Recent advances in the antioxidant activity of metal-curcumin complexes: A combined computational and experimental review
Free Radic Res. 2023 Dec 25:1-35. doi: 10.1080/10715762.2023.2298857. Online ahead of print.ABSTRACTCurcumin, an extensively studied phytochemical compound, has gained attention for its potential therapeutic applications across a spectrum of diseases. Its notable attributes include its relatively high tolerability within the human body and its perceived absence of adverse side effects. This review article presents a comprehensive overview of the antioxidant effects exhibited by complexes formed by curcumin and curcumin derived ligands with metals like Mn, Cu, Fe, Zn, Ga and In, which leads to toxic effects beyond a certain...
Source: Free Radical Research - December 25, 2023 Category: Research Authors: Ankit Mittal Mudita Nagpal Vinod Kumar Vashistha Richa Arora Upasana Issar Source Type: research
Omaveloxolone ameliorates isoproterenol-induced pathological cardiac hypertrophy in mice
In this study, an isoproterenol (ISO)-induced pathological cardiac hypertrophy model was established to investigate the protective effect of omaveloxolone in vivo and in vitro. Our study first confirmed that omaveloxolone administration improved ISO-induced pathological cardiac hypertrophy in mice and neonatal cardiomyocytes. Omaveloxolone administration also diminished ISO-induced cardiac oxidative stress, inflammation and cardiomyocyte apoptosis. In addition, omaveloxolone administration activated the Nrf2 signaling pathway, and Nrf2 knockdown almost completely abolished the cardioprotective effect of omaveloxolone, indi...
Source: Free Radical Research - December 25, 2023 Category: Research Authors: Li Xianchao Yang Wu Yunzhao Yang Yaohua Wu Xi Yu Wenjuan Hu Source Type: research
A novel AluYb8 insertion-associated non-coding RNA, lncMUTYH, impairs mitochondrial function and dampens the M2-like polarization of macrophages
In this study, we identified a novel transcript associated with the AluYb8MUTYH variant, which revealed that this transcript is about 780 nucleotides in length with a poly-A tail, lacks protein-coding potential, referred to as lncMUTYH. The results from the reporter gene system confirmed that the lncMUTYH down-regulates MUTYH1 expression at the translational level. Site-directed mutagenesis on the 5'-terminal exon sequences of α-MUTYH and lncMUTYH constructs revealed that lncMUTYH can act as a trans-regulator that depends on the partial base pairing between its exonized AluYb8 sequence and the 5'UTR of α-MUTYH to impede ...
Source: Free Radical Research - December 25, 2023 Category: Research Authors: Gaochao Dong Xuewen Yin Yingkuan Liang Jingwen Chen Jie Wang Feng Jiang Chaochen Wang Wenwen Guo Yaping Wang Source Type: research
Epoxides: an underestimated lipid oxidation product
Free Radic Res. 2023 Dec 20:1-48. doi: 10.1080/10715762.2023.2277142. Online ahead of print.ABSTRACTImmense gains in understanding of mechanisms and effects of lipid oxidation have been achieved in the nearly 90 years over which lipid oxidation has been an active research focus. Even so, the substantial questions still being raised about lipid oxidation in this special issue show clearly that missing pieces remain and must be considered for full accounting of this important reaction in any system. In this context, epoxides are spotlighted as a critical overlooked product of lipid autoxidation - underestimated in analysis, ...
Source: Free Radical Research - December 21, 2023 Category: Research Authors: Karen M Schaich Source Type: research
Pharmacological inhibition of SIRT-2 by AK-7 modulates redox status and apoptosis via regulating Nrf2 in an experimental model of chronic obstructive pulmonary disease: an invivo and insilico study
Free Radic Res. 2023 Dec 4:1-20. doi: 10.1080/10715762.2023.2288999. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) is defined by inflammation and emphysema. Sirtuins (SIRT) are NAD+-dependent histone deacetylases that regulate oxidative stress and inflammation. The present work investigates the modulatory role of SIRT-2 in experimental COPD model. Insilico comparative assessment of SIRT-2 inhibitors (AK-7 and AGK-2) by ADMET and molecular docking revealed AK-7 as suitable candidate for invivo application. COPD in mice was established by cigarette smoke (CS) exposure for 2 months. AK-7 (100 µg/...
Source: Free Radical Research - December 11, 2023 Category: Research Authors: Vandana Yadav Vinita Pandey Atul Srivastava Sangita Singh None Subhashini Source Type: research
