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Adherence to inhaled antibiotics in people with cystic fibrosis: insights from a virtual patient advisory board
CONCLUSIONS: PwCF on CFTR modulators are questioning the necessity of continuing chronic medications and therapies. Physicians are urged to carefully consider the balance between simplifying antibiotic treatment and the risk of clinical deterioration due to bacterial infections when making treatment decisions. Furthermore, the development and global harmonization of diagnostic tools for chronic lung damage and treatment guidelines are crucial to justify the demanding routines that PwCF must endure to manage their condition.The heterogeneity in patient journeys, diagnostic challenges, treatment complexity, and issues relate...
Source: Expert Review of Respiratory Medicine - October 11, 2023 Category: Respiratory Medicine Authors: Simone Gambazza Valerie Storms Vinay Purohit Source Type: research

What to do after immune-checkpoint inhibitors failure in advanced non-small cell lung cancer: an expert opinion and review
Expert Rev Respir Med. 2023 Oct 10. doi: 10.1080/17476348.2023.2268509. Online ahead of print.ABSTRACTINTRODUCTION: Immune-checkpoint inhibitors (IO) have significantly improved outcomes of patients with non-oncogene-addicted non-small cell lung cancer (NSCLC), becoming the first-line agents for advanced disease. However, resistance remains a significant clinical challenge, limiting their effectiveness.AREAS COVERED: Hereby, we addressed standard and innovative therapeutic approaches for NSCLC patients experiencing progression after IO treatment, discussing the emerging resistance mechanisms and the ongoing efforts to over...
Source: Expert Review of Respiratory Medicine - October 11, 2023 Category: Respiratory Medicine Authors: Alberto Giuseppe Agostara Laura Roazzi Federica Villa Rebecca Romano' Daniele Piscazzi Francesca Martinelli Gabriele Ciarlo Sara Oresti Francesca Travaglini Alessandro Marando Andrea Sartore Bianchi Laura Giannetta Giulio Cerea Salvatore Siena Elio Gregor Source Type: research

Is there cardiac autonomic dysfunction in children and adolescents with exercise-induced bronchospasm?
CONCLUSION: Young asthmatics with EIBA present a delay in the increase of the parasympathetic component after EVH when compared to asthmatics without EIBA.PMID:37795708 | DOI:10.1080/17476348.2023.2265819 (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - October 5, 2023 Category: Respiratory Medicine Authors: Polyanna Guerra Chaves Quirino Jos é Ângelo Rizzo Steve Hunter Edil de Albuquerque Rodrigues Filho Emanuel Sarinho Camila Matias de Almeida Santos Decio Medeiros Emilia Chagas Costa Alexandre S érgio Silva Breno Quintella Farah Marco Aur élio de Valoi Source Type: research

Is there cardiac autonomic dysfunction in children and adolescents with exercise-induced bronchoconstriction?
CONCLUSION: Young asthmatics with EIBA present a delay in the increase of the parasympathetic component after EVH when compared to asthmatics without EIBA.PMID:37795708 | DOI:10.1080/17476348.2023.2265819 (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - October 5, 2023 Category: Respiratory Medicine Authors: Polyanna Guerra Chaves Quirino Jos é Ângelo Rizzo Steve Hunter Edilde Albuquerque Rodrigues Filho Emanuel Sarinho Camila Matiasde Almeida Santos Decio Medeiros Emilia Chagas Costa Alexandre S érgio Silva Breno Quintella Farah Marco Aur éliode Valois C Source Type: research

Thoracic ultrasound-guided real-time pleural biopsy in the diagnosis of pleural diseases: a systematic review and meta-analysis
CONCLUSION: Conventional TUSPB has good pooled diagnostic yields and high safety. CEUS and UE are promising guidance tools for pleural biopsy with the potential to increase diagnostic yield.PMID:37787485 | DOI:10.1080/17476348.2023.2266377 (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - October 3, 2023 Category: Respiratory Medicine Authors: Qin Zhang Ming-Ming Deng Xue-Lian Li Ye Lu Gang Hou Source Type: research

Stratification of patients with KRAS-mutated advanced non-small cell lung cancer: improving prognostics
Expert Rev Respir Med. 2023 Sep 29. doi: 10.1080/17476348.2023.2265810. Online ahead of print.ABSTRACTINTRODUCTION: KRAS is the most frequently mutated oncogene in cancer and encodes a key signaling protein in tumors. Due to its high affinity for GTP and the lack of a large binding pocket that allosteric inhibitors can occupy, KRAS has long been considered 'non-druggable.' Finding effective treatment measures for patients with KRAS mutations is our top priority.AREAS COVERED: In this article, we will provide an overview of the KRAS pathway and review the current state of therapeutic strategies for targeting oncogenic KRAS,...
Source: Expert Review of Respiratory Medicine - September 30, 2023 Category: Respiratory Medicine Authors: Yuda Zhang Fanxu Zeng Shixuan Peng Yangqian Chen Wenjuan Jiang Zhan Wang Li Deng Zhe Huang Haoyue Qin Huan Yan Xing Zhang Lin Zhang Nong Yang Qian Gong Liang Zeng Yongchang Zhang Source Type: research

The potential clinical value of pairing procalcitonin and lung ultrasonography to guide antibiotic therapy in patients with community-acquired pneumonia: a narrative review
Expert Rev Respir Med. 2023 Sep 28:1-9. doi: 10.1080/17476348.2023.2254232. Online ahead of print.ABSTRACTINTRODUCTION: Lower respiratory tract infections (LRTIs) are among the most frequent infections and are prone to inappropriate antibiotic treatments. This results from a limited accuracy of diagnostic tools in identifying bacterial pneumonia. Lung ultrasound (LUS) has excellent sensitivity and specificity in diagnosing pneumonia. Additionally, elevated procalcitonin (PCT) levels correlate with an increased likelihood of bacterial infection. LUS and PCT appear to be complementary in identifying patients with bacterial p...
Source: Expert Review of Respiratory Medicine - September 28, 2023 Category: Respiratory Medicine Authors: C écile Bessat No émie Boillat-Blanco Werner C Albrich Source Type: research