IL1R2 promotes retinal angiogenesis to participate in retinopathy of prematurity by activating the HIF1 α/PFKFB3 pathway
In conclusion, IL1R2 facilitates the migration, angiogenesis, and proliferation of choroidal endothelial cells by activating the HIF1α/PFKFB3 pathway to regulate ROP progression.PMID:38097102 | DOI:10.1016/j.exer.2023.109750 (Source: Experimental Eye Research)
Source: Experimental Eye Research - December 14, 2023 Category: Opthalmology Authors: Na Zhou Li Liu Qiaolian Li Source Type: research
Crocetin inhibits choroidal neovascularization in both in vitro and in vivo models
Exp Eye Res. 2023 Dec 12:109751. doi: 10.1016/j.exer.2023.109751. Online ahead of print.ABSTRACTChoroidal neovascularization (CNV) is the primary pathogenic process underlying wet age-related macular degeneration, leading to severe vision loss. Despite current anti-vascular endothelial growth factor (VEGF) therapies, several limitations persist. Crocetin, a major bioactive constituent of saffron, exhibits multiple pharmacological activities, yet its role and mechanism in CNV remain unclear. Here, we investigated the potential effects of crocetin on CNV using in vitro and in vivo models. In human umbilical vein endothelial ...
Source: Experimental Eye Research - December 14, 2023 Category: Opthalmology Authors: Caixia Wang Xuejing Li Jing Su Jialiang Duan Yimin Yao Qingli Shang Source Type: research
IL1R2 promotes retinal angiogenesis to participate in retinopathy of prematurity by activating the HIF1 α/PFKFB3 pathway
In conclusion, IL1R2 facilitates the migration, angiogenesis, and proliferation of choroidal endothelial cells by activating the HIF1α/PFKFB3 pathway to regulate ROP progression.PMID:38097102 | DOI:10.1016/j.exer.2023.109750 (Source: Experimental Eye Research)
Source: Experimental Eye Research - December 14, 2023 Category: Opthalmology Authors: Na Zhou Li Liu Qiaolian Li Source Type: research
Crocetin inhibits choroidal neovascularization in both in vitro and in vivo models
Exp Eye Res. 2023 Dec 12:109751. doi: 10.1016/j.exer.2023.109751. Online ahead of print.ABSTRACTChoroidal neovascularization (CNV) is the primary pathogenic process underlying wet age-related macular degeneration, leading to severe vision loss. Despite current anti-vascular endothelial growth factor (VEGF) therapies, several limitations persist. Crocetin, a major bioactive constituent of saffron, exhibits multiple pharmacological activities, yet its role and mechanism in CNV remain unclear. Here, we investigated the potential effects of crocetin on CNV using in vitro and in vivo models. In human umbilical vein endothelial ...
Source: Experimental Eye Research - December 14, 2023 Category: Opthalmology Authors: Caixia Wang Xuejing Li Jing Su Jialiang Duan Yimin Yao Qingli Shang Source Type: research
IL1R2 promotes retinal angiogenesis to participate in retinopathy of prematurity by activating the HIF1 α/PFKFB3 pathway
In conclusion, IL1R2 facilitates the migration, angiogenesis, and proliferation of choroidal endothelial cells by activating the HIF1α/PFKFB3 pathway to regulate ROP progression.PMID:38097102 | DOI:10.1016/j.exer.2023.109750 (Source: Experimental Eye Research)
Source: Experimental Eye Research - December 14, 2023 Category: Opthalmology Authors: Na Zhou Li Liu Qiaolian Li Source Type: research
Crocetin inhibits choroidal neovascularization in both in vitro and in vivo models
Exp Eye Res. 2023 Dec 12:109751. doi: 10.1016/j.exer.2023.109751. Online ahead of print.ABSTRACTChoroidal neovascularization (CNV) is the primary pathogenic process underlying wet age-related macular degeneration, leading to severe vision loss. Despite current anti-vascular endothelial growth factor (VEGF) therapies, several limitations persist. Crocetin, a major bioactive constituent of saffron, exhibits multiple pharmacological activities, yet its role and mechanism in CNV remain unclear. Here, we investigated the potential effects of crocetin on CNV using in vitro and in vivo models. In human umbilical vein endothelial ...
Source: Experimental Eye Research - December 14, 2023 Category: Opthalmology Authors: Caixia Wang Xuejing Li Jing Su Jialiang Duan Yimin Yao Qingli Shang Source Type: research
IL1R2 promotes retinal angiogenesis to participate in retinopathy of prematurity by activating the HIF1 α/PFKFB3 pathway
In conclusion, IL1R2 facilitates the migration, angiogenesis, and proliferation of choroidal endothelial cells by activating the HIF1α/PFKFB3 pathway to regulate ROP progression.PMID:38097102 | DOI:10.1016/j.exer.2023.109750 (Source: Experimental Eye Research)
Source: Experimental Eye Research - December 14, 2023 Category: Opthalmology Authors: Na Zhou Li Liu Qiaolian Li Source Type: research
The role of the JAK/STAT3 signaling pathway in acquired corneal diseases
Exp Eye Res. 2023 Dec 9;238:109748. doi: 10.1016/j.exer.2023.109748. Online ahead of print.ABSTRACTAcquired corneal diseases such as dry eye disease (DED), keratitis and corneal alkali burns are significant contributors to vision impairment worldwide, and more effective and innovative therapies are urgently needed. The Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling pathway plays an indispensable role in cell metabolism, inflammation and the immune response. Studies have shown that regulators of this pathway are extensively expressed in the cornea, inducing significant activation of JA...
Source: Experimental Eye Research - December 11, 2023 Category: Opthalmology Authors: Dongjie Song Qianjie Yang Xiang Li Kuangqi Chen Jianping Tong Ye Shen Source Type: research
The role of the JAK/STAT3 signaling pathway in acquired corneal diseases
Exp Eye Res. 2023 Dec 9:109748. doi: 10.1016/j.exer.2023.109748. Online ahead of print.ABSTRACTAcquired corneal diseases such as dry eye disease (DED), keratitis and corneal alkali burns are significant contributors to vision impairment worldwide, and more effective and innovative therapies are urgently needed. The Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling pathway plays an indispensable role in cell metabolism, inflammation and the immune response. Studies have shown that regulators of this pathway are extensively expressed in the cornea, inducing significant activation of JAK/ST...
Source: Experimental Eye Research - December 11, 2023 Category: Opthalmology Authors: Dongjie Song Qianjie Yang Xiang Li Kuangqi Chen Jianping Tong Ye Shen Source Type: research
The role of the JAK/STAT3 signaling pathway in acquired corneal diseases
Exp Eye Res. 2023 Dec 9:109748. doi: 10.1016/j.exer.2023.109748. Online ahead of print.ABSTRACTAcquired corneal diseases such as dry eye disease (DED), keratitis and corneal alkali burns are significant contributors to vision impairment worldwide, and more effective and innovative therapies are urgently needed. The Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling pathway plays an indispensable role in cell metabolism, inflammation and the immune response. Studies have shown that regulators of this pathway are extensively expressed in the cornea, inducing significant activation of JAK/ST...
Source: Experimental Eye Research - December 11, 2023 Category: Opthalmology Authors: Dongjie Song Qianjie Yang Xiang Li Kuangqi Chen Jianping Tong Ye Shen Source Type: research
Verteporfin regulates corneal neovascularization through inhibition of YAP protein activation
Exp Eye Res. 2023 Dec 8:109747. doi: 10.1016/j.exer.2023.109747. Online ahead of print.ABSTRACTCorneal neovascularization (CNV) is a vision-threatening disease that is becoming a growing public health concern. While Yes-associated protein (YAP) plays a critical role in neovascular disease and allow for the sprouting angiogenesis. Verteporfin (VP) is a classical inhibitor of the YAP-TEAD complex, which is used for clinical treatment of neovascular macular degeneration through photodynamic therapy. The purpose of this study is to explore the effect of verteporfin (VP) on the inhibition of CNV and its potential mechanism. Rat...
Source: Experimental Eye Research - December 10, 2023 Category: Opthalmology Authors: Lei Lin Yu Zheng Qiyuan Li Yining Sun Yiwen Huang Lili Liang Liming Xu Yun-E Zhao Source Type: research
An enhanced model for environmental dry eye: Exploring pathological features and underlying factors
In conclusion, the modified "wire-meshing cylindrical board" model effectively overcomes the limitations of the traditional "jogging board " dry eye model and successfully simulates the etiology of prolonged visual fatigue. This innovative EDE model demonstrates a high degree of relevance to dry eye conditions resulting from prolonged visual tasks, with a high success rate of model induction. Moreover, it proves to be a simple, practical, and easily replicable model, making it highly suitable for further studies on prolonged visual fatigue and facilitating its widespread adoption in research and clinical applications.PMID:...
Source: Experimental Eye Research - December 10, 2023 Category: Opthalmology Authors: Baoqiang Dong Lei Zhao Jj Jiajia Yu Lilin Liu Tao Zuo Huimin Zhou Pin Ju Yuexin Li Yingyue Cao Source Type: research
Short peptides derived from pigment epithelium-derived factor attenuate retinal ischemia reperfusion injury through inhibition of apoptosis and inflammatory response in rats
Exp Eye Res. 2023 Dec 4:109743. doi: 10.1016/j.exer.2023.109743. Online ahead of print.ABSTRACTPigment epithelium-derived factor (PEDF) is widely recognized as a neuroprotective factor expressed in the retina and has shown therapeutic potential in several retinal diseases. Our study aimed to identify the neuroprotective fragment in PEDF and investigate its protective activity in retinas under ischemia-reperfusion (IR) condition. We synthesized a series of shorter synthetic peptides, 6-mer (Ser93-Gln98) and its d-form variant (6 dS) derived from the 44-mer (Val78-Thr121; a PEDF neurotrophic fragment), to determine their cyt...
Source: Experimental Eye Research - December 6, 2023 Category: Opthalmology Authors: Ming-Hui Sun Tsung-Chuan Ho Shu-I Yeh Show-Li Chen Yeou-Ping Tsao Source Type: research
Reduction of lens size in PAX6-related aniridia
Exp Eye Res. 2023 Dec 5;238:109746. doi: 10.1016/j.exer.2023.109746. Online ahead of print.ABSTRACTHeterozygous mutation of PAX6 in humans leads to congenital aniridia (OMIM 106210) which is typified by congenital iris and foveal defects, and later onset glaucoma, aniridic keratopathy, and cataract. Mice heterozygous for Pax6 mutations phenocopy many aspects of aniridia including the iris defects, keratopathy and cataract, although Pax6 mutant mice have small lenses, a phenotype which is not typically reported in human aniridia, perhaps due to difficulties in measuring lens diameter during typical ophthalmic examinations a...
Source: Experimental Eye Research - December 6, 2023 Category: Opthalmology Authors: Melinda K Duncan Alejandra Daruich Sophie Valleix Dominique Bremond-Gignac Source Type: research
Visualization of choroidal vasculature in pigmented mouse eyes from experimental models of AMD
Exp Eye Res. 2023 Dec 7;238:109741. doi: 10.1016/j.exer.2023.109741. Online ahead of print.ABSTRACTA variety of techniques exist to investigate retinal and choroidal vascular changes in experimental mouse models of human ocular diseases. While all have specific advantages, a method for evaluating the choroidal vasculature in pigmented mouse eyes has been more challenging especially for whole mount visualization and morphometric analysis. Here we report a simple, reliable technique involving bleaching pigment prior to immunostaining the vasculature in whole mounts of pigmented mouse choroids. Eyes from healthy adult pigment...
Source: Experimental Eye Research - December 6, 2023 Category: Opthalmology Authors: Imran A Bhutto D Scott McLeod Benjamin R Thomson Gerard A Lutty Malia M Edwards Source Type: research
