Role of cAMP/pCREB and GSK-3 β/NF-κB p65 signaling pathways in the renoprotective effect of mirabegron against renal ischemia-reperfusion injury in rats
Eur J Pharmacol. 2024 Apr 26:176617. doi: 10.1016/j.ejphar.2024.176617. Online ahead of print.ABSTRACTAcute kidney injury and other renal disorders are thought to be primarily caused by renal ischemia-reperfusion (RIR). Cyclic adenosine monophosphate (cAMP) has plenty of physiological pleiotropic effects and preserves tissue integrity and functions. This research aimed to examine the potential protective effects of the β3-adrenergic receptors agonist mirabegron in a rat model of RIR and its underlying mechanisms. Male rats enrolled in this work were given an oral dose of 30 mg/kg mirabegron for two days before surgical in...
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Marwa A Ahmed Esam O Kamel Ahmed M Abd-Eldayem Source Type: research

Research on the potential mechanism of Deapioplatycodin D against Pulmonary fibrosis based on bioinformatics and experimental verification
CONCLUSION: In short, these comprehensive analysis methods were employed to identify critical biomarkers closely related to PF, which helps to elucidate the pathogenesis and potential immunotherapy targets of PF. It also provides essential support for the potential of DPD against PF.PMID:38679121 | DOI:10.1016/j.ejphar.2024.176603 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Chao Li Aliya Abdurehim Shuang Zhao Qing Sun Jiawen Xu Junbo Xie Yanqing Zhang Source Type: research

Estradiol modulates the role of the spinal α < sub > 6 < /sub > -subunit containing GABA < sub > A < /sub > receptors in female rats with neuropathic pain
Eur J Pharmacol. 2024 Apr 26:176616. doi: 10.1016/j.ejphar.2024.176616. Online ahead of print.ABSTRACTThe purpose of this study was to investigate the mechanisms underlying sex differences in the role of spinal α6-subunit containing GABAA (α6GABAA) receptors in rats with neuropathic pain. Intrathecal 2,5-dihydro-7-methoxy-2-(4-methoxyphenyl)-3H-pyrazolo [4,3-c] quinoline-3-one (PZ-II-029, positive allosteric modulator of α6GABAA receptors) reduced tactile allodynia in female but not in male rats with neuropathic pain. PZ-II-029 was also more effective in females than males in inflammatory and nociplastic pain. Ovariecto...
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Erick J Rodr íguez-Palma Ana M Islas-Espinoza Itzel I Ramos-Rodr íguez Juan Miguel Piza ña-Encarnación Miguel Á Gutiérez-Agredano Ciciolil Morales-Moreno Alonso Fern ández-Guasti Vinicio Granados-Soto Source Type: research

Biochanin A: Disrupting the Inflammatory Vicious Cycle for Dry Eye Disease
This study investigated BCA's therapeutic potential for DED. Human corneal epithelial cells were cultured under hyperosmotic conditions to mimic DED. BCA treatment increased cell viability and decreased apoptosis and inflammatory cytokine expression. A DED mouse model was developed using female C57BL/6 mice in a controlled low-humidity environment combined with scopolamine injections. Mice received eye drops containing phosphate-buffered saline, low-dose BCA, or high-dose BCA. The effectiveness was evaluated by measuring tear volume, fluorescein staining, eye-closing ratio, corneal sensitivity and PAS staining. The levels ...
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Taige Chen Nan Zhou Qi Liang Qi Li Boda Li Yiran Chu Di Zhang Zeying Chen Jia-Ruei Tsao Xuebing Feng Kai Hu Source Type: research

Arctigenin induces activated HSCs quiescence via AMPK-PPAR γ pathway to ameliorate liver fibrosis in mice
Eur J Pharmacol. 2024 Apr 26:176629. doi: 10.1016/j.ejphar.2024.176629. Online ahead of print.ABSTRACTArctigenin (ATG), a traditional Chinese herbal medicine, is a natural lignan compound extracted from the seeds of burdock (Arctium lappa L, Asteraceae). As a natural product with multiple biological activities, the effect and mechanism of ATG against liver fibrosis are not fully elucidated yet. In current work, we first discovered that ATG could improve CCl4-induced liver injury reflected by lower plasma ALT and AST levels, liver coefficient and pathological scoring of ballooning. Furthermore, it also could reduce the posi...
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Mengjia Lv Shiyi Chen Mengwen Shan Yuan Si Chenggang Huang Jing Chen Likun Gong Source Type: research

Improving Chimeric Antigen Receptor T-cell therapies by using Artificial Intelligence and Internet of Things Technologies: A Narrative Review
Eur J Pharmacol. 2024 Apr 26:176618. doi: 10.1016/j.ejphar.2024.176618. Online ahead of print.ABSTRACTCancer poses a formidable challenge in the field of medical science, prompting the exploration of innovative and efficient treatment strategies. One revolutionary breakthrough in cancer therapy is Chimeric Antigen Receptor (CAR) T-cell therapy, an avant-garde method involving the customization of a patient's immune cells to combat cancer. Particularly successful in addressing blood cancers, CAR T-cell therapy introduces an unprecedented level of effectiveness, offering the prospect of sustained disease management. As ongoi...
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Alberto Boretti Source Type: research

Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps
CONCLUSIONS AND IMPLICATIONS: Puerarin promoted flap survival from ischemic injury through upregulation of TFEB-mediated autophagy and inhibition of oxidative stress. Our findings offered valuable support for the clinical application of Puerarin in the treatment of ischemic diseases, including random-pattern flaps.PMID:38679118 | DOI:10.1016/j.ejphar.2024.176621 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Yingying Lai Ningning Yang Donghao Shi Xianhui Ma Yingying Huang Jingzhou Lu Xuzi Zhang Hui Zhou Weiyang Gao Cong Mao Long Wang Source Type: research

APOB and CCL17 as Mediators in the Protective Effect of SGLT2 Inhibition against Myocardial Infarction: Insights from Proteome-wide Mendelian Randomization
CONCLUSION: Based on proteome-wide mendelian randomization, APOB and CCL17 were seen as mediators in the protective effect of SGLT2 inhibition against myocardial infarction.PMID:38679119 | DOI:10.1016/j.ejphar.2024.176619 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Lili Shi Gen Li Ningxin Hou Ling Tu Jun Li Jinlan Luo Shuiqing Hu Source Type: research

Role of cAMP/pCREB and GSK-3 β/NF-κB p65 signaling pathways in the renoprotective effect of mirabegron against renal ischemia-reperfusion injury in rats
Eur J Pharmacol. 2024 Apr 26:176617. doi: 10.1016/j.ejphar.2024.176617. Online ahead of print.ABSTRACTAcute kidney injury and other renal disorders are thought to be primarily caused by renal ischemia-reperfusion (RIR). Cyclic adenosine monophosphate (cAMP) has plenty of physiological pleiotropic effects and preserves tissue integrity and functions. This research aimed to examine the potential protective effects of the β3-adrenergic receptors agonist mirabegron in a rat model of RIR and its underlying mechanisms. Male rats enrolled in this work were given an oral dose of 30 mg/kg mirabegron for two days before surgical in...
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Marwa A Ahmed Esam O Kamel Ahmed M Abd-Eldayem Source Type: research

Research on the potential mechanism of Deapioplatycodin D against Pulmonary fibrosis based on bioinformatics and experimental verification
CONCLUSION: In short, these comprehensive analysis methods were employed to identify critical biomarkers closely related to PF, which helps to elucidate the pathogenesis and potential immunotherapy targets of PF. It also provides essential support for the potential of DPD against PF.PMID:38679121 | DOI:10.1016/j.ejphar.2024.176603 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Chao Li Aliya Abdurehim Shuang Zhao Qing Sun Jiawen Xu Junbo Xie Yanqing Zhang Source Type: research

Estradiol modulates the role of the spinal α < sub > 6 < /sub > -subunit containing GABA < sub > A < /sub > receptors in female rats with neuropathic pain
Eur J Pharmacol. 2024 Apr 26:176616. doi: 10.1016/j.ejphar.2024.176616. Online ahead of print.ABSTRACTThe purpose of this study was to investigate the mechanisms underlying sex differences in the role of spinal α6-subunit containing GABAA (α6GABAA) receptors in rats with neuropathic pain. Intrathecal 2,5-dihydro-7-methoxy-2-(4-methoxyphenyl)-3H-pyrazolo [4,3-c] quinoline-3-one (PZ-II-029, positive allosteric modulator of α6GABAA receptors) reduced tactile allodynia in female but not in male rats with neuropathic pain. PZ-II-029 was also more effective in females than males in inflammatory and nociplastic pain. Ovariecto...
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Erick J Rodr íguez-Palma Ana M Islas-Espinoza Itzel I Ramos-Rodr íguez Juan Miguel Piza ña-Encarnación Miguel Á Gutiérez-Agredano Ciciolil Morales-Moreno Alonso Fern ández-Guasti Vinicio Granados-Soto Source Type: research

Biochanin A: Disrupting the Inflammatory Vicious Cycle for Dry Eye Disease
This study investigated BCA's therapeutic potential for DED. Human corneal epithelial cells were cultured under hyperosmotic conditions to mimic DED. BCA treatment increased cell viability and decreased apoptosis and inflammatory cytokine expression. A DED mouse model was developed using female C57BL/6 mice in a controlled low-humidity environment combined with scopolamine injections. Mice received eye drops containing phosphate-buffered saline, low-dose BCA, or high-dose BCA. The effectiveness was evaluated by measuring tear volume, fluorescein staining, eye-closing ratio, corneal sensitivity and PAS staining. The levels ...
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Taige Chen Nan Zhou Qi Liang Qi Li Boda Li Yiran Chu Di Zhang Zeying Chen Jia-Ruei Tsao Xuebing Feng Kai Hu Source Type: research

Hypoxia-induced TRPM7 Promotes Glycolytic Metabolism and Progression in Hepatocellular Carcinoma
CONCLUSIONS: TRPM7 was directly transcriptionally regulated by HIF-1α, leading to glycolytic metabolic reprogramming and the promotion of HCC proliferation and metastasis in vitro and in vivo. Our findings suggest that TRPM7 might be a potential diagnostic indicator and therapeutic target for HCC.PMID:38677534 | DOI:10.1016/j.ejphar.2024.176601 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Fengbo Zhao Weili Yu Jingyan Hu Yi Xia YuXuan Li Siqi Liu Aifen Liu Chengniu Wang Hong Zhang Lei Zhang Jianwu Shi Source Type: research

Mechanisms and emerging strategies for irinotecan-induced diarrhea
Eur J Pharmacol. 2024 Apr 25:176614. doi: 10.1016/j.ejphar.2024.176614. Online ahead of print.ABSTRACTIrinotecan (also known as CPT-11) is a topoisomerase I inhibitor first approved for clinical use as an anticancer agent in 1996. Over the past more than two decades, it has been widely used for combination regimens to treat various malignancies, especially in gastrointestinal and lung cancers. However, severe dose-limiting toxicities, especially gastrointestinal toxicity such as late-onset diarrhea, were frequently observed in irinotecan-based therapy, thus largely limiting the clinical application of this agent. Current k...
Source: European Journal of Pharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Shengkun Xu Huiyin Lan Chengyi Huang Xingnan Ge Ji Zhu Source Type: research

Ginsenoside Rb1 ameliorates lipotoxicity-induced myocardial injury in diabetes mellitus by regulating Mfn2
CONCLUSION: GRb1 alleviated myocardial lipid accumulation and mitochondrial injury, and attenuated ventricular diastolic dysfunction in diabetic mice. The regulation of Mfn2 was involved in the protective effects of GRb1 against lipotoxic myocardial injury.PMID:38677536 | DOI:10.1016/j.ejphar.2024.176609 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 27, 2024 Category: Drugs & Pharmacology Authors: Louyin Ji Hui Han Xiaoli Shan Pei Zhao Huihua Chen Chen Zhang Ming Xu Rong Lu Wei Guo Source Type: research