Molecular and epigenetic mechanisms governing ocular surface squamous neoplasia: opportunities for diagnostics
Expert Rev Mol Diagn. 2023 Dec 22. doi: 10.1080/14737159.2023.2298681. Online ahead of print.ABSTRACTINTRODUCTION: Ocular surface squamous neoplasia (OSSN) is the most common ocular malignancy; the pathophysiology is influenced by molecular, genetic, and epigenetic mechanisms. The incidence of OSSN is associated with the anatomy and physiology of the ocular surface, limbal stem cell configuration, limbal vulnerability, cancer stem cells, dysplasia, neoplasia, angiogenesis, invasion, and metastasis. The key etiological factors involved are human papillomavirus (HPV), human immunodeficiency virus (HIV), immunosuppression, p5...
Source: Expert Review of Molecular Diagnostics - December 22, 2023 Category: Laboratory Medicine Authors: Bharat Gurnani Kirandeep Kaur Source Type: research

Advancements in protein glycosylation biomarkers for ovarian cancer through mass spectrometry-based approaches
Expert Rev Mol Diagn. 2023 Dec 19. doi: 10.1080/14737159.2023.2297933. Online ahead of print.ABSTRACTINTRODUCTION: Ovarian cancer, characterized by metastasis and reduced 5-year survival rates, stands as a substantial factor in the mortality of gynecological malignancies worldwide. The challenge of delayed diagnosis originates from vague early symptoms and the absence of efficient screening and diagnostic biomarkers for early cancer detection. Recent studies have explored the intricate interplay between ovarian cancer and protein glycosylation, unveiling the potential significance of glycosylation-oriented biomarkers.AREAS...
Source: Expert Review of Molecular Diagnostics - December 19, 2023 Category: Laboratory Medicine Authors: Jua Lee Ji Eun Park Daum Lee Nari Seo Hyun Joo An Source Type: research

How our molecular understanding of the pathogenesis of < em > Mycobacterium ulcerans < /em > infection can improve diagnosis of Buruli ulcer
Expert Rev Mol Diagn. 2023 Dec 11:1-4. doi: 10.1080/14737159.2023.2294333. Online ahead of print.NO ABSTRACTPMID:38073533 | DOI:10.1080/14737159.2023.2294333 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - December 11, 2023 Category: Laboratory Medicine Authors: Gerd Pluschke Louisa Warryn Source Type: research

How our molecular understanding of the pathogenesis of < em > mycobacterium ulcerans < /em > infection can improve diagnosis of Buruli ulcer
Expert Rev Mol Diagn. 2023 Dec 11. doi: 10.1080/14737159.2023.2294333. Online ahead of print.NO ABSTRACTPMID:38073533 | DOI:10.1080/14737159.2023.2294333 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - December 11, 2023 Category: Laboratory Medicine Authors: Gerd Pluschke Louisa Warryn Source Type: research

The challenges and potential in developing microRNA associated with regeneration as biomarkers to improve prognostication for liver failure syndromes and hepatocellular carcinoma
Expert Rev Mol Diagn. 2023 Dec 7. doi: 10.1080/14737159.2023.2292642. Online ahead of print.ABSTRACTINTRODUCTION: Determining the need for liver transplantation remains critical in the management of hepatocellular carcinoma (HCC) and liver failure syndromes (including acute liver failure and decompensated cirrhosis states). Conventional prognostic models utilize biomarkers of liver and non-liver failure and have limitations in their application. Novel biomarkers which predict regeneration may fulfil this niche. microRNA are implicated in health and disease and are present in abundance in the circulation. Despite this, they...
Source: Expert Review of Molecular Diagnostics - December 7, 2023 Category: Laboratory Medicine Authors: Oliver D Tavabie Siamak Salehi Varuna R Aluvihare Source Type: research