Role of kinin receptors in skin pigmentation
Eur J Pharmacol. 2024 Apr 9:176537. doi: 10.1016/j.ejphar.2024.176537. Online ahead of print.ABSTRACTPrevious studies have shown that all kinin system is constitutively expressed in the normal and inflamed skin, with a potential role in both physiological and pathological processes. However, the understanding regarding the involvement of the kinin system in skin pigmentation and pigmentation disorders remains incomplete. In this context, the present study was designed to determine the role of kinins in the Monobenzone (MBZ)-induced vitiligo-like model. Our findings showed that MBZ induces higher local skin depigmentation i...
Source: European Journal of Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Authors: Juliana de Cassia Pinto Ferreira Bruna Silva Soley Priscila Lucia Pawloski Camila Guimar ães Moreira Jo ão Bosco Pesquero Michael Bader Jo ão Batista Calixto Daniela Almeida Cabrini Michel Fleith Otuki Source Type: research
Celastrol alleviates airway hyperresponsiveness and inflammation in obese asthma through mediation of alveolar macrophage polarization
In conclusion, we demonstrated that celastrol assisted in mitigating various parameters of obese asthma by regulating the balance of M1/M2 AMs polarization.PMID:38604543 | DOI:10.1016/j.ejphar.2024.176560 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Authors: Yafeng Liang Sijia Shen Xiaoxiao Ye Weixi Zhang Xixi Lin Source Type: research
Novel combinatorial autophagy inhibition therapy for triple negative breast cancers
CONCLUSION: In this study, a novel combination between different autophagy inhibitors was identified which inhibited tumor cell proliferation in both chemosensitive and chemoresistant TNBC cells and could result in development of novel treatment modality against TNBC.PMID:38604544 | DOI:10.1016/j.ejphar.2024.176568 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Authors: Yomna S Abd El-Aziz Taymin du Toit-Thompson Matthew J McKay Mark P Molloy Shihani Stoner Betty McDowell Elizabeth Moon Loretta Sioson Amy Sheen Angela Chou Anthony J Gill Patric J Jansson Sumit Sahni Source Type: research
β-Lapachone, an NQO1 bioactivatable drug, prevents lung tumorigenesis in mice
In conclusion, our study suggests that long-term consumption of low-dose β-Lap could potentially be an effective therapeutic strategy for the prevention of lung premalignant lesions. However, further studies and clinical trials are necessary to validate our findings, determine the safety of long-term β-Lap usage in human, and promote the use of β-Lap in high-risk populations.PMID:38604545 | DOI:10.1016/j.ejphar.2024.176511 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Authors: Yaxin Chen Ruoyu Wu Xingyan Li Mengran Cao Mengdi Yang Bin Fu Chenyuan Xuan Chi Chen Yang Zhou Rong Hu Source Type: research
Role of kinin receptors in skin pigmentation
Eur J Pharmacol. 2024 Apr 9:176537. doi: 10.1016/j.ejphar.2024.176537. Online ahead of print.ABSTRACTPrevious studies have shown that all kinin system is constitutively expressed in the normal and inflamed skin, with a potential role in both physiological and pathological processes. However, the understanding regarding the involvement of the kinin system in skin pigmentation and pigmentation disorders remains incomplete. In this context, the present study was designed to determine the role of kinins in the Monobenzone (MBZ)-induced vitiligo-like model. Our findings showed that MBZ induces higher local skin depigmentation i...
Source: European Journal of Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Authors: Juliana de Cassia Pinto Ferreira Bruna Silva Soley Priscila Lucia Pawloski Camila Guimar ães Moreira Jo ão Bosco Pesquero Michael Bader Jo ão Batista Calixto Daniela Almeida Cabrini Michel Fleith Otuki Source Type: research
GSK0660 enhances antitumor immunotherapy by reducing PD-L1 expression
Eur J Pharmacol. 2024 Apr 8:176565. doi: 10.1016/j.ejphar.2024.176565. Online ahead of print.ABSTRACTBlockade of PD-1/PD-L1 immune checkpoint is wildly used for multiple types of cancer treatment, while the low response rate for patients is still completely unknown. As nuclear hormone receptor, PPARδ (peroxisome-proliferator-activated receptor) regulates cell proliferation, inflammation, and tumor progression, while the effect of PPARδ on tumor immune escape is still unclear. Here we found that PPARδ antagonist GSK0660 significantly reduced colon cancer cell PD-L1 protein and gene expression. Luciferase analysis showed ...
Source: European Journal of Pharmacology - April 10, 2024 Category: Drugs & Pharmacology Authors: Bibimaryam Khan Mingjun Chen Huijie Wang Afrasyab Khan Shakeel Hussain Juanjuan Shi Limin Yang Yongzhong Hou Source Type: research
GSK0660 enhances antitumor immunotherapy by reducing PD-L1 expression
Eur J Pharmacol. 2024 Apr 8:176565. doi: 10.1016/j.ejphar.2024.176565. Online ahead of print.ABSTRACTBlockade of PD-1/PD-L1 immune checkpoint is wildly used for multiple types of cancer treatment, while the low response rate for patients is still completely unknown. As nuclear hormone receptor, PPARδ (peroxisome-proliferator-activated receptor) regulates cell proliferation, inflammation, and tumor progression, while the effect of PPARδ on tumor immune escape is still unclear. Here we found that PPARδ antagonist GSK0660 significantly reduced colon cancer cell PD-L1 protein and gene expression. Luciferase analysis showed ...
Source: European Journal of Pharmacology - April 10, 2024 Category: Drugs & Pharmacology Authors: Bibimaryam Khan Mingjun Chen Huijie Wang Afrasyab Khan Shakeel Hussain Juanjuan Shi Limin Yang Yongzhong Hou Source Type: research
Alteration in DNA methylation patterns: Epigenetic signatures in gastrointestinal cancers
This study highlights alterations in DNA methylation in GI cancers. Understanding epigenetic differences among GI cancers may improve targeted therapies and lead to the discovery of new diagnostic biomarkers.PMID:38593929 | DOI:10.1016/j.ejphar.2024.176563 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 9, 2024 Category: Drugs & Pharmacology Authors: Zahra Heydari Farideh Moeinvaziri Seyed Mohammad Ali Mirazimi Fatemeh Dashti Olga Smirnova Anastasia Shpichka Hamed Mirzaei Peter Timashev Massoud Vosough Source Type: research
Ghrelin alleviates placental dysfunction by down-regulating NF- κB phosphorylation in LPS-induced rat model of preeclampsia
Eur J Pharmacol. 2024 Apr 7:176569. doi: 10.1016/j.ejphar.2024.176569. Online ahead of print.ABSTRACTIn our previous study, we uncovered that ghrelin promotes angiogenesis in human umbilical vein endothelial cells (HUVECs) in vitro by activating the Jagged1/Notch2/VEGF pathway in preeclampsia (PE). However, the regulatory effects of ghrelin on placental dysfunction in PE are unclear. Therefore, we applied Normal pregnant Sprague-Dawley (SD) rats, treated with lipopolysaccharide (LPS), to establish a PE-like rat model. The hematoxylin-eosin (HE) staining method and immunohistochemistry (IHC) technology were used to detect m...
Source: European Journal of Pharmacology - April 9, 2024 Category: Drugs & Pharmacology Authors: Jiayu Shen Ningning Hu Zetian Wang Lina Yang Rujun Chen Liwen Zhang Xiaoqin Wang Source Type: research
Toosendanin inhibits T-cell proliferation through the P38 MAPK signalling pathway
Eur J Pharmacol. 2024 Apr 6:176562. doi: 10.1016/j.ejphar.2024.176562. Online ahead of print.ABSTRACTIn recent years, immunosuppressants have shown significant success in the treatment of autoimmune diseases. Therefore, there is an urgent need to develop additional immunosuppressants that offer more options for patients. Toosendanin has been shown to have immunosuppressive activity in vitro as well as effects on autoimmune hepatitis (AIH) in vivo. Toosendanin did not induce apoptosis in activated T-cells but did affect the survival rate of naive T-cells. Toosendanin did not affect the expression of CD25 or secretion of IL-...
Source: European Journal of Pharmacology - April 8, 2024 Category: Drugs & Pharmacology Authors: Ting Zhang Xing-Yan Luo Lin Jing Chunfen Mo Huijie Guo Shuxia Yang Yantang Wang Ketian Zhao Yi Lai Yang Liu Source Type: research
Combining brief recall and ketamine treatment prevents stress-primed methamphetamine memory reinstatement via heightening mPFC GABA activity
This study aimed to assess whether brief recall of methamphetamine (MA) memory, when combined with ketamine (KE) treatment, may prevent stress-primed MA memory reinstatement. Combining 3-min recall and KE facilitated MA memory extinction and resistance to subsequent stress-primed reinstatement. Such combination also produced glutamate metabotropic receptor 5 (mGluR5) upregulation in animals' medial prefrontal cortex (mPFC) γ-amino-butyric acid (GABA) neuron. Accordingly, chemogenetic methods were employed to bi-directionally modulate mPFC GABA activity. Following brief recall and KE-produced MA memory extinction, intra-mP...
Source: European Journal of Pharmacology - April 8, 2024 Category: Drugs & Pharmacology Authors: Li-Han Sun Lung Yu Ya-Hsuan Chan Min-Han Chin Chi-Pin Lee Yi-Han Liao Source Type: research
Toosendanin inhibits T-cell proliferation through the P38 MAPK signalling pathway
Eur J Pharmacol. 2024 Apr 6:176562. doi: 10.1016/j.ejphar.2024.176562. Online ahead of print.ABSTRACTIn recent years, immunosuppressants have shown significant success in the treatment of autoimmune diseases. Therefore, there is an urgent need to develop additional immunosuppressants that offer more options for patients. Toosendanin has been shown to have immunosuppressive activity in vitro as well as effects on autoimmune hepatitis (AIH) in vivo. Toosendanin did not induce apoptosis in activated T-cells but did affect the survival rate of naive T-cells. Toosendanin did not affect the expression of CD25 or secretion of IL-...
Source: European Journal of Pharmacology - April 8, 2024 Category: Drugs & Pharmacology Authors: Ting Zhang Xing-Yan Luo Lin Jing Chunfen Mo Huijie Guo Shuxia Yang Yantang Wang Ketian Zhao Yi Lai Yang Liu Source Type: research
Combining brief recall and ketamine treatment prevents stress-primed methamphetamine memory reinstatement via heightening mPFC GABA activity
This study aimed to assess whether brief recall of methamphetamine (MA) memory, when combined with ketamine (KE) treatment, may prevent stress-primed MA memory reinstatement. Combining 3-min recall and KE facilitated MA memory extinction and resistance to subsequent stress-primed reinstatement. Such combination also produced glutamate metabotropic receptor 5 (mGluR5) upregulation in animals' medial prefrontal cortex (mPFC) γ-amino-butyric acid (GABA) neuron. Accordingly, chemogenetic methods were employed to bi-directionally modulate mPFC GABA activity. Following brief recall and KE-produced MA memory extinction, intra-mP...
Source: European Journal of Pharmacology - April 8, 2024 Category: Drugs & Pharmacology Authors: Li-Han Sun Lung Yu Ya-Hsuan Chan Min-Han Chin Chi-Pin Lee Yi-Han Liao Source Type: research
Resveratrol attenuates cyclosporin A-induced upregulation of the thromboxane A < sub > 2 < /sub > receptor and hypertension via the AMPK/SIRT1 and MAPK/NF- κB pathways in the rat mesenteric artery
In conclusion, resveratrol restored the cyclosporin A-induced upregulation of the thromboxane A2 receptor and hypertension via the AMPK/SIRT1 and MAPK/NF-κB pathways in rats.PMID:38582274 | DOI:10.1016/j.ejphar.2024.176543 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 6, 2024 Category: Drugs & Pharmacology Authors: Qian Li Hanjing Cao Xinya Xu Yumeng Chen Yufang Zhang Yanni Mi Xingmei Zhu Yongheng Shi Jiping Liu Bin Wang Cang-Bao Xu Chuan Wang Source Type: research
Continuous oral olanzapine or clozapine treatment initiated in adolescence has differential short- and long-term impacts on antipsychotic sensitivity than those initiated in adulthood
In this study we compared the short- and long-term behavioral effects of 21-day continuous oral olanzapine (7.5 mg/kg/day) or clozapine (30.0 mg/kg/day) administration in heathy or maternal immune activated adolescent (33-53 days old) or adult (80-100 days old) rats of both sexes. We used a conditioned avoidance response model to assess the drug-induced alterations in antipsychotic sensitivity. Here, we report that while under the chronic drug treatment period, olanzapine progressively increased its suppression of avoidance responding over time, especially when treatment was initiated in adulthood. Clozapine's suppression ...
Source: European Journal of Pharmacology - April 6, 2024 Category: Drugs & Pharmacology Authors: Ruiyong Wu Shinnyi Chou Ming Li Source Type: research
