Inhibition of Rho kinase (ROCK) impairs cytoskeletal contractility in human M üller glial cells without effects on cell viability, migration, and extracellular matrix production

In conclusion, pharmacological inhibition of ROCK in Müller cells could be a potentially promising approach to treat epiretinal membranes by preventing cell proliferation, contractility and transdifferentiation, without affecting cell viability.PMID:38043763 | DOI:10.1016/j.exer.2023.109745

Source: Experimental Eye Research - December 3, 2023 Category: Opthalmology Authors: Vinicius Moraes de Paiva Roda Rafael Andr é da Silva Paula Veloso Siqueira Gabriela de Jesus Lustoza-Costa Gabri élla Malheiros de Moraes Monique Matsuda D ânia Emi Hamassaki Marinilce Fagundes Santos Source Type: research