The Myelic Limited Dorsal Malformation: Prenatal Ultrasonographic Characteristics of an Intermediate Form of Dysraphism
Conclusion: Our series describe the ultrasonographic characteristics of an intermediate type of dysraphism and suggest that there is a continuum between MMC and LDM with numerous possibilities of hybrid forms (MyeLDM) sharing characteristics of both open and closed dysraphisms.Fetal Diagn Ther (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - October 29, 2021 Category: Perinatology & Neonatology Source Type: research
The Influence of Hyperoxygenation on Fetal Brain Vascularity Measured Using 3D Power Doppler Ultrasound and the Index “Fractional Moving Blood Volume”
Conclusion: Measurement of fetal cerebral vascularity by 3D-FMBV and 2D-FMBV was highly reproducible. The differing cerebral vascular changes seen with 60% but not 52% FiO2 suggest a possible “threshold effect” that may have influenced prior studies. Further studies are needed to assess cerebral effects of maternal hyperoxygenation on compromised fetuses.Fetal Diagn Ther (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - October 28, 2021 Category: Perinatology & Neonatology Source Type: research
Maternal Hyperoxygenation Testing in Fetuses with Hypoplastic Left-Heart Syndrome: Association with Postnatal Atrial Septal Restriction
Conclusion: Addition of MHO appears to improve the diagnostic ability of the Pvein VTI ratio to identify HLHS fetuses who undergo EAS. The Pvein VTI ratio change may more accurately identify fetuses who undergo EAS than change in PA PI and has less interobserver variability.Fetal Diagn Ther (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - October 21, 2021 Category: Perinatology & Neonatology Source Type: research
Is Cardiomegaly an Indication of “Heart-Sparing Effect” in Small Fetuses?
Conclusions: Our results show that in small fetuses with cardiomegaly, the heart maintains normal dimensions when normalized to cranial diameters and higher dimensions when normalized to long bones. This provides insight into cardiac adaptation to adverse intrauterine environment.Fetal Diagn Ther (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - October 15, 2021 Category: Perinatology & Neonatology Source Type: research
The Natural History of Trisomy 21: Outcome Data from a Large Tertiary Referral Centre
Conclusion: The risk of foetal loss in prenatally diagnosed T21 is high at 38% with an overall pregnancy loss rate of 41.1%. This information may be of benefit when counselling couples who are faced with a diagnosis of T21 particularly in the context of limited access to TOP.Fetal Diagn Ther (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - September 28, 2021 Category: Perinatology & Neonatology Source Type: research
Placental Abruption after Fetoscopic Laser Surgery in Twin-Twin Transfusion Syndrome: The Role of the Solomon Technique
Conclusion: The prevalence of placental abruption in TTTS after fetoscopic laser surgery is low, although it appears higher than in the overall population. Placental abruption is associated with a lower gestational age at birth, which is associated with severe cerebral injury. The rate of placental abruption was not significantly increased with the use of the Solomon technique. Continued research of placental abruption in TTTS is necessary to determine why the rate is higher than in the overall population.Fetal Diagn Ther (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - September 23, 2021 Category: Perinatology & Neonatology Source Type: research
Serial Monitoring and Hyperimmunoglobulin versus Standard of Care to Prevent Congenital Cytomegalovirus Infection: A Phase III Randomized Trial
Conclusions: Serial monitoring of CMV serostatus with CMV-HyperIg treatment was associated with a mild nonsignificant reduction in the vertical CMV transmission rate. Studies on the optimal preventive strategy are hampered by epidemiological and ethical challenges and should focus on GA-dependent transmission rates and accurate dating of infection.Fetal Diagn Ther (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - September 21, 2021 Category: Perinatology & Neonatology Source Type: research
Euploid First-Trimester Cystic Hygroma: A More Benign Entity than Previously Thought?
Conclusions: Counseling regarding outcomes in the setting of first-trimester septated cystic hygroma initially focuses on the strong likelihood of an abnormal karyotype, which occurs in 61% of cases. However, once fetal chromosomal abnormality is excluded, our results demonstrate only a 13% incidence of major structural fetal abnormality, which appears significantly less than previously reported. Normal fetuses have a 77% survival rate. These data represent the largest single-center study of first-trimester cystic hygroma with complete outcome data and therefore will be useful for contemporary patient counseling. Such coun...
Source: Fetal Diagnosis and Therapy - September 21, 2021 Category: Perinatology & Neonatology Source Type: research
Taiwanese Clinical Experience with Noninvasive Prenatal Testing for DiGeorge Syndrome
Conclusion: NIPT demonstrated good performance in DGS screening. Detection of 22q11.2 deletion could be combined with routine screening to facilitate proper intervention.Fetal Diagn Ther (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - September 16, 2021 Category: Perinatology & Neonatology Source Type: research
Fetal Ultrasonic Evaluation of Bronchial Morphology in Fetuses with Isomerism
Conclusions: Fetal ultrasound can detect the bronchial morphology and the presence of bronchial isomerism in fetuses with isomerism according to bronchial angles and the ratio of left/right bronchial angle.Fetal Diagn Ther (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - September 10, 2021 Category: Perinatology & Neonatology Source Type: research
Implementation Process and Evolution of a Laparotomy-Assisted 2-Port Fetoscopic Spina Bifida Closure Program
Conclusion: Implementation of a laparotomy-assisted 2-port fetoscopic spina bifida closure program through rigorous preparation and multispecialty team training may accelerate the learning curve and demonstrates favorable obstetric and perinatal outcomes.Fetal Diagn Ther (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - September 8, 2021 Category: Perinatology & Neonatology Source Type: research
Prenatal Percutaneous Fetoscopic Laser Photocoagulation of Chorioangioma: Report of Two Cases and Review of the Literature
Conclusion: Prenatal percutaneous fetoscopic laser photocoagulation improves survival in large chorioangioma, despite a risk of fetal death in utero.Fetal Diagn Ther (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - September 8, 2021 Category: Perinatology & Neonatology Source Type: research
Effect of Maternal and Fetal Characteristics in Feto-Placental Doppler and Impact of Using Adjusted Standards in the Definition of Fetal Growth Restriction at Term
This study aimed to determine the effect and clinical impact of physiological characteristics on the 95th/5th centile of the umbilical artery (UA) Doppler and the cerebroplacental ratio (CPR), at 36+ weeks.Methods: From the multicenter randomized trial “Ratio37,” we selected 4,505 low-risk pregnant women between June 2016 and January 2020. We registered physiological characteristics and the pulsatility indexes (PI) of the UA and middle cerebral artery (36–39 weeks). The 95th/5th centile of the UA PI and CPR was modeled by quantile regression . To evaluate the clinical impact of adjusting Doppler, we retrospectively a...
Source: Fetal Diagnosis and Therapy - September 7, 2021 Category: Perinatology & Neonatology Source Type: research
Growth Velocity and Doppler Evaluation to Predict Nonreassuring Fetal Heart Rate at Birth in Low-Risk Women: A Prospective, Longitudinal Study
Conclusion: Fetal growth velocity, EFW between 10 and 25th percentiles (EFWQ1), and abnormal CPR improves prediction of unplanned CS due to NRFHR among term AGA fetuses. This should be considered when counseling about the delivery method.Fetal Diagn Ther (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - August 31, 2021 Category: Perinatology & Neonatology Source Type: research
Ultrasound and Fetal MRI Complementary Contributions to Appropriate Counseling in Small Bowel Obstruction
Conclusion: Our study suggests that fetal MRI, when done in addition to prenatal ultrasound, is contributory in the management of fetuses with suspected bowel obstruction. MRI may be particularly useful in determining the location and origin of the bowel obstruction and in assessing the quality of the bowel distal to the obstruction, which might assist in the prediction of SBS and more detailed prenatal counseling.Fetal Diagn Ther (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - August 30, 2021 Category: Perinatology & Neonatology Source Type: research
