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Pneumothorax, pneumomediastinum, and subcutaneous emphysema in hospitalized COVID-19 patients: incidence, clinical characteristics, and outcomes
CONCLUSION: Although the occurrence of PTX/PNM/SCE in hospitalized COVID-19 patients was rare, it was associated with worse outcomes. Corticosteroids may contribute to the pathogenesis of these complications; however, further studies are needed to investigate this relationship in more detail.PMID:37675598 | DOI:10.1080/17476348.2023.2254689 (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - September 7, 2023 Category: Respiratory Medicine Authors: Aleksandra Murawska Baptista Jorge Sinclair De Fr ías Trisha Singh Ananya Vasudhar Jacob Guzzino Waheed Khalili Aysun Tekin Vikas Bansal Rahul Kashyap William J Joyce Patricia A Lewis Devang Sanghavi Tatjana Gavrancic Pablo Moreno Franco Source Type: research

The value of perioperative physical activity in older patients undergoing surgery for lung cancer
Expert Rev Respir Med. 2023 Sep 5. doi: 10.1080/17476348.2023.2255133. Online ahead of print.ABSTRACTINTRODUCTION: With a median age at diagnosis of 70, lung cancer represents an enormous public health problem among older Americans. An estimated 19,000 people age 65 and older undergo lung cancer surgery annually in the US. Older adults undergoing lung cancer surgery are often frail with limited physiologic reserves, multi-morbidities, and functional impairments. Physical function, dyspnea, and quality of life return to baseline slower in older adults compared with younger adults after lung surgery.AREAS COVERED: In this re...
Source: Expert Review of Respiratory Medicine - September 5, 2023 Category: Respiratory Medicine Authors: Dan J Raz Jae Y Kim Loretta Erhunwmunesee Sherry Hite Gouri Varatkar Virginia Sun Source Type: research

Mechanisms underlying corticosteroid resistance in patients with asthma: a review of current knowledge
Expert Rev Respir Med. 2023 Sep 4:1-15. doi: 10.1080/17476348.2023.2255124. Online ahead of print.ABSTRACTINTRODUCTION: Corticosteroids are the most cost-effective anti-inflammatory drugs available for the treatment of asthma. Despite their effectiveness, several asthmatic patients have corticosteroid resistance or insensitivity and exhibit a poor response. Corticosteroid insensitivity implies a poor prognosis due to challenges in finding alternative therapeutic options for asthma.AREAS COVERED: In this review, we describe asthma phenotypes and endotypes, as well as their differential responsiveness to corticosteroids. In ...
Source: Expert Review of Respiratory Medicine - September 1, 2023 Category: Respiratory Medicine Authors: Javier Milara Anselm Morell In és Roger Paula Montero Julio Cortijo Source Type: research

Mechanisms underlying corticosteroid resistance in patients with asthma: A review of current knowledge
Expert Rev Respir Med. 2023 Sep 1. doi: 10.1080/17476348.2023.2255124. Online ahead of print.ABSTRACTINTRODUCTION: Corticosteroids are the most cost-effective anti-inflammatory drugs available for the treatment of asthma. Despite their effectiveness, several asthmatic patients have corticosteroid resistance or insensitivity and exhibit a poor response. Corticosteroid insensitivity implies a poor prognosis due to challenges in finding alternative therapeutic options for asthma.AREAS COVERED: In this review, we describe asthma phenotypes and endotypes, as well as their differential responsiveness to corticosteroids. In addit...
Source: Expert Review of Respiratory Medicine - September 1, 2023 Category: Respiratory Medicine Authors: Javier Milara Anselm Morell In és Roger Paula Montero Julio Cortijo Source Type: research

Pharmacotherapy for obstructive sleep apnea: targeting specific pathophysiological traits
Expert Rev Respir Med. 2023 Aug 30:1-12. doi: 10.1080/17476348.2023.2241353. Online ahead of print.ABSTRACTINTRODUCTION: The pathophysiology of obstructive sleep apnea (OSA) is multi-factorial and complex. Varying OSA's pathophysiological traits have been identified, including pharyngeal collapsibility, upper airway muscle reactivity, arousal threshold, and regulation of the ventilatory drive. Being CPAP of difficult tolerance and other interventions reserved to specific subpopulations new pharmacological treatments for OSA might be resolutive.AREAS COVERED: Several existing and newly developed pharmacological drugs can im...
Source: Expert Review of Respiratory Medicine - August 30, 2023 Category: Respiratory Medicine Authors: Elisa Perger Simona Bertoli Carolina Lombardi Source Type: research

Severe pediatric asthma endotypes: current limits and future perspectives
Expert Rev Respir Med. 2023 Aug 30. doi: 10.1080/17476348.2023.2254234. Online ahead of print.ABSTRACTINTRODUCTION: Althoughrare, pediatric severe therapy-resistant asthma (STRA) is a highlyheterogeneous, resource-demanding disease that differs significantly fromsevere adult asthma and whose pathogenesis is still poorly understood.AREAS COVERED: This reviewsummarizes the latest ten years of English-written studies defining pediatricSTRA endotypes using lung-specific techniques such as bronchoalveolar lavageand endobronchial biopsy. Results of the studies and limits on the field arediscussed, together with some future persp...
Source: Expert Review of Respiratory Medicine - August 30, 2023 Category: Respiratory Medicine Authors: Beatrice Andrenacci Maria De Filippo Martina Votto Maria Sole Prevedoni Gorone Mara De Amici Stefania La Grutta Gian Luigi Marseglia Amelia Licari Source Type: research