Stratification of patients with KRAS-mutated advanced non-small cell lung cancer: improving prognostics
Expert Rev Respir Med. 2023 Sep 29. doi: 10.1080/17476348.2023.2265810. Online ahead of print.ABSTRACTINTRODUCTION: KRAS is the most frequently mutated oncogene in cancer and encodes a key signaling protein in tumors. Due to its high affinity for GTP and the lack of a large binding pocket that allosteric inhibitors can occupy, KRAS has long been considered 'non-druggable.' Finding effective treatment measures for patients with KRAS mutations is our top priority.AREAS COVERED: In this article, we will provide an overview of the KRAS pathway and review the current state of therapeutic strategies for targeting oncogenic KRAS,...
Source: Expert Review of Respiratory Medicine - September 30, 2023 Category: Respiratory Medicine Authors: Yuda Zhang Fanxu Zeng Shixuan Peng Yangqian Chen Wenjuan Jiang Zhan Wang Li Deng Zhe Huang Haoyue Qin Huan Yan Xing Zhang Lin Zhang Nong Yang Qian Gong Liang Zeng Yongchang Zhang Source Type: research

The potential clinical value of pairing procalcitonin and lung ultrasonography to guide antibiotic therapy in patients with community-acquired pneumonia: a narrative review
Expert Rev Respir Med. 2023 Sep 28:1-9. doi: 10.1080/17476348.2023.2254232. Online ahead of print.ABSTRACTINTRODUCTION: Lower respiratory tract infections (LRTIs) are among the most frequent infections and are prone to inappropriate antibiotic treatments. This results from a limited accuracy of diagnostic tools in identifying bacterial pneumonia. Lung ultrasound (LUS) has excellent sensitivity and specificity in diagnosing pneumonia. Additionally, elevated procalcitonin (PCT) levels correlate with an increased likelihood of bacterial infection. LUS and PCT appear to be complementary in identifying patients with bacterial p...
Source: Expert Review of Respiratory Medicine - September 28, 2023 Category: Respiratory Medicine Authors: C écile Bessat No émie Boillat-Blanco Werner C Albrich Source Type: research

Clinical predictors and outcomes of pulmonary infarction in patients with central pulmonary embolism
CONCLUSIONS: Aging is a protective factor against PI. In acute central PE, subjects with PI had higher odds of developing severe hypoxemic respiratory failure and requiring mechanical ventilation.PMID:37750314 | DOI:10.1080/17476348.2023.2263359 (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - September 26, 2023 Category: Respiratory Medicine Authors: Jose Manuel Martinez Manzano Kevin Bryan Lo Omar Cantu-Martinez Long Nguyen Brenda Chiang Simone A Jarrett Sahana Tito Alexander Prendergast Maria A Planchart Ferretto Willy Roque Ammaar Wattoo Zurab Azmaiparashvili Sadia Benzaquen Source Type: research

Epithelial alarmins: a new target to treat chronic respiratory diseases
Expert Rev Respir Med. 2023 Sep 25. doi: 10.1080/17476348.2023.2262920. Online ahead of print.ABSTRACTINTRODUCTION: In response to injury, epithelial cells release alarmins including thymic stromal lymphopoietin (TSLP), high mobility group-box-1 (HMGB1), interleukin (IL)-33 and -25 that can initiate innate immune responses. These alarmins are recognized as activators of T2-immune responses characteristic for asthma, but recent evidence highlighted their role in non-T2 inflammation, airway remodeling and pulmonary fibrosis making them an attractive therapeutic target for chronic respiratory diseases (CRD).AREAS COVERED: In ...
Source: Expert Review of Respiratory Medicine - September 25, 2023 Category: Respiratory Medicine Authors: Denislava Nedeva Krzysztof Kowal Stefan Mihaicuta Guillermo Guidos Fogelbach Paschalis Steiropoulos Herberto Jose Chong-Neto Angelica Tiotiu Source Type: research

Should we be screening for COPD? - looking through the lens of lung cancer screening
Expert Rev Respir Med. 2023 Sep 20. doi: 10.1080/17476348.2023.2259800. Online ahead of print.ABSTRACTINTRODUCTION: In May 2022, the US Preventive Services Task Force published their recommendation against screening for chronic obstructive pulmonary disease (COPD) in asymptomatic adults. However, we argue the routine use of spirometry in both asymptomatic and symptomatic high-risk smokers has utility.AREAS COVERED: We provide published and unpublished observations from a secondary analyses of the American College of Radiology Imaging Network(ACRIN), arm of the National Lung Screening Trial, including 18,643 high-risk curre...
Source: Expert Review of Respiratory Medicine - September 20, 2023 Category: Respiratory Medicine Authors: Robert P Young Raewyn J Scott Source Type: research