Hydrogen peroxide activates APE1/Ref-1 via NF- κB and Parkin: A role in liver cancer resistance to oxidative stress
Free Radic Res. 2023 Jun 26:1-31. doi: 10.1080/10715762.2023.2229509. Online ahead of print.ABSTRACTCancer cells exhibit an altered redox balance and aberrant redox signaling due to genetic, metabolic, and microenvironment-associated reprogramming. Persistently elevated levels of reactive oxygen species (ROS) contribute to many aspects of tumor development and progression. Emerging studies demonstrated the vital role of apurinic/apyrimidinic endonuclease 1 or reduction/oxidation (redox) factor 1(APE1/Ref-1) in the oxidative stress response and survival of cancer cells. APE1/Ref-1 is a multifunctional enzyme involved in the...
Source: Free Radical Research - June 26, 2023 Category: Research Authors: Ferbian Milas Siswanto Kenta Okukawa Akiyoshi Tamura Ami Oguro Susumu Imaoka Source Type: research
3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation
Free Radic Res. 2023 Jun 22:1-34. doi: 10.1080/10715762.2023.2229005. Online ahead of print.ABSTRACT3,6-Epidioxy-1,10-bisaboladiene (EDBD) is a bisabolane sesquiterpene endoperoxide that was isolated from an edible wild plant in Japan, Cacalia delphiniifolia. It showed partially apoptotic cell death through caspase activation against HL-60 cells. However, almost all of the cells had necrotic morphology. Thus, we examined the mechanism of action of EDBD on necrotic cell death. EDBD induced ferrous ion-dependent cell death which causes cell membrane damage, and its cell death form was like H2O2-induced necrosis in HL-60 cell...
Source: Free Radical Research - June 22, 2023 Category: Research Authors: Narandulam Usukhbayar Yukie Takano Shota Uesugi Makoto Muroi Hiroyuki Osada Ken-Ichi Kimura Source Type: research
