Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension

In conclusion, CRA attenuated the PDGF-PDGF receptor β-STAT3/NF-κB signaling axis in macrophages and PASMCs, and thus, ameliorated pulmonary vascular remodeling in PAH.PMID:38614383 | DOI:10.1016/j.ejphar.2024.176564

Source: European Journal of Pharmacology - April 13, 2024 Category: Drugs & Pharmacology Authors: Aya Yamamura Moe Fujiwara Akiko Kawade Taiki Amano Alamgir Hossain Md Junayed Nayeem Rubii Kondo Yoshiaki Suzuki Yasumichi Inoue Hidetoshi Hayashi Susumu Suzuki Motohiko Sato Hisao Yamamura Source Type: research