Repurposing the multiple sclerosis drug Siponimod for osteoporosis treatment
Eur J Pharmacol. 2024 Apr 29:176630. doi: 10.1016/j.ejphar.2024.176630. Online ahead of print.ABSTRACTOsteoporosis is the most common bone disorder, in which an imbalance between osteoclastic bone resorption and osteoblastic bone formation disrupts bone homeostasis. Osteoporosis management using anti-osteoclastic agents is a promising strategy; however, this remains an unmet need. Sphingosine-1-phosphate (S1P) and its receptors (S1PRs) are essential for maintaining bone homeostasis. Here, we identified that Siponimod, a Food and Drug Administration-approved S1PR antagonist for the treatment of multiple sclerosis, shows pro...
Source: European Journal of Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Sitao Hu Yangyang Hu Zenglin Tan Chengyu Zhou Cheng Zhang Sheng Yin Xiaojun Chen Kai Chen Lu Wang Lei Chen Source Type: research

Combination of dasatinib and quercetin alleviates heat stress-induced cognitive deficits in aged and young adult male mice
CONCLUSIONS: First, our data show that the aged male mice are more vulnerable to HS-induced cognitive deficits than those of the young adult male mice. Second, we demonstrate that combination of D and Q therapy attenuates cognitive deficits in heat stressed aged or young adult male mice via broad normalization of the brain-gut-endotoxin axis function.PMID:38692425 | DOI:10.1016/j.ejphar.2024.176631 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Xiaojing Lin Kangli Zhang Chenyi Li Kewei Liu Yanping Sun Wei Wu Kai Liu Xeuqing Yi Xiaowen Wang Zixuan Qu Xiaohong Liu Yao Xing M J Walker Qinglei Gong Ruoxu Liu Xiaoming Xu Cheng-Hsien Lin Gang Sun Source Type: research

Repurposing the multiple sclerosis drug Siponimod for osteoporosis treatment
Eur J Pharmacol. 2024 Apr 29:176630. doi: 10.1016/j.ejphar.2024.176630. Online ahead of print.ABSTRACTOsteoporosis is the most common bone disorder, in which an imbalance between osteoclastic bone resorption and osteoblastic bone formation disrupts bone homeostasis. Osteoporosis management using anti-osteoclastic agents is a promising strategy; however, this remains an unmet need. Sphingosine-1-phosphate (S1P) and its receptors (S1PRs) are essential for maintaining bone homeostasis. Here, we identified that Siponimod, a Food and Drug Administration-approved S1PR antagonist for the treatment of multiple sclerosis, shows pro...
Source: European Journal of Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Sitao Hu Yangyang Hu Zenglin Tan Chengyu Zhou Cheng Zhang Sheng Yin Xiaojun Chen Kai Chen Lu Wang Lei Chen Source Type: research

Combination of dasatinib and quercetin alleviates heat stress-induced cognitive deficits in aged and young adult male mice
CONCLUSIONS: First, our data show that the aged male mice are more vulnerable to HS-induced cognitive deficits than those of the young adult male mice. Second, we demonstrate that combination of D and Q therapy attenuates cognitive deficits in heat stressed aged or young adult male mice via broad normalization of the brain-gut-endotoxin axis function.PMID:38692425 | DOI:10.1016/j.ejphar.2024.176631 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Xiaojing Lin Kangli Zhang Chenyi Li Kewei Liu Yanping Sun Wei Wu Kai Liu Xeuqing Yi Xiaowen Wang Zixuan Qu Xiaohong Liu Yao Xing M J Walker Qinglei Gong Ruoxu Liu Xiaoming Xu Cheng-Hsien Lin Gang Sun Source Type: research

Repurposing the multiple sclerosis drug Siponimod for osteoporosis treatment
Eur J Pharmacol. 2024 Apr 29:176630. doi: 10.1016/j.ejphar.2024.176630. Online ahead of print.ABSTRACTOsteoporosis is the most common bone disorder, in which an imbalance between osteoclastic bone resorption and osteoblastic bone formation disrupts bone homeostasis. Osteoporosis management using anti-osteoclastic agents is a promising strategy; however, this remains an unmet need. Sphingosine-1-phosphate (S1P) and its receptors (S1PRs) are essential for maintaining bone homeostasis. Here, we identified that Siponimod, a Food and Drug Administration-approved S1PR antagonist for the treatment of multiple sclerosis, shows pro...
Source: European Journal of Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Sitao Hu Yangyang Hu Zenglin Tan Chengyu Zhou Cheng Zhang Sheng Yin Xiaojun Chen Kai Chen Lu Wang Lei Chen Source Type: research

Oridonin promotes RSL3-induced ferroptosis in breast cancer cells by regulating the oxidative stress signaling pathway JNK/Nrf2/HO-1
This study provides a theoretical basis for the application of ORI based on the mechanism of ferroptosis, and provides potential natural drug candidates for cancer prevention and treatment.PMID:38685305 | DOI:10.1016/j.ejphar.2024.176620 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Shiying Ye Xiangyan Hu Shaowei Sun Bo Su Jiye Cai Jinhuan Jiang Source Type: research

MiR-29a efficiently suppresses the generation of reactive oxygen species and α-synuclein in a cellular model of Parkinson's disease by potentially targeting GSK-3β
This study explored the protective role of miR-29a in a cellular model of PD using SH-SY5Y cell lines through iTRAQ-based quantitative proteomic and biochemistry analysis. The findings showed that using a miR-29a mimic in SH-SY5Y cells treated with 1-methyl-4-phenylpyridinium (MPP+) significantly decreased cell death and increased mitochondrial membrane potential. It also reduced mitochondrial reactive oxygen species (ROS) and the production of α-synuclein. Subsequent heatmap analysis using iTRAQ-based quantitative proteomics revealed remarkably contrasting protein expression profiles for 882 genes when comparing the grou...
Source: European Journal of Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Ya-Ling Yang Tsu-Kung Lin Ying-Hsien Huang Source Type: research

Peptide PDRPS6 Attenuates Myocardial Ischemia Injury by Improving Mitochondrial Function
This study aimed to investigate the function and mechanism of action of PDRPS6 in I/R injury. In vivo, PDRPS6 ameliorated myocardial tissue injury and cardiomyocyte apoptosis and decreased cardiac function induced by I/R injury in rats. PDRPS6 supplementation significantly reduced apoptosis in vitro. Mechanistically, PDRPS6 improved mitochondrial function by decreasing reactive oxygen species (ROS) levels, maintaining mitochondrial membrane potential (MMP), and inhibiting mitochondrial fission. Pull-down assay analyses revealed that phosphoglycerate mutase 5 (PGAM5) may be the target of PDRPS6, which can lead to the dephos...
Source: European Journal of Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Mengwen Feng Li Zhang Anwen Yin Han Zhang Xueping Wu Lingmei Qian Source Type: research

Oridonin promotes RSL3-induced ferroptosis in breast cancer cells by regulating the oxidative stress signaling pathway JNK/Nrf2/HO-1
This study provides a theoretical basis for the application of ORI based on the mechanism of ferroptosis, and provides potential natural drug candidates for cancer prevention and treatment.PMID:38685305 | DOI:10.1016/j.ejphar.2024.176620 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Shiying Ye Xiangyan Hu Shaowei Sun Bo Su Jiye Cai Jinhuan Jiang Source Type: research

MiR-29a efficiently suppresses the generation of reactive oxygen species and α-synuclein in a cellular model of Parkinson's disease by potentially targeting GSK-3β
This study explored the protective role of miR-29a in a cellular model of PD using SH-SY5Y cell lines through iTRAQ-based quantitative proteomic and biochemistry analysis. The findings showed that using a miR-29a mimic in SH-SY5Y cells treated with 1-methyl-4-phenylpyridinium (MPP+) significantly decreased cell death and increased mitochondrial membrane potential. It also reduced mitochondrial reactive oxygen species (ROS) and the production of α-synuclein. Subsequent heatmap analysis using iTRAQ-based quantitative proteomics revealed remarkably contrasting protein expression profiles for 882 genes when comparing the grou...
Source: European Journal of Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Ya-Ling Yang Tsu-Kung Lin Ying-Hsien Huang Source Type: research

Peptide PDRPS6 Attenuates Myocardial Ischemia Injury by Improving Mitochondrial Function
This study aimed to investigate the function and mechanism of action of PDRPS6 in I/R injury. In vivo, PDRPS6 ameliorated myocardial tissue injury and cardiomyocyte apoptosis and decreased cardiac function induced by I/R injury in rats. PDRPS6 supplementation significantly reduced apoptosis in vitro. Mechanistically, PDRPS6 improved mitochondrial function by decreasing reactive oxygen species (ROS) levels, maintaining mitochondrial membrane potential (MMP), and inhibiting mitochondrial fission. Pull-down assay analyses revealed that phosphoglycerate mutase 5 (PGAM5) may be the target of PDRPS6, which can lead to the dephos...
Source: European Journal of Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Mengwen Feng Li Zhang Anwen Yin Han Zhang Xueping Wu Lingmei Qian Source Type: research

Arctigenin induces activated HSCs quiescence via AMPK-PPAR γ pathway to ameliorate liver fibrosis in mice
Eur J Pharmacol. 2024 Apr 26:176629. doi: 10.1016/j.ejphar.2024.176629. Online ahead of print.ABSTRACTArctigenin (ATG), a traditional Chinese herbal medicine, is a natural lignan compound extracted from the seeds of burdock (Arctium lappa L, Asteraceae). As a natural product with multiple biological activities, the effect and mechanism of ATG against liver fibrosis are not fully elucidated yet. In current work, we first discovered that ATG could improve CCl4-induced liver injury reflected by lower plasma ALT and AST levels, liver coefficient and pathological scoring of ballooning. Furthermore, it also could reduce the posi...
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Mengjia Lv Shiyi Chen Mengwen Shan Yuan Si Chenggang Huang Jing Chen Likun Gong Source Type: research

Improving Chimeric Antigen Receptor T-cell therapies by using Artificial Intelligence and Internet of Things Technologies: A Narrative Review
Eur J Pharmacol. 2024 Apr 26:176618. doi: 10.1016/j.ejphar.2024.176618. Online ahead of print.ABSTRACTCancer poses a formidable challenge in the field of medical science, prompting the exploration of innovative and efficient treatment strategies. One revolutionary breakthrough in cancer therapy is Chimeric Antigen Receptor (CAR) T-cell therapy, an avant-garde method involving the customization of a patient's immune cells to combat cancer. Particularly successful in addressing blood cancers, CAR T-cell therapy introduces an unprecedented level of effectiveness, offering the prospect of sustained disease management. As ongoi...
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Alberto Boretti Source Type: research

Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps
CONCLUSIONS AND IMPLICATIONS: Puerarin promoted flap survival from ischemic injury through upregulation of TFEB-mediated autophagy and inhibition of oxidative stress. Our findings offered valuable support for the clinical application of Puerarin in the treatment of ischemic diseases, including random-pattern flaps.PMID:38679118 | DOI:10.1016/j.ejphar.2024.176621 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Yingying Lai Ningning Yang Donghao Shi Xianhui Ma Yingying Huang Jingzhou Lu Xuzi Zhang Hui Zhou Weiyang Gao Cong Mao Long Wang Source Type: research

APOB and CCL17 as Mediators in the Protective Effect of SGLT2 Inhibition against Myocardial Infarction: Insights from Proteome-wide Mendelian Randomization
CONCLUSION: Based on proteome-wide mendelian randomization, APOB and CCL17 were seen as mediators in the protective effect of SGLT2 inhibition against myocardial infarction.PMID:38679119 | DOI:10.1016/j.ejphar.2024.176619 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Lili Shi Gen Li Ningxin Hou Ling Tu Jun Li Jinlan Luo Shuiqing Hu Source Type: research