Targeting the aryl hydrocarbon receptor with FICZ regulates IL-2 and immune infiltration to alleviate Hashimoto's thyroiditis in mice
In conclusion, targeting the AhR with FICZ regulates IL-2 and immune infiltration to alleviate experimental HT, shedding new light on the therapeutic intervention of this prevalent disease.PMID:38621508 | DOI:10.1016/j.ejphar.2024.176588 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 15, 2024 Category: Drugs & Pharmacology Authors: Zhengzheng Liao Xianzhong Zeng Xiaoling Guo Qing Shi Ziyun Tang Ping Li Cuiyun Chen Mengxia Chen Jianrong Chen Jixiong Xu Yaojun Cai Source Type: research
Single Nucleotide Polymorphism-based Biomarker in Primary Hypertension
In conclusion, SNP research in primary hypertension is rapidly evolving with emerging technologies and methodologies that have the potential to transform the knowledge about genetic basis related to the condition. These advances hold promise for personalized prevention and treatment strategies tailored to an individual's genetic profile ultimately improving patient outcomes and reducing healthcare costs.PMID:38621507 | DOI:10.1016/j.ejphar.2024.176584 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 15, 2024 Category: Drugs & Pharmacology Authors: None Laxmi Pougang Golmei Shriyansh Srivastava Sachin Kumar Source Type: research
Targeting the aryl hydrocarbon receptor with FICZ regulates IL-2 and immune infiltration to alleviate Hashimoto's thyroiditis in mice
In conclusion, targeting the AhR with FICZ regulates IL-2 and immune infiltration to alleviate experimental HT, shedding new light on the therapeutic intervention of this prevalent disease.PMID:38621508 | DOI:10.1016/j.ejphar.2024.176588 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 15, 2024 Category: Drugs & Pharmacology Authors: Zhengzheng Liao Xianzhong Zeng Xiaoling Guo Qing Shi Ziyun Tang Ping Li Cuiyun Chen Mengxia Chen Jianrong Chen Jixiong Xu Yaojun Cai Source Type: research
The role of hydrogen in the prevention and treatment of coronary atherosclerotic heart disease
Eur J Pharmacol. 2024 Apr 12:176586. doi: 10.1016/j.ejphar.2024.176586. Online ahead of print.ABSTRACTCoronary atherosclerotic heart disease (CHD) is a primary cardiovascular disease caused by atherosclerosis (AS), which is characterized by chronic inflammation and lipid oxidative deposition. Molecular hydrogen (H2) is an effective anti-inflammatory agent and has potential to ameliorate glycolipid metabolism disorders, which is believed to exert beneficial effects on the prevention and treatment of CHD. It is suggested that H2 reduces inflammation in CHD by regulating multiple pathways, including NF-κB inflammatory pathwa...
Source: European Journal of Pharmacology - April 14, 2024 Category: Drugs & Pharmacology Authors: Yunxi Chen Youzhen Wei Wenjie Tang Source Type: research
Corrigendum to "The prophylaxis and treatment potential of supplements for COVID-19" [Eur. J. Pharmacol. 887 (15 November 2020) 173530]
Eur J Pharmacol. 2024 Apr 12;972:176571. doi: 10.1016/j.ejphar.2024.176571. Online ahead of print.NO ABSTRACTPMID:38614058 | DOI:10.1016/j.ejphar.2024.176571 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 13, 2024 Category: Drugs & Pharmacology Authors: Adeleh Sahebnasagh Fatemeh Saghafi Razieh Avan Amirhosein Khoshi Masoud Khataminia Mohammadreza Safdari Solomon Habtemariam Hassan Rezai Ghaleno Seyed Mohammad Nabavi Source Type: research
Involvement of necroptotic cell death in macrophages in progression of bleomycin and LPS-induced acute exacerbation of idiopathic pulmonary fibrosis
In this study, we investigated the mechanism underlying AE of IPF, using bleomycin (BLM) and lipopolysaccharide (LPS) (BLM+LPS)-treated mice. The mice were treated with a single dose of 1.5 mg/kg BLM (on day 0) and/or 0.5 mg/kg LPS (on day 14), and maintained for another 7 days (total 21 days). Administration of BLM+LPS more severely aggravated the respiratory function, fibrosis, and inflammation in the lungs, together with the elevated interleukin-6 level in bronchoalveolar lavage fluid, than the control or BLM alone-treated mice. Moreover, the terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay dem...
Source: European Journal of Pharmacology - April 13, 2024 Category: Drugs & Pharmacology Authors: Atsushi Koike Kaoruko Hayashi Ko Fujimori Source Type: research
Proteasome activation is critical for cell death induced by inhibitors of polo-like kinase 1 (PLK1) in multiple cancers
In this study, we found that GW843682X and BI2536, two inhibitors of PLK1, significantly induced cell death in multiple type cells. The induction of cell death was related to the preferring expression of PLK1. However, in human umbilical vascular endothelial cells (HUVEC) and human colorectal carcinoma cells, which expressed higher levels of both PLK1 and PLK2, PLK1 inhibitors induced very low levels of cell death. Clinical analysis reveals PLK1 presence in 26 of 30 NPC tumor tissues. In in vivo NPC lung metastasis nude mouse models, PLK1 inhibitors decreased NPC progress. Mechanistically, the PLK1 inhibitor did not activa...
Source: European Journal of Pharmacology - April 13, 2024 Category: Drugs & Pharmacology Authors: Yufei Wang Guihua Wang Wei Xiang Xueting Liu Manli Jiang Jinyue Hu Source Type: research
Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension
In conclusion, CRA attenuated the PDGF-PDGF receptor β-STAT3/NF-κB signaling axis in macrophages and PASMCs, and thus, ameliorated pulmonary vascular remodeling in PAH.PMID:38614383 | DOI:10.1016/j.ejphar.2024.176564 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 13, 2024 Category: Drugs & Pharmacology Authors: Aya Yamamura Moe Fujiwara Akiko Kawade Taiki Amano Alamgir Hossain Md Junayed Nayeem Rubii Kondo Yoshiaki Suzuki Yasumichi Inoue Hidetoshi Hayashi Susumu Suzuki Motohiko Sato Hisao Yamamura Source Type: research
Corrigendum to "The prophylaxis and treatment potential of supplements for COVID-19" [Eur. J. Pharmacol. 887 (15 November 2020) 173530]
Eur J Pharmacol. 2024 Apr 12;972:176571. doi: 10.1016/j.ejphar.2024.176571. Online ahead of print.NO ABSTRACTPMID:38614058 | DOI:10.1016/j.ejphar.2024.176571 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 13, 2024 Category: Drugs & Pharmacology Authors: Adeleh Sahebnasagh Fatemeh Saghafi Razieh Avan Amirhosein Khoshi Masoud Khataminia Mohammadreza Safdari Solomon Habtemariam Hassan Rezai Ghaleno Seyed Mohammad Nabavi Source Type: research
Involvement of necroptotic cell death in macrophages in progression of bleomycin and LPS-induced acute exacerbation of idiopathic pulmonary fibrosis
In this study, we investigated the mechanism underlying AE of IPF, using bleomycin (BLM) and lipopolysaccharide (LPS) (BLM+LPS)-treated mice. The mice were treated with a single dose of 1.5 mg/kg BLM (on day 0) and/or 0.5 mg/kg LPS (on day 14), and maintained for another 7 days (total 21 days). Administration of BLM+LPS more severely aggravated the respiratory function, fibrosis, and inflammation in the lungs, together with the elevated interleukin-6 level in bronchoalveolar lavage fluid, than the control or BLM alone-treated mice. Moreover, the terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay dem...
Source: European Journal of Pharmacology - April 13, 2024 Category: Drugs & Pharmacology Authors: Atsushi Koike Kaoruko Hayashi Ko Fujimori Source Type: research
Proteasome activation is critical for cell death induced by inhibitors of polo-like kinase 1 (PLK1) in multiple cancers
In this study, we found that GW843682X and BI2536, two inhibitors of PLK1, significantly induced cell death in multiple type cells. The induction of cell death was related to the preferring expression of PLK1. However, in human umbilical vascular endothelial cells (HUVEC) and human colorectal carcinoma cells, which expressed higher levels of both PLK1 and PLK2, PLK1 inhibitors induced very low levels of cell death. Clinical analysis reveals PLK1 presence in 26 of 30 NPC tumor tissues. In in vivo NPC lung metastasis nude mouse models, PLK1 inhibitors decreased NPC progress. Mechanistically, the PLK1 inhibitor did not activa...
Source: European Journal of Pharmacology - April 13, 2024 Category: Drugs & Pharmacology Authors: Yufei Wang Guihua Wang Wei Xiang Xueting Liu Manli Jiang Jinyue Hu Source Type: research
Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension
In conclusion, CRA attenuated the PDGF-PDGF receptor β-STAT3/NF-κB signaling axis in macrophages and PASMCs, and thus, ameliorated pulmonary vascular remodeling in PAH.PMID:38614383 | DOI:10.1016/j.ejphar.2024.176564 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 13, 2024 Category: Drugs & Pharmacology Authors: Aya Yamamura Moe Fujiwara Akiko Kawade Taiki Amano Alamgir Hossain Md Junayed Nayeem Rubii Kondo Yoshiaki Suzuki Yasumichi Inoue Hidetoshi Hayashi Susumu Suzuki Motohiko Sato Hisao Yamamura Source Type: research
Celastrol alleviates airway hyperresponsiveness and inflammation in obese asthma through mediation of alveolar macrophage polarization
In conclusion, we demonstrated that celastrol assisted in mitigating various parameters of obese asthma by regulating the balance of M1/M2 AMs polarization.PMID:38604543 | DOI:10.1016/j.ejphar.2024.176560 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Authors: Yafeng Liang Sijia Shen Xiaoxiao Ye Weixi Zhang Xixi Lin Source Type: research
Novel combinatorial autophagy inhibition therapy for triple negative breast cancers
CONCLUSION: In this study, a novel combination between different autophagy inhibitors was identified which inhibited tumor cell proliferation in both chemosensitive and chemoresistant TNBC cells and could result in development of novel treatment modality against TNBC.PMID:38604544 | DOI:10.1016/j.ejphar.2024.176568 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Authors: Yomna S Abd El-Aziz Taymin du Toit-Thompson Matthew J McKay Mark P Molloy Shihani Stoner Betty McDowell Elizabeth Moon Loretta Sioson Amy Sheen Angela Chou Anthony J Gill Patric J Jansson Sumit Sahni Source Type: research
β-Lapachone, an NQO1 bioactivatable drug, prevents lung tumorigenesis in mice
In conclusion, our study suggests that long-term consumption of low-dose β-Lap could potentially be an effective therapeutic strategy for the prevention of lung premalignant lesions. However, further studies and clinical trials are necessary to validate our findings, determine the safety of long-term β-Lap usage in human, and promote the use of β-Lap in high-risk populations.PMID:38604545 | DOI:10.1016/j.ejphar.2024.176511 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Authors: Yaxin Chen Ruoyu Wu Xingyan Li Mengran Cao Mengdi Yang Bin Fu Chenyuan Xuan Chi Chen Yang Zhou Rong Hu Source Type: research
