Lung fibroblast-derived extracellular vesicles and soluble factors alleviate elastase-induced lung injury
In conclusion, this study highlights the therapeutic potential of both lung fibroblast-derived EV- and SF-enriched concentrates for the treatment of lung injury and emphysema.PMID:38677537 | DOI:10.1016/j.ejphar.2024.176612 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Luke van der Koog Myrthe J Boerrigter Iris C Gorter Reinoud Gosens Anika Nagelkerke Source Type: research

IL-12p40 deletion reduces M1 macrophage polarization and alleviates cardiac remodeling via regulating Th17 cells differentiation, but not γδT 17 cells, in TAC mice
CONCLUSION: Mainly Th17 cells but not γδT17 cells secrete IL-17, which mediates IL-12p40, promotes the polarization of proinflammatory macrophages, and exacerbates cardiac remodeling in TAC mice. IL-12p40 may be a potential target for the prevention and treatment of cardiac remodeling.PMID:38677538 | DOI:10.1016/j.ejphar.2024.176602 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Heng Pan Qingwei Ji Mengmeng Zhao Zihui Zheng Xiyi Lu Yongqi Feng Liren Gan Jing Ye Jun Wan Di Ye Source Type: research

Hypoxia-induced TRPM7 Promotes Glycolytic Metabolism and Progression in Hepatocellular Carcinoma
CONCLUSIONS: TRPM7 was directly transcriptionally regulated by HIF-1α, leading to glycolytic metabolic reprogramming and the promotion of HCC proliferation and metastasis in vitro and in vivo. Our findings suggest that TRPM7 might be a potential diagnostic indicator and therapeutic target for HCC.PMID:38677534 | DOI:10.1016/j.ejphar.2024.176601 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Fengbo Zhao Weili Yu Jingyan Hu Yi Xia YuXuan Li Siqi Liu Aifen Liu Chengniu Wang Hong Zhang Lei Zhang Jianwu Shi Source Type: research

Mechanisms and emerging strategies for irinotecan-induced diarrhea
Eur J Pharmacol. 2024 Apr 25:176614. doi: 10.1016/j.ejphar.2024.176614. Online ahead of print.ABSTRACTIrinotecan (also known as CPT-11) is a topoisomerase I inhibitor first approved for clinical use as an anticancer agent in 1996. Over the past more than two decades, it has been widely used for combination regimens to treat various malignancies, especially in gastrointestinal and lung cancers. However, severe dose-limiting toxicities, especially gastrointestinal toxicity such as late-onset diarrhea, were frequently observed in irinotecan-based therapy, thus largely limiting the clinical application of this agent. Current k...
Source: European Journal of Pharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Shengkun Xu Huiyin Lan Chengyi Huang Xingnan Ge Ji Zhu Source Type: research

Ginsenoside Rb1 ameliorates lipotoxicity-induced myocardial injury in diabetes mellitus by regulating Mfn2
CONCLUSION: GRb1 alleviated myocardial lipid accumulation and mitochondrial injury, and attenuated ventricular diastolic dysfunction in diabetic mice. The regulation of Mfn2 was involved in the protective effects of GRb1 against lipotoxic myocardial injury.PMID:38677536 | DOI:10.1016/j.ejphar.2024.176609 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Louyin Ji Hui Han Xiaoli Shan Pei Zhao Huihua Chen Chen Zhang Ming Xu Rong Lu Wei Guo Source Type: research

Lung fibroblast-derived extracellular vesicles and soluble factors alleviate elastase-induced lung injury
In conclusion, this study highlights the therapeutic potential of both lung fibroblast-derived EV- and SF-enriched concentrates for the treatment of lung injury and emphysema.PMID:38677537 | DOI:10.1016/j.ejphar.2024.176612 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Luke van der Koog Myrthe J Boerrigter Iris C Gorter Reinoud Gosens Anika Nagelkerke Source Type: research

IL-12p40 deletion reduces M1 macrophage polarization and alleviates cardiac remodeling via regulating Th17 cells differentiation, but not γδT 17 cells, in TAC mice
CONCLUSION: Mainly Th17 cells but not γδT17 cells secrete IL-17, which mediates IL-12p40, promotes the polarization of proinflammatory macrophages, and exacerbates cardiac remodeling in TAC mice. IL-12p40 may be a potential target for the prevention and treatment of cardiac remodeling.PMID:38677538 | DOI:10.1016/j.ejphar.2024.176602 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Heng Pan Qingwei Ji Mengmeng Zhao Zihui Zheng Xiyi Lu Yongqi Feng Liren Gan Jing Ye Jun Wan Di Ye Source Type: research

Endoplasmic reticulum stress produced by Thapsigargin affects the occurrence of spike-wave discharge by modulating unfolded protein response pathways and activating immune responses in a dose-dependent manner
In conclusion, our findings indicate that Tg affects SWD occurrence by modulating the unfolded protein response pathway and activating inflammatory processes in a dose-dependent manner.PMID:38670446 | DOI:10.1016/j.ejphar.2024.176613 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 26, 2024 Category: Drugs & Pharmacology Authors: Sabriye Karadenizli Ta şkin Deniz Şahin Fazilet Dede Zehra Seda Ünal Halbutoğullari Mehmet Sarihan Sema Kurnaz Özbek Özgür Doğa Özsoy Murat Kasap Yusufhan Yazir Nurbay Ate ş Source Type: research

Bazedoxifene attenuates dextran sodium sulfate-induced colitis in mice through gut microbiota modulation and inhibition of STAT3 and NF- κB pathways
This study highlights gut microbiota's role in IBD drug development, offering insights for BZA's future development and its clinical applications.PMID:38663540 | DOI:10.1016/j.ejphar.2024.176611 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 25, 2024 Category: Drugs & Pharmacology Authors: Liumei Liang Jingdan Zhang Junxiong Chen Yu Tian Weiqian Li Mengchen Shi Sijing Cheng Yinhai Zheng Chen Wang Huanliang Liu Xiangling Yang Weibiao Ye Source Type: research

Inhibition of voltage-gated potassium channel by aripiprazole in rabbit coronary arterial smooth muscle cells
In this study, we evaluated the effect of aripiprazole on voltage-gated potassium (Kv) channels in rabbit coronary arterial smooth muscle cells using the patch clamp technique. Aripiprazole reduced the Kv current in a concentration-dependent manner with a half-maximal inhibitory concentration of 0.89 ± 0.20 μM and a Hill coefficient of 1.30 ± 0.25. The inhibitory effect of aripiprazole on Kv channels was voltage-dependent, and an additional aripiprazole-induced decrease in the Kv current was observed in the voltage range of full channel activation. The decay rate of Kv channel inactivation was accelerated by aripiprazol...
Source: European Journal of Pharmacology - April 25, 2024 Category: Drugs & Pharmacology Authors: Minji Kang Seo-Yeong Mun Wenwen Zhuang Minju Park Junsu Jeong Hongzoo Park Won-Kyo Jung Il-Whan Choi Sunghun Na Won Sun Park Source Type: research

Cycloheptylprodigiosin from marine bacterium Spartinivicinus ruber MCCC 1K03745 < sup > T < /sup > induces a novel form of cell death characterized by Golgi disruption and enhanced secretion of cathepsin D in Non-small cell lung cancer cell lines
In this study, cycloheptylprodigiosin (S-1) is extracted from marine bacterium Spartinivicinus ruber MCCC 1K03745T, and its anticancer property was investigated. It exhibits remarkable cytotoxicity against a panel of human lung cancer cell lines, with the IC50 values ranging from 84.89 nM to 661.2 nM. After 6 hours of treatment, S-1 gradually accumulates on mitochondria and lysosomes. While lower doses of S-1 induce cell cycle arrest, treatment with higher doses results in cell death in apoptotic independent manner in both NCI-H1299 and NCI-H460 cell lines. Interestingly, treatment with S-1 leads to the accumulation of LC3...
Source: European Journal of Pharmacology - April 25, 2024 Category: Drugs & Pharmacology Authors: Xiaosi Lin Le Dong Qing Miao Zhaobin Huang Fang Wang Source Type: research

Bazedoxifene attenuates dextran sodium sulfate-induced colitis in mice through gut microbiota modulation and inhibition of STAT3 and NF- κB pathways
This study highlights gut microbiota's role in IBD drug development, offering insights for BZA's future development and its clinical applications.PMID:38663540 | DOI:10.1016/j.ejphar.2024.176611 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 25, 2024 Category: Drugs & Pharmacology Authors: Liumei Liang Jingdan Zhang Junxiong Chen Yu Tian Weiqian Li Mengchen Shi Sijing Cheng Yinhai Zheng Chen Wang Huanliang Liu Xiangling Yang Weibiao Ye Source Type: research

Inhibition of voltage-gated potassium channel by aripiprazole in rabbit coronary arterial smooth muscle cells
In this study, we evaluated the effect of aripiprazole on voltage-gated potassium (Kv) channels in rabbit coronary arterial smooth muscle cells using the patch clamp technique. Aripiprazole reduced the Kv current in a concentration-dependent manner with a half-maximal inhibitory concentration of 0.89 ± 0.20 μM and a Hill coefficient of 1.30 ± 0.25. The inhibitory effect of aripiprazole on Kv channels was voltage-dependent, and an additional aripiprazole-induced decrease in the Kv current was observed in the voltage range of full channel activation. The decay rate of Kv channel inactivation was accelerated by aripiprazol...
Source: European Journal of Pharmacology - April 25, 2024 Category: Drugs & Pharmacology Authors: Minji Kang Seo-Yeong Mun Wenwen Zhuang Minju Park Junsu Jeong Hongzoo Park Won-Kyo Jung Il-Whan Choi Sunghun Na Won Sun Park Source Type: research

Cycloheptylprodigiosin from marine bacterium Spartinivicinus ruber MCCC 1K03745 < sup > T < /sup > induces a novel form of cell death characterized by Golgi disruption and enhanced secretion of cathepsin D in Non-small cell lung cancer cell lines
In this study, cycloheptylprodigiosin (S-1) is extracted from marine bacterium Spartinivicinus ruber MCCC 1K03745T, and its anticancer property was investigated. It exhibits remarkable cytotoxicity against a panel of human lung cancer cell lines, with the IC50 values ranging from 84.89 nM to 661.2 nM. After 6 hours of treatment, S-1 gradually accumulates on mitochondria and lysosomes. While lower doses of S-1 induce cell cycle arrest, treatment with higher doses results in cell death in apoptotic independent manner in both NCI-H1299 and NCI-H460 cell lines. Interestingly, treatment with S-1 leads to the accumulation of LC3...
Source: European Journal of Pharmacology - April 25, 2024 Category: Drugs & Pharmacology Authors: Xiaosi Lin Le Dong Qing Miao Zhaobin Huang Fang Wang Source Type: research

Telmisartan ameliorates nephropathy and restores the hippo pathway in rats with metabolic syndrome
Eur J Pharmacol. 2024 Apr 21;973:176605. doi: 10.1016/j.ejphar.2024.176605. Online ahead of print.ABSTRACTThe main objective of this study was to determine if the telmisartan-ameliorative effects of metabolic syndrome (MetS)-evoked nephropathy are attributed to the Hippo pathway. A secondary objective was to investigate the potential of vitamin D3 to enhance telmisartan-favourable effects. A diet composed of 24% fat and 3% salt, along with drinking water containing 10% fructose, was administered for 12 weeks to induce MetS. MetS-rats were given telmisartan (5 mg/kg/day), vitamin D3 (10 μg/kg/day) or both by gavage, starti...
Source: European Journal of Pharmacology - April 23, 2024 Category: Drugs & Pharmacology Authors: Badria Mohamed Salah A Ghareib Amira Ebrahim Alsemeh Shaimaa S El-Sayed Source Type: research