Cytisine-N-methylene-(5,7,4 < sup >'< /sup > -trihydroxy)- isoflavone ameliorates ischemic stroke-induced brain injury in mouse by regulating the oxidative stress and BDNF-Trkb/Akt pathway
CONCLUSIONS: Our study suggests that LY01 reversed ischemic stroke by reducing oxidative stress and activating the BDNF-TrkB/Akt pathway and exerted a neuroprotective action against OGD/R injury via attenuation, a novel approach was suggested to treat ischemic stroke. Our observations justify the traditional use of LY01 for a treatment of IS in nervous system.PMID:38493912 | DOI:10.1016/j.ejphar.2024.176512 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 17, 2024 Category: Drugs & Pharmacology Authors: Yongbiao Li Fangcheng Fan Qingshan Liu Source Type: research
Protein phosphorylation and kinases: Potential therapeutic targets in necroptosis
Eur J Pharmacol. 2024 Mar 15:176508. doi: 10.1016/j.ejphar.2024.176508. Online ahead of print.ABSTRACTNecroptosis is a pivotal contributor to the pathogenesis of various human diseases, including those affecting the nervous system, cardiovascular system, pulmonary system, and kidneys. Extensive investigations have elucidated the mechanisms and physiological ramifications of necroptosis. Among these, protein phosphorylation emerges as a paramount regulatory process, facilitating the activation or inhibition of specific proteins through the addition of phosphate groups to their corresponding amino acid residues. Currently, t...
Source: European Journal of Pharmacology - March 17, 2024 Category: Drugs & Pharmacology Authors: Yihui Shi Chengkun Wu Jiayi Shi Taotao Gao Huabin Ma Long Li Yufen Zhao Source Type: research
Ethyl pyruvate ameliorates acute respiratory distress syndrome in mice
In this study, ethyl pyruvate (EP), a known inhibitor of HMGB1, was tested in the model of murine ARDS induced in C57BL/6 mice by intranasal administration of polyinosinic:polycytidylic (poly(I:C)). Intraperitoneal administration of EP ameliorated the ARDS-related histopathological changes in the lungs of poly(I:C)-induced ARDS and decreased numbers of immune cells in the lungs, broncho-alveolar lavage fluid and draining lymph nodes (DLN). Specifically, fewer CD8+ T cells and less activated CD4+ T cells were observed in DLN. Consequently, the lungs of EP-treated animals had fewer damage-inflicting CD8+ cells and macrophage...
Source: European Journal of Pharmacology - March 17, 2024 Category: Drugs & Pharmacology Authors: Dragica Mi ćanović Milica Lazarevi ć Jelena Kula š Sanja Despotovi ć Goran Stegnjai ć Bojan Jevti ć Ivan Koprivica Ivana Mirkov Suzana Stanisavljevi ć Neda Nikolovski Đorđe Miljković Tamara Saksida Source Type: research
Semaglutide 6-months therapy of type 2 diabetes mellitus restores adipose progenitors potential to develop metabolically active adipocytes
CONCLUSIONS: Our study has revealed that semaglutide 6-month therapy has not only systemic anorexigenic effects, but can markedly improve adipose tissue health. We have demonstrated critical restoration of ADSC renewal functions, which potentially can be involved in semaglutide based weight loss.PMID:38493915 | DOI:10.1016/j.ejphar.2024.176476 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 17, 2024 Category: Drugs & Pharmacology Authors: I Stafeev M Agareva S Michurina A Tomilova E Shestakova E Zubkova M Sineokaya E Ratner M Menshikov Ye Parfyonova M Shestakova Source Type: research
Coenzyme Q10 in atherosclerosis
Eur J Pharmacol. 2024 Mar 15:176481. doi: 10.1016/j.ejphar.2024.176481. Online ahead of print.ABSTRACTAtherosclerotic disease is a chronic disease that predominantly affects the elderly and is the most common cause of cardiovascular death worldwide. Atherosclerosis is closely related to processes such as abnormal lipid transport and metabolism, impaired endothelial function, inflammation, and oxidative stress. Coenzyme Q10 (CoQ10) is a key component of complex Ⅰ in the electron transport chain and an important endogenous antioxidant that may play a role in decelerating the progression of atherosclerosis. Here, the differ...
Source: European Journal of Pharmacology - March 17, 2024 Category: Drugs & Pharmacology Authors: Minjun Liao Xueke He Yangyang Zhou Weiqiang Peng Xiao-Mei Zhao Miao Jiang Source Type: research
Role of monocarboxylate transporters in AMPK-mediated protection against excitotoxic injury in the rat retina
In this study, we examined the distribution and expression levels of MCT1 and MCT2 in the retina and analyzed the effects of pharmacological inhibition of MCTs on the protective effects of metformin and 5-aminoimidazole-4-carboxamide (AICAR), activators of AMPK, against NMDA-induced retinal injury in rats. MCT1 was expressed in the blood vessels, processes of astrocytes and Müller cells, and inner segments of photoreceptors in the rat retina, whereas MCT2 was expressed in neuronal cells in the ganglion cell layer (GCL) and in astrocyte processes. The expression levels of MCT2, but not MCT1, decreased one day after intravi...
Source: European Journal of Pharmacology - March 17, 2024 Category: Drugs & Pharmacology Authors: Honoka Yamagishi Nozomu Kirai Akane Morita Toshihide Kashihara Tsutomu Nakahara Source Type: research
Isradipine, an L-type calcium channel blocker, attenuates cocaine effects in mice by reducing central glutamate release
Eur J Pharmacol. 2024 Mar 14:176489. doi: 10.1016/j.ejphar.2024.176489. Online ahead of print.ABSTRACTSubstance abuse disorder is a chronic condition for which pharmacological treatment options remain limited. L-type calcium channels (LTCC) have been implicated in drug-related plasticity and behavior. Specifically, dopaminergic neurons in the mesocorticolimbic pathway express Cav1.2 and Cav1.3 channels, which may regulate dopaminergic activity associated with reward behavior. Therefore, this study aimed to investigate the hypothesis that pre-administration of the LTCC blocker, isradipine can mitigate the effects of cocaine...
Source: European Journal of Pharmacology - March 16, 2024 Category: Drugs & Pharmacology Authors: Anna Luiza Diniz Lima Emanuele Guimar ães Silva Pablo Leal Cardozo Maria Carolina Machado da Silva Su élyn Koerich Fab íola Mara Ribeiro Fabr ício A Moreira Luciene Bruno Vieira Source Type: research
JAK2/STAT3 as a new potential target to manage neurodegenerative diseases: An interactive review
Eur J Pharmacol. 2024 Mar 14:176490. doi: 10.1016/j.ejphar.2024.176490. Online ahead of print.ABSTRACTNeurodegenerative diseases (NDDs) are a collection of incapacitating disorders in which neuroinflammation and neuronal apoptosis are major pathological consequences due to oxidative stress. Neuroinflammation manifests in the impacted cerebral areas as a result of pro-inflammatory cytokines stimulating the Janus Kinase2 (JAK2)/Signal Transducers and Activators of Transcription3 (STAT3) pathway via neuronal cells. The pro-inflammatory cytokines bind to their respective receptor in the neuronal cells and allow activation of J...
Source: European Journal of Pharmacology - March 16, 2024 Category: Drugs & Pharmacology Authors: Siva Prasad Panda Adarsh Kesharwani Samaresh Datta D S N B K Prasanth Sunil Kumar Panda Ajay Guru Source Type: research
Inhibition of both NOX and TNF- α exerts substantial renoprotective effects in renal ischemia reperfusion injury rat model
CONCLUSIONS: Our findings show that applying a multitarget network pharmacology approach allows synergistic renoprotective effect in ischemic AKI and might pave the way towards translational success.PMID:38492877 | DOI:10.1016/j.ejphar.2024.176507 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 16, 2024 Category: Drugs & Pharmacology Authors: Amina A Bayoumi Enssaf Ahmad Ahmad Islam A A E-H Ibrahim Mona F Mahmoud Mahmoud H Elbatreek Source Type: research
Sex differences in luteinizing hormone aggravates A β deposition in APP/PS1 and Aβ < sub > 1-42 < /sub > -induced mouse models of Alzheimer's disease
Eur J Pharmacol. 2024 Mar 14:176485. doi: 10.1016/j.ejphar.2024.176485. Online ahead of print.ABSTRACTAlzheimer's disease (AD) exhibits a higher incidence rate among older women, and dysregulation of the hypothalamic-pituitary-gonadal (HPG) axis during aging is associated with cognitive impairments and the development of dementia. luteinizing hormone (LH) has an important role in CNS function, such as mediating neuronal pregnenolone production, and modulating neuronal plasticity and cognition. The sex differences in LH and its impact on Aβ deposition in AD individuals remain unclear, with no reported specific mechanisms. ...
Source: European Journal of Pharmacology - March 16, 2024 Category: Drugs & Pharmacology Authors: Yongming Jia Xinzhe Du Yanan Wang Qinghua Song Ling He Source Type: research
Skeletal muscle atrophy after sciatic nerve damage: Mechanistic insights
Eur J Pharmacol. 2024 Mar 14:176506. doi: 10.1016/j.ejphar.2024.176506. Online ahead of print.ABSTRACTSciatic nerve injury leads to molecular events that cause muscular dysfunction advancement in atrophic conditions. Nerve damage renders muscles permanently relaxed which elevates intracellular resting Ca2+ levels. Increased Ca2+ levels are associated with several cellular signaling pathways including AMPK, cGMP, PLC-β, CERB, and calcineurin. Also, multiple enzymes involved in the tricarboxylic acid cycle and oxidative phosphorylation are activated by Ca2+ influx into mitochondria during muscle contraction, to meet increas...
Source: European Journal of Pharmacology - March 16, 2024 Category: Drugs & Pharmacology Authors: Aarti Yadav Rajesh Dabur Source Type: research
Isradipine, an L-type calcium channel blocker, attenuates cocaine effects in mice by reducing central glutamate release
Eur J Pharmacol. 2024 Mar 14:176489. doi: 10.1016/j.ejphar.2024.176489. Online ahead of print.ABSTRACTSubstance abuse disorder is a chronic condition for which pharmacological treatment options remain limited. L-type calcium channels (LTCC) have been implicated in drug-related plasticity and behavior. Specifically, dopaminergic neurons in the mesocorticolimbic pathway express Cav1.2 and Cav1.3 channels, which may regulate dopaminergic activity associated with reward behavior. Therefore, this study aimed to investigate the hypothesis that pre-administration of the LTCC blocker, isradipine can mitigate the effects of cocaine...
Source: European Journal of Pharmacology - March 16, 2024 Category: Drugs & Pharmacology Authors: Anna Luiza Diniz Lima Emanuele Guimar ães Silva Pablo Leal Cardozo Maria Carolina Machado da Silva Su élyn Koerich Fab íola Mara Ribeiro Fabr ício A Moreira Luciene Bruno Vieira Source Type: research
JAK2/STAT3 as a new potential target to manage neurodegenerative diseases: An interactive review
Eur J Pharmacol. 2024 Mar 14:176490. doi: 10.1016/j.ejphar.2024.176490. Online ahead of print.ABSTRACTNeurodegenerative diseases (NDDs) are a collection of incapacitating disorders in which neuroinflammation and neuronal apoptosis are major pathological consequences due to oxidative stress. Neuroinflammation manifests in the impacted cerebral areas as a result of pro-inflammatory cytokines stimulating the Janus Kinase2 (JAK2)/Signal Transducers and Activators of Transcription3 (STAT3) pathway via neuronal cells. The pro-inflammatory cytokines bind to their respective receptor in the neuronal cells and allow activation of J...
Source: European Journal of Pharmacology - March 16, 2024 Category: Drugs & Pharmacology Authors: Siva Prasad Panda Adarsh Kesharwani Samaresh Datta D S N B K Prasanth Sunil Kumar Panda Ajay Guru Source Type: research
Inhibition of both NOX and TNF- α exerts substantial renoprotective effects in renal ischemia reperfusion injury rat model
CONCLUSIONS: Our findings show that applying a multitarget network pharmacology approach allows synergistic renoprotective effect in ischemic AKI and might pave the way towards translational success.PMID:38492877 | DOI:10.1016/j.ejphar.2024.176507 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 16, 2024 Category: Drugs & Pharmacology Authors: Amina A Bayoumi Enssaf Ahmad Ahmad Islam A A E-H Ibrahim Mona F Mahmoud Mahmoud H Elbatreek Source Type: research
Sex differences in luteinizing hormone aggravates A β deposition in APP/PS1 and Aβ < sub > 1-42 < /sub > -induced mouse models of Alzheimer's disease
Eur J Pharmacol. 2024 Mar 14:176485. doi: 10.1016/j.ejphar.2024.176485. Online ahead of print.ABSTRACTAlzheimer's disease (AD) exhibits a higher incidence rate among older women, and dysregulation of the hypothalamic-pituitary-gonadal (HPG) axis during aging is associated with cognitive impairments and the development of dementia. luteinizing hormone (LH) has an important role in CNS function, such as mediating neuronal pregnenolone production, and modulating neuronal plasticity and cognition. The sex differences in LH and its impact on Aβ deposition in AD individuals remain unclear, with no reported specific mechanisms. ...
Source: European Journal of Pharmacology - March 16, 2024 Category: Drugs & Pharmacology Authors: Yongming Jia Xinzhe Du Yanan Wang Qinghua Song Ling He Source Type: research
