Intraocular pressure across the lifespan of Tg-MYOC < sup > Y437H < /sup > mice
In this study, we compiled the model's intraocular pressure (IOP) data recorded in our laboratory from 2017 to 2023 and selected representative eyes to measure the outflow facility (Cr), a critical parameter indicating the condition of the conventional TM pathway. We found that Tg-MYOCY437H mice aged 4-12 months exhibited significantly higher IOPs than age-matched C57BL/6 mice. Notably, a decline in IOP was observed in Tg-MYOCY437H mice at 17-24 months of age, a phenomenon not attributable to the gene dosage of mutant myocilin. Measurements of the Cr of Tg-MYOCY437H mice indicated that the age-related IOP reduction was not...
Source: Experimental Eye Research - March 7, 2024 Category: Opthalmology Authors: Xiaoyan Zhang Gaiping Xi Pengchao Feng Cong Li Markus H Kuehn Wei Zhu Source Type: research
Characterization of lncRNA and mRNA profiles in ciliary body in experimental myopia
Exp Eye Res. 2024 Feb 29;241:109849. doi: 10.1016/j.exer.2024.109849. Online ahead of print.ABSTRACTCurrently, researchers have mainly focused on the role of the tissues of the posterior segment of the eyes in the development of myopia. However, the ciliary body, an anterior ocular tissue that contracts to initiate the process of accommodation, may also play an important role in the progression of myopia due to the increased demand for near work. In the present study, we established a lens-induced myopia (LIM) animal model in guinea pigs and investigated the molecular changes in the ciliary body associated with the develop...
Source: Experimental Eye Research - March 2, 2024 Category: Opthalmology Authors: Shanshan Wu Jiawen Hao Dadong Guo Zhongyu Ma Qiuxin Wu Ming Zhang Hongsheng Bi Source Type: research
Characterization of lncRNA and mRNA profiles in ciliary body in experimental myopia
Exp Eye Res. 2024 Feb 29:109849. doi: 10.1016/j.exer.2024.109849. Online ahead of print.ABSTRACTCurrently, researchers have mainly focused on the role of the tissues of the posterior segment of the eyes in the development of myopia. However, the ciliary body, an anterior ocular tissue that contracts to initiate the process of accommodation, may also play an important role in the progression of myopia due to the increased demand for near work. In the present study, we established a lens-induced myopia (LIM) animal model in guinea pigs and investigated the molecular changes in the ciliary body associated with the development...
Source: Experimental Eye Research - March 2, 2024 Category: Opthalmology Authors: Shanshan Wu Jiawen Hao Dadong Guo Zhongyu Ma Qiuxin Wu Ming Zhang Hongsheng Bi Source Type: research
Characterization of lncRNA and mRNA profiles in ciliary body in experimental myopia
Exp Eye Res. 2024 Feb 29:109849. doi: 10.1016/j.exer.2024.109849. Online ahead of print.ABSTRACTCurrently, researchers have mainly focused on the role of the tissues of the posterior segment of the eyes in the development of myopia. However, the ciliary body, an anterior ocular tissue that contracts to initiate the process of accommodation, may also play an important role in the progression of myopia due to the increased demand for near work. In the present study, we established a lens-induced myopia (LIM) animal model in guinea pigs and investigated the molecular changes in the ciliary body associated with the development...
Source: Experimental Eye Research - March 2, 2024 Category: Opthalmology Authors: Shanshan Wu Jiawen Hao Dadong Guo Zhongyu Ma Qiuxin Wu Ming Zhang Hongsheng Bi Source Type: research
A minimally invasive method for diagnosing diseases of the eye
Exp Eye Res. 2024 Feb 28:109848. doi: 10.1016/j.exer.2024.109848. Online ahead of print.NO ABSTRACTPMID:38428474 | DOI:10.1016/j.exer.2024.109848 (Source: Experimental Eye Research)
Source: Experimental Eye Research - March 1, 2024 Category: Opthalmology Authors: Vera B Morhenn Jonathan N Mansbridge Harvey Fishman Source Type: research
A minimally invasive method for diagnosing diseases of the eye
Exp Eye Res. 2024 Feb 28:109848. doi: 10.1016/j.exer.2024.109848. Online ahead of print.NO ABSTRACTPMID:38428474 | DOI:10.1016/j.exer.2024.109848 (Source: Experimental Eye Research)
Source: Experimental Eye Research - March 1, 2024 Category: Opthalmology Authors: Vera B Morhenn Jonathan N Mansbridge Harvey Fishman Source Type: research
In vivo quasi-elastic light scattering detects molecular changes in the lenses of adolescents with Down syndrome
Exp Eye Res. 2024 Feb 2;241:109818. doi: 10.1016/j.exer.2024.109818. Online ahead of print.ABSTRACTDown syndrome (DS) is the most common chromosomal disorder in humans. DS is associated with increased prevalence of several ocular sequelae, including characteristic blue-dot cerulean cataract. DS is accompanied by age-dependent accumulation of Alzheimer's disease (AD) amyloid-β (Aβ) peptides and amyloid pathology in the brain and comorbid early-onset Aβ amyloidopathy and colocalizing cataracts in the lens. Quasi-elastic light scattering (QLS) is an established optical technique that noninvasively measures changes in prote...
Source: Experimental Eye Research - February 29, 2024 Category: Opthalmology Authors: Srikant Sarangi Olga Minaeva Danielle M Ledoux Douglas S Parsons Juliet A Moncaster Caitlin A Black Jeffrey Hollander Yorghos Tripodis John I Clark David G Hunter Lee E Goldstein Source Type: research
Causal associations of refractive error and early age-related macular degeneration: A Mendelian randomization study
This study aims to determine the risk associated with early age-related macular degeneration (AMD) due to refractive errors (RE) using an analysis of genome-wide association study (GWAS) data through the two-sample Mendelian randomization approach. Single-nucleotide polymorphisms (SNPs) linked to refractive errors (RE) were obtained from numerous GWAS studies involving individuals of European descent. The data for early AMD was obtained from a diverse, multiethnic GWAS meta-analysis that included 105,248 participants (14,034 cases and 91,214 controls). The primary outcome measure focused on the rise in early AMD risk corre...
Source: Experimental Eye Research - February 29, 2024 Category: Opthalmology Authors: Lingling Wang Wenlong Wei YongJi Zhao Sixi Chen Dongjing Wu Mengjun Tu Source Type: research
Detection of retinal dysfunction induced by HCN channel inhibitors using multistep light stimulus and long-duration light stimulus ERG in rats
This study revealed that the retinal dysfunction by HCN channel inhibitors in rats can be detected by multistep light stimulus ERG. Additionally, we identified that the inhibition of feedback current and the sustained responses in the photoreceptor cells cause the retinal dysfunction of HCN channel inhibitors in rats.PMID:38401854 | DOI:10.1016/j.exer.2024.109847 (Source: Experimental Eye Research)
Source: Experimental Eye Research - February 24, 2024 Category: Opthalmology Authors: Naohisa Umeya Yuki Yoshizawa Kosuke Fukuda Keigo Ikeda Mami Kamada Hiroshi Inada Toru Usui Izuru Miyawaki Source Type: research
Extracellular vesicle biomarkers in ocular fluids associated with ophthalmic diseases
Exp Eye Res. 2024 Feb 22:109831. doi: 10.1016/j.exer.2024.109831. Online ahead of print.ABSTRACTExtracellular vesicles (EVs) are released as highly stable lipid bilayer particles carrying proteins, lipids, glycans and miRNAs. The contents of EVs vary based on the cellular origin, biogenesis route and the functional state of the cell suggesting certain diseased conditions. A growing body of evidence show that EVs carry important molecules implicated in the development and progression of ophthalmic diseases. EVs associated with ophthalmic diseases are mainly carried by one of the three ocular biofluids which include tears, a...
Source: Experimental Eye Research - February 24, 2024 Category: Opthalmology Authors: Thomas Michael Shiju Alex Yuan Source Type: research
Detection of retinal dysfunction induced by HCN channel inhibitors using multistep light stimulus and long-duration light stimulus ERG in rats
This study revealed that the retinal dysfunction by HCN channel inhibitors in rats can be detected by multistep light stimulus ERG. Additionally, we identified that the inhibition of feedback current and the sustained responses in the photoreceptor cells cause the retinal dysfunction of HCN channel inhibitors in rats.PMID:38401854 | DOI:10.1016/j.exer.2024.109847 (Source: Experimental Eye Research)
Source: Experimental Eye Research - February 24, 2024 Category: Opthalmology Authors: Naohisa Umeya Yuki Yoshizawa Kosuke Fukuda Keigo Ikeda Mami Kamada Hiroshi Inada Toru Usui Izuru Miyawaki Source Type: research
Extracellular vesicle biomarkers in ocular fluids associated with ophthalmic diseases
Exp Eye Res. 2024 Feb 22:109831. doi: 10.1016/j.exer.2024.109831. Online ahead of print.ABSTRACTExtracellular vesicles (EVs) are released as highly stable lipid bilayer particles carrying proteins, lipids, glycans and miRNAs. The contents of EVs vary based on the cellular origin, biogenesis route and the functional state of the cell suggesting certain diseased conditions. A growing body of evidence show that EVs carry important molecules implicated in the development and progression of ophthalmic diseases. EVs associated with ophthalmic diseases are mainly carried by one of the three ocular biofluids which include tears, a...
Source: Experimental Eye Research - February 24, 2024 Category: Opthalmology Authors: Thomas Michael Shiju Alex Yuan Source Type: research
Detection of retinal dysfunction induced by HCN channel inhibitors using multistep light stimulus and long-duration light stimulus ERG in rats
This study revealed that the retinal dysfunction by HCN channel inhibitors in rats can be detected by multistep light stimulus ERG. Additionally, we identified that the inhibition of feedback current and the sustained responses in the photoreceptor cells cause the retinal dysfunction of HCN channel inhibitors in rats.PMID:38401854 | DOI:10.1016/j.exer.2024.109847 (Source: Experimental Eye Research)
Source: Experimental Eye Research - February 24, 2024 Category: Opthalmology Authors: Naohisa Umeya Yuki Yoshizawa Kosuke Fukuda Keigo Ikeda Mami Kamada Hiroshi Inada Toru Usui Izuru Miyawaki Source Type: research
Extracellular vesicle biomarkers in ocular fluids associated with ophthalmic diseases
Exp Eye Res. 2024 Feb 22:109831. doi: 10.1016/j.exer.2024.109831. Online ahead of print.ABSTRACTExtracellular vesicles (EVs) are released as highly stable lipid bilayer particles carrying proteins, lipids, glycans and miRNAs. The contents of EVs vary based on the cellular origin, biogenesis route and the functional state of the cell suggesting certain diseased conditions. A growing body of evidence show that EVs carry important molecules implicated in the development and progression of ophthalmic diseases. EVs associated with ophthalmic diseases are mainly carried by one of the three ocular biofluids which include tears, a...
Source: Experimental Eye Research - February 24, 2024 Category: Opthalmology Authors: Thomas Michael Shiju Alex Yuan Source Type: research
Detection of retinal dysfunction induced by HCN channel inhibitors using multistep light stimulus and long-duration light stimulus ERG in rats
This study revealed that the retinal dysfunction by HCN channel inhibitors in rats can be detected by multistep light stimulus ERG. Additionally, we identified that the inhibition of feedback current and the sustained responses in the photoreceptor cells cause the retinal dysfunction of HCN channel inhibitors in rats.PMID:38401854 | DOI:10.1016/j.exer.2024.109847 (Source: Experimental Eye Research)
Source: Experimental Eye Research - February 24, 2024 Category: Opthalmology Authors: Naohisa Umeya Yuki Yoshizawa Kosuke Fukuda Keigo Ikeda Mami Kamada Hiroshi Inada Toru Usui Izuru Miyawaki Source Type: research
