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Serum Sema7A is increased in patients with acute aortic dissection
CONCLUSIONS: Sema7A is highly expressed in patients with AAD. Sema7A might be a valuable biomarker for the early diagnosis of AAD and has the potential to differentiate AAD from AMI and PE.PMID:37698489 | DOI:10.1080/14737159.2023.2254693 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - September 12, 2023 Category: Laboratory Medicine Authors: Xing Lyu Xin Liu Hui Gong Yang Liu Zhifang Zhou Min Hu Xiangyu Zhang Source Type: research

Global polymorphism of < em > Plasmodium falciparum < /em > histidine rich proteins 2/3 and impact on malaria rapid diagnostic test detection: a systematic review and meta-analysis
CONCLUSIONS: PfHRP2/3 are highly polymorphic and current findings are insufficient, conflicting and not convincing enough to conclude on the role of PfHRP2/3 sequence polymorphism in PfHRP2-based RDT detection.PMID:37698448 | DOI:10.1080/14737159.2023.2255136 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - September 12, 2023 Category: Laboratory Medicine Authors: Loick P Kojom Foko Jahnvi Jakhan Geetika Narang Vineeta Singh Source Type: research

Biomarkers to guide immunomodulatory treatment: where do we stand?
Expert Rev Mol Diagn. 2023 Sep 10. doi: 10.1080/14737159.2023.2258063. Online ahead of print.ABSTRACTINTRODUCTION: This review summarizes current progress in the development of biomarkers to guide immunotherapy in oncology, rheumatology and critical illness.AREAS COVERED: An extensive literature search was performed about biomarkers classifying patients' immune responses to guide immunotherapy in oncology, rheumatology and critical illness. Surface markers, such as programmed death-ligand 1 (PD-L1), genetic biomarkers, such as tumor mutation load, and circulating tumor DNA are biomarkers associated with the effectiveness o...
Source: Expert Review of Molecular Diagnostics - September 11, 2023 Category: Laboratory Medicine Authors: Evdoxia Kyriazopoulou Evangelos J Giamarellos-Bourboulis Karolina Akinosoglou Source Type: research

Point-of-care testing for viral-associated pulmonary aspergillosis
Expert Rev Mol Diagn. 2023 Sep 9. doi: 10.1080/14737159.2023.2257597. Online ahead of print.ABSTRACTINTRODUCTION: Over the last years, severe respiratory viral infections, particularly those caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the influenza virus, have emerged as risk factor for viral-associated pulmonary aspergillosis (VAPA) among critically ill patients. Delays in diagnosis of VAPA are associated with increased mortality. Point-of-care-tests may play an important role in earlier diagnosis of VAPA and thus improve patient outcomes.AREAS COVERED: The following review will give an upda...
Source: Expert Review of Molecular Diagnostics - September 9, 2023 Category: Laboratory Medicine Authors: Robina Aerts Brice Autier Maximilian Gornicec Juergen Prattes Katrien Lagrou Jean-Pierre Gangneux Martin Hoenigl Source Type: research

External quality assessment for the molecular detection of microsatellite instability in China, 2021-2022
CONCLUSION: The molecular detection of MSI in China exhibited an improvement in a 2-year EQA study. Participation in EQA program is an efficient way of assessing the performance of laboratories and improving their ability.PMID:37682059 | DOI:10.1080/14737159.2023.2257133 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - September 8, 2023 Category: Laboratory Medicine Authors: Xueliang Wang Xiaoyu Fan Qianming Bai Chunli Shi Yanqun Xiao Source Type: research

Reprogramming of lipid metabolism in hepatocellular carcinoma resulting in downregulation of phosphatidylcholines used as potential markers for diagnosis and prediction
CONCLUSIONS: PCs serve as potential plasma biomarkers and help identify patients with HBVLD at risk of HCC who should be screened for early diagnosis and intervention.PMID:37672012 | DOI:10.1080/14737159.2023.2254884 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - September 6, 2023 Category: Laboratory Medicine Authors: Kang Li Wanting Shi Yi Song Lin Qin Chaoran Zang Tingting Mei Ang Li Qingkun Song Yonghong Zhang Source Type: research

The diagnostic and prognostic value of tsRNAs in gastric cancers: a systematic review and meta-analysis
CONCLUSIONS: tsRNAs have potential clinical application in GC diagnosis and prognosis evaluation. It is necessary to further assess and verify the practicability and feasibility of additional specific tsRNAs as GC markers in the future.PMID:37649251 | DOI:10.1080/14737159.2023.2254237 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - August 31, 2023 Category: Laboratory Medicine Authors: Hua Gao Qiankun Zhang Weibing Wu Jing Gu Jia Li Source Type: research

The diagnostic and prognostic value of tsRnas in gastric cancers: a systematic review and meta-analysis
CONCLUSIONS: tsRNAs have potential clinical application in GC diagnosis and prognosis evaluation. It is necessary to further assess and verify the practicability and feasibility of additional specific tsRNAs as GC markers in the future.PMID:37649251 | DOI:10.1080/14737159.2023.2254237 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - August 31, 2023 Category: Laboratory Medicine Authors: Hua Gao Qiankun Zhang Weibing Wu Jing Gu Jia Li Source Type: research