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Usefulness of an RNA extraction-free test for the multiplexed detection of ALK , ROS1 , and RET gene fusions in in real life FFPE specimens of non-small cell lung cancers
CONCLUSIONS: Overall, the HTG EdgeSeq assay offers comparable sensitivities and specificity than other RNA sequencing techniques, with the advantage that it can be used on very small and old samples collected multicentrically.PMID:37906110 | DOI:10.1080/14737159.2023.2277367 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - October 31, 2023 Category: Laboratory Medicine Authors: Damiola Francesca Alberti Laurent Mansuet-Lupo Audrey Damotte Diane Hofman V éronique Tixier Lucie Penault-Llorca Fr éderique Rouquette Isabelle Vignaud Jean Michel Cazes Aurelie Forest Fabien Begueret Hugues Gibault Laure Badoual C écile Cayre Anne Ta Source Type: research

Functional proteomic analysis, a missing piece for understanding clonal evolution and cooperation in the tissue microecology
Expert Rev Mol Diagn. 2023 Oct 30. doi: 10.1080/14737159.2023.2277371. Online ahead of print.NO ABSTRACTPMID:37902050 | DOI:10.1080/14737159.2023.2277371 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - October 30, 2023 Category: Laboratory Medicine Authors: Mariaelena Pierobon Emanuel F Petricoin Source Type: research

LncRNA NR2F1-AS1 as a potential biomarker for prognosis in cancer patients: meta and bioinformatics analysis
CONCLUSION: Upregulation of LncRNA NR2F1-AS1 was associated with poor prognosis and advanced clinicopathologic features of tumor patients.PMID:37902251 | DOI:10.1080/14737159.2023.2277521 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - October 30, 2023 Category: Laboratory Medicine Authors: Lu Tang Qing-Mei Liu Shuang Zhang Jun Zhou Source Type: research

Required improvements for cerebrospinal fluid-based biomarker tests of Alzheimer's disease
Expert Rev Mol Diagn. 2023 Oct 30. doi: 10.1080/14737159.2023.2276918. Online ahead of print.ABSTRACTINTRODUCTION: Cerebrospinal fluid (CSF) biomarkers represent a well-established tool for diagnosing Alzheimer's disease (AD), independently from the clinical stage, by reflecting the presence of brain amyloidosis (A+) and tauopathy (T+). In front of this important achievement, so far, (i) CSF AD biomarkers have not yet been adopted for routine clinical use in all Centers dedicated to AD, mainly due to inter-lab variation and lack of internationally accepted cutoff values; (ii) we do need to add other biomarkers more suitabl...
Source: Expert Review of Molecular Diagnostics - October 30, 2023 Category: Laboratory Medicine Authors: Lorenzo Gaetani Davide Chiasserini Federico Paolini Paoletti Giovanni Bellomo Lucilla Parnetti Source Type: research

Beyond blood biomarkers: the role of SelectMDX in clinically significant prostate cancer identification
Expert Rev Mol Diagn. 2023 Oct 28. doi: 10.1080/14737159.2023.2277366. Online ahead of print.ABSTRACTINTRODUCTION: New potential biomarkers to pre-intervention identification of a clinically significant prostate cancer (csPCa) will prevent overdiagnosis and overtreatment and limit quality of life impairment of PCa patients.AREAS COVERED: We have developed a comprehensive review focusing our research on the increasing knowledge of the role of SelectMDX® in csPCa detection. Areas identified as clinically relevant are the ability of SelectMDX® to predict csPCa in active surveillance setting, its predictive ability when comb...
Source: Expert Review of Molecular Diagnostics - October 28, 2023 Category: Laboratory Medicine Authors: Matteo Ferro Martina Maggi Giuseppe Lucarelli Ugo Giovanni Falagario Francesco Del Giudice Felice Crocetto Biagio Barone Evelina La Civita Francesco Lasorsa Antonio Brescia Michele Catellani Gian Maria Busetto Octavian Sabin Tataru Daniela Terracciano Source Type: research

Implementing individualized quality control plans and managing risk at the point-of-care for molecular diagnostics
Expert Rev Mol Diagn. 2023 Oct 28. doi: 10.1080/14737159.2023.2277374. Online ahead of print.ABSTRACTINTRODUCTION: Faster turnaround times can lead to rapid patient treatment. Implementing a POC molecular COVID-19 test requires careful planning. In the POC setting, there are numerous operators and regular monitoring of their activities is key to the successful implementation of a POC molecular test. Test errors can arise from samples, operators, reagents, the testing system, and even from the environment. These sources of error should be considered when implementing a new test.AREAS COVERED: We outline the importance of es...
Source: Expert Review of Molecular Diagnostics - October 28, 2023 Category: Laboratory Medicine Authors: Erving T Laryea James H Nichols Source Type: research

An update on current and novel molecular diagnostics for the diagnosis of invasive fungal infections
Expert Rev Mol Diagn. 2023 Oct 6:1-18. doi: 10.1080/14737159.2023.2267977. Online ahead of print.ABSTRACTBACKGROUND: Invasive fungal infections cause millions of infections annually, but diagnosis remains challenging. There is an increased need for low-cost, easy to use, highly sensitive and specific molecular assays that can differentiate between colonized and pathogenic organisms from different clinical specimens.AREAS COVERED: We reviewed the literature evaluating the current state of molecular diagnostics for invasive fungal infections, focusing on current and novel molecular tests such as polymerase chain reaction (PC...
Source: Expert Review of Molecular Diagnostics - October 6, 2023 Category: Laboratory Medicine Authors: Jeffrey D Jenks P Lewis White Sarah E Kidd Tyler Goshia Stephanie I Fraley Martin Hoenigl George R Thompson Source Type: research