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Potential use of heat shock protein 90 as a biomarker for the diagnosis of human diseases
Expert Rev Mol Diagn. 2023 Aug 14. doi: 10.1080/14737159.2023.2246883. Online ahead of print.ABSTRACTINTRODUCTION: The heat shock protein 90 (Hsp90) is a protein involved in many different biological processes and especially in cell survival. Some of these functions require the participation of other biological molecules, so Hsp90 is a chaperone that takes part in many protein-protein interactions working as a critical signaling hub protein. As a member of the heat shock protein family, Hsp90 expression is regulated under certain environmental and/or stressful situations, therefore Hsp90 concentration can be monitored and ...
Source: Expert Review of Molecular Diagnostics - August 14, 2023 Category: Laboratory Medicine Authors: Ane Rivas-Macho Mar ía V Romeo Elisabeth Rackles Garbi ñe Olabarria Juan Manuel Falcon-Perez Jes ús Berganza-Granda Aitziber L Cortajarena Felipe Go ñi-de-Cerio Source Type: research

Anti-citrullinated protein antibodies as biomarkers in rheumatoid arthritis
Expert Rev Mol Diagn. 2023 Aug 14. doi: 10.1080/14737159.2023.2247986. Online ahead of print.ABSTRACTINTRODUCTION: The serological biomarker anti-citrullinated protein antibodies (ACPAs) may have several functions but is especially important for the diagnosis of rheumatoid arthritis (RA) along with clinical symptoms.AREAS COVERED: This review provides an overview of ACPAs, which are useful in RA diagnostics and may improve understanding of disease etiology. PubMed was searched with combinations of words related to antibodies recognizing epitopes containing the post-translationally modified amino acid citrulline in combinat...
Source: Expert Review of Molecular Diagnostics - August 14, 2023 Category: Laboratory Medicine Authors: Nicole Hartwig Trier Gunnar Houen Source Type: research

Research tests for the diagnosis of tuberculosis infection
Expert Rev Mol Diagn. 2023 Aug 10:1-13. doi: 10.1080/14737159.2023.2240230. Online ahead of print.ABSTRACTINTRODUCTION: Despite huge efforts, tuberculosis (TB) is still a major public health threat worldwide, it is estimated that a quarter of the global population is infected by Mycobacterium tuberculosis (Mtb). For controlling TB and reducing Mtb transmission it is fundamental to diagnose TB infection (TBI) as well as the progressors from TBI to disease to identify those requiring preventive therapy. At present, there is no gold standard test for TBI diagnosis although several new methodologies have been attempted.AREAS C...
Source: Expert Review of Molecular Diagnostics - August 10, 2023 Category: Laboratory Medicine Authors: Tonino Alonzi Federica Repele Delia Goletti Source Type: research

The significance of tissue-agnostic biomarkers in solid tumors: the more the merrier?
Expert Rev Mol Diagn. 2023 Aug 8:1-12. doi: 10.1080/14737159.2023.2245752. Online ahead of print.ABSTRACTINTRODUCTION: To date, several emerging biomarkers have gained considerable interest in the field of predictive molecular oncology. The advent of precision medicine has led to the development of innovative drugs targeting rare molecular pathways independently from histology, defined as tissue-agnostic drugs.AREAS COVERED: Although there is a lot of promise for this new tissue-agnostic model in the oncological scenario, crucial issues from both the diagnostic and therapeutic standpoint are emerging. This review aims to c...
Source: Expert Review of Molecular Diagnostics - August 8, 2023 Category: Laboratory Medicine Authors: Valerio Gristina Pasquale Pisapia Nadia Barraco Francesco Pepe Federica Iacono Maria La Mantia Marta Peri Antonio Galvano Lorena Incorvaia Giuseppe Badalamenti Viviana Bazan Giancarlo Troncone Antonio Russo Umberto Malapelle Source Type: research

Cystic echinococcosis microRnas as potential non-invasive biomarkers: current insights and upcoming perspective
Expert Rev Mol Diagn. 2023 Aug 8. doi: 10.1080/14737159.2023.2246367. Online ahead of print.ABSTRACTINTRODUCTION: Echinococcosis, also known as hydatidosis, is a zoonotic foodborne disease occurred by infection with the larvae of Echinococcus spp. which can lead to the development of hydatid cysts in various organs of the host. The diagnosis of echinococcosis remains challenging due to limited diagnostic tools.AREAS COVERED: In recent years, microRNAs (miRNAs) have emerged as a promising biomarker for various infectious diseases, including those caused by helminths. Recent studies have identified several novel miRNAs in Ec...
Source: Expert Review of Molecular Diagnostics - August 8, 2023 Category: Laboratory Medicine Authors: Bentolhoda Habibi Shirzad Gholami Abouzar Bagheri Mahdi Fakhar Alimohammad Moradi Mohammad Amin Khazeei Tabari Source Type: research

Clinical validation of a single NGS targeted panel pipeline using the KAPA HyperChoice system for detection of germline, somatic and mitochondrial sequence and copy number variants
CONCLUSION: Results of the laboratory quality improvement study focused on a single NGS pipeline that includes both nuclear and mitochondrial genomes demonstrated utility in the clinical setting to assess a range of referral reasons, necessary due to the complex molecular etiology of human genetic disorders, while reducing costs and turnaround times.PMID:37542410 | DOI:10.1080/14737159.2023.2245747 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - August 5, 2023 Category: Laboratory Medicine Authors: Jennifer Kerkhof Cassandra Rastin Laila Schenkel Hanxin Lin Bekim Sadikovic Source Type: research