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Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease
Expert Rev Mol Diagn. 2023 Aug 1:1-12. doi: 10.1080/14737159.2023.2242779. Online ahead of print.ABSTRACTINTRODUCTION: The non-invasive identification of liver fibrosis related to Non-Alcoholic Fatty Liver Disease is crucial for risk-stratification of patients. Currently, the reference standard to stage hepatic fibrosis relies on liver biopsy, but multiple approaches are developed to allow for non-invasive diagnosis and risk stratification. Non-invasive tests, including blood-based scores and vibration-controlled transient elastography, have been widely validated and represent a good surrogate for risk stratification accor...
Source: Expert Review of Molecular Diagnostics - July 28, 2023 Category: Laboratory Medicine Authors: Angelo Armandi Maurice Michel Kamela Gjini Tilman Emrich Elisabetta Bugianesi Jorn M Schattenberg Source Type: research
One biomarker does not fit all: tailoring anti-infective therapy through utilization of procalcitonin and other specific biomarkers
Expert Rev Mol Diagn. 2023 Jul 31:1-14. doi: 10.1080/14737159.2023.2242782. Online ahead of print.ABSTRACTINTRODUCTION: Considering the ongoing increase in antibiotic resistance, the importance of judicious use of antibiotics through reduction of exposure is crucial. Adding procalcitonin (PCT) and other biomarkers to pathogen-specific tests may help to further improve antibiotic therapy algorithms and advance antibiotic stewardship programs to achieve these goals.AREAS COVERED: In recent years, several trials have investigated the inclusion of biomarkers such as PCT into clinical decision-making algorithms. For adult patie...
Source: Expert Review of Molecular Diagnostics - July 28, 2023 Category: Laboratory Medicine Authors: Lennart Essmann Yannick Wirz Claudia Gregoriano Philipp Schuetz Source Type: research
Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease
Expert Rev Mol Diagn. 2023 Aug 1:1-12. doi: 10.1080/14737159.2023.2242779. Online ahead of print.ABSTRACTINTRODUCTION: The non-invasive identification of liver fibrosis related to Non-Alcoholic Fatty Liver Disease is crucial for risk-stratification of patients. Currently, the reference standard to stage hepatic fibrosis relies on liver biopsy, but multiple approaches are developed to allow for non-invasive diagnosis and risk stratification. Non-invasive tests, including blood-based scores and vibration-controlled transient elastography, have been widely validated and represent a good surrogate for risk stratification accor...
Source: Expert Review of Molecular Diagnostics - July 28, 2023 Category: Laboratory Medicine Authors: Angelo Armandi Maurice Michel Kamela Gjini Tilman Emrich Elisabetta Bugianesi Jorn M Schattenberg Source Type: research
One biomarker does not fit all: tailoring anti-infective therapy through utilization of procalcitonin and other specific biomarkers
Expert Rev Mol Diagn. 2023 Jul 31:1-14. doi: 10.1080/14737159.2023.2242782. Online ahead of print.ABSTRACTINTRODUCTION: Considering the ongoing increase in antibiotic resistance, the importance of judicious use of antibiotics through reduction of exposure is crucial. Adding procalcitonin (PCT) and other biomarkers to pathogen-specific tests may help to further improve antibiotic therapy algorithms and advance antibiotic stewardship programs to achieve these goals.AREAS COVERED: In recent years, several trials have investigated the inclusion of biomarkers such as PCT into clinical decision-making algorithms. For adult patie...
Source: Expert Review of Molecular Diagnostics - July 28, 2023 Category: Laboratory Medicine Authors: Lennart Essmann Yannick Wirz Claudia Gregoriano Philipp Schuetz Source Type: research
Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease
Expert Rev Mol Diagn. 2023 Aug 1:1-12. doi: 10.1080/14737159.2023.2242779. Online ahead of print.ABSTRACTINTRODUCTION: The non-invasive identification of liver fibrosis related to Non-Alcoholic Fatty Liver Disease is crucial for risk-stratification of patients. Currently, the reference standard to stage hepatic fibrosis relies on liver biopsy, but multiple approaches are developed to allow for non-invasive diagnosis and risk stratification. Non-invasive tests, including blood-based scores and vibration-controlled transient elastography, have been widely validated and represent a good surrogate for risk stratification accor...
Source: Expert Review of Molecular Diagnostics - July 28, 2023 Category: Laboratory Medicine Authors: Angelo Armandi Maurice Michel Kamela Gjini Tilman Emrich Elisabetta Bugianesi Jorn M Schattenberg Source Type: research
One biomarker does not fit all: tailoring anti-infective therapy through utilization of procalcitonin and other specific biomarkers
Expert Rev Mol Diagn. 2023 Jul 31:1-14. doi: 10.1080/14737159.2023.2242782. Online ahead of print.ABSTRACTINTRODUCTION: Considering the ongoing increase in antibiotic resistance, the importance of judicious use of antibiotics through reduction of exposure is crucial. Adding procalcitonin (PCT) and other biomarkers to pathogen-specific tests may help to further improve antibiotic therapy algorithms and advance antibiotic stewardship programs to achieve these goals.AREAS COVERED: In recent years, several trials have investigated the inclusion of biomarkers such as PCT into clinical decision-making algorithms. For adult patie...
Source: Expert Review of Molecular Diagnostics - July 28, 2023 Category: Laboratory Medicine Authors: Lennart Essmann Yannick Wirz Claudia Gregoriano Philipp Schuetz Source Type: research
Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease
Expert Rev Mol Diagn. 2023 Aug 1:1-12. doi: 10.1080/14737159.2023.2242779. Online ahead of print.ABSTRACTINTRODUCTION: The non-invasive identification of liver fibrosis related to Non-Alcoholic Fatty Liver Disease is crucial for risk-stratification of patients. Currently, the reference standard to stage hepatic fibrosis relies on liver biopsy, but multiple approaches are developed to allow for non-invasive diagnosis and risk stratification. Non-invasive tests, including blood-based scores and vibration-controlled transient elastography, have been widely validated and represent a good surrogate for risk stratification accor...
Source: Expert Review of Molecular Diagnostics - July 28, 2023 Category: Laboratory Medicine Authors: Angelo Armandi Maurice Michel Kamela Gjini Tilman Emrich Elisabetta Bugianesi Jorn M Schattenberg Source Type: research
One biomarker does not fit all: tailoring anti-infective therapy through utilization of procalcitonin and other specific biomarkers
Expert Rev Mol Diagn. 2023 Jul 31:1-14. doi: 10.1080/14737159.2023.2242782. Online ahead of print.ABSTRACTINTRODUCTION: Considering the ongoing increase in antibiotic resistance, the importance of judicious use of antibiotics through reduction of exposure is crucial. Adding procalcitonin (PCT) and other biomarkers to pathogen-specific tests may help to further improve antibiotic therapy algorithms and advance antibiotic stewardship programs to achieve these goals.AREAS COVERED: In recent years, several trials have investigated the inclusion of biomarkers such as PCT into clinical decision-making algorithms. For adult patie...
Source: Expert Review of Molecular Diagnostics - July 28, 2023 Category: Laboratory Medicine Authors: Lennart Essmann Yannick Wirz Claudia Gregoriano Philipp Schuetz Source Type: research
Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease
Expert Rev Mol Diagn. 2023 Jul 28. doi: 10.1080/14737159.2023.2242779. Online ahead of print.ABSTRACTINTRODUCTION: The non-invasive identification of liver fibrosis related to Non-Alcoholic Fatty Liver Disease is crucial for risk-stratification of patients. Currently, the reference standard to stage hepatic fibrosis relies on liver biopsy, but multiple approaches are developed to allow for non-invasive diagnosis and risk stratification. Non-invasive tests, including blood-based scores and vibration-controlled transient elastography, have been widely validated and represent a good surrogate for risk stratification according...
Source: Expert Review of Molecular Diagnostics - July 28, 2023 Category: Laboratory Medicine Authors: Angelo Armandi Maurice Michel Kamela Gjini Tilman Emrich Elisabetta Bugianesi J örn M Schattenberg Source Type: research
One biomarker does not fit all: tailoring anti-infective therapy through utilization of procalcitonin and other specific biomarkers
Expert Rev Mol Diagn. 2023 Jul 31:1-14. doi: 10.1080/14737159.2023.2242782. Online ahead of print.ABSTRACTINTRODUCTION: Considering the ongoing increase in antibiotic resistance, the importance of judicious use of antibiotics through reduction of exposure is crucial. Adding procalcitonin (PCT) and other biomarkers to pathogen-specific tests may help to further improve antibiotic therapy algorithms and advance antibiotic stewardship programs to achieve these goals.AREAS COVERED: In recent years, several trials have investigated the inclusion of biomarkers such as PCT into clinical decision-making algorithms. For adult patie...
Source: Expert Review of Molecular Diagnostics - July 28, 2023 Category: Laboratory Medicine Authors: Lennart Essmann Yannick Wirz Claudia Gregoriano Philipp Schuetz Source Type: research
Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease
Expert Rev Mol Diagn. 2023 Jul 28. doi: 10.1080/14737159.2023.2242779. Online ahead of print.ABSTRACTINTRODUCTION: The non-invasive identification of liver fibrosis related to Non-Alcoholic Fatty Liver Disease is crucial for risk-stratification of patients. Currently, the reference standard to stage hepatic fibrosis relies on liver biopsy, but multiple approaches are developed to allow for non-invasive diagnosis and risk stratification. Non-invasive tests, including blood-based scores and vibration-controlled transient elastography, have been widely validated and represent a good surrogate for risk stratification according...
Source: Expert Review of Molecular Diagnostics - July 28, 2023 Category: Laboratory Medicine Authors: Angelo Armandi Maurice Michel Kamela Gjini Tilman Emrich Elisabetta Bugianesi J örn M Schattenberg Source Type: research
One biomarker does not fit all: tailoring anti-infective therapy through utilization of procalcitonin and other specific biomarkers
Expert Rev Mol Diagn. 2023 Jul 28. doi: 10.1080/14737159.2023.2242782. Online ahead of print.ABSTRACTINTRODUCTION: Considering the ongoing increase in antibiotic resistance, the importance of judicious use of antibiotics through reduction of exposure is crucial. Adding procalcitonin (PCT) and other biomarkers to pathogen-specific tests may help to further improve antibiotic therapy algorithms and advance antibiotic stewardship programs to achieve these goals.AREAS COVERED: In recent years, several trials have investigated the inclusion of biomarkers such as PCT into clinical decision-making algorithms. For adult patients, ...
Source: Expert Review of Molecular Diagnostics - July 28, 2023 Category: Laboratory Medicine Authors: Lennart Essmann Yannick Wirz Claudia Gregoriano Philipp Schuetz Source Type: research
Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease
Expert Rev Mol Diagn. 2023 Jul 28. doi: 10.1080/14737159.2023.2242779. Online ahead of print.ABSTRACTINTRODUCTION: The non-invasive identification of liver fibrosis related to Non-Alcoholic Fatty Liver Disease is crucial for risk-stratification of patients. Currently, the reference standard to stage hepatic fibrosis relies on liver biopsy, but multiple approaches are developed to allow for non-invasive diagnosis and risk stratification. Non-invasive tests, including blood-based scores and vibration-controlled transient elastography, have been widely validated and represent a good surrogate for risk stratification according...
Source: Expert Review of Molecular Diagnostics - July 28, 2023 Category: Laboratory Medicine Authors: Angelo Armandi Maurice Michel Kamela Gjini Tilman Emrich Elisabetta Bugianesi J örn M Schattenberg Source Type: research
One biomarker does not fit all: tailoring anti-infective therapy through utilization of procalcitonin and other specific biomarkers
Expert Rev Mol Diagn. 2023 Jul 28. doi: 10.1080/14737159.2023.2242782. Online ahead of print.ABSTRACTINTRODUCTION: Considering the ongoing increase in antibiotic resistance, the importance of judicious use of antibiotics through reduction of exposure is crucial. Adding procalcitonin (PCT) and other biomarkers to pathogen-specific tests may help to further improve antibiotic therapy algorithms and advance antibiotic stewardship programs to achieve these goals.AREAS COVERED: In recent years, several trials have investigated the inclusion of biomarkers such as PCT into clinical decision-making algorithms. For adult patients, ...
Source: Expert Review of Molecular Diagnostics - July 28, 2023 Category: Laboratory Medicine Authors: Lennart Essmann Yannick Wirz Claudia Gregoriano Philipp Schuetz Source Type: research
Promotor methylation in ocular surface squamous neoplasia development: epigenetics implications in molecular diagnosis
Expert Rev Mol Diagn. 2023 Jul 26. doi: 10.1080/14737159.2023.2240238. Online ahead of print.ABSTRACTINTRODUCTION: Cancer is heavily influenced by epigenetic mechanisms that include DNA methylation, histone modifications and non-coding RNA. A considerable proportion of human malignancies are believed to be associated with global DNA hypomethylation, with localized hypermethylation at promoters of certain genes.AREA COVERED: The present review aims to emphasize on recent investigations on the epigenetic landscape of ocular surface squamous neoplasia, that could be targeted/explored using novel approaches such as personalize...
Source: Expert Review of Molecular Diagnostics - July 26, 2023 Category: Laboratory Medicine Authors: Kourosh Shahraki Kianoush Shahraki Paria Ghasemi Boroumand Roghayeh Sheervalilou Source Type: research