Sodium tanshinone IIA sulfonate suppresses microglia polarization and neuroinflammation possibly via regulating miR-125b-5p/STAT3 axis to ameliorate neuropathic pain
This study aimed to investigate the effect of STS and elucidate possible mechanisms in a rat model of spared nerve injury. In vivo experiments, STS and AG490 were administered intraperitoneally once daily for 14 consecutive days after surgery. The results showed that the expression of miR-125b-5p in the spinal dorsal horn was substantially reduced, whereas signal transducer and activator of transcription 3 (STAT3) signaling was increased. After treatment with STS, the mechanical thresholds, expression of miR-125b-5p, and microglial M2 marker such as Arg-1 in the spinal cord horn increased significantly, whereas multiple pr...
Source: European Journal of Pharmacology - March 29, 2024 Category: Drugs & Pharmacology Authors: Jie Zeng Wei-Wei Gao Hao Yang Ya-Nang Wang Yang Mei Ting-Ting Liu Min Wang Li Tang Dong-Chuan Ma Wei Li Source Type: research
Integrative experimental validation of concomitant miRNAs and transcription factors with differentially expressed genes in acute myocardial infarction
Eur J Pharmacol. 2024 Mar 27:176540. doi: 10.1016/j.ejphar.2024.176540. Online ahead of print.ABSTRACTIdentification of concomitant miRNAs and transcription factors (TFs) with differential expression (DEGs) in MI is crucial for understanding holistic gene regulation, identifying key regulators, and precision in biomarker and therapeutic target discovery. We performed a comprehensive analysis using Affymetrix microarray data, advanced bioinformatic tools, and experimental validation to explore potential biomarkers associated with human pathology. The search strategy includes the identification of the GSE83500 dataset, compr...
Source: European Journal of Pharmacology - March 29, 2024 Category: Drugs & Pharmacology Authors: Vikash Sharma Jitender Singh Ashish Kumar Samarth Kansara Md Sayeed Akhtar Mohd Faiyaz Khan Saad A Aldosari Monalisa Mukherjee Arun K Sharma Source Type: research
Involvement of ferroptosis in eribulin-induced cytotoxicity in ovarian clear cell carcinoma
This study aimed to investigate the involvement of ferroptosis and its mechanism in the antitumor activity of eribulin in OCCC cells and a mouse xenograft model. We found that eribulin-induced cell death was reduced by ferroptosis inhibitors; deferoxamine, an iron chelator and ferrostatin-1, a lipid peroxidation inhibitor. Eribulin increased the levels of intracellular iron, reactive oxygen species (ROS), and lipid peroxides, and increased the mitochondrial membrane potential. Eribulin downregulated the expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), the mitochondrial enzym...
Source: European Journal of Pharmacology - March 29, 2024 Category: Drugs & Pharmacology Authors: Mana Azumi Kazuya Kusama Mikihiro Yoshie Saya Nakano Atsuya Tsuru Tomoyasu Kato Kazuhiro Tamura Source Type: research
Compound Z526 alleviates chemotherapy-induced cachectic muscle loss by ameliorating oxidative stress-driven protein metabolic imbalance and apoptosis
Eur J Pharmacol. 2024 Mar 27:176538. doi: 10.1016/j.ejphar.2024.176538. Online ahead of print.ABSTRACTChemotherapy is one of the primary and indispensable intervention against cancers though it is always accompanied by severe side effects especially cachexia. Cachexia is a fatal metabolic disorder syndrome, mainly characterized by muscle loss. Oxidative stress is the key factor that trigger cachectic muscle loss by inducing imbalance in protein metabolism and apoptosis. Here, we showed an oral compound (Z526) exhibited potent alleviating effects on C2C12 myotube atrophy induced by various chemotherapeutic agents in vitro a...
Source: European Journal of Pharmacology - March 29, 2024 Category: Drugs & Pharmacology Authors: Xiaofan Gu Shanshan Lu Meng Fan Shuang Xu Guangyu Lin Yun Zhao Weili Zhao Xuan Liu Xiaochun Dong Xiongwen Zhang Source Type: research
Blocking Orai1 constitutive activity inhibits B-cell cancer migration and synergistically acts with drugs to reduce B-CLL cell survival
Eur J Pharmacol. 2024 Mar 27;971:176515. doi: 10.1016/j.ejphar.2024.176515. Online ahead of print.ABSTRACTOrai1 channel capacity to control store-operated Ca2+ entry (SOCE) and B-cell functions is poorly understood and more specifically in B-cell cancers, including human lymphoma and leukemia. As compared to normal B-cells, Orai1 is overexpressed in B-chronic lymphocytic leukemia (B-CLL) and contributes in resting B-CLL to mediate an elevated basal Ca2+ level through a constitutive Ca2+ entry, and in BCR-activated B-cell to regulate the Ca2+ signaling response. Such observations were confirmed in human B-cell lymphoma and ...
Source: European Journal of Pharmacology - March 28, 2024 Category: Drugs & Pharmacology Authors: Julien Scaviner Cristina Bagacean Berthou Christian Yves Renaudineau Olivier Mignen Souleymane Abdoul-Azize Source Type: research
Blocking Orai1 constitutive activity inhibits B-cell cancer migration and synergistically acts with drugs to reduce B-CLL cell survival
Eur J Pharmacol. 2024 Mar 26:176515. doi: 10.1016/j.ejphar.2024.176515. Online ahead of print.ABSTRACTOrai1 channel capacity to control store-operated Ca2+ entry (SOCE) and B-cell functions is poorly understood and more specifically in B-cell cancers, including human lymphoma and leukemia. As compared to normal B-cells, Orai1 is overexpressed in B-chronic lymphocytic leukemia (B-CLL) and contributes in resting B-CLL to mediate an elevated basal Ca2+ level through a constitutive Ca2+ entry, and in BCR-activated B-cell to regulate the Ca2+ signaling response. Such observations were confirmed in human B-cell lymphoma and leuk...
Source: European Journal of Pharmacology - March 28, 2024 Category: Drugs & Pharmacology Authors: Julien Scaviner Cristina Bagacean Berthou Christian Yves Renaudineau Olivier Mignen Souleymane Abdoul-Azize Source Type: research
Changes in cardiovascular autonomic control induced by chronic inhibition of acetylcholinesterase during pyridostigmine or donepezil treatment of spontaneously hypertensive rats
In conclusion, vagal tone was lower in SHR compared with WKY, but was enhanced by chronic PYR treatment in both strains. Thus, chronic peripheral, but not central, acetylcholinesterase inhibition has major effects on HR and its variability in both normotensive and hypertensive rats.PMID:38537804 | DOI:10.1016/j.ejphar.2024.176526 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 27, 2024 Category: Drugs & Pharmacology Authors: Michal Bencze Almos Boro š Michal Behuliak Anna Vav řínová Ivfana Van ěčková Josef Zicha Source Type: research
Inhibition of melanoma cell migration and invasion by natural coumarin auraptene through regulating EMT markers and reducing MMP-2 and MMP-9 activity
In this study, we aimed to investigate whether AUR could induce inhibitory effects on the migration and invasion of melanoma cells. B16F10 melanoma cells were treated with different concentrations of AUR and the viability of cells was evaluated by alamarBlue assay. Then, cells were treated with 20 μM AUR, and wound healing, invasion, and adhesion assays were carried out. In addition, the activity of matrix metalloproteinase-2 (MMP-2) and MMP-9 was assessed by gelatin zymography and the expression of genes related to epithelial-mesenchymal transition (EMT) was investigated by qPCR. Finally, the interactions between AUR and...
Source: European Journal of Pharmacology - March 27, 2024 Category: Drugs & Pharmacology Authors: Fatemehsadat Hosseini Abdolreza Ahmadi Halimeh Hassanzade Shahin Gharedaghi Fatemeh B Rassouli Khadijeh Jamialahmadi Source Type: research
Potential targets for the treatment of MI: GRP75-mediated Ca < sup > 2+ < /sup > transfer in MAM
Eur J Pharmacol. 2024 Mar 23:176530. doi: 10.1016/j.ejphar.2024.176530. Online ahead of print.ABSTRACTAfter myocardial infarction (MI), there is a notable disruption in cellular calcium ion homeostasis and mitochondrial function, which is believed to be intricately linked to endoplasmic reticulum (ER) stress. This research endeavors to elucidate the involvement of glucose regulated protein 75 (GRP75) in post-MI calcium ion homeostasis and mitochondrial function. In MI rats, symptoms of myocardial injury were accompanied by an increase in the activation of ER stress. Moreover, in oxygen-glucose deprivation (OGD)-induced car...
Source: European Journal of Pharmacology - March 25, 2024 Category: Drugs & Pharmacology Authors: Chenyan Zhang Bowen Liu Jiaxing Sheng Jia Wang Weijie Zhu Chen Xie Xuan Zhou Yuxin Zhang Qinghai Meng Yu Li Source Type: research
Deciphering the dual role of N-methyl-D-Aspartate receptor in postoperative cognitive dysfunction: A comprehensive review
Eur J Pharmacol. 2024 Mar 23:176520. doi: 10.1016/j.ejphar.2024.176520. Online ahead of print.ABSTRACTPostoperative cognitive dysfunction (POCD) is a common complication following surgery, adversely impacting patients' recovery, increasing the risk of negative outcomes, prolonged hospitalization, and higher mortality rates. The N-methyl-D-aspartate (NMDA) receptor, crucial for learning, memory, and synaptic plasticity, plays a significant role in the development of POCD. Various perioperative factors, including age and anesthetic use, can reduce NMDA receptor function, while surgical stress, inflammation, and pain may lead...
Source: European Journal of Pharmacology - March 25, 2024 Category: Drugs & Pharmacology Authors: Shaodi Guan Yali Li Yueyang Xin Danning Wang Pei Lu Fanglong Han Hui Xu Source Type: research
Potential targets for the treatment of MI: GRP75-mediated Ca < sup > 2+ < /sup > transfer in MAM
Eur J Pharmacol. 2024 Mar 23:176530. doi: 10.1016/j.ejphar.2024.176530. Online ahead of print.ABSTRACTAfter myocardial infarction (MI), there is a notable disruption in cellular calcium ion homeostasis and mitochondrial function, which is believed to be intricately linked to endoplasmic reticulum (ER) stress. This research endeavors to elucidate the involvement of glucose regulated protein 75 (GRP75) in post-MI calcium ion homeostasis and mitochondrial function. In MI rats, symptoms of myocardial injury were accompanied by an increase in the activation of ER stress. Moreover, in oxygen-glucose deprivation (OGD)-induced car...
Source: European Journal of Pharmacology - March 25, 2024 Category: Drugs & Pharmacology Authors: Chenyan Zhang Bowen Liu Jiaxing Sheng Jia Wang Weijie Zhu Chen Xie Xuan Zhou Yuxin Zhang Qinghai Meng Yu Li Source Type: research
Deciphering the dual role of N-methyl-D-Aspartate receptor in postoperative cognitive dysfunction: A comprehensive review
Eur J Pharmacol. 2024 Mar 23:176520. doi: 10.1016/j.ejphar.2024.176520. Online ahead of print.ABSTRACTPostoperative cognitive dysfunction (POCD) is a common complication following surgery, adversely impacting patients' recovery, increasing the risk of negative outcomes, prolonged hospitalization, and higher mortality rates. The N-methyl-D-aspartate (NMDA) receptor, crucial for learning, memory, and synaptic plasticity, plays a significant role in the development of POCD. Various perioperative factors, including age and anesthetic use, can reduce NMDA receptor function, while surgical stress, inflammation, and pain may lead...
Source: European Journal of Pharmacology - March 25, 2024 Category: Drugs & Pharmacology Authors: Shaodi Guan Yali Li Yueyang Xin Danning Wang Pei Lu Fanglong Han Hui Xu Source Type: research
Potential targets for the treatment of MI: GRP75-mediated Ca < sup > 2+ < /sup > transfer in MAM
Eur J Pharmacol. 2024 Mar 23:176530. doi: 10.1016/j.ejphar.2024.176530. Online ahead of print.ABSTRACTAfter myocardial infarction (MI), there is a notable disruption in cellular calcium ion homeostasis and mitochondrial function, which is believed to be intricately linked to endoplasmic reticulum (ER) stress. This research endeavors to elucidate the involvement of glucose regulated protein 75 (GRP75) in post-MI calcium ion homeostasis and mitochondrial function. In MI rats, symptoms of myocardial injury were accompanied by an increase in the activation of ER stress. Moreover, in oxygen-glucose deprivation (OGD)-induced car...
Source: European Journal of Pharmacology - March 25, 2024 Category: Drugs & Pharmacology Authors: Chenyan Zhang Bowen Liu Jiaxing Sheng Jia Wang Weijie Zhu Chen Xie Xuan Zhou Yuxin Zhang Qinghai Meng Yu Li Source Type: research
Deciphering the dual role of N-methyl-D-Aspartate receptor in postoperative cognitive dysfunction: A comprehensive review
Eur J Pharmacol. 2024 Mar 23:176520. doi: 10.1016/j.ejphar.2024.176520. Online ahead of print.ABSTRACTPostoperative cognitive dysfunction (POCD) is a common complication following surgery, adversely impacting patients' recovery, increasing the risk of negative outcomes, prolonged hospitalization, and higher mortality rates. The N-methyl-D-aspartate (NMDA) receptor, crucial for learning, memory, and synaptic plasticity, plays a significant role in the development of POCD. Various perioperative factors, including age and anesthetic use, can reduce NMDA receptor function, while surgical stress, inflammation, and pain may lead...
Source: European Journal of Pharmacology - March 25, 2024 Category: Drugs & Pharmacology Authors: Shaodi Guan Yali Li Yueyang Xin Danning Wang Pei Lu Fanglong Han Hui Xu Source Type: research
FGF17 protects cerebral ischemia reperfusion-induced blood-brain barrier disruption via FGF receptor 3-mediated PI3K/AKT signaling pathway
Eur J Pharmacol. 2024 Mar 22:176521. doi: 10.1016/j.ejphar.2024.176521. Online ahead of print.ABSTRACTMaintaining blood-brain barrier (BBB) integrity is critical components of therapeutic approach for ischemic stroke. Fibroblast growth factor 17 (FGF17), a member of FGF8 superfamily, exhibits the strongest expression throughout the wall of all major arteries during development. However, its molecular action and potential protective role on brain endothelial cells after stroke remains unclear. Here, we observed reduced levels of FGF17 in the serum of patients with ischemic stroke, as well as in the brains of mice subjected ...
Source: European Journal of Pharmacology - March 24, 2024 Category: Drugs & Pharmacology Authors: Wen-Ting Huang Xiong-Jian Chen Yu-Kai Lin Jun-Feng Shi Hong Li Hao-Di Wu Ruo-Lin Jiang Shuai Chen Xue Wang Xian-Xi Tan Ke-Yang Chen Peng Wang Source Type: research
