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Current and emerging biomarkers for ulcerative colitis
Expert Rev Mol Diagn. 2023 Nov 7:1-13. doi: 10.1080/14737159.2023.2279611. Online ahead of print.ABSTRACTINTRODUCTION: Ulcerative colitis (UC) is a chronic illness requiring lifelong management that could be enhanced by personalizing care using biomarkers.AREAS COVERED: The main biomarker discovery modalities are reviewed, highlighting recent results across the spectrum of applications, including diagnostics (serum anti-αvβ6 antibodies achieving an area under the curve [AUC] = 0.99; serum oncostatin M AUC = 0.94), disease activity assessment (fecal calprotectin and serum trefoil factor 3: AUC > 0.90), prognostication ...
Source: Expert Review of Molecular Diagnostics - November 7, 2023 Category: Laboratory Medicine Authors: Jan K Nowak Rahul Kalla Jack Satsangi Source Type: research

Cross-sectional risk models using quantitative fecal hemoglobin in colorectal cancer screening: a systematic review
CONCLUSION: FIT-based risk models have the potential to improve the yield of CRC screening. Unfortunately, all included publications had a high risk of bias and most risk models have not yet been externally validated. The prospect of improved CRC screening with risk models should encourage more rigorous evaluation in existing screening programs.PMID:37930046 | DOI:10.1080/14737159.2023.2279607 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - November 6, 2023 Category: Laboratory Medicine Authors: Tim Kortlever Willemijn de Klaver Manon van der Vlugt Gerrit Meijer Evelien Dekker Patrick Bossuyt Source Type: research

Challenges associated with using extracellular vesicles as biomarkers in neurodegenerative disease
Expert Rev Mol Diagn. 2023 Nov 2:1-15. doi: 10.1080/14737159.2023.2277373. Online ahead of print.ABSTRACTINTRODUCTION: The hunt for new biomarkers - for the diagnosis of subcategories of disease, or for the monitoring of the efficacy of novel therapeutics - is an increasingly relevant challenge in the current era of precision medicine. In neurodegenerative research, the aim is to look for simple tools which can predict cognitive or motor decline early, and to determine whether these can also be used to test the efficacy of new interventions. Extracellular vesicles (EVs) are thought to play an important role in intercellula...
Source: Expert Review of Molecular Diagnostics - November 2, 2023 Category: Laboratory Medicine Authors: Yvonne Couch Source Type: research

Lessons from the pandemic: new best practices in selecting molecular diagnostics for point-of-care testing of infectious diseases in sub-saharan Africa
Expert Rev Mol Diagn. 2023 Oct 31. doi: 10.1080/14737159.2023.2277368. Online ahead of print.ABSTRACTINTRODUCTION: Point-of-care molecular diagnostics offer solutions to the limited diagnostic availability and accessibility in resource-limited settings. During the COVID-19 pandemic, molecular diagnostics became essential tools for accurate detection and monitoring of SARS-CoV-2. The unprecedented demand for molecular diagnostics presented challenges and catalyzed innovations which may provide lessons for the future selection of point-of-care molecular diagnostics.AREAS COVERED: We searched PubMed from January 2020-August 2...
Source: Expert Review of Molecular Diagnostics - November 1, 2023 Category: Laboratory Medicine Authors: Mamadu Baldeh Flavia K Bawa Faiza U Bawah Martin Chamai Francis Dzabeng Waleed M A Jebreel Jean-Bertin B Kabuya Shola K Molemodile Dele-Olowu Erick Odoyo Dimbintsoa Rakotomalala Robinson Aubrey J Cunnington Source Type: research

A systematic review and meta-analysis on the relative and attributable risk of Helicobacter pylori infection and cardia and non-cardia gastric cancer
CONCLUSIONS: This meta-analysis summarizes prospective evidence for the association between H. pylori infection and GC, providing robust estimates for the attributable risk and potential impact of H. pylori-targeting GC prevention programs.PROSPERO REGISTRATION: CRD42021274120.PMID:37905778 | DOI:10.1080/14737159.2023.2277377 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - October 31, 2023 Category: Laboratory Medicine Authors: Jianhua Gu Feifan He Gary M Clifford Minjuan Li Zhiyuan Fan Xinqing Li Shaoming Wang Wenqiang Wei Source Type: research

Usefulness of an RNA extraction-free test for the multiplexed detection of ALK , ROS1 , and RET gene fusions in in real life FFPE specimens of non-small cell lung cancers
CONCLUSIONS: Overall, the HTG EdgeSeq assay offers comparable sensitivities and specificity than other RNA sequencing techniques, with the advantage that it can be used on very small and old samples collected multicentrically.PMID:37906110 | DOI:10.1080/14737159.2023.2277367 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - October 31, 2023 Category: Laboratory Medicine Authors: Damiola Francesca Alberti Laurent Mansuet-Lupo Audrey Damotte Diane Hofman V éronique Tixier Lucie Penault-Llorca Fr éderique Rouquette Isabelle Vignaud Jean Michel Cazes Aurelie Forest Fabien Begueret Hugues Gibault Laure Badoual C écile Cayre Anne Ta Source Type: research

Functional proteomic analysis, a missing piece for understanding clonal evolution and cooperation in the tissue microecology
Expert Rev Mol Diagn. 2023 Oct 30. doi: 10.1080/14737159.2023.2277371. Online ahead of print.NO ABSTRACTPMID:37902050 | DOI:10.1080/14737159.2023.2277371 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - October 30, 2023 Category: Laboratory Medicine Authors: Mariaelena Pierobon Emanuel F Petricoin Source Type: research

LncRNA NR2F1-AS1 as a potential biomarker for prognosis in cancer patients: meta and bioinformatics analysis
CONCLUSION: Upregulation of LncRNA NR2F1-AS1 was associated with poor prognosis and advanced clinicopathologic features of tumor patients.PMID:37902251 | DOI:10.1080/14737159.2023.2277521 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - October 30, 2023 Category: Laboratory Medicine Authors: Lu Tang Qing-Mei Liu Shuang Zhang Jun Zhou Source Type: research