Recommendations on scuba diving in Birt-Hogg-Dub é syndrome
Expert Rev Respir Med. 2023 Nov 22:1-6. doi: 10.1080/17476348.2023.2284375. Online ahead of print.ABSTRACTINTRODUCTION: Although very uncommon, severe injury and death can occur during scuba diving. One of the main causes of scuba diving fatalities is pulmonary barotrauma due to significant changes in ambient pressure. Pathology of the lung parenchyma, such as cystic lesions, might increase the risk of pulmonary barotrauma.AREAS COVERED: Birt-Hogg-Dubé syndrome (BHD), caused by pathogenic variants in the FLCN gene, is characterized by skin fibrofolliculomas, an increased risk of renal cell carcinoma, multiple lung cysts a...
Source: Expert Review of Respiratory Medicine - November 22, 2023 Category: Respiratory Medicine Authors: L van Riel R A van Hulst L van Hest Rja van Moorselaar B G Boerrigter S M Franken Rmf Wolthuis H J Dubbink S J Marciniak N Gupta I van de Beek A C Houweling Source Type: research

Multidisciplinary bronchopulmonary dysplasia care
The objective of this article is to review and synthesize the available literature regarding multidisciplinary care in infants and children with established BPD, and to provide a framework that can guide clinical practice and future research.AREAS COVERED: A literature search was conducted using Ovid MEDLINE, CINAHL, and Embase and several components of multidisciplinary management of BPD were identified and reviewed, including chronic care, team development, team members, discharge planning, and outpatient care.EXPERT OPINION: Establishing a core multidisciplinary group familiar with the chronicity of established BPD is r...
Source: Expert Review of Respiratory Medicine - November 20, 2023 Category: Respiratory Medicine Authors: Audrey N Miller Edward G Shepherd George El-Ferzli Leif D Nelin Source Type: research

Progress in genome-inspired treatment decisions for multifocal lung adenocarcinoma
Expert Rev Respir Med. 2023 Nov 20. doi: 10.1080/17476348.2023.2286277. Online ahead of print.ABSTRACTINTRODUCTION: Multifocal lung adenocarcinoma (MFLA) is becoming increasingly recognized as a distinct subset of lung cancer, with unique biology, disease course, and treatment outcomes. While definitions remain controversial, MFLA is characterized by the development and concurrent presence of multiple independent (non-metastatic) lesions on the lung adenocarcinoma spectrum. Disease progression typically follows an indolent course measured in years, with a lower propensity for nodal and distant metastases than other more co...
Source: Expert Review of Respiratory Medicine - November 20, 2023 Category: Respiratory Medicine Authors: Chelsea L Powell Sahar A Saddoughi Dennis A Wigle Source Type: research

Multidisciplinary bronchopulmonary dysplasia care
The objective of this article is to review and synthesize the available literature regarding multidisciplinary care in infants and children with established BPD, and to provide a framework that can guide clinical practice and future research.AREAS COVERED: A literature search was conducted using Ovid MEDLINE, CINAHL, and Embase and several components of multidisciplinary management of BPD were identified and reviewed, including chronic care, team development, team members, discharge planning, and outpatient care.EXPERT OPINION: Establishing a core multidisciplinary group familiar with the chronicity of established BPD is r...
Source: Expert Review of Respiratory Medicine - November 20, 2023 Category: Respiratory Medicine Authors: Audrey N Miller Edward G Shepherd George El-Ferzli Leif D Nelin Source Type: research

Progress in genome-inspired treatment decisions for multifocal lung adenocarcinoma
Expert Rev Respir Med. 2023 Nov 20. doi: 10.1080/17476348.2023.2286277. Online ahead of print.ABSTRACTINTRODUCTION: Multifocal lung adenocarcinoma (MFLA) is becoming increasingly recognized as a distinct subset of lung cancer, with unique biology, disease course, and treatment outcomes. While definitions remain controversial, MFLA is characterized by the development and concurrent presence of multiple independent (non-metastatic) lesions on the lung adenocarcinoma spectrum. Disease progression typically follows an indolent course measured in years, with a lower propensity for nodal and distant metastases than other more co...
Source: Expert Review of Respiratory Medicine - November 20, 2023 Category: Respiratory Medicine Authors: Chelsea L Powell Sahar A Saddoughi Dennis A Wigle Source Type: research

Multidisciplinary bronchopulmonary dysplasia care
The objective of this article is to review and synthesize the available literature regarding multidisciplinary care in infants and children with established BPD, and to provide a framework that can guide clinical practice and future research.AREAS COVERED: A literature search was conducted using Ovid MEDLINE, CINAHL, and Embase and several components of multidisciplinary management of BPD were identified and reviewed, including chronic care, team development, team members, discharge planning, and outpatient care.EXPERT OPINION: Establishing a core multidisciplinary group familiar with the chronicity of established BPD is r...
Source: Expert Review of Respiratory Medicine - November 20, 2023 Category: Respiratory Medicine Authors: Audrey N Miller Edward G Shepherd George El-Ferzli Leif D Nelin Source Type: research

Demystifying controversies in preschool wheeze
Expert Rev Respir Med. 2023 Nov 18:1-9. doi: 10.1080/17476348.2023.2283128. Online ahead of print.ABSTRACTINTRODUCTION: Wheezing disorders in preschool children are common. Current treatment approaches assume all preschool wheezers are the same and will respond to a short course of oral corticosteroids (OCS) during acute attacks and subsequent maintenance inhaled corticosteroids (ICS) to prevent future attacks. But we have increasing evidence showing preschool wheezing disorders are markedly heterogeneous and the response to corticosteroids either during acute attacks or as maintenance therapy can be variable between patie...
Source: Expert Review of Respiratory Medicine - November 18, 2023 Category: Respiratory Medicine Authors: Frank M Smith Sejal Saglani Source Type: research

A narrative review of nontuberculous mycobacterial pulmonary disease: microbiology, epidemiology, diagnosis, and management challenges
Expert Rev Respir Med. 2023 Nov 14. doi: 10.1080/17476348.2023.2283135. Online ahead of print.ABSTRACTINTRODUCTION: Nontuberculous mycobacteria (NTM) are a diverse group of mycobacterial species that are ubiquitous in the environment. They are opportunistic pathogens that can cause a range of diseases in both animals and humans, especially in individuals with underlying structural lung disease or compromised immune systems.AREAS COVERED: This paper provides an in-depth analysis of NTM infections, including microbiology, environmental sources and transmission pathways, risk factors for disease, epidemiology, clinical manife...
Source: Expert Review of Respiratory Medicine - November 14, 2023 Category: Respiratory Medicine Authors: Kamal Hamed Glenn Tillotson Source Type: research

Role of radiation in oligometastases and oligoprogression in metastatic non-small cell lung cancer: consensus and controversy
Expert Rev Respir Med. 2023 Nov 14. doi: 10.1080/17476348.2023.2284362. Online ahead of print.ABSTRACTINTRODUCTION: The oligometastatic state in non-small cell lung cancer (NSCLC) has recently become well-established. However, the specific definition of oligometastases remains unclear. Several smaller randomized studies have investigated the safety and efficacy of radiation as metastasis-directed therapy (MDT) in oligometastatic NSCLC, which have led the way to larger studies currently accruing patients globally.AREAS COVERED: This review covers the definitions of 'oligometastases' and explains why the oligometastatic stat...
Source: Expert Review of Respiratory Medicine - November 14, 2023 Category: Respiratory Medicine Authors: Abhishek Kumar Joseph K Salama Source Type: research

A narrative review of nontuberculous mycobacterial pulmonary disease: microbiology, epidemiology, diagnosis, and management challenges
Expert Rev Respir Med. 2023 Nov 14. doi: 10.1080/17476348.2023.2283135. Online ahead of print.ABSTRACTINTRODUCTION: Nontuberculous mycobacteria (NTM) are a diverse group of mycobacterial species that are ubiquitous in the environment. They are opportunistic pathogens that can cause a range of diseases in both animals and humans, especially in individuals with underlying structural lung disease or compromised immune systems.AREAS COVERED: This paper provides an in-depth analysis of NTM infections, including microbiology, environmental sources and transmission pathways, risk factors for disease, epidemiology, clinical manife...
Source: Expert Review of Respiratory Medicine - November 14, 2023 Category: Respiratory Medicine Authors: Kamal Hamed Glenn Tillotson Source Type: research

Role of radiation in oligometastases and oligoprogression in metastatic non-small cell lung cancer: consensus and controversy
Expert Rev Respir Med. 2023 Nov 14. doi: 10.1080/17476348.2023.2284362. Online ahead of print.ABSTRACTINTRODUCTION: The oligometastatic state in non-small cell lung cancer (NSCLC) has recently become well-established. However, the specific definition of oligometastases remains unclear. Several smaller randomized studies have investigated the safety and efficacy of radiation as metastasis-directed therapy (MDT) in oligometastatic NSCLC, which have led the way to larger studies currently accruing patients globally.AREAS COVERED: This review covers the definitions of 'oligometastases' and explains why the oligometastatic stat...
Source: Expert Review of Respiratory Medicine - November 14, 2023 Category: Respiratory Medicine Authors: Abhishek Kumar Joseph K Salama Source Type: research

A narrative review of nontuberculous mycobacterial pulmonary disease: microbiology, epidemiology, diagnosis, and management challenges
Expert Rev Respir Med. 2023 Nov 14. doi: 10.1080/17476348.2023.2283135. Online ahead of print.ABSTRACTINTRODUCTION: Nontuberculous mycobacteria (NTM) are a diverse group of mycobacterial species that are ubiquitous in the environment. They are opportunistic pathogens that can cause a range of diseases in both animals and humans, especially in individuals with underlying structural lung disease or compromised immune systems.AREAS COVERED: This paper provides an in-depth analysis of NTM infections, including microbiology, environmental sources and transmission pathways, risk factors for disease, epidemiology, clinical manife...
Source: Expert Review of Respiratory Medicine - November 14, 2023 Category: Respiratory Medicine Authors: Kamal Hamed Glenn Tillotson Source Type: research