Expert Review of Molecular Diagnostics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Efficient screening strategies for severe combined immunodeficiencies in newborns
Expert Rev Mol Diagn. 2023 Aug 21:1-11. doi: 10.1080/14737159.2023.2244879. Online ahead of print.ABSTRACTINTRODUCTION: Severe combined immunodeficiency (SCID) is one of the most severe forms of inborn errors of immunity (IEI), affecting both cellular and humoral immunity. Without curative treatment such as hematopoietic stem cell transplantation or gene therapy, affected infants die within the first year of life. Due to the severity of the disease, asymptomatic status early in life, and improved survival in the absence of pretransplant infections, SCID was considered a suitable candidate for newborn screening (NBS).AREAS ...
Source: Expert Review of Molecular Diagnostics - August 21, 2023 Category: Laboratory Medicine Authors: Maartje Blom Robbert G M Bredius Miriam van der Burg Source Type: research

Cancer cell-derived extracellular vesicles activate hepatic stellate cells in colorectal cancer
Expert Rev Mol Diagn. 2023 Aug 21:1-7. doi: 10.1080/14737159.2023.2246893. Online ahead of print.ABSTRACTColorectal cancer (CRC) is the 2nd leading cause of cancer-related deaths worldwide, primarily due to the development of metastatic disease. The liver is the most frequently affected site. The metastatic cascade relies on a complex interaction between the immune system, tumor, and distant organs. Communication between the tumor and the metastatic site can be mediated by tumor-derived extracellular vesicles (EVs) and their cargo. The mechanisms underlying this process are starting to be understood through research that h...
Source: Expert Review of Molecular Diagnostics - August 21, 2023 Category: Laboratory Medicine Authors: Bhavik Y Patel Rahul Bhome Daniel S K Liu Elisa Giovannetti Nabeel Merali John N Primrose Alex H Mirnezami Timothy A Rockall Nicola Annels Adam E Frampton Source Type: research

Potential use of heat shock protein 90 as a biomarker for the diagnosis of human diseases
Expert Rev Mol Diagn. 2023 Aug 21:1-10. doi: 10.1080/14737159.2023.2246883. Online ahead of print.ABSTRACTINTRODUCTION: The heat shock protein 90 (Hsp90) is a protein involved in many different biological processes and especially in cell survival. Some of these functions require the participation of other biological molecules, so Hsp90 is a chaperone that takes part in many protein-protein interactions working as a critical signaling hub protein. As a member of the heat shock protein family, Hsp90 expression is regulated under certain environmental and/or stressful situations, therefore Hsp90 concentration can be monitored...
Source: Expert Review of Molecular Diagnostics - August 14, 2023 Category: Laboratory Medicine Authors: Ane Rivas-Macho Mar ía V Romeo Elisabeth Rackles Garbi ñe Olabarria Juan Manuel Falcon-Perez Jes ús Berganza-Granda Aitziber L Cortajarena Felipe Go ñi-de-Cerio Source Type: research

Anti-citrullinated protein antibodies as biomarkers in rheumatoid arthritis
Expert Rev Mol Diagn. 2023 Aug 21:1-17. doi: 10.1080/14737159.2023.2247986. Online ahead of print.ABSTRACTINTRODUCTION: The serological biomarker anti-citrullinated protein antibodies (ACPAs) may have several functions but is especially important for the diagnosis of rheumatoid arthritis (RA) along with clinical symptoms.AREAS COVERED: This review provides an overview of ACPAs, which are useful in RA diagnostics and may improve our understanding of disease etiology. PubMed was searched with combinations of words related to antibodies recognizing epitopes containing the post-translationally modified amino acid citrulline in...
Source: Expert Review of Molecular Diagnostics - August 14, 2023 Category: Laboratory Medicine Authors: Nicole Hartwig Trier Gunnar Houen Source Type: research

Potential use of heat shock protein 90 as a biomarker for the diagnosis of human diseases
Expert Rev Mol Diagn. 2023 Aug 14. doi: 10.1080/14737159.2023.2246883. Online ahead of print.ABSTRACTINTRODUCTION: The heat shock protein 90 (Hsp90) is a protein involved in many different biological processes and especially in cell survival. Some of these functions require the participation of other biological molecules, so Hsp90 is a chaperone that takes part in many protein-protein interactions working as a critical signaling hub protein. As a member of the heat shock protein family, Hsp90 expression is regulated under certain environmental and/or stressful situations, therefore Hsp90 concentration can be monitored and ...
Source: Expert Review of Molecular Diagnostics - August 14, 2023 Category: Laboratory Medicine Authors: Ane Rivas-Macho Mar ía V Romeo Elisabeth Rackles Garbi ñe Olabarria Juan Manuel Falcon-Perez Jes ús Berganza-Granda Aitziber L Cortajarena Felipe Go ñi-de-Cerio Source Type: research

Anti-citrullinated protein antibodies as biomarkers in rheumatoid arthritis
Expert Rev Mol Diagn. 2023 Aug 14. doi: 10.1080/14737159.2023.2247986. Online ahead of print.ABSTRACTINTRODUCTION: The serological biomarker anti-citrullinated protein antibodies (ACPAs) may have several functions but is especially important for the diagnosis of rheumatoid arthritis (RA) along with clinical symptoms.AREAS COVERED: This review provides an overview of ACPAs, which are useful in RA diagnostics and may improve understanding of disease etiology. PubMed was searched with combinations of words related to antibodies recognizing epitopes containing the post-translationally modified amino acid citrulline in combinat...
Source: Expert Review of Molecular Diagnostics - August 14, 2023 Category: Laboratory Medicine Authors: Nicole Hartwig Trier Gunnar Houen Source Type: research