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From biochemical markers to molecular endotypes of osteoarthritis: a review on validated biomarkers
Expert Rev Mol Diagn. 2024 Feb 14:1-16. doi: 10.1080/14737159.2024.2315282. Online ahead of print.ABSTRACTINTRODUCTION: Osteoarthritis (OA) affects over 500 million people worldwide. OA patients are symptomatically treated, and current therapies exhibit marginal efficacy and frequently carry safety-risks associated with chronic use. No disease-modifying therapies have been approved to date leaving surgical joint replacement as a last resort. To enable effective patient care and successful drug development there is an urgent need to uncover the pathobiological drivers of OA and how these translate into disease endotypes. En...
Source: Expert Review of Molecular Diagnostics - February 14, 2024 Category: Laboratory Medicine Authors: Monica T Hannani Christian S Thudium Morten A Karsdal Christoph Ladel Ali Mobasheri Melanie Uebelhoer Jonathan Larkin Jaume Bacardit Andr é Struglics Anne-Christine Bay-Jensen Source Type: research

Point-of-care urine tenofovir monitoring of adherence to drive interventions for HIV treatment and prevention
Expert Rev Mol Diagn. 2024 Feb 14:1-7. doi: 10.1080/14737159.2024.2312122. Online ahead of print.ABSTRACTINTRODUCTION: Although effective antiretroviral and pre-exposure prophylaxis/PrEP regimens are available globally, adherence challenges persist. Objective measures of adherence can both measure adherence accurately and can be used to drive interventions. The first point-of-care pharmacologic adherence measure, urine tenofovir testing using a lateral flow assay, is now available.AREAS COVERED: This review examines the ability of pharmacologic metrics of adherence to predict HIV and PrEP clinical outcomes and the past use...
Source: Expert Review of Molecular Diagnostics - February 14, 2024 Category: Laboratory Medicine Authors: Matthew Spinelli Monica Gandhi Source Type: research

Fast detection of bacterial gut pathogens on miniaturized devices: an overview
Expert Rev Mol Diagn. 2024 Feb 13:1-18. doi: 10.1080/14737159.2024.2316756. Online ahead of print.ABSTRACTINTRODUCTION: Gut microbes pose challenges like colon inflammation, deadly diarrhea, antimicrobial resistance dissemination, and chronic disease onset. Development of early, rapid and specific diagnosis tools is essential for improving infection control. Point-of-care testing (POCT) systems offer rapid, sensitive, low-cost and sample-to-answer methods for microbe detection from various clinical and environmental samples, bringing the advantages of portability, automation, and simple operation.AREAS COVERED: Rapid detec...
Source: Expert Review of Molecular Diagnostics - February 13, 2024 Category: Laboratory Medicine Authors: Gratiela Gradisteanu Pircalabioru Mina Raileanu Mihai Viorel Dionisie Irina-Oana Lixandru-Petre Ciprian Iliescu Source Type: research

The impact of companion diagnostic testing on medical decision making and IVD regulations
Expert Rev Mol Diagn. 2024 Feb 12:1-3. doi: 10.1080/14737159.2024.2317976. Online ahead of print.NO ABSTRACTPMID:38346227 | DOI:10.1080/14737159.2024.2317976 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - February 12, 2024 Category: Laboratory Medicine Authors: Jan Tr øst Jørgensen Source Type: research

Emerging prognostic biomarkers in advanced cutaneous melanoma: a literature update
Expert Rev Mol Diagn. 2024 Feb 9:1-18. doi: 10.1080/14737159.2024.2314574. Online ahead of print.ABSTRACTINTRODUCTION: Over the past two years, the scientific community has witnessed an exponential growth in research focused on identifying prognostic biomarkers for melanoma, both in pre-clinical and clinical settings. This surge in studies reflects the need of developing effective prognostic indicators in the field of melanoma.AREAS COVERED: The aim of this work is to review the scientific literature on the most recent findings on the development or validation of prognostic biomarkers in melanoma, in the attempt of providi...
Source: Expert Review of Molecular Diagnostics - February 9, 2024 Category: Laboratory Medicine Authors: Gabriele Roccuzzo Eleonora Bongiovanni Luca Tonella Valentina Pala Sara Marchisio Alessia Ricci Rebecca Senetta Luca Bertero Simone Ribero Enrico Berrino Caterina Marchi ò Anna Sapino Pietro Quaglino Paola Cassoni Source Type: research

Polymerase Spiral Reaction (PSR) as a point-of-care diagnostic assay: A systematic review
CONCLUSION: Polymerase spiral reaction promises to be an optimistic isothermal assay; however, a huge research gap can be attributed to the lack of statistical and clinical evidence to validate the assay. Adequate research, focused on optimization, coupled with statistical and clinical validation, can help in estimating its true diagnostic potential and applicability.REGISTRATION AND PROTOCOL: A detailed protocol of this review is registered and available in Prospero (registration number CRD42023406265).PMID:38329468 | DOI:10.1080/14737159.2024.2315286 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - February 8, 2024 Category: Laboratory Medicine Authors: Rashi Dixit Naveen Kumar Kodali Manisha Biswal John Antony Jude Prakash Natarajan Gopalan Padma Das Sujit Kumar Behera Source Type: research

Tumor-infiltrating lymphocytes as a prognostic and predictive factor for Melanoma
This article encompasses the assessment of TILs, the role of TILs in the immune microenvironment, TILs as a prognostic factor, TILs as a predictive factor for immunotherapy response, and clinical applications of TILs in the treatment of cutaneous melanoma.EXPERT OPINION: Tumor-infiltrating lymphocytes play a heterogeneous role in cutaneous melanoma. While they have historically been associated with improved survival, their status as independent prognostic or predictive factors remains uncertain. Novel methods of TIL assessment, such as determination of TIL subtypes and molecular signaling, demonstrate potential for predict...
Source: Expert Review of Molecular Diagnostics - February 5, 2024 Category: Laboratory Medicine Authors: Gracia Maria Vargas Neha Shafique Xiaowei Xu Giorgos Karakousis Source Type: research

Multi-omics and single-cell sequencing analyses reveal the potential significance of circadian pathways in cancer therapy
CONCLUSIONS: The circadian rhythm pathway may be a breakthrough point in regulating the tumor microenvironment meanwhile a suitable immunotherapy method in the future.PMID:38288973 | DOI:10.1080/14737159.2023.2296668 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - January 30, 2024 Category: Laboratory Medicine Authors: Hao Lai Xiaoyun Xiang Xingqing Long Zuyuan Chen Yanling Liu Xiaoliang Huang Source Type: research

The game changer: UCH-L1 and GFAP-based blood test as the first marketed in vitro diagnostic test for mild traumatic brain injury
Expert Rev Mol Diagn. 2024 Jan 26:1-11. doi: 10.1080/14737159.2024.2306876. Online ahead of print.ABSTRACTINTRODUCTION: Major organ-based in vitro diagnostic (IVD) tests like ALT/AST for the liver and cardiac troponins for the heart are established, but an approved IVD blood test for the brain has been missing, highlighting a gap in medical diagnostics.AREAS COVERED: In response to this need, Abbott Diagnostics secured FDA clearance in 2021 for the i-STAT Alinity™, a point-of-care plasma blood test for mild traumatic brain injury (TBI). BioMerieux VIDAS, also approved in Europe, utilizes two brain-derived protein biomark...
Source: Expert Review of Molecular Diagnostics - January 26, 2024 Category: Laboratory Medicine Authors: Firas Kobeissy Rawad Daniel Arja Jennifer C Munoz Deborah A Shear Janice Gilsdorf Jiepei Zhu Hamad Yadikar William Haskins J Adrian Tyndall Kevin K Wang Source Type: research

< em > SOWAHB < /em > polymorphisms affect thyroid cancer risk in the Chinese Han population
CONCLUSION: SOWAHB SNPs were related to the occurrence of TC, and rs2703129 may be a protective site for TC.PMID:38263767 | DOI:10.1080/14737159.2024.2305183 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - January 24, 2024 Category: Laboratory Medicine Authors: Man Zhang Jing Liang Junhui Han Wenjing Zhang Panpan Wan Leteng Yang Xufeng Zang Wanli Ren Ling Zhang Hao Dai Yue Wu Tianbo Jin Source Type: research

Optimization of time interval for the measurement of plasma lipids for cardiovascular disease risk assessment
CONCLUSIONS: Testing patients for lipids who have a higher baseline risk more often could identify high-risk patients sooner, allowing for earlier and more effective therapeutic intervention.PMID:38252511 | DOI:10.1080/14737159.2024.2306127 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - January 22, 2024 Category: Laboratory Medicine Authors: Maureen Sampson Anna Wolska Rafael Zubiran Justine Cole Marcelo Amar Alan T Remaley Source Type: research

Rapid and reliable testing for clinically actionable EGFR mutations in non-small cell lung cancer using the Idylla < sup > TM < /sup > platform: a real-world two-center experience in Greece
CONCLUSION: The frequency of EGFR mutations was as expected for a Caucasian population. The Idylla EGFR test performance is comparable to reference methods and with a shorter TAT. Adding a concurrent plasma Idylla test to tissue NGS testing increases the detection rate of EGFR mutations in NSCLC.PMID:38193169 | DOI:10.1080/14737159.2024.2303320 (Source: Expert Review of Molecular Diagnostics)
Source: Expert Review of Molecular Diagnostics - January 9, 2024 Category: Laboratory Medicine Authors: Kleita Michaelidou Ioannis Karniadakis Varvara Pantelaion Chara Koutoulaki Eleni Boukla Konstantinos Folinas Pantelis Dimaras Maria A Papadaki Anastasios V Koutsopoulos Dimitrios Mavroudis Christine Vourlakou Konstantinos Mavridis Sofia Agelaki Source Type: research

Molecular biomarkers of diffuse axonal injury: recent advances and future perspectives
Expert Rev Mol Diagn. 2024 Jan 5:1-9. doi: 10.1080/14737159.2024.2303319. Online ahead of print.ABSTRACTINTRODUCTION: Diffuse axonal injury (DAI), with high mortality and morbidity both in children and adults, is one of the most severe pathological consequences of traumatic brain injury. Currently, clinical diagnosis, disease assessment, disability identification, and postmortem diagnosis of DAI is mainly limited by the absent of specific molecular biomarkers.AREAS COVERED: In this review, we first introduce the pathophysiology of DAI, summarized the reported biomarkers in previous animal and human studies, and then the mo...
Source: Expert Review of Molecular Diagnostics - January 6, 2024 Category: Laboratory Medicine Authors: Youyou Zhang Zhaoyang Li Hui Wang Zhiyong Pei Shuquan Zhao Source Type: research

Molecular biomarkers of diffuse axonal injury: recent advances and future perspectives
Expert Rev Mol Diagn. 2024 Jan 5. doi: 10.1080/14737159.2024.2303319. Online ahead of print.ABSTRACTINTRODUCTION: Diffuse axonal injury (DAI), with high mortality and morbidity both in children and adults, is one of the most severe pathological consequences of traumatic brain injury. Currently, clinical diagnosis, disease assessment, disability identification, and postmortem diagnosis of DAI is mainly limited by the absent of specific molecular biomarkers.AREAS COVERED: In this review, we first introduce the pathophysiology of DAI, summarized the reported biomarkers in previous animal and human studies, and then the molecu...
Source: Expert Review of Molecular Diagnostics - January 6, 2024 Category: Laboratory Medicine Authors: Youyou Zhang Zhaoyang Li Hui Wang Zhiyong Pei Shuquan Zhao Source Type: research