Interactions between calcium regulatory pathways and mechanosensitive channels in airways
Expert Rev Respir Med. 2023 Oct 31. doi: 10.1080/17476348.2023.2276732. Online ahead of print.ABSTRACTINTRODUCTION: Asthma is a chronic lung disease influenced by environmental and inflammatory triggers and involving complex signaling pathways across resident airway cells such as epithelium, airway smooth muscle, fibroblasts, and immune cells. While our understanding of asthma pathophysiology is continually progressing, there is a growing realization that cellular microdomains play critical roles in mediating signaling relevant to asthma in the context of contractility and remodeling. Mechanosensitive pathways are increasi...
Source: Expert Review of Respiratory Medicine - October 31, 2023 Category: Respiratory Medicine Authors: Yang Yao Niyati A Borkar Mengning Zheng Shengyu Wang Christina M Pabelick Elizabeth R Vogel Y S Prakash Source Type: research

Time to treat the climate and nature crisis as one indivisible global health emergency
Expert Rev Respir Med. 2023 Oct 30:1-3. doi: 10.1080/17476348.2023.2276515. Online ahead of print.NO ABSTRACTPMID:37902073 | DOI:10.1080/17476348.2023.2276515 (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - October 30, 2023 Category: Respiratory Medicine Authors: Kamran Abbasi Parveen Ali Virginia Barbour Thomas Benfield Kirsten Bibbins-Domingo Gregory E Erhabor Stephen Hancocks Richard Horton Laurie Laybourn-Langton Robert Mash Peush Sahni Wadeia Mohammad Sharief Paul Yonga Chris Zielinski Source Type: research

Exploring the complex relationship between the lung microbiome and ventilator-associated pneumonia
Expert Rev Respir Med. 2023 Oct 23:1-13. doi: 10.1080/17476348.2023.2273424. Online ahead of print.ABSTRACTINTRODUCTION: Understanding the presence and function of a diverse lung microbiome in acute lung infections, particularly ventilator-associated pneumonia (VAP), is still limited, evidencing significant gaps in our knowledge.AREAS COVERED: In this comprehensive narrative review, we aim to elucidate the contribution of the respiratory microbiome in the development of VAP by examining the current knowledge on the interactions among microorganisms. By exploring these intricate connections, we endeavor to enhance our under...
Source: Expert Review of Respiratory Medicine - October 24, 2023 Category: Respiratory Medicine Authors: Ingrid G Bustos Ignacio Mart ín-Loeches Alejandro Acosta-Gonz ález Sanjay H Chotirmall Robert P Dickson Luis Felipe Reyes Source Type: research

Phenotype and endotype based treatment of preschool wheeze
Expert Rev Respir Med. 2023 Oct 24:1-12. doi: 10.1080/17476348.2023.2271832. Online ahead of print.ABSTRACTINTRODUCTION: Preschool wheeze (PSW) is a significant public health issue, with a high presentation rate to emergency departments, recurrent symptoms, and severe exacerbations. A heterogenous condition, PSW comprises several phenotypes that may relate to a range of pathobiological mechanisms. However, treating PSW remains largely generalized to inhaled corticosteroids and a short acting beta agonist, guided by symptom-based labels that often do not reflect underlying pathways of disease.AREAS COVERED: We review the ob...
Source: Expert Review of Respiratory Medicine - October 24, 2023 Category: Respiratory Medicine Authors: Sormeh Salehian Louise Fleming Sejal Saglani Adnan Custovic Source Type: research

Exploring the complex relationship between the lung microbiome and ventilator-associated pneumonia
Expert Rev Respir Med. 2023 Oct 23:1-13. doi: 10.1080/17476348.2023.2273424. Online ahead of print.ABSTRACTINTRODUCTION: Understanding the presence and function of a diverse lung microbiome in acute lung infections, particularly ventilator-associated pneumonia (VAP), is still limited, evidencing significant gaps in our knowledge.AREAS COVERED: In this comprehensive narrative review, we aim to elucidate the contribution of the respiratory microbiome in the development of VAP by examining the current knowledge on the interactions among microorganisms. By exploring these intricate connections, we endeavor to enhance our under...
Source: Expert Review of Respiratory Medicine - October 24, 2023 Category: Respiratory Medicine Authors: Ingrid G Bustos Ignacio Mart ín-Loeches Alejandro Acosta-Gonz ález Sanjay H Chotirmall Robert P Dickson Luis Felipe Reyes Source Type: research

Phenotype and endotype based treatment of preschool wheeze
Expert Rev Respir Med. 2023 Oct 24:1-12. doi: 10.1080/17476348.2023.2271832. Online ahead of print.ABSTRACTINTRODUCTION: Preschool wheeze (PSW) is a significant public health issue, with a high presentation rate to emergency departments, recurrent symptoms, and severe exacerbations. A heterogenous condition, PSW comprises several phenotypes that may relate to a range of pathobiological mechanisms. However, treating PSW remains largely generalized to inhaled corticosteroids and a short acting beta agonist, guided by symptom-based labels that often do not reflect underlying pathways of disease.AREAS COVERED: We review the ob...
Source: Expert Review of Respiratory Medicine - October 24, 2023 Category: Respiratory Medicine Authors: Sormeh Salehian Louise Fleming Sejal Saglani Adnan Custovic Source Type: research

Exploring the complex relationship between the lung microbiome and ventilator-associated pneumonia
Expert Rev Respir Med. 2023 Oct 23:1-13. doi: 10.1080/17476348.2023.2273424. Online ahead of print.ABSTRACTINTRODUCTION: Understanding the presence and function of a diverse lung microbiome in acute lung infections, particularly ventilator-associated pneumonia (VAP), is still limited, evidencing significant gaps in our knowledge.AREAS COVERED: In this comprehensive narrative review, we aim to elucidate the contribution of the respiratory microbiome in the development of VAP by examining the current knowledge on the interactions among microorganisms. By exploring these intricate connections, we endeavor to enhance our under...
Source: Expert Review of Respiratory Medicine - October 24, 2023 Category: Respiratory Medicine Authors: Ingrid G Bustos Ignacio Mart ín-Loeches Alejandro Acosta-Gonz ález Sanjay H Chotirmall Robert P Dickson Luis Felipe Reyes Source Type: research

Phenotype and endotype based treatment of preschool wheeze
Expert Rev Respir Med. 2023 Oct 24:1-12. doi: 10.1080/17476348.2023.2271832. Online ahead of print.ABSTRACTINTRODUCTION: Preschool wheeze (PSW) is a significant public health issue, with a high presentation rate to emergency departments, recurrent symptoms, and severe exacerbations. A heterogenous condition, PSW comprises several phenotypes that may relate to a range of pathobiological mechanisms. However, treating PSW remains largely generalized to inhaled corticosteroids and a short acting beta agonist, guided by symptom-based labels that often do not reflect underlying pathways of disease.AREAS COVERED: We review the ob...
Source: Expert Review of Respiratory Medicine - October 24, 2023 Category: Respiratory Medicine Authors: Sormeh Salehian Louise Fleming Sejal Saglani Adnan Custovic Source Type: research

Exploring the complex relationship between the lung microbiome and ventilator-associated pneumonia
Expert Rev Respir Med. 2023 Oct 23. doi: 10.1080/17476348.2023.2273424. Online ahead of print.ABSTRACTINTRODUCTION: Understanding the presence and function of a diverse lung microbiome in acute lung infections, particularly ventilator-associated pneumonia (VAP), is still limited, evidencing significant gaps in our knowledge.AREAS COVERED: In this comprehensive narrative review, we aim to elucidate the contribution of the respiratory microbiome in the development of VAP by examining the current knowledge on the interactions among microorganisms. By exploring these intricate connections, we endeavor to enhance our understand...
Source: Expert Review of Respiratory Medicine - October 24, 2023 Category: Respiratory Medicine Authors: Ingrid G Bustos Ignacio Mart ín-Loeches Alejandro Acosta-Gonz ález Sanjay H Chotirmall Robert P Dickson Luis Felipe Reyes Source Type: research

Phenotype and endotype based treatment of preschool wheeze
Expert Rev Respir Med. 2023 Oct 24:1-12. doi: 10.1080/17476348.2023.2271832. Online ahead of print.ABSTRACTINTRODUCTION: Preschool wheeze (PSW) is a significant public health issue, with a high presentation rate to emergency departments, recurrent symptoms, and severe exacerbations. A heterogenous condition, PSW comprises several phenotypes that may relate to a range of pathobiological mechanisms. However, treating PSW remains largely generalized to inhaled corticosteroids and a short acting beta agonist, guided by symptom-based labels that often do not reflect underlying pathways of disease.AREAS COVERED: We review the ob...
Source: Expert Review of Respiratory Medicine - October 24, 2023 Category: Respiratory Medicine Authors: Sormeh Salehian Louise Fleming Sejal Saglani Adnan Custovic Source Type: research