of bioactive eicosanoids, including pro-inflammation, pro-angiogenesis and pro-thrombosis species that, when produced in excess, are an underlying cause of pathology. Conversely, some products of ARA oxidation possess ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: J Thomas Brenna Marina G Sergeeva Nikolay B Pestov Tatyana V Korneenko Mikhail S Shchepinov Source Type: research
Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen
This study revealed that blue light irradiation triggered apoptosis and oxidative stress in all-trans-retinal (atRAL)-exposed ARPE-19 cells by generating singlet oxygen (1O2), leading to significant cell death. We found that astaxanthin, a potent anti-oxidative xanthophyll abundant in several marine organisms including microalgae, salmon, and shrimp, significantly suppresses blue light-induced apoptotic cell death of atRAL-exposed ARPE-19 cells by scavenging 1O2. Mechanistic studies using the blue-light irradiated cells also demonstrated that the cytoprotective effects of astaxanthin can be attributed to scavenging of 1O2 ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Mana Kitao Ai Yamaguchi Takuma Tomioka Kenji Kai Yuki Kamei Kenji Sugimoto Mitsugu Akagawa Source Type: research
Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy
This study provides a novel insight into germacrone-mediated protection against DN progression and further confirms that antioxidant pharmacological strategies facilitate the treatment of DN.PMID:37897414 | DOI:10.1080/10715762.2023.2277143 (Source: Free Radical Research)
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Yunguang Wang Xinxin He Mengjiao Xue Wenbo Sun Qiang He Juan Jin Source Type: research
Arachidonic acid: reconciling the dichotomy of its oxidative cascade through specific deuteration
Free Radic Res. 2023 Oct 28:1-11. doi: 10.1080/10715762.2023.2277145. Online ahead of print.ABSTRACTA new approach to attenuating pathological inflammatory reactions by buffering the eicosanoid pathways with oxidation-resistant hexadeuterated arachidonic acid (D-ARA) is discussed. Enzymatic processing of ARA, released by phospholipase A2, by lipoxygenases, cyclooxygenases, and cytochromes yields a wide range of bioactive eicosanoids, including pro-inflammation, pro-angiogenesis and pro-thrombosis species that, when produced in excess, are an underlying cause of pathology. Conversely, some products of ARA oxidation possess ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: J Thomas Brenna Marina G Sergeeva Nikolay B Pestov Tatyana V Korneenko Mikhail S Shchepinov Source Type: research
Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen
This study revealed that blue light irradiation triggered apoptosis and oxidative stress in all-trans-retinal (atRAL)-exposed ARPE-19 cells by generating singlet oxygen (1O2), leading to significant cell death. We found that astaxanthin, a potent anti-oxidative xanthophyll abundant in several marine organisms including microalgae, salmon, and shrimp, significantly suppresses blue light-induced apoptotic cell death of atRAL-exposed ARPE-19 cells by scavenging 1O2. Mechanistic studies using the blue-light irradiated cells also demonstrated that the cytoprotective effects of astaxanthin can be attributed to scavenging of 1O2 ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Mana Kitao Ai Yamaguchi Takuma Tomioka Kenji Kai Yuki Kamei Kenji Sugimoto Mitsugu Akagawa Source Type: research
