Arachidonic Acid: Reconciling the Dichotomy of its Oxidative Cascade through Specific Deuteration
Free Radic Res. 2023 Oct 28:1-16. doi: 10.1080/10715762.2023.2277145. Online ahead of print.ABSTRACTA new approach to attenuating pathological inflammatory reactions by buffering the eicosanoid pathways with oxidation-resistant hexadeuterated arachidonic acid (D-ARA) is discussed. Enzymatic processing of ARA, released by phospholipase A2, by lipoxygenases, cyclooxygenases, and cytochromes yields a wide range of bioactive eicosanoids, including pro-inflammation, pro-angiogenesis and pro-thrombosis species that, when produced in excess, are an underlying cause of pathology. Conversely, some products of ARA oxidation possess ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: J Thomas Brenna Marina G Sergeeva Nikolay B Pestov Tatyana V Korneenko Mikhail S Shchepinov Source Type: research
Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen
This study revealed that blue light irradiation triggered apoptosis and oxidative stress in all-trans-retinal (atRAL)-exposed ARPE-19 cells by generating singlet oxygen (1O2), leading to significant cell death. We found that astaxanthin, a potent anti-oxidative xanthophyll abundant in several marine organisms including microalgae, salmon, and shrimp, significantly suppresses blue light-induced apoptotic cell death of atRAL-exposed ARPE-19 cells by scavenging 1O2. Mechanistic studies using the blue-light irradiated cells also demonstrated that the cytoprotective effects of astaxanthin can be attributed to scavenging of 1O2 ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Mana Kitao Ai Yamaguchi Takuma Tomioka Kenji Kai Yuki Kamei Kenji Sugimoto Mitsugu Akagawa Source Type: research
Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy
This study provides a novel insight into germacrone-mediated protection against DN progression and further confirms that antioxidant pharmacological strategies facilitate the treatment of DN.PMID:37897414 | DOI:10.1080/10715762.2023.2277143 (Source: Free Radical Research)
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Yunguang Wang Xinxin He Mengjiao Xue Wenbo Sun Qiang He Juan Jin Source Type: research
Arachidonic Acid: Reconciling the Dichotomy of its Oxidative Cascade through Specific Deuteration
Free Radic Res. 2023 Oct 28:1-16. doi: 10.1080/10715762.2023.2277145. Online ahead of print.ABSTRACTA new approach to attenuating pathological inflammatory reactions by buffering the eicosanoid pathways with oxidation-resistant hexadeuterated arachidonic acid (D-ARA) is discussed. Enzymatic processing of ARA, released by phospholipase A2, by lipoxygenases, cyclooxygenases, and cytochromes yields a wide range of bioactive eicosanoids, including pro-inflammation, pro-angiogenesis and pro-thrombosis species that, when produced in excess, are an underlying cause of pathology. Conversely, some products of ARA oxidation possess ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: J Thomas Brenna Marina G Sergeeva Nikolay B Pestov Tatyana V Korneenko Mikhail S Shchepinov Source Type: research
Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen
This study revealed that blue light irradiation triggered apoptosis and oxidative stress in all-trans-retinal (atRAL)-exposed ARPE-19 cells by generating singlet oxygen (1O2), leading to significant cell death. We found that astaxanthin, a potent anti-oxidative xanthophyll abundant in several marine organisms including microalgae, salmon, and shrimp, significantly suppresses blue light-induced apoptotic cell death of atRAL-exposed ARPE-19 cells by scavenging 1O2. Mechanistic studies using the blue-light irradiated cells also demonstrated that the cytoprotective effects of astaxanthin can be attributed to scavenging of 1O2 ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Mana Kitao Ai Yamaguchi Takuma Tomioka Kenji Kai Yuki Kamei Kenji Sugimoto Mitsugu Akagawa Source Type: research
Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy
This study provides a novel insight into germacrone-mediated protection against DN progression and further confirms that antioxidant pharmacological strategies facilitate the treatment of DN.PMID:37897414 | DOI:10.1080/10715762.2023.2277143 (Source: Free Radical Research)
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Yunguang Wang Xinxin He Mengjiao Xue Wenbo Sun Qiang He Juan Jin Source Type: research
Arachidonic Acid: Reconciling the Dichotomy of its Oxidative Cascade through Specific Deuteration
Free Radic Res. 2023 Oct 28:1-16. doi: 10.1080/10715762.2023.2277145. Online ahead of print.ABSTRACTA new approach to attenuating pathological inflammatory reactions by buffering the eicosanoid pathways with oxidation-resistant hexadeuterated arachidonic acid (D-ARA) is discussed. Enzymatic processing of ARA, released by phospholipase A2, by lipoxygenases, cyclooxygenases, and cytochromes yields a wide range of bioactive eicosanoids, including pro-inflammation, pro-angiogenesis and pro-thrombosis species that, when produced in excess, are an underlying cause of pathology. Conversely, some products of ARA oxidation possess ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: J Thomas Brenna Marina G Sergeeva Nikolay B Pestov Tatyana V Korneenko Mikhail S Shchepinov Source Type: research
Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen
This study revealed that blue light irradiation triggered apoptosis and oxidative stress in all-trans-retinal (atRAL)-exposed ARPE-19 cells by generating singlet oxygen (1O2), leading to significant cell death. We found that astaxanthin, a potent anti-oxidative xanthophyll abundant in several marine organisms including microalgae, salmon, and shrimp, significantly suppresses blue light-induced apoptotic cell death of atRAL-exposed ARPE-19 cells by scavenging 1O2. Mechanistic studies using the blue-light irradiated cells also demonstrated that the cytoprotective effects of astaxanthin can be attributed to scavenging of 1O2 ...
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Mana Kitao Ai Yamaguchi Takuma Tomioka Kenji Kai Yuki Kamei Kenji Sugimoto Mitsugu Akagawa Source Type: research
Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy
This study provides a novel insight into germacrone-mediated protection against DN progression and further confirms that antioxidant pharmacological strategies facilitate the treatment of DN.PMID:37897414 | DOI:10.1080/10715762.2023.2277143 (Source: Free Radical Research)
Source: Free Radical Research - October 28, 2023 Category: Research Authors: Yunguang Wang Xinxin He Mengjiao Xue Wenbo Sun Qiang He Juan Jin Source Type: research
Rhabdomyolysis aggravates renal iron accumulation and acute kidney injury in a humanized mouse model of sickle cell disease
Free Radic Res. 2023 Oct 15:1-9. doi: 10.1080/10715762.2023.2269313. Online ahead of print.ABSTRACTIndividuals with sickle cell disease (SCD) are at greater risk of rhabdomyolysis, a potentially life-threatening condition resulting from the breakdown of skeletal muscle fibers. Acute kidney injury (AKI) is one of the most severe complications of rhabdomyolysis. Chronic kidney and cardiovascular disease, which account for SCD mortality, are long-term consequences of AKI. Although SCD elevates the risks of rhabdomyolysis-induced sudden death, the mechanisms that underlie rhabdomyolysis-induced AKI in SCD are unclear. In the p...
Source: Free Radical Research - October 16, 2023 Category: Research Authors: Jada D Williams Ravi Kumar Jeremiah M Afolabi Frank Park Adebowale Adebiyi Source Type: research
