Regulation mechanisms of sea cucumber peptides against scopolamine-induced memory disorder and novel memory-improving peptides identification
This study further explored the memory-improving mechanisms of sea cucumber peptides using scopolamine-induced memory-impaired mice and identified novel memory-improving peptides within low molecular weight peptide fractions. The sea cucumber peptides were categorized into three groups based on their molecular weights: SCP-L (molecular weight greater than 10 kDa), SCP-M (weight between 3 kDa and 10 kDa), and SCP-S (molecular weight less than 3 kDa). The results showed that SCP-S improved behavioral performance by regulating cholinergic system disorder and reducing oxidative stress levels, distinguishing itself from SCP-M a...
Source: European Journal of Pharmacology - February 18, 2024 Category: Drugs & Pharmacology Authors: Zhiqiang Lu Jingqi Yang Xiaomeng Xu Ruowen Liu Songyi Lin Source Type: research
Inhibition of Alzheimer's disease by 4-octyl itaconate revealed by RNA-seq transcriptome analysis
CONCLUSIONS: Overall, the results of this study demonstrated that 4-OI improved cognitive deficits in AD mice, confirming the therapeutic effect of 4-OI on AD.PMID:38369275 | DOI:10.1016/j.ejphar.2024.176432 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - February 18, 2024 Category: Drugs & Pharmacology Authors: Yingchao Liu Pengcheng Xia Shuai Zong Ni Zheng Xiaolin Cui Cuicui Wang Miaomiao Wang Xueying Wang Shuyi Yu Hao Zhao Zhiming Lu Source Type: research
Tetrahydroberberine alleviates high-fat diet-induced hyperlipidemia in mice via augmenting lipoprotein assembly-induced clearance of low-density lipoprotein and intermediate-density lipoprotein
Eur J Pharmacol. 2024 Feb 16:176433. doi: 10.1016/j.ejphar.2024.176433. Online ahead of print.ABSTRACTThe promotion of excess low-density lipoprotein (LDL) clearance stands as an effective clinical approach for treating hyperlipidemia. Tetrahydroberberine, a metabolite of berberine, exhibits superior bioavailability compared to berberine and demonstrates a pronounced hypolipidemic effect. Despite these characteristics, the impact of tetrahydroberberine on improving excessive LDL clearance in hyperlipidemia has remained unexplored. Thus, this study investigates the potential effects of tetrahydroberberine on high-fat diet-i...
Source: European Journal of Pharmacology - February 18, 2024 Category: Drugs & Pharmacology Authors: Guilan Wei Ning Huang Mengyao Li Fengkun Guan Liping Chen Yingyi Liao Xingyu Xie Yucui Li Ziren Su Jiannan Chen Yuhong Liu Source Type: research
Regulation mechanisms of sea cucumber peptides against scopolamine-induced memory disorder and novel memory-improving peptides identification
This study further explored the memory-improving mechanisms of sea cucumber peptides using scopolamine-induced memory-impaired mice and identified novel memory-improving peptides within low molecular weight peptide fractions. The sea cucumber peptides were categorized into three groups based on their molecular weights: SCP-L (molecular weight greater than 10 kDa), SCP-M (weight between 3 kDa and 10 kDa), and SCP-S (molecular weight less than 3 kDa). The results showed that SCP-S improved behavioral performance by regulating cholinergic system disorder and reducing oxidative stress levels, distinguishing itself from SCP-M a...
Source: European Journal of Pharmacology - February 18, 2024 Category: Drugs & Pharmacology Authors: Zhiqiang Lu Jingqi Yang Xiaomeng Xu Ruowen Liu Songyi Lin Source Type: research
Inhibition of Alzheimer's disease by 4-octyl itaconate revealed by RNA-seq transcriptome analysis
CONCLUSIONS: Overall, the results of this study demonstrated that 4-OI improved cognitive deficits in AD mice, confirming the therapeutic effect of 4-OI on AD.PMID:38369275 | DOI:10.1016/j.ejphar.2024.176432 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - February 18, 2024 Category: Drugs & Pharmacology Authors: Yingchao Liu Pengcheng Xia Shuai Zong Ni Zheng Xiaolin Cui Cuicui Wang Miaomiao Wang Xueying Wang Shuyi Yu Hao Zhao Zhiming Lu Source Type: research
Tetrahydroberberine alleviates high-fat diet-induced hyperlipidemia in mice via augmenting lipoprotein assembly-induced clearance of low-density lipoprotein and intermediate-density lipoprotein
Eur J Pharmacol. 2024 Feb 16:176433. doi: 10.1016/j.ejphar.2024.176433. Online ahead of print.ABSTRACTThe promotion of excess low-density lipoprotein (LDL) clearance stands as an effective clinical approach for treating hyperlipidemia. Tetrahydroberberine, a metabolite of berberine, exhibits superior bioavailability compared to berberine and demonstrates a pronounced hypolipidemic effect. Despite these characteristics, the impact of tetrahydroberberine on improving excessive LDL clearance in hyperlipidemia has remained unexplored. Thus, this study investigates the potential effects of tetrahydroberberine on high-fat diet-i...
Source: European Journal of Pharmacology - February 18, 2024 Category: Drugs & Pharmacology Authors: Guilan Wei Ning Huang Mengyao Li Fengkun Guan Liping Chen Yingyi Liao Xingyu Xie Yucui Li Ziren Su Jiannan Chen Yuhong Liu Source Type: research
Regulation mechanisms of sea cucumber peptides against scopolamine-induced memory disorder and novel memory-improving peptides identification
This study further explored the memory-improving mechanisms of sea cucumber peptides using scopolamine-induced memory-impaired mice and identified novel memory-improving peptides within low molecular weight peptide fractions. The sea cucumber peptides were categorized into three groups based on their molecular weights: SCP-L (molecular weight greater than 10 kDa), SCP-M (weight between 3 kDa and 10 kDa), and SCP-S (molecular weight less than 3 kDa). The results showed that SCP-S improved behavioral performance by regulating cholinergic system disorder and reducing oxidative stress levels, distinguishing itself from SCP-M a...
Source: European Journal of Pharmacology - February 18, 2024 Category: Drugs & Pharmacology Authors: Zhiqiang Lu Jingqi Yang Xiaomeng Xu Ruowen Liu Songyi Lin Source Type: research
Inhibition of Alzheimer's disease by 4-octyl itaconate revealed by RNA-seq transcriptome analysis
CONCLUSIONS: Overall, the results of this study demonstrated that 4-OI improved cognitive deficits in AD mice, confirming the therapeutic effect of 4-OI on AD.PMID:38369275 | DOI:10.1016/j.ejphar.2024.176432 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - February 18, 2024 Category: Drugs & Pharmacology Authors: Yingchao Liu Pengcheng Xia Shuai Zong Ni Zheng Xiaolin Cui Cuicui Wang Miaomiao Wang Xueying Wang Shuyi Yu Hao Zhao Zhiming Lu Source Type: research
A peripheral blood mononuclear cell-based in vitro model: A tool to explore indoleamine 2, 3-dioxygenase-1 (IDO1)
CONCLUSION: IDO1 inhibition did not change T lymphocyte proliferation. We present herein an in vitro experimental model suitable to measure IDO1 expression and activity in circulating myeloid cells.PMID:38367683 | DOI:10.1016/j.ejphar.2024.176420 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - February 17, 2024 Category: Drugs & Pharmacology Authors: Milene Gon çalves Alessia Furgiuele Emanuela Rasini Massimiliano Legnaro Marco Ferrari Alessandra Luini Paulo Rodrigues-Santos Francisco Caramelo Franca Marino Frederico C Pereira Marco Cosentino Source Type: research
Toxicology, pharmacokinetics, and immunogenicity studies of CCR4-IL2 bispecific immunotoxin in rats and minipigs
In this study, we have performed non-GLP (Good Laboratory Practice) toxicology, pharmacokinetics, immunogenicity studies of CCR4-IL2-IT in both rats and minipigs. CCR4-IL2-IT demonstrated excellent safety profiles in both rats and minipigs. The maximum tolerated dose of CCR4-IL2-IT was determined as 0.4 mg/kg in both rats and minipigs. Complete blood count and chemistry analysis did not show significant difference for all measured parameters between the blood samples of pre-injection versus post-injection from the five-day toxicology studies of CCT4-IL2-IT in both rats and minipigs. Histology analysis did not show differen...
Source: European Journal of Pharmacology - February 17, 2024 Category: Drugs & Pharmacology Authors: Zhaohui Wang Rashmi Ramakrishna Yong Wang Yue Qiu Jihong Ma Danielle Mintzlaff Huiping Zhang Bing Li Benjamin Hammell M Scott Lucia Elizabeth Pomfret An-Jey Su Kia M Washington David W Mathes Zhirui Wang Source Type: research
Metformin improves obesity-related oligoasthenospermia via regulating the expression of HSL in testis in mice
This study was performed to confirm whether obesity contributes to oligoasthenospermia as well as the underlying mechanisms in mice fed with a high fat diet (HFD). Meanwhile, the actions of metformin, a drug of well-known weight-lowering effect, on sperm quality in obese mice were investigated. Our results showed that HFD feeding reduced sperm quality and steroid hormone levels in mice, associated with disruptions in testicular histomorphology and spermatogenesis. Moreover, obesity increased sperm apoptosis. These effects could be prevented by metformin treatment in HFD-fed mice. Mechanistically, an increasement in lipid c...
Source: European Journal of Pharmacology - February 17, 2024 Category: Drugs & Pharmacology Authors: Jinhui Dong Xiaohui Tong Jing Xu Min Pan Lei Wang Fei Xu Yajuan Wang Li Li Tongsheng Wang Source Type: research
A peripheral blood mononuclear cell-based in vitro model: A tool to explore indoleamine 2, 3-dioxygenase-1 (IDO1)
CONCLUSION: IDO1 inhibition did not change T lymphocyte proliferation. We present herein an in vitro experimental model suitable to measure IDO1 expression and activity in circulating myeloid cells.PMID:38367683 | DOI:10.1016/j.ejphar.2024.176420 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - February 17, 2024 Category: Drugs & Pharmacology Authors: Milene Gon çalves Alessia Furgiuele Emanuela Rasini Massimiliano Legnaro Marco Ferrari Alessandra Luini Paulo Rodrigues-Santos Francisco Caramelo Franca Marino Frederico C Pereira Marco Cosentino Source Type: research
Toxicology, pharmacokinetics, and immunogenicity studies of CCR4-IL2 bispecific immunotoxin in rats and minipigs
In this study, we have performed non-GLP (Good Laboratory Practice) toxicology, pharmacokinetics, immunogenicity studies of CCR4-IL2-IT in both rats and minipigs. CCR4-IL2-IT demonstrated excellent safety profiles in both rats and minipigs. The maximum tolerated dose of CCR4-IL2-IT was determined as 0.4 mg/kg in both rats and minipigs. Complete blood count and chemistry analysis did not show significant difference for all measured parameters between the blood samples of pre-injection versus post-injection from the five-day toxicology studies of CCT4-IL2-IT in both rats and minipigs. Histology analysis did not show differen...
Source: European Journal of Pharmacology - February 17, 2024 Category: Drugs & Pharmacology Authors: Zhaohui Wang Rashmi Ramakrishna Yong Wang Yue Qiu Jihong Ma Danielle Mintzlaff Huiping Zhang Bing Li Benjamin Hammell M Scott Lucia Elizabeth Pomfret An-Jey Su Kia M Washington David W Mathes Zhirui Wang Source Type: research
Metformin improves obesity-related oligoasthenospermia via regulating the expression of HSL in testis in mice
This study was performed to confirm whether obesity contributes to oligoasthenospermia as well as the underlying mechanisms in mice fed with a high fat diet (HFD). Meanwhile, the actions of metformin, a drug of well-known weight-lowering effect, on sperm quality in obese mice were investigated. Our results showed that HFD feeding reduced sperm quality and steroid hormone levels in mice, associated with disruptions in testicular histomorphology and spermatogenesis. Moreover, obesity increased sperm apoptosis. These effects could be prevented by metformin treatment in HFD-fed mice. Mechanistically, an increasement in lipid c...
Source: European Journal of Pharmacology - February 17, 2024 Category: Drugs & Pharmacology Authors: Jinhui Dong Xiaohui Tong Jing Xu Min Pan Lei Wang Fei Xu Yajuan Wang Li Li Tongsheng Wang Source Type: research
γ-Glutamylcysteine ameliorates blood-brain barrier permeability and neutrophil extracellular traps formation after ischemic stroke by modulating Wnt/β-catenin signalling in mice
In this study, we aimed to investigate the protective effects of γ-Glutamylcysteine (γ-GC), an immediate precursor of GSH, against BBB breakdown and NET formation after ischemic stroke. Our data indicated that γ-GC treatment effectively attenuated BBB damage, decreased neutrophil infiltration, and suppressed the release of NETs, ultimately leading to the amelioration of ischemic injury. Transcriptomic data and subsequent validation studies revealed that mechanistically, γ-GC exerts its effect by activating the Wnt/β-catenin pathway after ischemic stroke. This research suggests that γ-GC may hold promise as a therapeu...
Source: European Journal of Pharmacology - February 16, 2024 Category: Drugs & Pharmacology Authors: Xinya Gu Mengqi Dong Shengnan Xia Huiqin Li Xinyu Bao Xiang Cao Yun Xu Source Type: research
