Sodium valproate treatment reverses endothelial dysfunction in aorta from rabbits with acute myocardial infarction
In this study, AMI was induced in New Zealand White rabbits by occluding the left circumflex coronary artery for 1 h, followed by reperfusion. The animals were distributed into three experimental groups: the sham-operated group (SHAM), the AMI group and the AMI + VPA group (AMI treated with VPA 500 mg/kg/day). After 5 weeks, abdominal aorta was removed and used for isometric recording of tension in organ baths or protein expression by Western blot, and plasma for the determination of nitrate/nitrite (NOx) levels by colorimetric assay. Our results indicated that AMI induced a reduction of the endothelium-dependent response ...
Source: European Journal of Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Authors: Sol Guerra-Ojeda Andrea Suarez Bego ña Belmonte Patricia Marchio Patricia Genov és Oscar Julian Arias Martin Aldasoro Jos é M Vila Eva Serna Maria D Mauricio Source Type: research
Sulforaphane's role in Redefining autophagic Responses in depression associated with polycystic ovarian syndrome: Unveiling the SIRT1/AMPK/LKB1 pathway connection
Eur J Pharmacol. 2024 Mar 2:176477. doi: 10.1016/j.ejphar.2024.176477. Online ahead of print.ABSTRACTPolycystic ovarian syndrome (PCOS) has been associated with depression and suicidal ideations in females. Studies have highlighted the role of autophagic deficiency in depression pathogenesis. Sulforaphane (SFN) is a natural product that improved autophagic deficiency and showed antidepressant activity in depressed patients. Herein, the study aimed to evaluate the impact of using SFN on depression-associated with PCOS via hippocampal energy sensors and cellular bioenergetics. PCOS was induced by administering letrozole (1 m...
Source: European Journal of Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Authors: Ahmed S Kamel Sarah S El-Sayed Nesrine S El Sayed Source Type: research
Tetrandrine alleviates pulmonary fibrosis by inhibiting alveolar epithelial cell senescence through PINK1/Parkin-mediated mitophagy
Eur J Pharmacol. 2024 Mar 2:176459. doi: 10.1016/j.ejphar.2024.176459. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a fatal and insidious interstitial lung disease. So far, there are no effective drugs for preventing the disease process. Cellular senescence plays a critical role in the development of IPF, with the senescence and insufficient mitophagy of alveolar epithelial cells being implicated in its pathogenesis. Tetrandrine is a natural alkaloid which is now produced synthetically. It was known that the tetrandrine has anti-fibrotic effects, but the efficacy and mechanisms are still not well ev...
Source: European Journal of Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Authors: Lanhe Chu Jinzhong Zhuo Haohua Huang Weimou Chen Wenshan Zhong Jinming Zhang Xiaojing Meng Fei Zhou Shaoxi Cai Mengchen Zou Hangming Dong Source Type: research
Sodium valproate treatment reverses endothelial dysfunction in aorta from rabbits with acute myocardial infarction
In this study, AMI was induced in New Zealand White rabbits by occluding the left circumflex coronary artery for 1 h, followed by reperfusion. The animals were distributed into three experimental groups: the sham-operated group (SHAM), the AMI group and the AMI + VPA group (AMI treated with VPA 500 mg/kg/day). After 5 weeks, abdominal aorta was removed and used for isometric recording of tension in organ baths or protein expression by Western blot, and plasma for the determination of nitrate/nitrite (NOx) levels by colorimetric assay. Our results indicated that AMI induced a reduction of the endothelium-dependent response ...
Source: European Journal of Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Authors: Sol Guerra-Ojeda Andrea Suarez Bego ña Belmonte Patricia Marchio Patricia Genov és Oscar Julian Arias Martin Aldasoro Jos é M Vila Eva Serna Maria D Mauricio Source Type: research
Sulforaphane's role in Redefining autophagic Responses in depression associated with polycystic ovarian syndrome: Unveiling the SIRT1/AMPK/LKB1 pathway connection
Eur J Pharmacol. 2024 Mar 2:176477. doi: 10.1016/j.ejphar.2024.176477. Online ahead of print.ABSTRACTPolycystic ovarian syndrome (PCOS) has been associated with depression and suicidal ideations in females. Studies have highlighted the role of autophagic deficiency in depression pathogenesis. Sulforaphane (SFN) is a natural product that improved autophagic deficiency and showed antidepressant activity in depressed patients. Herein, the study aimed to evaluate the impact of using SFN on depression-associated with PCOS via hippocampal energy sensors and cellular bioenergetics. PCOS was induced by administering letrozole (1 m...
Source: European Journal of Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Authors: Ahmed S Kamel Sarah S El-Sayed Nesrine S El Sayed Source Type: research
Tetrandrine alleviates pulmonary fibrosis by inhibiting alveolar epithelial cell senescence through PINK1/Parkin-mediated mitophagy
Eur J Pharmacol. 2024 Mar 2:176459. doi: 10.1016/j.ejphar.2024.176459. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a fatal and insidious interstitial lung disease. So far, there are no effective drugs for preventing the disease process. Cellular senescence plays a critical role in the development of IPF, with the senescence and insufficient mitophagy of alveolar epithelial cells being implicated in its pathogenesis. Tetrandrine is a natural alkaloid which is now produced synthetically. It was known that the tetrandrine has anti-fibrotic effects, but the efficacy and mechanisms are still not well ev...
Source: European Journal of Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Authors: Lanhe Chu Jinzhong Zhuo Haohua Huang Weimou Chen Wenshan Zhong Jinming Zhang Xiaojing Meng Fei Zhou Shaoxi Cai Mengchen Zou Hangming Dong Source Type: research
Sodium valproate treatment reverses endothelial dysfunction in aorta from rabbits with acute myocardial infarction
In this study, AMI was induced in New Zealand White rabbits by occluding the left circumflex coronary artery for 1 h, followed by reperfusion. The animals were distributed into three experimental groups: the sham-operated group (SHAM), the AMI group and the AMI + VPA group (AMI treated with VPA 500 mg/kg/day). After 5 weeks, abdominal aorta was removed and used for isometric recording of tension in organ baths or protein expression by Western blot, and plasma for the determination of nitrate/nitrite (NOx) levels by colorimetric assay. Our results indicated that AMI induced a reduction of the endothelium-dependent response ...
Source: European Journal of Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Authors: Sol Guerra-Ojeda Andrea Suarez Bego ña Belmonte Patricia Marchio Patricia Genov és Oscar Julian Arias Martin Aldasoro Jos é M Vila Eva Serna Maria D Mauricio Source Type: research
Sulforaphane's role in Redefining autophagic Responses in depression associated with polycystic ovarian syndrome: Unveiling the SIRT1/AMPK/LKB1 pathway connection
Eur J Pharmacol. 2024 Mar 2:176477. doi: 10.1016/j.ejphar.2024.176477. Online ahead of print.ABSTRACTPolycystic ovarian syndrome (PCOS) has been associated with depression and suicidal ideations in females. Studies have highlighted the role of autophagic deficiency in depression pathogenesis. Sulforaphane (SFN) is a natural product that improved autophagic deficiency and showed antidepressant activity in depressed patients. Herein, the study aimed to evaluate the impact of using SFN on depression-associated with PCOS via hippocampal energy sensors and cellular bioenergetics. PCOS was induced by administering letrozole (1 m...
Source: European Journal of Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Authors: Ahmed S Kamel Sarah S El-Sayed Nesrine S El Sayed Source Type: research
Tetrandrine alleviates pulmonary fibrosis by inhibiting alveolar epithelial cell senescence through PINK1/Parkin-mediated mitophagy
Eur J Pharmacol. 2024 Mar 2:176459. doi: 10.1016/j.ejphar.2024.176459. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a fatal and insidious interstitial lung disease. So far, there are no effective drugs for preventing the disease process. Cellular senescence plays a critical role in the development of IPF, with the senescence and insufficient mitophagy of alveolar epithelial cells being implicated in its pathogenesis. Tetrandrine is a natural alkaloid which is now produced synthetically. It was known that the tetrandrine has anti-fibrotic effects, but the efficacy and mechanisms are still not well ev...
Source: European Journal of Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Authors: Lanhe Chu Jinzhong Zhuo Haohua Huang Weimou Chen Wenshan Zhong Jinming Zhang Xiaojing Meng Fei Zhou Shaoxi Cai Mengchen Zou Hangming Dong Source Type: research
Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats
CONCLUSION: This study demonstrated for the first time that spinal BRD4 contributes to pyroptosis and switch of microglia polarization via STING-IRF3 signaling pathway during the development of morphine tolerance, which extend the understanding of the neuroinflammation mechanism of morphine tolerance and provide an alternative strategy for the precaution against of this medical condition.PMID:38432572 | DOI:10.1016/j.ejphar.2024.176428 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 3, 2024 Category: Drugs & Pharmacology Authors: Xiaoqian Jia Jie Ju Zheng Li Xiaoling Peng Jihong Wang Feng Gao Source Type: research
MFG-E8 induces epithelial-mesenchymal transition and anoikis resistance to promote the metastasis of pancreatic cancer cells
Eur J Pharmacol. 2024 Feb 29:176462. doi: 10.1016/j.ejphar.2024.176462. Online ahead of print.ABSTRACTPancreatic cancer is an extremely malignant tumor, and only a few clinical treatment options exist. MFG-E8 and kindlin-2 all play an important role in cancer progression. However, the specific mechanism occurring between MFG-E8, kindlin-2 and the migration and invasion of pancreatic cancer cells remains unelucidated. To unravel the specific mechanism, this study assessed the potential association between MFG-E8 and kindlin-2 as well as the involvement of MFG-E8 in pancreatic cancer using two pancreatic cancer cell lines (M...
Source: European Journal of Pharmacology - March 2, 2024 Category: Drugs & Pharmacology Authors: Wuming Liu Yifan Ren Tao Wang Mengzhou Wang Yujia Xu Jia Zhang Jianbin Bi Zheng Wu Yi Lv Rongqian Wu Source Type: research
The psychomotor, reinforcing, and discriminative stimulus effects of synthetic cathinone mexedrone in male mice and rats
Eur J Pharmacol. 2024 Feb 29:176466. doi: 10.1016/j.ejphar.2024.176466. Online ahead of print.ABSTRACTThe chronic use of the novel synthetic cathinone mexedrone, like other psychoactive drugs, can be considered addictive, with a high potential for abuse and the ability to cause psychological dependence in certain users. However, little is known about the neurobehavioral effects of mexedrone in association with its potential for abuse. We investigated the abuse potential for mexedrone abuse through multiple behavioral tests. In addition, serotonin transporter (SERT) levels were measured in the synaptosome of the dorsal stri...
Source: European Journal of Pharmacology - March 2, 2024 Category: Drugs & Pharmacology Authors: Kyung Oh Jeon Oc-Hee Kim Soo Yeon Seo Jaesuk Yun Choon-Gon Jang Ri-Na Lim Tae Wan Kim Chae Ha Yang Seong Shoon Yoon Eun Young Jang Source Type: research
siRNA as potential therapeutic strategy for hypertension
Eur J Pharmacol. 2024 Feb 29:176467. doi: 10.1016/j.ejphar.2024.176467. Online ahead of print.ABSTRACTHypertension, a well-known cardiovascular disorder noticed by rise in blood pressure, poses a significant global health challenge. The development RNA interfering (RNAi)-based therapies offers a ground-breaking molecular tool, holds promise for addressing hypertension's intricate molecular mechanisms. Harnessing the power of small interfering RNA (siRNA), researchers aim to selectively target and modulate genes associated with hypertension. Furthermore, they aim to downregulate the levels of mRNA by activating cellular nuc...
Source: European Journal of Pharmacology - March 2, 2024 Category: Drugs & Pharmacology Authors: Srushti Tanna Gaurav Doshi Angel Godad Source Type: research
FDA compound library screening Baicalin upregulates TREM2 for the treatment of cerebral ischemia-reperfusion injury
In this study, we employed a high-throughput screening (HTS) strategy to evaluate 2625 compounds from the (Food and Drug Administration) FDA library in vitro to identify compounds that upregulate the TREM2 receptor on microglia. Through this screening, we identified Baicalin as a potential drug for AIS treatment. Baicalin, a flavonoid compound extracted and isolated from the root of Scutellaria baicalensis, demonstrated promising results. Next, we established an in vivo mouse model of cerebral ischemia-reperfusion injury (MCAO/R) and an in vitro microglia cell of oxygen-glucose deprivation reperfusion (OGD/R) to investigat...
Source: European Journal of Pharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Hongxia Wang Jialiang Ma Xiaoling Li Yanhui Peng Manxia Wang Source Type: research
Punicalagin promotes mincle-mediated phagocytosis of macrophages via the NF- κB and MAPK signaling pathways
In this study, we found that pre-treatment with PUN significantly enhanced phagocytosis by macrophages in a time- and dose-dependent manner in vitro. Moreover, KEGG enrichment analysis by RNA-sequencing showed that differentially expressed genes following PUN treatment were significantly enriched in phagocyte-related receptors, such as the C-type lectin receptor signaling pathway. Among the C-type lectin receptor family, Mincle (Clec4e) significantly increased at the mRNA and protein level after PUN treatment, as shown by qRT-PCR and western blotting. Small interfering RNA (siRNA) mediated knockdown of Mincle in macrophage...
Source: European Journal of Pharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Shuangqin Yin Weihong Dai Tianyin Kuang Jing Zhou Li Luo Shengxiang Ao Xue Yang Hongyan Xiao Lin Qiao Rixing Wang Fei Wang Caihong Yun Shaowen Cheng Junyu Zhu Huaping Liang Source Type: research
