Inhibition of Rho kinase (ROCK) impairs cytoskeletal contractility in human M üller glial cells without effects on cell viability, migration, and extracellular matrix production
In conclusion, pharmacological inhibition of ROCK in Müller cells could be a potentially promising approach to treat epiretinal membranes by preventing cell proliferation, contractility and transdifferentiation, without affecting cell viability.PMID:38043763 | DOI:10.1016/j.exer.2023.109745 (Source: Experimental Eye Research)
Source: Experimental Eye Research - December 3, 2023 Category: Opthalmology Authors: Vinicius Moraes de Paiva Roda Rafael Andr é da Silva Paula Veloso Siqueira Gabriela de Jesus Lustoza-Costa Gabri élla Malheiros de Moraes Monique Matsuda D ânia Emi Hamassaki Marinilce Fagundes Santos Source Type: research
URP20 improves corneal injury caused by alkali burns combined with pathogenic bacterial infection in rats
In conclusion, URP20 could improve corneal injury combined with bacterial infection in rats caused by alkali burns through antibacterial, anti-NV, and antioxidant activities.PMID:38042515 | DOI:10.1016/j.exer.2023.109739 (Source: Experimental Eye Research)
Source: Experimental Eye Research - December 2, 2023 Category: Opthalmology Authors: Yan Gong Jian Gao Meng Li Xiao-Lin Zhang Yan-Hong Liao Yong-Bo Bao Source Type: research
URP20 improves corneal injury caused by alkali burns combined with pathogenic bacterial infection in rats
In conclusion, URP20 could improve corneal injury combined with bacterial infection in rats caused by alkali burns through antibacterial, anti-NV, and antioxidant activities.PMID:38042515 | DOI:10.1016/j.exer.2023.109739 (Source: Experimental Eye Research)
Source: Experimental Eye Research - December 2, 2023 Category: Opthalmology Authors: Yan Gong Jian Gao Meng Li Xiao-Lin Zhang Yan-Hong Liao Yong-Bo Bao Source Type: research
Impact of a 50bp insertion/deletion polymorphism of the superoxide dismutase-1 on oxidative stress status and risk of keratoconus
Exp Eye Res. 2023 Nov 29:109742. doi: 10.1016/j.exer.2023.109742. Online ahead of print.ABSTRACTKeratoconus (KC) is characterized by the predominant primary ectatic disease, affecting the cornea, necessitating corneal transplants in some cases. While some loci associated with KC risk have been identified, the understanding of the disease remains limited. Superoxide dismutase (SOD) enzymes play a crucial role in countering the reactive oxygen species and providing protection against oxidative stress (OS). Accordingly, the objective of this study was to investigate a potential association of a 50 nucleotide base pairs (bp) i...
Source: Experimental Eye Research - December 1, 2023 Category: Opthalmology Authors: Mohammad Reza Sedaghat Hamidreza Shiri Jalil Tavakkol-Afshari Mohammad Erfan Nourouzmahani Faegheh Bahri Saba Fooladi Hamed Momeni-Moghaddam Zeynab Danesh Amin Reza Nikpoor Mohammad Amin Momeni-Moghaddam Mohammad Hadi Nematollahi Javad Sadeghi Source Type: research
Impact of a 50bp insertion/deletion polymorphism of the superoxide dismutase-1 on oxidative stress status and risk of keratoconus
Exp Eye Res. 2023 Nov 29:109742. doi: 10.1016/j.exer.2023.109742. Online ahead of print.ABSTRACTKeratoconus (KC) is characterized by the predominant primary ectatic disease, affecting the cornea, necessitating corneal transplants in some cases. While some loci associated with KC risk have been identified, the understanding of the disease remains limited. Superoxide dismutase (SOD) enzymes play a crucial role in countering the reactive oxygen species and providing protection against oxidative stress (OS). Accordingly, the objective of this study was to investigate a potential association of a 50 nucleotide base pairs (bp) i...
Source: Experimental Eye Research - December 1, 2023 Category: Opthalmology Authors: Mohammad Reza Sedaghat Hamidreza Shiri Jalil Tavakkol-Afshari Mohammad Erfan Nourouzmahani Faegheh Bahri Saba Fooladi Hamed Momeni-Moghaddam Zeynab Danesh Amin Reza Nikpoor Mohammad Amin Momeni-Moghaddam Mohammad Hadi Nematollahi Javad Sadeghi Source Type: research
Influence of sex on chronic steroid-induced glaucoma: 24-Weeks follow-up study in rats
The objective was to evaluate ocular changes based on sex in steroid-induced glaucoma models in rats comparing healthy controls, over 24 weeks follow-up. Eighty-nine Long-Evans rats (38 males and 51 females) with steroid-induced glaucoma were analysed. Two steroid-induced glaucoma models were generated by injecting poly-co-lactic-glycolic acid microspheres loaded with dexamethasone (MMDEX model) and dexamethasone-fibronectin (MMDEXAFIBRO model) into the ocular anterior chamber. Intraocular pressure was measured by rebound tonometer Tonolab®. Neuroretinal function was analysed using dark- and light-adapted electroretinogra...
Source: Experimental Eye Research - November 30, 2023 Category: Opthalmology Authors: M J Rodrigo T Martinez-Rincon M Subias S Mendez-Martinez D Garcia-Herranz J Garcia-Feijoo R Herrero-Vanrell L Pablo I Bravo-Osuna I Munuera E Garcia-Martin Source Type: research
Proteomic analysis of aqueous humor reveals novel regulators of diabetic macular edema
Exp Eye Res. 2023 Nov 17:109724. doi: 10.1016/j.exer.2023.109724. Online ahead of print.ABSTRACTDiabetic macular edema (DME) is the most common cause of blindness in patients with diabetic retinopathy. To investigate the proteomic profiles of the aqueous humor (AH) of individuals with diabetic macular edema (DME), AH samples were collected from patients with non-diabetes mellitus (NDM), DM, nonproliferative diabetic retinopathy (NPDR), and DME. We performed comparative proteomic analyses using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and bioinformatics analyses. We identified 425 proteins in these AH sampl...
Source: Experimental Eye Research - November 19, 2023 Category: Opthalmology Authors: Yue Zhang Manhong Xu Hongbo He Shaojie Ren Xin Chen Yan Zhang Jinying An Xinjun Ren Xiaomin Zhang Minglian Zhang Zhiqiang Liu Xiaorong Li Source Type: research
Proteomic analysis of aqueous humor reveals novel regulators of diabetic macular edema
Exp Eye Res. 2023 Nov 17:109724. doi: 10.1016/j.exer.2023.109724. Online ahead of print.ABSTRACTDiabetic macular edema (DME) is the most common cause of blindness in patients with diabetic retinopathy. To investigate the proteomic profiles of the aqueous humor (AH) of individuals with diabetic macular edema (DME), AH samples were collected from patients with non-diabetes mellitus (NDM), DM, nonproliferative diabetic retinopathy (NPDR), and DME. We performed comparative proteomic analyses using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and bioinformatics analyses. We identified 425 proteins in these AH sampl...
Source: Experimental Eye Research - November 19, 2023 Category: Opthalmology Authors: Yue Zhang Manhong Xu Hongbo He Shaojie Ren Xin Chen Yan Zhang Jinying An Xinjun Ren Xiaomin Zhang Minglian Zhang Zhiqiang Liu Xiaorong Li Source Type: research
Proteomic analysis of aqueous humor reveals novel regulators of diabetic macular edema
Exp Eye Res. 2023 Nov 17:109724. doi: 10.1016/j.exer.2023.109724. Online ahead of print.ABSTRACTDiabetic macular edema (DME) is the most common cause of blindness in patients with diabetic retinopathy. To investigate the proteomic profiles of the aqueous humor (AH) of individuals with diabetic macular edema (DME), AH samples were collected from patients with non-diabetes mellitus (NDM), DM, nonproliferative diabetic retinopathy (NPDR), and DME. We performed comparative proteomic analyses using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and bioinformatics analyses. We identified 425 proteins in these AH sampl...
Source: Experimental Eye Research - November 19, 2023 Category: Opthalmology Authors: Yue Zhang Manhong Xu Hongbo He Shaojie Ren Xin Chen Yan Zhang Jinying An Xinjun Ren Xiaomin Zhang Minglian Zhang Zhiqiang Liu Xiaorong Li Source Type: research
Proteomic analysis of aqueous humor reveals novel regulators of diabetic macular edema
Exp Eye Res. 2023 Nov 17:109724. doi: 10.1016/j.exer.2023.109724. Online ahead of print.ABSTRACTDiabetic macular edema (DME) is the most common cause of blindness in patients with diabetic retinopathy. To investigate the proteomic profiles of the aqueous humor (AH) of individuals with diabetic macular edema (DME), AH samples were collected from patients with non-diabetes mellitus (NDM), DM, nonproliferative diabetic retinopathy (NPDR), and DME. We performed comparative proteomic analyses using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and bioinformatics analyses. We identified 425 proteins in these AH sampl...
Source: Experimental Eye Research - November 19, 2023 Category: Opthalmology Authors: Yue Zhang Manhong Xu Hongbo He Shaojie Ren Xin Chen Yan Zhang Jinying An Xinjun Ren Xiaomin Zhang Minglian Zhang Zhiqiang Liu Xiaorong Li Source Type: research
Proteomic analysis of aqueous humor reveals novel regulators of diabetic macular edema
Exp Eye Res. 2023 Nov 17:109724. doi: 10.1016/j.exer.2023.109724. Online ahead of print.ABSTRACTDiabetic macular edema (DME) is the most common cause of blindness in patients with diabetic retinopathy. To investigate the proteomic profiles of the aqueous humor (AH) of individuals with diabetic macular edema (DME), AH samples were collected from patients with non-diabetes mellitus (NDM), DM, nonproliferative diabetic retinopathy (NPDR), and DME. We performed comparative proteomic analyses using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and bioinformatics analyses. We identified 425 proteins in these AH sampl...
Source: Experimental Eye Research - November 19, 2023 Category: Opthalmology Authors: Yue Zhang Manhong Xu Hongbo He Shaojie Ren Xin Chen Yan Zhang Jinying An Xinjun Ren Xiaomin Zhang Minglian Zhang Zhiqiang Liu Xiaorong Li Source Type: research
Proteomic analysis of aqueous humor reveals novel regulators of diabetic macular edema
Exp Eye Res. 2023 Nov 17:109724. doi: 10.1016/j.exer.2023.109724. Online ahead of print.ABSTRACTDiabetic macular edema (DME) is the most common cause of blindness in patients with diabetic retinopathy. To investigate the proteomic profiles of the aqueous humor (AH) of individuals with diabetic macular edema (DME), AH samples were collected from patients with non-diabetes mellitus (NDM), DM, nonproliferative diabetic retinopathy (NPDR), and DME. We performed comparative proteomic analyses using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and bioinformatics analyses. We identified 425 proteins in these AH sampl...
Source: Experimental Eye Research - November 19, 2023 Category: Opthalmology Authors: Yue Zhang Manhong Xu Hongbo He Shaojie Ren Xin Chen Yan Zhang Jinying An Xinjun Ren Xiaomin Zhang Minglian Zhang Zhiqiang Liu Xiaorong Li Source Type: research
Proteomic analysis of aqueous humor reveals novel regulators of diabetic macular edema
Exp Eye Res. 2023 Nov 17:109724. doi: 10.1016/j.exer.2023.109724. Online ahead of print.ABSTRACTDiabetic macular edema (DME) is the most common cause of blindness in patients with diabetic retinopathy. To investigate the proteomic profiles of the aqueous humor (AH) of individuals with diabetic macular edema (DME), AH samples were collected from patients with non-diabetes mellitus (NDM), DM, nonproliferative diabetic retinopathy (NPDR), and DME. We performed comparative proteomic analyses using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and bioinformatics analyses. We identified 425 proteins in these AH sampl...
Source: Experimental Eye Research - November 19, 2023 Category: Opthalmology Authors: Yue Zhang Manhong Xu Hongbo He Shaojie Ren Xin Chen Yan Zhang Jinying An Xinjun Ren Xiaomin Zhang Minglian Zhang Zhiqiang Liu Xiaorong Li Source Type: research
Proteomic analysis of aqueous humor reveals novel regulators of diabetic macular edema
Exp Eye Res. 2023 Nov 17:109724. doi: 10.1016/j.exer.2023.109724. Online ahead of print.ABSTRACTDiabetic macular edema (DME) is the most common cause of blindness in patients with diabetic retinopathy. To investigate the proteomic profiles of the aqueous humor (AH) of individuals with diabetic macular edema (DME), AH samples were collected from patients with non-diabetes mellitus (NDM), DM, nonproliferative diabetic retinopathy (NPDR), and DME. We performed comparative proteomic analyses using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and bioinformatics analyses. We identified 425 proteins in these AH sampl...
Source: Experimental Eye Research - November 19, 2023 Category: Opthalmology Authors: Yue Zhang Manhong Xu Hongbo He Shaojie Ren Xin Chen Yan Zhang Jinying An Xinjun Ren Xiaomin Zhang Minglian Zhang Zhiqiang Liu Xiaorong Li Source Type: research
Proteomic analysis of aqueous humor reveals novel regulators of diabetic macular edema
Exp Eye Res. 2023 Nov 17:109724. doi: 10.1016/j.exer.2023.109724. Online ahead of print.ABSTRACTDiabetic macular edema (DME) is the most common cause of blindness in patients with diabetic retinopathy. To investigate the proteomic profiles of the aqueous humor (AH) of individuals with diabetic macular edema (DME), AH samples were collected from patients with non-diabetes mellitus (NDM), DM, nonproliferative diabetic retinopathy (NPDR), and DME. We performed comparative proteomic analyses using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and bioinformatics analyses. We identified 425 proteins in these AH sampl...
Source: Experimental Eye Research - November 19, 2023 Category: Opthalmology Authors: Yue Zhang Manhong Xu Hongbo He Shaojie Ren Xin Chen Yan Zhang Jinying An Xinjun Ren Xiaomin Zhang Minglian Zhang Zhiqiang Liu Xiaorong Li Source Type: research
