Dl-3-n-Butylphthalide Improves Stroke Outcomes after Focal Ischemic Stroke in Mouse Model by Inhibiting the Pyroptosis-regulated Cell Death and Ameliorating Neuroinflammation
Eur J Pharmacol. 2024 Apr 16:176593. doi: 10.1016/j.ejphar.2024.176593. Online ahead of print.ABSTRACTRecent studies have highlighted the involvement of pyroptosis-mediated cell death and neuroinflammation in ischemic stroke (IS) pathogenesis. DL-3-n-butylphthalide (NBP), a synthesized compound based on an extract from seeds of Apium graveolens, possesses a broad range of biological effects. However, the efficacy and the underlying mechanisms of NBP in IS remain contentious. Herein, we investigated the therapeutic effects of NBP and elucidated its potential mechanisms in neuronal cell pyroptosis and microglia inflammatory ...
Source: European Journal of Pharmacology - April 18, 2024 Category: Drugs & Pharmacology Authors: Mengru Ge Lingting Jin Can Cui Yingying Han Hongxia Li Xue Gao Gang Li Hongxiang Yu Bei Zhang Source Type: research
Wogonoside alleviates microglia-mediated neuroinflammation via TLR4/MyD88/NF- κB signaling axis after spinal cord injury
This study employed in silico, in vitro, and in vivo methodologies to investigate the impact of WG on microglia-mediated neuroinflammation after SCI. In the in silico experiment, we identified 15 potential target genes of WG associated with SCI. These genes were linked to the regulation of inflammatory response and immune defense. Molecular docking maps revealed toll-like receptor 4 as a molecular target for WG, demonstrating binding through a hydrogen bond (Lys263, Ser120). In lipopolysaccharide-stimulated BV2 cells and SCI mice, WG significantly attenuated microglial activation and facilitated a phenotype shift from M1 t...
Source: European Journal of Pharmacology - April 18, 2024 Category: Drugs & Pharmacology Authors: Ruyi Zhu Yaling Zhang Weitai He Yanan Sun Xin Zhao Yaping Yan Qian Zhang Source Type: research
The antidiabetic drug ipragliflozin induces vasorelaxation of rabbit femoral artery by activating a Kv channel, the SERCA pump, and the PKA signaling pathway
Eur J Pharmacol. 2024 Apr 16;972:176589. doi: 10.1016/j.ejphar.2024.176589. Online ahead of print.ABSTRACTWe explored the vasorelaxant effects of ipragliflozin, a sodium-glucose cotransporter-2 inhibitor, on rabbit femoral arterial rings. Ipragliflozin relaxed phenylephrine-induced pre-contracted rings in a dose-dependent manner. Pre-treatment with the ATP-sensitive K+ channel inhibitor glibenclamide (10 μM), the inwardly rectifying K+ channel inhibitor Ba2+ (50 μM), or the Ca2+-sensitive K+ channel inhibitor paxilline (10 μM) did not influence the vasorelaxant effect. However, the voltage-dependent K+ (Kv) channel inhi...
Source: European Journal of Pharmacology - April 17, 2024 Category: Drugs & Pharmacology Authors: Minju Park Seo-Yeong Mun Wenwen Zhuang Junsu Jeong Hye Ryung Kim Hongzoo Park Eun-Taek Han Jin-Hee Han Wanjoo Chun Hongliang Li Won Sun Park Source Type: research
The antidiabetic drug ipragliflozin induces vasorelaxation of rabbit femoral artery by activating a Kv channel, the SERCA pump, and the PKA signaling pathway
Eur J Pharmacol. 2024 Apr 15:176589. doi: 10.1016/j.ejphar.2024.176589. Online ahead of print.ABSTRACTWe explored the vasorelaxant effects of ipragliflozin, a sodium-glucose cotransporter-2 inhibitor, on rabbit femoral arterial rings. Ipragliflozin relaxed phenylephrine-induced pre-contracted rings in a dose-dependent manner. Pre-treatment with the ATP-sensitive K+ channel inhibitor glibenclamide (10 μM), the inwardly rectifying K+ channel inhibitor Ba2+ (50 μM), or the Ca2+-sensitive K+ channel inhibitor paxilline (10 μM) did not influence the vasorelaxant effect. However, the voltage-dependent K+ (Kv) channel inhibito...
Source: European Journal of Pharmacology - April 17, 2024 Category: Drugs & Pharmacology Authors: Minju Park Seo-Yeong Mun Wenwen Zhuang Junsu Jeong Hye Ryung Kim Hongzoo Park Eun-Taek Han Jin-Hee Han Wanjoo Chun Hongliang Li Won Sun Park Source Type: research
Single Nucleotide Polymorphism-based Biomarker in Primary Hypertension
In conclusion, SNP research in primary hypertension is rapidly evolving with emerging technologies and methodologies that have the potential to transform the knowledge about genetic basis related to the condition. These advances hold promise for personalized prevention and treatment strategies tailored to an individual's genetic profile ultimately improving patient outcomes and reducing healthcare costs.PMID:38621507 | DOI:10.1016/j.ejphar.2024.176584 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 15, 2024 Category: Drugs & Pharmacology Authors: None Laxmi Pougang Golmei Shriyansh Srivastava Sachin Kumar Source Type: research
Targeting the aryl hydrocarbon receptor with FICZ regulates IL-2 and immune infiltration to alleviate Hashimoto's thyroiditis in mice
In conclusion, targeting the AhR with FICZ regulates IL-2 and immune infiltration to alleviate experimental HT, shedding new light on the therapeutic intervention of this prevalent disease.PMID:38621508 | DOI:10.1016/j.ejphar.2024.176588 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 15, 2024 Category: Drugs & Pharmacology Authors: Zhengzheng Liao Xianzhong Zeng Xiaoling Guo Qing Shi Ziyun Tang Ping Li Cuiyun Chen Mengxia Chen Jianrong Chen Jixiong Xu Yaojun Cai Source Type: research
Single Nucleotide Polymorphism-based Biomarker in Primary Hypertension
In conclusion, SNP research in primary hypertension is rapidly evolving with emerging technologies and methodologies that have the potential to transform the knowledge about genetic basis related to the condition. These advances hold promise for personalized prevention and treatment strategies tailored to an individual's genetic profile ultimately improving patient outcomes and reducing healthcare costs.PMID:38621507 | DOI:10.1016/j.ejphar.2024.176584 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 15, 2024 Category: Drugs & Pharmacology Authors: None Laxmi Pougang Golmei Shriyansh Srivastava Sachin Kumar Source Type: research
Targeting the aryl hydrocarbon receptor with FICZ regulates IL-2 and immune infiltration to alleviate Hashimoto's thyroiditis in mice
In conclusion, targeting the AhR with FICZ regulates IL-2 and immune infiltration to alleviate experimental HT, shedding new light on the therapeutic intervention of this prevalent disease.PMID:38621508 | DOI:10.1016/j.ejphar.2024.176588 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 15, 2024 Category: Drugs & Pharmacology Authors: Zhengzheng Liao Xianzhong Zeng Xiaoling Guo Qing Shi Ziyun Tang Ping Li Cuiyun Chen Mengxia Chen Jianrong Chen Jixiong Xu Yaojun Cai Source Type: research
The role of hydrogen in the prevention and treatment of coronary atherosclerotic heart disease
Eur J Pharmacol. 2024 Apr 12:176586. doi: 10.1016/j.ejphar.2024.176586. Online ahead of print.ABSTRACTCoronary atherosclerotic heart disease (CHD) is a primary cardiovascular disease caused by atherosclerosis (AS), which is characterized by chronic inflammation and lipid oxidative deposition. Molecular hydrogen (H2) is an effective anti-inflammatory agent and has potential to ameliorate glycolipid metabolism disorders, which is believed to exert beneficial effects on the prevention and treatment of CHD. It is suggested that H2 reduces inflammation in CHD by regulating multiple pathways, including NF-κB inflammatory pathwa...
Source: European Journal of Pharmacology - April 14, 2024 Category: Drugs & Pharmacology Authors: Yunxi Chen Youzhen Wei Wenjie Tang Source Type: research
Corrigendum to "The prophylaxis and treatment potential of supplements for COVID-19" [Eur. J. Pharmacol. 887 (15 November 2020) 173530]
Eur J Pharmacol. 2024 Apr 12;972:176571. doi: 10.1016/j.ejphar.2024.176571. Online ahead of print.NO ABSTRACTPMID:38614058 | DOI:10.1016/j.ejphar.2024.176571 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 13, 2024 Category: Drugs & Pharmacology Authors: Adeleh Sahebnasagh Fatemeh Saghafi Razieh Avan Amirhosein Khoshi Masoud Khataminia Mohammadreza Safdari Solomon Habtemariam Hassan Rezai Ghaleno Seyed Mohammad Nabavi Source Type: research
Involvement of necroptotic cell death in macrophages in progression of bleomycin and LPS-induced acute exacerbation of idiopathic pulmonary fibrosis
In this study, we investigated the mechanism underlying AE of IPF, using bleomycin (BLM) and lipopolysaccharide (LPS) (BLM+LPS)-treated mice. The mice were treated with a single dose of 1.5 mg/kg BLM (on day 0) and/or 0.5 mg/kg LPS (on day 14), and maintained for another 7 days (total 21 days). Administration of BLM+LPS more severely aggravated the respiratory function, fibrosis, and inflammation in the lungs, together with the elevated interleukin-6 level in bronchoalveolar lavage fluid, than the control or BLM alone-treated mice. Moreover, the terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay dem...
Source: European Journal of Pharmacology - April 13, 2024 Category: Drugs & Pharmacology Authors: Atsushi Koike Kaoruko Hayashi Ko Fujimori Source Type: research
Proteasome activation is critical for cell death induced by inhibitors of polo-like kinase 1 (PLK1) in multiple cancers
In this study, we found that GW843682X and BI2536, two inhibitors of PLK1, significantly induced cell death in multiple type cells. The induction of cell death was related to the preferring expression of PLK1. However, in human umbilical vascular endothelial cells (HUVEC) and human colorectal carcinoma cells, which expressed higher levels of both PLK1 and PLK2, PLK1 inhibitors induced very low levels of cell death. Clinical analysis reveals PLK1 presence in 26 of 30 NPC tumor tissues. In in vivo NPC lung metastasis nude mouse models, PLK1 inhibitors decreased NPC progress. Mechanistically, the PLK1 inhibitor did not activa...
Source: European Journal of Pharmacology - April 13, 2024 Category: Drugs & Pharmacology Authors: Yufei Wang Guihua Wang Wei Xiang Xueting Liu Manli Jiang Jinyue Hu Source Type: research
Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension
In conclusion, CRA attenuated the PDGF-PDGF receptor β-STAT3/NF-κB signaling axis in macrophages and PASMCs, and thus, ameliorated pulmonary vascular remodeling in PAH.PMID:38614383 | DOI:10.1016/j.ejphar.2024.176564 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 13, 2024 Category: Drugs & Pharmacology Authors: Aya Yamamura Moe Fujiwara Akiko Kawade Taiki Amano Alamgir Hossain Md Junayed Nayeem Rubii Kondo Yoshiaki Suzuki Yasumichi Inoue Hidetoshi Hayashi Susumu Suzuki Motohiko Sato Hisao Yamamura Source Type: research
Corrigendum to "The prophylaxis and treatment potential of supplements for COVID-19" [Eur. J. Pharmacol. 887 (15 November 2020) 173530]
Eur J Pharmacol. 2024 Apr 12;972:176571. doi: 10.1016/j.ejphar.2024.176571. Online ahead of print.NO ABSTRACTPMID:38614058 | DOI:10.1016/j.ejphar.2024.176571 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 13, 2024 Category: Drugs & Pharmacology Authors: Adeleh Sahebnasagh Fatemeh Saghafi Razieh Avan Amirhosein Khoshi Masoud Khataminia Mohammadreza Safdari Solomon Habtemariam Hassan Rezai Ghaleno Seyed Mohammad Nabavi Source Type: research
Involvement of necroptotic cell death in macrophages in progression of bleomycin and LPS-induced acute exacerbation of idiopathic pulmonary fibrosis
In this study, we investigated the mechanism underlying AE of IPF, using bleomycin (BLM) and lipopolysaccharide (LPS) (BLM+LPS)-treated mice. The mice were treated with a single dose of 1.5 mg/kg BLM (on day 0) and/or 0.5 mg/kg LPS (on day 14), and maintained for another 7 days (total 21 days). Administration of BLM+LPS more severely aggravated the respiratory function, fibrosis, and inflammation in the lungs, together with the elevated interleukin-6 level in bronchoalveolar lavage fluid, than the control or BLM alone-treated mice. Moreover, the terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay dem...
Source: European Journal of Pharmacology - April 13, 2024 Category: Drugs & Pharmacology Authors: Atsushi Koike Kaoruko Hayashi Ko Fujimori Source Type: research
