Molecular dissection of anti-colon cancer activity of NARI-29: Special focus on H < sub > 2 < /sub > O < sub > 2 < /sub > modulated NF- κB and death receptor signaling
Free Radic Res. 2023 Jul 31:1-20. doi: 10.1080/10715762.2023.2243029. Online ahead of print.ABSTRACTAccumulating evidence attributes the role of aldose reductase (AR) in modulating ROS and inflammation which are the main factor responsible for cancer progression and drug resistance. Epalrestat is the only AR inhibitor being used in Asian countries. It did not make it to the markets of the USA and Europe due to marginal efficacy as an antioxidant and anti-inflammatory agent owing to difficulty reaching intracellular targets. In our previous studies, we attempted to synthesize the epalrestat analogs and reported that the com...
Source: Free Radical Research - July 31, 2023 Category: Research Authors: Syamprasad Np Bishal Rajdev Siddhi Jain Jagadeesh Kumar Gangasani Jayathirtha Rao Vaidya Vgm Naidu Source Type: research
Association of circulatory PCSK-9 with biomarkers of redox imbalance and inflammatory cascades in the prognosis of diabetes and associated complications: a pilot study in the Indian population
Free Radic Res. 2023 Jul 22:1-14. doi: 10.1080/10715762.2023.2237180. Online ahead of print.ABSTRACTABSTRACTSBesides the profound role of proprotein convertase subtilisin/kexin type-9 (PCSK-9) in LDL-C regulation, its association with other metabolic complications cannot be disregarded. The co-existence of redox imbalance and inflammatory cascades has greatly reflected the etiology of hyperglycemia. Therefore, we studied the association of PCSK-9 with inflammation and oxidative stress biomarkers to predict its role in the prognosis of diabetes and its associated complications in the Indian population. This pilot study exam...
Source: Free Radical Research - July 17, 2023 Category: Research Authors: Mohd Waiz Sahir Sultan Alvi M Salman Khan Source Type: research
Association of Circulatory PCSK-9 with Biomarkers of Redox Imbalance and Inflammatory Cascades in the Prognosis of Diabetes and Associated Complications: A Pilot Study in the Indian Population
Free Radic Res. 2023 Jul 17:1-15. doi: 10.1080/10715762.2023.2237180. Online ahead of print.ABSTRACTAbstractsBesides the profound role of proprotein convertase subtilisin/kexin type-9 (PCSK-9) in LDL-C regulation, its association with other metabolic complications cannot be disregarded. The co-existence of redox imbalance and inflammatory cascades has greatly reflected the etiology of hyperglycemia. Therefore, we studied the association of PCSK-9 with inflammation and oxidative stress biomarkers to predict its role in the prognosis of diabetes and its associated complications in the Indian population. This pilot study exam...
Source: Free Radical Research - July 17, 2023 Category: Research Authors: Mohd Waiz Sahir Sultan Alvi M Salman Khan Source Type: research
Formation of free radicals in Chi-aroma Baijiu during aging process with fat pork
This study aimed to investigate the free radicals' formation pathway in Chi-aroma Baijiu during aged fat pork soaking by using electron paramagnetic resonance (EPR) and spin trapping with 5,5-dimethyl-1-pyrrolin-n-oxide (DMPO). The alkyl radical adducts (DMPO-R) and hydroxyl radical adducts (DMPO-OH) were detected in Baijiu after soaking the fat pork for aging. During the preparation process of aged fat pork, alkoxy radicals adduct (DMPO-RO) were mainly detected since lipid oxidation. Oleic acid and linoleic acid, the two main unsaturated fatty acids in fat pork, produced alkoxy radicals in the oxidation process. The total...
Source: Free Radical Research - July 4, 2023 Category: Research Authors: Fengjiao Zhang Renjie Zhang Songgui He Jingyi Guan Zhaoxing Feng Zhenqiang Wu Source Type: research
