Corrigendum to "Allicin improves endoplasmic reticulum stress-related cognitive deficits via PERK/Nrf2 antioxidative signaling pathway" [Europ. J. Pharmacol. 762 (2015) 239-246]
Eur J Pharmacol. 2024 Apr 3:176555. doi: 10.1016/j.ejphar.2024.176555. Online ahead of print.NO ABSTRACTPMID:38575420 | DOI:10.1016/j.ejphar.2024.176555 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 4, 2024 Category: Drugs & Pharmacology Authors: Yao-Feng Zhu Xian-Hui Li Zhi-Peng Yuan Chun-Yan Li Rong-Bo Tian Wei Jia Zhu-Ping Xiao Source Type: research

Alnustone promotes megakaryocyte differentiation and platelet production via the interleukin-17A/interleukin-17A receptor/Src/RAC1/MEK/ERK signaling pathway
CONCLUSIONS: Alnustone can promote megakaryocyte differentiation and platelet production via the interleukin-17A/interleukin-17A receptor/Src/RAC1/MEK/ERK signaling pathway and thus provides a new therapeutic strategy for the treatment of thrombocytopenia.PMID:38570080 | DOI:10.1016/j.ejphar.2024.176548 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Yueyue Li Jia Lai Mei Ran Taian Yi Ling Zhou Jiesi Luo Xiaoxi Liu Xiaoqin Tang Miao Huang Xiang Xie Li Hong Yan Yang Wenjun Zou Jianming Wu Source Type: research

New insights into the characterization of the mechanism of action of hyoscine butylbromide in the human colon ex vivo
CONCLUSIONS: This study demonstrates that HBB inhibits neural cholinergic contractions associated to muscarinic (mainly M3) receptors. HBB has a potential role in reducing colonic spasm induced by the release of acetylcholine from enteric motor neurons and from an atypical source including a potential non-neuronal origin.PMID:38570081 | DOI:10.1016/j.ejphar.2024.176550 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Sara Traserra Luis Gerardo Alcal á-González Claudia Barber Stefania Landolfi Carolina Malagelada Robert Lange Sylvie Forestier Maura Corsetti Marcel Jimenez Source Type: research

Small-molecule targeting PKM2 provides a molecular basis of lactylation-dependent fibroblast-like synoviocytes proliferation inhibition against rheumatoid arthritis
Eur J Pharmacol. 2024 Apr 1:176551. doi: 10.1016/j.ejphar.2024.176551. Online ahead of print.ABSTRACTFibroblast-like synoviocytes (FLS) play an important role in rheumatoid arthritis (RA)-related swelling and bone damage. Therefore, novel targets for RA therapy in FLS are urgently discovered for improving pathologic phenomenon, especially joint damage and dyskinesia. Here, we suggested that pyruvate kinase M2 (PKM2) in FLS represented a pharmacological target for RA treatment by antimalarial drug artemisinin (ART). We demonstrated that ART selectively inhibited human RA-FLS and rat collagen-induced arthritis (CIA)-FLS prol...
Source: European Journal of Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Yan-Hang Wang Peng Gao Yu-Qi Wang Lu-Zheng Xu Ke-Wu Zeng Peng-Fei Tu Source Type: research

Alnustone promotes megakaryocyte differentiation and platelet production via the interleukin-17A/interleukin-17A receptor/Src/RAC1/MEK/ERK signaling pathway
CONCLUSIONS: Alnustone can promote megakaryocyte differentiation and platelet production via the interleukin-17A/interleukin-17A receptor/Src/RAC1/MEK/ERK signaling pathway and thus provides a new therapeutic strategy for the treatment of thrombocytopenia.PMID:38570080 | DOI:10.1016/j.ejphar.2024.176548 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Yueyue Li Jia Lai Mei Ran Taian Yi Ling Zhou Jiesi Luo Xiaoxi Liu Xiaoqin Tang Miao Huang Xiang Xie Li Hong Yan Yang Wenjun Zou Jianming Wu Source Type: research

New insights into the characterization of the mechanism of action of hyoscine butylbromide in the human colon ex vivo
CONCLUSIONS: This study demonstrates that HBB inhibits neural cholinergic contractions associated to muscarinic (mainly M3) receptors. HBB has a potential role in reducing colonic spasm induced by the release of acetylcholine from enteric motor neurons and from an atypical source including a potential non-neuronal origin.PMID:38570081 | DOI:10.1016/j.ejphar.2024.176550 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Sara Traserra Luis Gerardo Alcal á-González Claudia Barber Stefania Landolfi Carolina Malagelada Robert Lange Sylvie Forestier Maura Corsetti Marcel Jimenez Source Type: research

Small-molecule targeting PKM2 provides a molecular basis of lactylation-dependent fibroblast-like synoviocytes proliferation inhibition against rheumatoid arthritis
Eur J Pharmacol. 2024 Apr 1:176551. doi: 10.1016/j.ejphar.2024.176551. Online ahead of print.ABSTRACTFibroblast-like synoviocytes (FLS) play an important role in rheumatoid arthritis (RA)-related swelling and bone damage. Therefore, novel targets for RA therapy in FLS are urgently discovered for improving pathologic phenomenon, especially joint damage and dyskinesia. Here, we suggested that pyruvate kinase M2 (PKM2) in FLS represented a pharmacological target for RA treatment by antimalarial drug artemisinin (ART). We demonstrated that ART selectively inhibited human RA-FLS and rat collagen-induced arthritis (CIA)-FLS prol...
Source: European Journal of Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Yan-Hang Wang Peng Gao Yu-Qi Wang Lu-Zheng Xu Ke-Wu Zeng Peng-Fei Tu Source Type: research

Metabolomics analysis revealed the neuroprotective role of 2-phosphoglyceric acid in hypoxic-ischemic brain damage through GPX4/ACSL4 axis regulation
Eur J Pharmacol. 2024 Mar 31;971:176539. doi: 10.1016/j.ejphar.2024.176539. Online ahead of print.ABSTRACTHypoxic-ischemic brain damage (HIBD) is a cerebral injury resulting from the combination of ischemia and hypoxia in neonatal brain tissue. Presently, there exists no efficacious remedy for HIBD. A mounting body of evidence indicates that dynamic metabolites formed during metabolic procedures assume a vital role in neuronal maturation and recuperation. However, it remains unclear whether any endogenous metabolites are involved in the pathogenesis of HIBD. Here, an untargeted metabolomics analysis was conducted by gas ch...
Source: European Journal of Pharmacology - April 2, 2024 Category: Drugs & Pharmacology Authors: Haocong Chen Yimingjiang Wusiman Jing Zhao Wenyi Zhang Wenjuan Liu Shuyan Wang Gang Qian Guangming Zhang Meini Le Xiaohua Dong Source Type: research

Liraglutide and Naringenin relieve depressive symptoms in mice by enhancing Neurogenesis and reducing inflammation
Eur J Pharmacol. 2024 Mar 30:176525. doi: 10.1016/j.ejphar.2024.176525. Online ahead of print.ABSTRACTDepression is a debilitating mental disease that negatively impacts individuals' lives and society. Novel hypotheses have been recently proposed to improve our understanding of depression pathogenesis. Impaired neuroplasticity and upregulated neuro-inflammation add-on to the disturbance in monoamine neurotransmitters and therefore require novel anti-depressants to target them simultaneously. Recent reports demonstrate the antidepressant effect of the anti-diabetic drug liraglutide. Similarly, the natural flavonoid naringen...
Source: European Journal of Pharmacology - April 1, 2024 Category: Drugs & Pharmacology Authors: Yara S Abdelkawy Mona Elharoun Eman Sheta Ihab Talat Abdel-Raheem Hisham A Nematalla Source Type: research

Resveratrol protects cardiomyocytes against ischemia/reperfusion-induced ferroptosis via inhibition of the VDAC1/GPX4 pathway
In conclusion, Res pretreatment could protect the myocardium against MIRI-induced ferroptosis via the VDAC1/GPX4 signaling pathway.PMID:38561102 | DOI:10.1016/j.ejphar.2024.176524 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 1, 2024 Category: Drugs & Pharmacology Authors: Tie Hu Hua-Xi Zou Ze-Yu Zhang Yi-Cheng Wang Fa-Jia Hu Wen-Xiong Huang Ji-Chun Liu Song-Qing Lai Huang Huang Source Type: research

Pirfenidone and nintedanib attenuates pulmonary artery endothelial and smooth muscle cells transformations induced by IL-11
This study provided also evidence of the inhibitory effect of PFD and NTD on IL-11-induced endothelial and muscle cells proliferation and senescence. The inhibitory effect of these drugs on monocyte arrest and angiogenesis was also studied. Finally, we observed that IL-11 induced canonical signal transducer and activator of transcription 3 (STAT3) and non-canonical mitogen-activated protein kinase 1/2 (ERK1/2) phosphorylation, but, PFD and NTD only inhibited ERK1/2 phosphorylation. Therefore, this study provided evidence of the inhibitory effect of NTD and PFD on markers of pulmonary artery remodeling induced by IL-11.PMID...
Source: European Journal of Pharmacology - April 1, 2024 Category: Drugs & Pharmacology Authors: In és Roger Paula Montero Javier Milara Julio Cortijo Source Type: research

Pharmacological evaluation of new generation OXIZID synthetic cannabinoid receptor agonists
Eur J Pharmacol. 2024 Mar 30:176549. doi: 10.1016/j.ejphar.2024.176549. Online ahead of print.ABSTRACTSynthetic cannabinoid receptor agonists (SCRAs) remain one the largest classes of new psychoactive substances, and are increasingly associated with severe adverse effects and death compared to the phytocannabinoid Δ9-tetrahydrocannabinol (THC). In the attempt to circumvent the rapid emergence of novel SCRAs, several nations have implemented 'generic' legislations, or 'class-wide' bans based on common structural scaffolds. However, this has only encouraged the incorporation of new chemical entities, including distinct core...
Source: European Journal of Pharmacology - April 1, 2024 Category: Drugs & Pharmacology Authors: Monica Patel Xiaoxi Zheng Luli R Akinfiresoye Cassandra Prioleau Teneille D Walker Michelle Glass Julie A Marusich Source Type: research

Liraglutide and Naringenin relieve depressive symptoms in mice by enhancing Neurogenesis and reducing inflammation
Eur J Pharmacol. 2024 Mar 30:176525. doi: 10.1016/j.ejphar.2024.176525. Online ahead of print.ABSTRACTDepression is a debilitating mental disease that negatively impacts individuals' lives and society. Novel hypotheses have been recently proposed to improve our understanding of depression pathogenesis. Impaired neuroplasticity and upregulated neuro-inflammation add-on to the disturbance in monoamine neurotransmitters and therefore require novel anti-depressants to target them simultaneously. Recent reports demonstrate the antidepressant effect of the anti-diabetic drug liraglutide. Similarly, the natural flavonoid naringen...
Source: European Journal of Pharmacology - April 1, 2024 Category: Drugs & Pharmacology Authors: Yara S Abdelkawy Mona Elharoun Eman Sheta Ihab Talat Abdel-Raheem Hisham A Nematalla Source Type: research

Resveratrol protects cardiomyocytes against ischemia/reperfusion-induced ferroptosis via inhibition of the VDAC1/GPX4 pathway
In conclusion, Res pretreatment could protect the myocardium against MIRI-induced ferroptosis via the VDAC1/GPX4 signaling pathway.PMID:38561102 | DOI:10.1016/j.ejphar.2024.176524 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 1, 2024 Category: Drugs & Pharmacology Authors: Tie Hu Hua-Xi Zou Ze-Yu Zhang Yi-Cheng Wang Fa-Jia Hu Wen-Xiong Huang Ji-Chun Liu Song-Qing Lai Huang Huang Source Type: research

Pirfenidone and nintedanib attenuates pulmonary artery endothelial and smooth muscle cells transformations induced by IL-11
This study provided also evidence of the inhibitory effect of PFD and NTD on IL-11-induced endothelial and muscle cells proliferation and senescence. The inhibitory effect of these drugs on monocyte arrest and angiogenesis was also studied. Finally, we observed that IL-11 induced canonical signal transducer and activator of transcription 3 (STAT3) and non-canonical mitogen-activated protein kinase 1/2 (ERK1/2) phosphorylation, but, PFD and NTD only inhibited ERK1/2 phosphorylation. Therefore, this study provided evidence of the inhibitory effect of NTD and PFD on markers of pulmonary artery remodeling induced by IL-11.PMID...
Source: European Journal of Pharmacology - April 1, 2024 Category: Drugs & Pharmacology Authors: In és Roger Paula Montero Javier Milara Julio Cortijo Source Type: research