Skeletal muscle atrophy after sciatic nerve damage: Mechanistic insights
Eur J Pharmacol. 2024 Mar 14:176506. doi: 10.1016/j.ejphar.2024.176506. Online ahead of print.ABSTRACTSciatic nerve injury leads to molecular events that cause muscular dysfunction advancement in atrophic conditions. Nerve damage renders muscles permanently relaxed which elevates intracellular resting Ca2+ levels. Increased Ca2+ levels are associated with several cellular signaling pathways including AMPK, cGMP, PLC-β, CERB, and calcineurin. Also, multiple enzymes involved in the tricarboxylic acid cycle and oxidative phosphorylation are activated by Ca2+ influx into mitochondria during muscle contraction, to meet increas...
Source: European Journal of Pharmacology - March 16, 2024 Category: Drugs & Pharmacology Authors: Aarti Yadav Rajesh Dabur Source Type: research

Curcumin analogue NL04 inhibits spinal cord central sensitization in rats with bone cancer pain by inhibiting NLRP3 inflammasome activation and reducing IL-1 β production
Eur J Pharmacol. 2024 Mar 13:176480. doi: 10.1016/j.ejphar.2024.176480. Online ahead of print.ABSTRACTThe management and therapy of bone cancer pain (BCP) remain formidable clinical challenges. Curcumin and its analogues have been shown to have anti-inflammatory and analgesic properties. In the present study, we investigated the efficacy of curcumin analogue NL04 (NL04) in modulating inflammation in spinal dorsal horn (SDH), thereby exploring its potential to reduce central sensitization of BCP in a rat model. Differing doses of NL04 and curcumin were administered intrathecally either once (on day 12 of BCP) or over seven ...
Source: European Journal of Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Liping Chen Bohan Hua Qiuli He Zixin Han Yahui Wang Yujing Chen Huadong Ni Zefeng Zhu Longsheng Xu Ming Yao Chaobo Ni Source Type: research

Corrigendum to "Na(+)-dependent inactivation of vascular Na(+)/Ca(2+) exchanger responsible for reduced peripheral blood flow in neuropathic pain model" [Eur. J. Pharmacol. 910 (2021) 174448]
Eur J Pharmacol. 2024 Mar 14:176495. doi: 10.1016/j.ejphar.2024.176495. Online ahead of print.NO ABSTRACTPMID:38490839 | DOI:10.1016/j.ejphar.2024.176495 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: H Ishida M Yamaguchi S Y Saito T Furukawa J L Shannonhouse Y S Kim T Ishikawa Source Type: research

Curcumin analogue NL04 inhibits spinal cord central sensitization in rats with bone cancer pain by inhibiting NLRP3 inflammasome activation and reducing IL-1 β production
Eur J Pharmacol. 2024 Mar 13:176480. doi: 10.1016/j.ejphar.2024.176480. Online ahead of print.ABSTRACTThe management and therapy of bone cancer pain (BCP) remain formidable clinical challenges. Curcumin and its analogues have been shown to have anti-inflammatory and analgesic properties. In the present study, we investigated the efficacy of curcumin analogue NL04 (NL04) in modulating inflammation in spinal dorsal horn (SDH), thereby exploring its potential to reduce central sensitization of BCP in a rat model. Differing doses of NL04 and curcumin were administered intrathecally either once (on day 12 of BCP) or over seven ...
Source: European Journal of Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Liping Chen Bohan Hua Qiuli He Zixin Han Yahui Wang Yujing Chen Huadong Ni Zefeng Zhu Longsheng Xu Ming Yao Chaobo Ni Source Type: research

Corrigendum to "Na(+)-dependent inactivation of vascular Na(+)/Ca(2+) exchanger responsible for reduced peripheral blood flow in neuropathic pain model" [Eur. J. Pharmacol. 910 (2021) 174448]
Eur J Pharmacol. 2024 Mar 14:176495. doi: 10.1016/j.ejphar.2024.176495. Online ahead of print.NO ABSTRACTPMID:38490839 | DOI:10.1016/j.ejphar.2024.176495 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: H Ishida M Yamaguchi S Y Saito T Furukawa J L Shannonhouse Y S Kim T Ishikawa Source Type: research

Blocking of FGFR4 signaling by F30 inhibits hepatocellular carcinoma cell proliferation through HMOX1-dependent ferroptosis pathway
We report here that F30 could effectively induce ferroptosis in HCC cells. The concentrations of cellular ferrous iron, the peroxidation of cell membranes and the homeostasis of reduced glutathione (GSH)/oxidized glutathione disulfide (GSSG) were dysregulated by F30, thereby affecting cellular redox status. Induction of ferroptosis in HCC by F30 was inhibited by specific ferroptosis inhibitor ferrostatin-1. F30 upregulates various ferroptosis-related genes, including the heme oxygenase enzymes 1 (HMOX1), a key mediator of redox regulation. Surprisingly, F30-induced ferroptosis in HCC is dependent on HMOX1. The dysregulatio...
Source: European Journal of Pharmacology - March 14, 2024 Category: Drugs & Pharmacology Authors: Fengyu Huang Xueqin Shi Meng Hu Hang Yan Xiaohui Li Yujie Ding Xinxin Zheng Xiaojun Cai Shijie Dai Qinqin Xia Yuepiao Cai Source Type: research

The role of astrocytic γ-aminobutyric acid in the action of inhalational anesthetics
CONCLUSIONS: MAOB knockout mice showed reduced sensitivity to the hypnotic and immobilizing effects of isoflurane, sevoflurane, and desflurane. Behavioral tests revealed that the hypnotic and immobilizing effects of inhalational anesthetics would be mediated by astrocytic GABA.PMID:38484926 | DOI:10.1016/j.ejphar.2024.176494 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 14, 2024 Category: Drugs & Pharmacology Authors: Dongwook Won Elliot H Lee Jee-Eun Chang Min-Ho Nam Ki Duk Park Soo-Jin Oh Jin-Young Hwang Source Type: research

Blocking of FGFR4 signaling by F30 inhibits hepatocellular carcinoma cell proliferation through HMOX1-dependent ferroptosis pathway
We report here that F30 could effectively induce ferroptosis in HCC cells. The concentrations of cellular ferrous iron, the peroxidation of cell membranes and the homeostasis of reduced glutathione (GSH)/oxidized glutathione disulfide (GSSG) were dysregulated by F30, thereby affecting cellular redox status. Induction of ferroptosis in HCC by F30 was inhibited by specific ferroptosis inhibitor ferrostatin-1. F30 upregulates various ferroptosis-related genes, including the heme oxygenase enzymes 1 (HMOX1), a key mediator of redox regulation. Surprisingly, F30-induced ferroptosis in HCC is dependent on HMOX1. The dysregulatio...
Source: European Journal of Pharmacology - March 14, 2024 Category: Drugs & Pharmacology Authors: Fengyu Huang Xueqin Shi Meng Hu Hang Yan Xiaohui Li Yujie Ding Xinxin Zheng Xiaojun Cai Shijie Dai Qinqin Xia Yuepiao Cai Source Type: research

The role of astrocytic γ-aminobutyric acid in the action of inhalational anesthetics
CONCLUSIONS: MAOB knockout mice showed reduced sensitivity to the hypnotic and immobilizing effects of isoflurane, sevoflurane, and desflurane. Behavioral tests revealed that the hypnotic and immobilizing effects of inhalational anesthetics would be mediated by astrocytic GABA.PMID:38484926 | DOI:10.1016/j.ejphar.2024.176494 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 14, 2024 Category: Drugs & Pharmacology Authors: Dongwook Won Elliot H Lee Jee-Eun Chang Min-Ho Nam Ki Duk Park Soo-Jin Oh Jin-Young Hwang Source Type: research

Activation of CaMKII/HDAC4 by SDF1 contributes to pulmonary arterial hypertension via stabilization Runx2
Eur J Pharmacol. 2024 Mar 11;970:176483. doi: 10.1016/j.ejphar.2024.176483. Online ahead of print.ABSTRACTStromal derived factor 1 (SDF1) has been shown to be involved in the pathogenesis of pulmonary artery hypertension (PAH). However, the detailed molecular mechanisms remain unclear. To address this, we utilized primary cultured rat pulmonary artery smooth muscle cells (PASMCs) and monocrotaline (MCT)-induced PAH rat models to investigate the mechanisms of SDF1 driving PASMCs proliferation and pulmonary arterial remodeling. SDF1 increased runt-related transcription factor 2 (Runx2) acetylation by Calmodulin (CaM)-depende...
Source: European Journal of Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Authors: Yuqian Chen Jin Liu Qianqian Zhang Limin Chai Huan Chen Danyang Li Yan Wang Yuanjie Qiu Nirui Shen Jia Zhang Qingting Wang Jian Wang Xinming Xie Shaojun Li Manxiang Li Source Type: research

Arglabin: A mediator of inflammasome modulated and independent myocardial injury (PARA-AMI study)
CONCLUSION: Arglabin imparted partial cardio-protection via an inflammasome-dependent pathway and mediated injury through the inflammasome-independent pathway.PMID:38479722 | DOI:10.1016/j.ejphar.2024.176465 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Authors: Khushboo Bisht Vipin Kumar Verma Zia Abdullah Vaishali Prajapati Narang Rajiv Jagriti Bhatia Ruma Ray Tapas Chandra Nag Dharamvir Singh Arya Source Type: research

Targeting oncogenic kinases: Insights on FDA approved tyrosine kinase inhibitors
Eur J Pharmacol. 2024 Mar 9:176484. doi: 10.1016/j.ejphar.2024.176484. Online ahead of print.ABSTRACTProtein kinases play pivotal roles in various biological functions, influencing cell differentiation, promoting survival, and regulating the cell cycle. The disruption of protein kinase activity is intricately linked to pathways in tumor development. This manuscript explores the transformative impact of protein kinase inhibitors on cancer therapy, particularly their efficacy in cases driven by targeted mutations. Focusing on key tyrosine kinase inhibitors (TKIs) like Bcr-Abl, Epidermal Growth Factor Receptor (EGFR), and Vas...
Source: European Journal of Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Sahil Hussain Mohd Mursal Garima Verma Syed Misbahul Hasan Mohemmed Faraz Khan Source Type: research

Targeting oncogenic kinases: Insights on FDA approved tyrosine kinase inhibitors
Eur J Pharmacol. 2024 Mar 9:176484. doi: 10.1016/j.ejphar.2024.176484. Online ahead of print.ABSTRACTProtein kinases play pivotal roles in various biological functions, influencing cell differentiation, promoting survival, and regulating the cell cycle. The disruption of protein kinase activity is intricately linked to pathways in tumor development. This manuscript explores the transformative impact of protein kinase inhibitors on cancer therapy, particularly their efficacy in cases driven by targeted mutations. Focusing on key tyrosine kinase inhibitors (TKIs) like Bcr-Abl, Epidermal Growth Factor Receptor (EGFR), and Vas...
Source: European Journal of Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Sahil Hussain Mohd Mursal Garima Verma Syed Misbahul Hasan Mohemmed Faraz Khan Source Type: research

Targeting oncogenic kinases: Insights on FDA approved tyrosine kinase inhibitors
Eur J Pharmacol. 2024 Mar 9:176484. doi: 10.1016/j.ejphar.2024.176484. Online ahead of print.ABSTRACTProtein kinases play pivotal roles in various biological functions, influencing cell differentiation, promoting survival, and regulating the cell cycle. The disruption of protein kinase activity is intricately linked to pathways in tumor development. This manuscript explores the transformative impact of protein kinase inhibitors on cancer therapy, particularly their efficacy in cases driven by targeted mutations. Focusing on key tyrosine kinase inhibitors (TKIs) like Bcr-Abl, Epidermal Growth Factor Receptor (EGFR), and Vas...
Source: European Journal of Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Sahil Hussain Mohd Mursal Garima Verma Syed Misbahul Hasan Mohemmed Faraz Khan Source Type: research

Pyroptosis in myocardial ischemia/reperfusion and its therapeutic implications
Eur J Pharmacol. 2024 Mar 8:176464. doi: 10.1016/j.ejphar.2024.176464. Online ahead of print.ABSTRACTIschemic heart disease, a prevalent cardiovascular disease with global significance, is associated with substantial morbidity. Timely and successful reperfusion is crucial for reducing infarct size and enhancing clinical outcomes. However, reperfusion may induce additional myocardium injury, manifesting as myocardial ischemia/reperfusion (MI/R) injury. Pyroptosis is a regulated cell death pathway, the signaling pathway of which is activated during MI/R injury. In this process, the inflammasomes are triggered, initiating the...
Source: European Journal of Pharmacology - March 10, 2024 Category: Drugs & Pharmacology Authors: Yin Liu Xi Li Tingting Sun Tao Li Qian Li Source Type: research