Retinal microcirculation: A window into systemic circulation and metabolic disease
Exp Eye Res. 2024 Apr 3;242:109885. doi: 10.1016/j.exer.2024.109885. Online ahead of print.ABSTRACTThe retinal microcirculation system constitutes a unique terminal vessel bed of the systemic circulation, and its perfusion status is directly associated with the neural function of the retina. This vascular network, essential for nourishing various layers of the retina, comprises two primary microcirculation systems: the retinal microcirculation and the choroidal microcirculation, with each system supplying blood to distinct retinal layers and maintaining the associated neural function. The blood flow of those capillaries is...
Source: Experimental Eye Research - April 4, 2024 Category: Opthalmology Authors: Yue Yuan Meiyuan Dong Song Wen Xinlu Yuan Ligang Zhou Source Type: research
Retinal microcirculation: A window into systemic circulation and metabolic disease
Exp Eye Res. 2024 Apr 3;242:109885. doi: 10.1016/j.exer.2024.109885. Online ahead of print.ABSTRACTThe retinal microcirculation system constitutes a unique terminal vessel bed of the systemic circulation, and its perfusion status is directly associated with the neural function of the retina. This vascular network, essential for nourishing various layers of the retina, comprises two primary microcirculation systems: the retinal microcirculation and the choroidal microcirculation, with each system supplying blood to distinct retinal layers and maintaining the associated neural function. The blood flow of those capillaries is...
Source: Experimental Eye Research - April 4, 2024 Category: Opthalmology Authors: Yue Yuan Meiyuan Dong Song Wen Xinlu Yuan Ligang Zhou Source Type: research
Retinal microcirculation: A window into systemic circulation and metabolic disease
Exp Eye Res. 2024 Apr 2:109885. doi: 10.1016/j.exer.2024.109885. Online ahead of print.ABSTRACTThe retinal microcirculation system constitutes a unique terminal vessel bed of the systemic circulation, and its perfusion status is directly associated with the neural function of the retina. This vascular network, essential for nourishing various layers of the retina, comprises two primary microcirculation systems: the retinal microcirculation and the choroidal microcirculation, with each system supplying blood to distinct retinal layers and maintaining the associated neural function. The blood flow of those capillaries is reg...
Source: Experimental Eye Research - April 4, 2024 Category: Opthalmology Authors: Yue Yuan Meiyuan Dong Song Wen Xinlu Yuan Ligang Zhou Source Type: research
Two-phase mechanism in the treatment of corneal stromal fibrosis with topical losartan
Exp Eye Res. 2024 Apr 1:109884. doi: 10.1016/j.exer.2024.109884. Online ahead of print.ABSTRACTRecent studies in rabbits and case reports in humans have demonstrated the efficacy of topical losartan in the treatment of corneal scarring fibrosis after a wide range of injuries, including chemical burns, infections, surgical complications, and some diseases. It is hypothesized that the effect of losartan on the fibrotic corneal stroma occurs through a two-phase process in which losartan first triggers the elimination of myofibroblasts by directing their apoptosis via inhibition of extracellular signal-regulated kinase (ERK)-m...
Source: Experimental Eye Research - April 3, 2024 Category: Opthalmology Authors: Steven E Wilson Source Type: research
Tamoxifen protects photoreceptors in the sodium iodate model
Exp Eye Res. 2024 Apr 1:109879. doi: 10.1016/j.exer.2024.109879. Online ahead of print.ABSTRACTBecause the selective estrogen receptor modulator tamoxifen was shown to be retina-protective in the light damage and rd10 models of retinal degeneration, the purpose of this study was to test whether tamoxifen is retina-protective in a model where retinal pigment epithelium (RPE) toxicity appears to be the primary insult: the sodium iodate (NaIO3) model. C57Bl/6J mice were given oral tamoxifen (in the diet) or the same diet lacking tamoxifen, then given an intraperitoneal injection of NaIO3 at 25 mg/kg. The mice were imaged a we...
Source: Experimental Eye Research - April 3, 2024 Category: Opthalmology Authors: Timothy T Lee Brent A Bell Brandon D Anderson Ying Song Joshua L Dunaief Source Type: research
Two-phase mechanism in the treatment of corneal stromal fibrosis with topical losartan
Exp Eye Res. 2024 Apr 1:109884. doi: 10.1016/j.exer.2024.109884. Online ahead of print.ABSTRACTRecent studies in rabbits and case reports in humans have demonstrated the efficacy of topical losartan in the treatment of corneal scarring fibrosis after a wide range of injuries, including chemical burns, infections, surgical complications, and some diseases. It is hypothesized that the effect of losartan on the fibrotic corneal stroma occurs through a two-phase process in which losartan first triggers the elimination of myofibroblasts by directing their apoptosis via inhibition of extracellular signal-regulated kinase (ERK)-m...
Source: Experimental Eye Research - April 3, 2024 Category: Opthalmology Authors: Steven E Wilson Source Type: research
Tamoxifen protects photoreceptors in the sodium iodate model
Exp Eye Res. 2024 Apr 1:109879. doi: 10.1016/j.exer.2024.109879. Online ahead of print.ABSTRACTBecause the selective estrogen receptor modulator tamoxifen was shown to be retina-protective in the light damage and rd10 models of retinal degeneration, the purpose of this study was to test whether tamoxifen is retina-protective in a model where retinal pigment epithelium (RPE) toxicity appears to be the primary insult: the sodium iodate (NaIO3) model. C57Bl/6J mice were given oral tamoxifen (in the diet) or the same diet lacking tamoxifen, then given an intraperitoneal injection of NaIO3 at 25 mg/kg. The mice were imaged a we...
Source: Experimental Eye Research - April 3, 2024 Category: Opthalmology Authors: Timothy T Lee Brent A Bell Brandon D Anderson Ying Song Joshua L Dunaief Source Type: research
Nicotinamide promotes the differentiation of functional corneal endothelial cells from human embryonic stem cells
Exp Eye Res. 2024 Mar 30:109883. doi: 10.1016/j.exer.2024.109883. Online ahead of print.ABSTRACTCorneal transplantation represents the primary therapeutic approach for managing corneal endothelial dysfunction, but corneal donors remain scarce. Anterior chamber cell injection emerges as a highly promising alternative strategy for corneal transplantation, with pluripotent stem cells (PSC) demonstrating considerable potential as an optimal cell source. Nevertheless, only a few studies have explored the differentiation of functional corneal endothelial-like cells originating from PSC. In this investigation, a chemical-defined ...
Source: Experimental Eye Research - April 1, 2024 Category: Opthalmology Authors: Dulei Zou Ting Wang Wenjing Li Xin Wang Bochao Ma Xiangyue Hu Qingjun Zhou Zongyi Li Weiyun Shi Haoyun Duan Source Type: research
Nicotinamide promotes the differentiation of functional corneal endothelial cells from human embryonic stem cells
Exp Eye Res. 2024 Mar 30:109883. doi: 10.1016/j.exer.2024.109883. Online ahead of print.ABSTRACTCorneal transplantation represents the primary therapeutic approach for managing corneal endothelial dysfunction, but corneal donors remain scarce. Anterior chamber cell injection emerges as a highly promising alternative strategy for corneal transplantation, with pluripotent stem cells (PSC) demonstrating considerable potential as an optimal cell source. Nevertheless, only a few studies have explored the differentiation of functional corneal endothelial-like cells originating from PSC. In this investigation, a chemical-defined ...
Source: Experimental Eye Research - April 1, 2024 Category: Opthalmology Authors: Dulei Zou Ting Wang Wenjing Li Xin Wang Bochao Ma Xiangyue Hu Qingjun Zhou Zongyi Li Weiyun Shi Haoyun Duan Source Type: research
Analysis aqueous humor lipid profile of neovascular glaucoma secondary to diabetic retinopathy and lipidomic alteration response to anti-VEGF treatment
This study included 13 NVG patients and 20 control subjects. Based on LipidSearch software, 639 lipid species across 33 lipid classes were detected in the participants' AH. The combination of univariate and multivariate statistical analyses yielded 53 differentially expressed lipids (VIP >1 and P < 0.05). In addition, 9 lipids were found to be differentially expressed before and after the intravitreal conbercept injections in the NVG patients. Significant alterations in the metabolic pathways of glycerophospholipid and glycerolipid exhibited notable changes. Our results highlighted the lipid changes in patients' AH i...
Source: Experimental Eye Research - March 30, 2024 Category: Opthalmology Authors: Xiaoyun Wang Xiaohua Ma Jingyao Song Bing Liu Jiawei Wang Source Type: research
Optimizing retinal ganglion cell nuclear staining for automated cell counting
Exp Eye Res. 2024 Mar 28:109881. doi: 10.1016/j.exer.2024.109881. Online ahead of print.ABSTRACTThe retinal ganglion cells (RGCs) serve as the critical pathway for transmitting visual information from the retina to the brain, yet they can be dramatically impacted by diseases such as glaucoma. When investigating disease processes affecting RGCs in mouse models, accurately quantifying affected cells becomes essential. However, the use of pan RGC markers like RBPMS or THY1 presents challenges in accurate total cell counting. While Brn3a serves as a reliable RGC nuclear marker for automated counting, it fails to encompass all ...
Source: Experimental Eye Research - March 30, 2024 Category: Opthalmology Authors: Fangyu Lin Su-Ting Lin Jiaxing Wang Eldon E Geisert Source Type: research
Analysis aqueous humor lipid profile of neovascular glaucoma secondary to diabetic retinopathy and lipidomic alteration response to anti-VEGF treatment
This study included 13 NVG patients and 20 control subjects. Based on LipidSearch software, 639 lipid species across 33 lipid classes were detected in the participants' AH. The combination of univariate and multivariate statistical analyses yielded 53 differentially expressed lipids (VIP >1 and P < 0.05). In addition, 9 lipids were found to be differentially expressed before and after the intravitreal conbercept injections in the NVG patients. Significant alterations in the metabolic pathways of glycerophospholipid and glycerolipid exhibited notable changes. Our results highlighted the lipid changes in patients' AH i...
Source: Experimental Eye Research - March 30, 2024 Category: Opthalmology Authors: Xiaoyun Wang Xiaohua Ma Jingyao Song Bing Liu Jiawei Wang Source Type: research
Optimizing retinal ganglion cell nuclear staining for automated cell counting
Exp Eye Res. 2024 Mar 28:109881. doi: 10.1016/j.exer.2024.109881. Online ahead of print.ABSTRACTThe retinal ganglion cells (RGCs) serve as the critical pathway for transmitting visual information from the retina to the brain, yet they can be dramatically impacted by diseases such as glaucoma. When investigating disease processes affecting RGCs in mouse models, accurately quantifying affected cells becomes essential. However, the use of pan RGC markers like RBPMS or THY1 presents challenges in accurate total cell counting. While Brn3a serves as a reliable RGC nuclear marker for automated counting, it fails to encompass all ...
Source: Experimental Eye Research - March 30, 2024 Category: Opthalmology Authors: Fangyu Lin Su-Ting Lin Jiaxing Wang Eldon E Geisert Source Type: research
Fibronectin binds integrin α5β1 to regulate macular neovascularization through the Wnt/β-catenin signaling pathway
In conclusion, FN may be a potential new molecular target for the prevention and treatment of subretinal fibrosis and MNV.PMID:38552713 | DOI:10.1016/j.exer.2024.109880 (Source: Experimental Eye Research)
Source: Experimental Eye Research - March 29, 2024 Category: Opthalmology Authors: Xiaoran Zhao Liting Hu Guibo Liu Xiaoni Yin Qingyun Gong Ying Li Qinghua Li Yuzheng Zhou Yibin Sun Chunyan Guo Zhaodong Du Source Type: research
Fibronectin binds integrin α5β1 to regulate macular neovascularization through the Wnt/β-catenin signaling pathway
In conclusion, FN may be a potential new molecular target for the prevention and treatment of subretinal fibrosis and MNV.PMID:38552713 | DOI:10.1016/j.exer.2024.109880 (Source: Experimental Eye Research)
Source: Experimental Eye Research - March 29, 2024 Category: Opthalmology Authors: Xiaoran Zhao Liting Hu Guibo Liu Xiaoni Yin Qingyun Gong Ying Li Qinghua Li Yuzheng Zhou Yibin Sun Chunyan Guo Zhaodong Du Source Type: research
