Relevance of fetal brain MRI compared to ultrasound for detecting cerebral anomalies in fetuses with cleft lip and/or palate: a cohort study
Conclusion: Fetal brain MRI should be proposed in cases of clefts associated with other anomalies or if US examination is limited by local conditions. MRI could also be discussed in cases of isolated CLP but should not be performed in cases of isolated cleft lip (CL). (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - January 9, 2023 Category: Perinatology & Neonatology Source Type: research
Feasibility of non-gated dynamic fetal cardiac MRI for identification of fetal cardiovascular anatomy
Introduction: To evaluate the feasibility of identifying the fetal cardiac and thoracic vascular structures with non-gated dynamic balanced steady-state free precession (SSFP) MRI sequences.
Methods: We retrospectively assessed the visibility of cardiovascular anatomy in 60 fetuses without suspicion of congenital heart defect. Non-gated dynamic balanced SSFP sequences were acquired in three anatomic planes of the fetal thorax. The images were analyzed following a segmental approach in consensus reading by an experienced pediatric cardiologist and radiologist. An imaging score was defined by giving one point to each visual...
Source: Fetal Diagnosis and Therapy - January 7, 2023 Category: Perinatology & Neonatology Source Type: research
Successful treatment of bronchopulmonary sequestration by radiofrequency ablation of feeding artery
Conclusion : with proper technique , RFA can be safely used to ablate feeding artery in BPS (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - December 28, 2022 Category: Perinatology & Neonatology Source Type: research
Common arterial trunk in fetal life: accuracy of diagnosis and prediction of outcome
Conclusion
CAT is a condition that if evaluated by experts, can be diagnosed with a high degree of accuracy. It remains an entity with high perinatal mortality. Its most important prognostic factor is its association with other anomalies. In isolated cases, the presence of a dysplastic truncal valve and a stenotic flow increase the chances of perinatal death. (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - December 27, 2022 Category: Perinatology & Neonatology Source Type: research
Noninvasive prenatal diagnosis of beta-thalassemia disease by using digital PCR analysis of cell-free fetal DNA in maternal plasma
Conclusions: The method of analyzing cff-DNA in maternal plasma by dPCR is efficient for prenatal diagnosis of beta-thalassemia. (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - December 27, 2022 Category: Perinatology & Neonatology Source Type: research
Hydrops fetalis associated with fetal hemoglobin H-Pakse disease
Conclusion: Fetuses with Hb H-PS may be associated with hydrops fetalis, usually occurring at mid-pregnancy. The hydrops tends to improve in late gestation. If they can pass through this most critical period in utero without anemic insults in developing organs, good long-term prognos is can be expected. This successful prenatal diagnosis and intrauterine treatment may encourage care providers to pay more attention to fetal Hb H-PS disease, to prevent anemic hypoxia in developing organs and adult diseases of fetal origin. (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - December 27, 2022 Category: Perinatology & Neonatology Source Type: research
Intrafetal laser therapy is a feasible treatment for different fetal conditions: a systematic review
Discussion: Our analysis suggests that IFL is a feasible technique for the management of different fetal conditions. However, the overall risk of PTB and its related morbidity and mortality, ranges from 12.5% in BPS to 87.5% in SCT. This could aid in decision making during prenatal counselling. However final perinatal outcome depends on the severity of the disease itself. (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - December 23, 2022 Category: Perinatology & Neonatology Source Type: research
Routine Ultrasound at 30th –33rd weeks versus 30th–33rd and 35th–37th weeks in Low-Risk Pregnancies: A Randomized Trial
Conclusion: A later ultrasound (35 –37 weeks) had a high accuracy for detection of FGR and had a higher correlation between EFW and birthweight centiles. Furthermore, it was also associated with lower adverse perinatal outcomes compared to an earlier ultrasound.Fetal Diagn Ther (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - December 19, 2022 Category: Perinatology & Neonatology Source Type: research
Variant in ACTG2 causing megacystis microcolon hypoperistalsis syndrome and severe familial postpartum bleeding
This report describes a pregnant woman with a history of bowel obstruction, urine retention and heavy postpartum bleeding where ultrasound findings of fetal megacystis during pregnancy led to genetic testing in the family. The fetus, the pregnant woman and four female family members were heterozygous for a pathogenic variant detected in the ACTG2 gene. The fetus was treated successfully for hydronephrosis using vesicoamniotic shunting.
Discussion
Early diagnosis of a fetus with MMIHS is important to secure multidisciplinary prenatal and neonatal treatment. Furthermore, gene testing must be considered when a woman present...
Source: Fetal Diagnosis and Therapy - December 12, 2022 Category: Perinatology & Neonatology Source Type: research
Type Ⅱ left pulmonary artery sling associated with double outlet right ventricle diagnosed by fetal echocardiography and postnatal computer tomography
We present a case of type ⅡLPAS associated with double outlet right ventricle diagnosed by fetal echocardiography and postnatal computer tomography. Prenatal diagnosis of LPAS will facilitate postnatal care and timely treatment. (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - December 12, 2022 Category: Perinatology & Neonatology Source Type: research
Bruck Syndrome: Beyond the Obvious
Conclusion: To our knowledge, this is the first case of Bruck Syndrome prenatally confirmed by chromosomal microarray analysis and the second reported case with an extra-skeletal abnormality. This case highlights the importance of comprehensive fetal morphological assessment during pregnancy, as diagnosis of an additional abnormality has the potential to impact both management and prognosis. (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - December 7, 2022 Category: Perinatology & Neonatology Source Type: research
Subamniotic haemorrhage, a possible new presentation of fetal and neonatal alloimmune thrombocytopenia
The study titled, ‘Subamniotic Hemorrhage, a Possible New Presentation of Fetal and Neonatal Alloimmune Thrombocytopenia’ Giesbers et al reports that histologically this hematoma consisted mainly of degenerated blood with fibrin and nucleated fetal erythrocytes under the amnion. The authors state that the placent al parenchyma had a normal maturation with focal ischemia, a low-grade chronic villitis of unknown etiology and part from the subamniotic hematoma, a subchorionic hematoma was also present in the maternal compartment. The nucleated fetal erythrocytes were also visualized by an immunohistochemical st aining for...
Source: Fetal Diagnosis and Therapy - December 5, 2022 Category: Perinatology & Neonatology Source Type: research
Fetal Endoscopic Tracheal Intubation: modification of the FETI procedure to establish an airway in a fetus with a congenital cervical teratoma.
Conclusion: The modified FETI procedure described in this report represents another technique that can be used to establish an airway in fetuses with challenging upper airway anatomy, potentially mitigating the risks associated with an EXIT procedure. (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - December 1, 2022 Category: Perinatology & Neonatology Source Type: research
Subsequent pregnancy outcomes after open in utero spina bifida repair
Introduction: Fetal spina bifida (SB) repair is a distinct therapeutic option in selected cases. Since this procedure may not only be associated with short-term obstetrical complications, the aim of this study was to assess the outcomes of subsequent pregnancies after open fetal SB repair.
Methods: 138 patients having had open fetal SB repair at our center received a questionnaire regarding the occurrence, course and outcome of subsequent pregnancies. Additionally, medical records were reviewed. All subsequent pregnancies with complete outcome data that progressed beyond 20 gestatio nal weeks (GW) were included for furth...
Source: Fetal Diagnosis and Therapy - December 1, 2022 Category: Perinatology & Neonatology Source Type: research
In utero Treatment of Congenital High Airway Obstruction Syndrome via Fetal Laryngoscopy and EXIT Procedure
Conclusion: The primary goal of fetoscopic airway evaluation and intervention is not necessarily to perform definitive stabilization of the airway but rather to achieve sufficient decompression of the trachea to reverse fetal hydrops and salvage pulmonary development. In utero fetoscopic treatment may allow for prolongation of the pregnancy with delivery at or near term via EXIT procedure for definitive neonatal airway stabilization.Fetal Diagn Ther (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - December 1, 2022 Category: Perinatology & Neonatology Source Type: research
