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Extracorporeal membrane oxygenation for COVID-19 and influenza associated acute respiratory distress syndrome: a systematic review
CONCLUSION: The use of ECMO significantly reduced in-hospital mortality in COVID-19- associated ARDS, which may be related to the advances in ECMO-related techniques and the increased experience of clinicians. However, the incidence of bleeding complications remains high.PMID:37847592 | DOI:10.1080/17476348.2023.2272704 (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - October 17, 2023 Category: Respiratory Medicine Authors: Lian Wang Dongguang Wang Tianli Zhang Ying He Hong Fan Yonggang Zhang Source Type: research

Pathogenesis and management of emphysema in people with HIV
Expert Rev Respir Med. 2023 Oct 17. doi: 10.1080/17476348.2023.2272702. Online ahead of print.ABSTRACTINTRODUCTION: Since early in the HIV epidemic, emphysema has been identified among people with HIV (PWH) and has been associated with increased mortality. Smoking cessation is key to risk reduction. Health maintenance for PWH and emphysema should ensure appropriate vaccination and lung cancer screening. Treatment should adhere to inhaler guidelines for the general population, but inhaled corticosteroid (ICS) should be used with caution. Frontiers in treatment include targeted therapeutics. Major knowledge gaps exist in the...
Source: Expert Review of Respiratory Medicine - October 17, 2023 Category: Respiratory Medicine Authors: Jonah S Kreniske Robert J Kaner Marshall J Glesby Source Type: research

Persistent respiratory symptoms associated with post-covid condition (Long covid) in children: a systematic review and analysis of current gaps and future perspectives
Expert Rev Respir Med. 2023 Oct 16. doi: 10.1080/17476348.2023.2271836. Online ahead of print.ABSTRACTINTRODUCTION: There is increasing evidence that also children can develop Long Covid. However, there are no specific reviews providing a clear description of reported respiratory symptoms and potential diagnostics.AREAS COVERED: we performed on Pubmed a systematic search of studies conducted on children aged less than 18 years with previous SARS-CoV-2 infection complaining about persistent respiratory symptoms; the aim of our review is to characterize the incidence, pattern and duration of respiratory symptoms after the ac...
Source: Expert Review of Respiratory Medicine - October 16, 2023 Category: Respiratory Medicine Authors: Laura Martino Rosa Morello Cristina De Rose Danilo Buonsenso Source Type: research

What to do after immune-checkpoint inhibitors failure in advanced non-small cell lung cancer: an expert opinion and review
Expert Rev Respir Med. 2023 Oct 10. doi: 10.1080/17476348.2023.2268509. Online ahead of print.ABSTRACTINTRODUCTION: Immune-checkpoint inhibitors (IO) have significantly improved outcomes of patients with non-oncogene-addicted non-small cell lung cancer (NSCLC), becoming the first-line agents for advanced disease. However, resistance remains a significant clinical challenge, limiting their effectiveness.AREAS COVERED: Hereby, we addressed standard and innovative therapeutic approaches for NSCLC patients experiencing progression after IO treatment, discussing the emerging resistance mechanisms and the ongoing efforts to over...
Source: Expert Review of Respiratory Medicine - October 11, 2023 Category: Respiratory Medicine Authors: Alberto Giuseppe Agostara Laura Roazzi Federica Villa Rebecca Romano' Daniele Piscazzi Francesca Martinelli Gabriele Ciarlo Sara Oresti Francesca Travaglini Alessandro Marando Andrea Sartore Bianchi Laura Giannetta Giulio Cerea Salvatore Siena Elio Gregor Source Type: research

Adherence to inhaled antibiotics in people with cystic fibrosis: insights from a virtual patient advisory board
CONCLUSIONS: PwCF on CFTR modulators are questioning the necessity of continuing chronic medications and therapies. Physicians are urged to carefully consider the balance between simplifying antibiotic treatment and the risk of clinical deterioration due to bacterial infections when making treatment decisions. Furthermore, the development and global harmonization of diagnostic tools for chronic lung damage and treatment guidelines are crucial to justify the demanding routines that PwCF must endure to manage their condition.The heterogeneity in patient journeys, diagnostic challenges, treatment complexity, and issues relate...
Source: Expert Review of Respiratory Medicine - October 11, 2023 Category: Respiratory Medicine Authors: Simone Gambazza Valerie Storms Vinay Purohit Source Type: research